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Thesis (Ph. D.)--University of Chicago, Committee on Human Nutrition and Nutritional Biology, March 2001. / Includes bibliographical references. Also available on the Internet.

Thesis (Ph. D.)--University of Sydney, 2008. / Title from title screen (viewed Jan. 28, 2009) Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Public Health, Faculty of Medicine. Includes bibliographical references and list of publications. Also available in print form.

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Made available in DSpace on 2014-06-11T19:32:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-11-05Bitstream added on 2014-06-13T21:03:37Z : No. of bitstreams: 1 vannini_fcd_dr_botfm.pdf: 438750 bytes, checksum: 52c4a11cc872d6dddca37fa4ef815423 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / As doenças cardiovasculares são a causa mais frequente de morte em pacientes em hemodiálise (HD). A calcificação vascular (CV) é extremamente comum nesses pacientes, e está associada com vários desfechos clínicos, como isquemia cardíaca e mortalidade cardiovascular. A CV está associada com fatores de risco tradicionais como aterosclerose, idade, hipertensão arterial, diabetes mellitus (DM) e dislipidemia, e a fatores de risco não tradicionais, como inflamação, hiperfosfatemia e hiperparatireoidismo. Este estudo de coorte prospectivo observacional teve como objetivo avaliar em pacientes em HD a presença e progressão da CV e a evolução nutricional, assim como identificar variáveis associadas com a progressão da CV e depleção do estado nutricional. Também foi determinado, após 24 meses, o impacto da CV e de variáveis clínicas, demográficas e nutricionais sobre a ocorrência de eventos cardiovasculares e óbito. Quarenta e nove pacientes em HD por no mínimo 90 dias foram incluídos. Ao início do seguimento e após 12 meses foi estimado o escore de calcificação vascular (ECV) pelos métodos de Kauppila e de Adragão, assim como avaliados marcadores clínicos, nutricionais, dialíticos, bioquímicos, hemotológicos e inflamatórios. Duas análise foram realizadas, a primeira com todos os pacientes e a segunda, incluindo apenas aqueles com menos de 60 anos. O modelo de regressão logística foi utilizado para avaliar preditores independentes da presença, progressão e velocidade de progressão da CV, assim como da depleção do estado nutricional, definido pela variação negativa do ângulo de fase (Â) obtido pela biompedância ou mudança da classificação do estado nutricional de bem nutrido para desnutrido pela avaliação subjetiva global (SGA). O modelo múltiplo de regressão de Cox foi utilizado para identificar... / Cardiovascular diseases are the most frequent causes of death in hemodialysis (HD) patients. Vascular calcification (VC) is very common in these patients, and it is associated with many adverse clinical outcomes, including ischemic cardiac events and subsequent cardiovascular mortality. VC has been associated with numerous „traditional‟ risk factors to atherosclerosis such as aging, hypertension, diabetes or dyslipidemia, as well as with „nontraditional‟ risk factors, such as inflammation, hyper phosphatemia, and hyperparathyroidism. This prospective observational cohort study was designed in order to evaluate HD patients regarding the presence and progression of VC, nutritional evolution, as well as to identify variables associated with VC progression rate and nutritional impairment. Also, we aimed to determine the impact of VC and nutritional characteristics on cardiovascular outcomes and death risk. Forty-nine patients on regular HD over at least 90 days were included. At baseline and after 12 months, VC scores (VCS) were estimated by Kauppila and Adragão methods; nutritional and clinical assessment were performed, dialytic, biochemical, hematologic, and inflammatory markers were obtained. After the follow-up, cardiovascular events and deaths from all causes were recorded over an additional 24 month period. Two analyses were performed, the first with all patients and the second involving those younger than 60 years old. Binary logistic regression models were constructed to evaluate independent predictors of VC presence, progression, and progression rate as well as nutritional impairment, defined by the negative variation of phase angle (A0) in the electrical bioimpedance or subjective global assessment (SGA) change from well-nourished to malnourished. The Cox proportional regression model was used to... (Complete abstract click electