Digital Forensic investigations play a vital role in our technologically enhanced world, and it may incorporate a number of different types of evidence — ranging from digital to physical. During a Digital Forensics investigation an investigator may formulate a number of hypotheses, and in order to reason objectively about them, an investigator must take into account such evidence in its entirety, relying on multiple sources. When formulating such objective reasoning an investigator must take into account not only inculpatory evidence but also exculpatory evidence and evidence of tampering. In addition, the investigator must factor in the reliability of the evidence used, the potential for error (tool and human based) and they must factor in the certainty with which they can make various claims. By doing so and creating a detailed audit trail of all actions performed by the investigator they can be better prepared against challenges against their work when it is presented. An investigator must also take into account the dynamic aspects of an investigation, such as certain evidence no longer being admissible, and they must continuously factor these aspects into their reasoning, to ensure that their conclusions still hold. Investigations may draw over a large period of time, and should the relevant information not be captured in detail, it may be lost or forgotten, affecting the reliability of an investigator’s findings and affecting future investigators’ capability to build on and continue an investigator’s work. In this dissertation we investigate whether it is possible to provide a formalised means for capturing and encoding an investigator’s reasoning process, in a detailed and structured manner. By this we mean we would like to capture and encode an investigator’s hypotheses, their arguments, their conclusions and the certainty with which they can make such claims, as well as the various pieces of evidence (digital and physical) that they use as a foundation for their arguments. We also want to capture the steps an investigator took when formulating these arguments and the steps an investigator took in order to get evidence into its intended form. The capturing of such a detailed reasoning process helps to allow for a more thorough reconstruction of an investigator’s finding, further improving the reliability that can be placed in them. By encoding the investigator’s reasoning process, an investigator can more easily receive feedback on the impacts that the various dynamic aspects of an investigation have upon their reasoning. In order to achieve these goals, our dissertation presents a model, called the Chain of Findings, allowing investigators to formulate and capture their reasoning process throughout the investigation, using a combination of goal-driven and data-driven approaches. When formulating their reasoning, the model allows investigators to treat evidence, digital and physical, uniformly as building blocks for their arguments and capture detailed information of how and why they serve their role in an investigator’s reasoning process. In addition, the Chain of Findings offers a number of other uses and benefits including the training of investigators and Digital Forensic Readiness. / Dissertation (MSc)--University of Pretoria, 2013. / gm2014 / Computer Science / unrestricted

This study examines long-term direct and indirect Historic Copper Inuit-European and European intersocietal interaction in the western/central Canadian Arctic periphery. Utilizing theoretical perspectives deriving from World-System Theory and moderate relativist orientations, and, embracing ethnographic, ethnohistorical and archaeological methodologies, the historic process by which the Historic Copper Inuit living externally to the modern capitalist World-System, came into contact with and were gradually incorporated within this expanding global system of interconnected states is examined. The process leading to the ultimate incorporation of the Historic Copper Inuit within the World-System is scrutinized through chronological stages and, utilizing two-views; the perspective of the Historic Copper Inuit mediating the penetration of the World-System, and through a perspective based on World-System orientations.

This study examines long-term direct and indirect Historic Copper Inuit-European and European intersocietal interaction in the western/central Canadian Arctic periphery. Utilizing theoretical perspectives deriving from World-System Theory and moderate relativist orientations, and, embracing ethnographic, ethnohistorical and archaeological methodologies, the historic process by which the Historic Copper Inuit living externally to the modern capitalist World-System, came into contact with and were gradually incorporated within this expanding global system of interconnected states is examined. The process leading to the ultimate incorporation of the Historic Copper Inuit within the World-System is scrutinized through chronological stages and, utilizing two-views; the perspective of the Historic Copper Inuit mediating the penetration of the World-System, and through a perspective based on World-System orientations.

Clinical research is conducted to advance human medicine by developing efficacious treatments and improving patient outcomes when new therapies are developed and implemented. Clinical trials are a subset of the types of clinical research conducted on human volunteers in the development of new drugs, devices and other therapies. Prior to the start of a trial, a country’s regulatory authority must review the trial to ensure it is scientifically and ethically sound. In Canada, the regulatory authority is Health Canada. The International Conference on Harmonization (ICH) of technical requirements for the registration of pharmaceutics for humans aims to provide ethical and scientific quality standards for design, conduct, data collection and reporting in clinical trials. The Good Clinical Practice (GCP) Guidelines were created by the ICH Steering Committee to assure the public that rights, safety and well being of subjects are protected according to the Declaration of Helsinki, and the clinical data obtained in a ICH/GCP compliant clinical trial will meet regulatory requirements. Health Canada has adopted the ICH/GCP Guidelines and therefore, in Canada, all clinical trials involving humans must comply with these Guidelines. The clinical trial coordinator is an important and central position on the research team executing many trial duties and communications. Regulatory authorities, Research Ethics Boards and the sponsor, overlook the role and responsibilities of a highly trained clinical coordinator, despite their vital and central position. The GCP Guidelines also fail to address the role and responsibilities of a clinical coordinator. Disconnect between guidelines, regulatory expectations and actual trial conduct provides an apparent need to formalize and clearly define the role and scope of a clinical coordinator. The Registered Nurse (RN) brings professionalism, knowledge, skill and a holistic perspective to the expanded role of a clinical coordinator and to the clinical trial. Highly trained health professionals are capable of assuming more responsibilities and executing clinical trial design, setup and management as compared to the traditional administrative roles of the clinical coordinator. The expanded role of the clinical coordinator is especially beneficial for Principal Investigator initiated trials due to limited research personnel and resources. Postoperative adhesions are a common complication following pelvic surgery, therefore, this clinical trial is relevant and a response to a healthcare need. My graduate studies focused on the development and set up of the clinical trial Protocol ADE002-2013 Phase I Trial of L-Alanyl-L-Glutamine for the Reduction of Peritoneal Adhesions in Adult Females Undergoing Myomectomy. My thesis is a discussion of general Canadian clinical trial research information followed by an explanation of how we executed the information to design and set up our PI initiated clinical trial. The value of the expanded role of the clinical coordinator as a member of the research team will also be discussed.

A crime scene is a vital part of an investigation. There are however, depending on the situation and crime, issues connected to physically being at the scene; risk of contamination, destruction of evidence or other issues can hinder the criminal investigators to stay, visit or revisit the scene. It is therefore important to visually capture the crime scene and any possible evidence in order to aid the investigation. This thesis aims to, with an initial research question, map out the main visual documentation needs, wishes and challenges that criminal investigators face during an investigation. In addition, with a second research question, it aims to address these in a Virtual Reality (VR) design and, with a third research question, explore however other professions in the investigation process could benefit from it. This was conducted through a literature review, interviews, workshops and iterations with the approach of the Double Diamond Model of Design. The results from the interviews were thematically analyzed and ultimately summarized into five key themes. These, together with various design criteria and principals, acted as design guidelines when creating a high fidelity VR design. The first two research questions were presented through the key themes and the VR design. The results of the third research question indicated that, besides criminal investigators, both prosecutors and criminal scene investigators may benefit from a VR design, although in different ways. A VR design can, in conclusion, address the needs, wishes and challenges of criminal investigators by being developed as a compiled visualization and collaboration tool. / En brottsplats är en vital del av en brottsundersökning. Det finns emellertid, beroende på situation och brott, problem som är kopplade till att fysiskt befinna sig på brottsplatsen. Risk för kontamination, förstörelse av bevis eller andra problem kan hindra brottsutredarna att stanna, besöka eller återvända till brottsplatsen. Det är därför viktigt att visuellt dokumentara brottsplatsen och eventuella bevis för att bistå utredningen. Detta masterarbete ämnar att, med en första forskningsfråga, kartlägga de viktigaste behoven, önskemålen och utmaningarna gällande visuell dokumentation, som brottsutredare möter under en utredning. Vidare ämnar projektet att, med en andra forskningsfråga, möta dessa i en Virtuell Verklighet (VR) -design och, med en tredje forskningsfråga, undersöka hur andra yrkesgrupper i en utredningsprocess skulle kunna dra nytta av den. Detta genomfördes genom en litteraturstudie, intervjuer, workshops och iterationer grundat i tillvägagångssättet Double Diamond Model of Design. Resultaten från intervjuerna analyserades tematiskt och sammanfattades i fem huvudteman. Dessa teman, tillsammans med olika designkriterier och principer, agerade designriktlinjer vid skapandet av en high-fidelity VR-design. De två första frågorna presenterades genom nyckeltemana och VR-designen. Resultaten gällande den tredje forskningsfrågan visar att, utöver brottsutredare, både åklagare och kriminaltekniker kan dra nytta av en VR-design, även om på olika vis. Sammanfattningsvis kan en VRdesign möta utredarnas behov, önskemål och utmaningar gällande visuell dokumentation genom att utvecklas som ett kompilerat visualiserings- och samarbetsverktyg.

The purpose of this research was to evaluate the existing procedures that investigators in South Africa follow in utilising the information contained in the victim statement in the investigation of rape, with the intention of determining the strengths and weaknesses of the procedures and of considering how these procedures can be improved. The researcher explored how investigators internationally use information contained in the victim statement in the successful investigation of rape and read extensively on the topic in international literature sources. The researcher also evaluated the current methods that investigators within the South African Police Service (SAPS) use. The researcher made use of an empirical research design because of the limited information available on the topic of the research, and a qualitative research approach, which enabled real-life observations. Simple random sampling was used to select 20 uniform members as well as 20 investigators of rape incidents for interviewing. Purposive sampling was used to select two public prosecutors attached to the Sexual Offences Court. Data were obtained from their real-life experiences through interviewing them and data were further collected through case studies of case dockets. / Police Practice / M. Tech. (Forensic Investigation)

abstract: With new trends in drug development and testing, it must be determined whether the current state of balance of ethos (the moral norm) and regula (the legal framework) can successfully protect patients while keeping the door to scientific innovation open. The rise of the Clinician Investigator (CI) in both academic and private research introduces a challenge to the protection of subjects in the conflicting dual role of physician and scientist. Despite the constant evolution of regulation and ethical standards, questions about the roles' combined effectiveness in relation to this challenge persist. Carl Elliot describes the suicide of a patient-subject enrolled in an industry-funded physician-run anti-psychotic pharmaceutical drug trial in a 2010 Mother Jones article. Elliot provides a personal account of discrepancies seen in the ethical principles of beneficence, respect for subjects and justice. Through analysis of the problems presented in the case as a model for potential dangers in clinical research, the effectiveness of ethics and law in protecting human subjects is examined. While the lag between ethical standard and regulation has historically shown to cause similar issues, the misconception of current regulation and ethical standards may be contributing to the decrease in subject protections. After IRB approval of subject protections in the research protocol, CIs have been shown to downgrade their responsibility to maintaining ethos through the course of the trial. And, despite their experience in patient-centered ethos as a physician, CIs may be inclined to substitute these values for the ethos of a researcher, with the goal to avoid therapeutic misconception. Maintaining personal responsibility for subjects beyond regulatory structure, and promoting the welfare of the subjects in regards to the ethical standard of research investigators, will provide added security for subjects and decrease opportunity for exploitation in future research. / Dissertation/Thesis / M.S. Biology 2012

The purpose of this research was to evaluate the existing procedures that investigators in South Africa follow in utilising the information contained in the victim statement in the investigation of rape, with the intention of determining the strengths and weaknesses of the procedures and of considering how these procedures can be improved. The researcher explored how investigators internationally use information contained in the victim statement in the successful investigation of rape and read extensively on the topic in international literature sources. The researcher also evaluated the current methods that investigators within the South African Police Service (SAPS) use. The researcher made use of an empirical research design because of the limited information available on the topic of the research, and a qualitative research approach, which enabled real-life observations. Simple random sampling was used to select 20 uniform members as well as 20 investigators of rape incidents for interviewing. Purposive sampling was used to select two public prosecutors attached to the Sexual Offences Court. Data were obtained from their real-life experiences through interviewing them and data were further collected through case studies of case dockets. / Police Practice / M. Tech. (Forensic Investigation)

Made available in DSpace on 2016-03-15T14:17:04Z (GMT). No. of bitstreams: 2 6.pdf: 3467689 bytes, checksum: baa8b0680264144c21042cc121db924b (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015 / Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil. / Os Ensaios Clínicos são o tipo de pesquisa considerado, atualmente, como padrão ouro da medicina baseada em evidências. Boa parte das pesquisas deste tipo conduzidas no Brasil é patrocinada por indústrias multinacionais. Contudo, apesar de o Brasil contar com centros de pesquisa preparados para conduzir os Ensaios Clínicos desenhados e patrocinados por estas indústrias, não se vê a mesma desenvoltura quando se trata de projetos institucionais nacionais, isto é, desenhados e operacionalizados por investigadores de institutos de pesquisa brasileiros. Esta carência de conhecimento em planejamento e gestão de um Ensaio Clínico torna-se crítica no momento em que o investigador se dispõe a conduzir um projeto institucional, uma vez que nestes casos, de acordo com a ANVISA, o responsável pela condução e coordenação da pesquisa é chamado de "Investigador-Patrocinador", devendo cumprir com todas as exigências atribuídas ao papel de investigador e ao papel de patrocinador. Este trabalho apresenta uma proposta de manual que poderá servir como instrumento de consulta para pesquisas conduzidas por Investigadores-Patrocinadores de Ensaios Clínicos e de guia para mapeamentos de processos e criação de ferramentas específicas para seus projetos. O manual foi elaborado após uma exaustiva pesquisa, análise documental e compilação das principais regulamentações de pesquisa clínica publicadas no país, entrevistas com Investigadores-Patrocinadores brasileiros, modelagem e validação dos processos envolvidos em um Ensaio Clínico. Este estudo apresenta descrições e ferramentas sobre as etapas e os requerimentos envolvidos na condução de um Ensaio Clínico na condição de Investigador-Patrocinador. / The Clinical Trials are, currently, the gold standard research of evidence-based medicine. Much of this type of research conducted in Brazil is sponsored by multinational industries. However, despite Brazil have research sites ready and prepared to conduct clinical trials designed and sponsored by these industries, it is not possible to see the same resourcefulness when it comes to national institutional projects, i.e., designed and operated by investigators from Brazilian research institutes. This lack of knowledge in planning and management of a clinical trial becomes critical when the investigator is willing to conduct an institutional project, since in these cases, according to ANVISA, the responsible person for conducting and coordinating the research is called "Sponsor-Investigator" and must comply with all the requirements assigned to the investigator and the sponsor. This work presents a manual proposal that could be used as a reference tool for researches conducted by "SponsorInvestigators" of Clinical Trials and as a guide for the processes mapping and creation of specific tools for their projects. The manual was prepared after extensive research, document analysis and compilation of the main regulations of clinical research published in the country, interviews with Brazilian "Sponsors-Investigators", modeling and validation of the processes involved within a clinical research. This study presents descriptions and tools on the steps and requirements involved in the conduction of a clinical trial in a Sponsor- Investigator condition.

Den 1 juli 2018 implementerades den så kallade samtyckeslagen i Sverige, vilket bland annat innebar en revidering i våldtäktsbestämmelsen. Från att vara krav på våld, hot, tvång eller utnyttjande av särskild utsatt situation för straffansvar till dagens rekvisit brist på frivillighet. Debatten kring en samtyckesreglering har pågått under en längre tid i Sverige, där det ej införts tidigare dels på grund av att risken att fokus på målsägande i utredningar och rättegångar skulle bli för stort. Syftet med rapporten är därmed att undersöka hur arbetssättet hos brottsutredarna har förändrats sedan lagändringen, samt vad de upplever för eventuella svårigheter och möjligheter i arbetet. Detta har studerats genom fem semistrukturerade intervjuer med utredare anställda av Polismyndigheten med kravet att de ska ha utrett våldtäktsärenden både innan och efter lagändringen. Genom studiens resultat uppkom fem huvudteman; Bevisning, Rättssäkerhet, Vidareutbildning, Målsägandebiträdets roll och Frozen fright. Kort sammanfattat ansåg informanterna att arbetssättet överlag var oförändrat, dock med andra typer av frågor i förhör med målsägande och misstänkt. De upplevde det nya rekvisitet som tydligt men det gick att antyda att de hade önskat mer utbildning i samband med implementeringen. Ett målsägandebiträde spelar enligt informanterna en stor roll i utredningen och kan vara till stor hjälp i deras arbete. Frozen fright är enligt utredarna ett vanligt förekommande tillstånd bland personer utsatta för våldtäkt och det har undersökts i syfte att det med dagens lagstiftning klassas som en våldtäkt om någon utnyttjar en person som befinner sig i denna utsatta situation. Förhoppningen är att rapportens slutsatser kan användas vid implementering av lagar i Brottsbalken samt bidra med kunskap i det fortsatta brottsutredande arbetet och inom rättsväsendet. / The 1st of July 2018 the consent law was implemented in Sweden, which among other things meant a revision in the Rape Act. From requirements of violence, threat, constraint or exploitation of a particularly vulnerable situation for criminal liability to today's necessary prerequisite lack of free will. The debate on consent regulation has been on for a long time in Sweden, with the main reason for not being introduced earlier is because of the risk that focus on the plaintiff in investigations and trials would be too big. The purpose of this report is hence to investigate how the way of working among the criminal investigators has been altered since the change in the law, and what difficulties and possibilities they experience in their work. This have been studied through five semi-structured interviews with investigators employed by the Swedish police authority with the requirement that they should have been investigating rape cases both before and after the change in the law. Five main themes arose through the study's results; Evidence, Legal certainty, Education, The role of the plaintiff’s counsel and Frozen fright. In short, the investigators considered that their way of working was generally unchanged, but with other types of questions in questioning of the plaintiff and suspect. They perceived the new prerequisite as easy to interpret, however, the implementation could have come with more education. According to the informants, a plaintiff’s counsel plays a major role in the investigation and can be of great help in their work. Frozen fright is according to the investigators a common condition among people exposed to rape, in current jurisdiction, it is classified as rape if someone exploits a person who is in this vulnerable situation, therefore why this is studied. The expectation is that the report’s conclusions can be used in the implementation of laws and contribute with knowledge in the continued criminal investigation and in the judiciary.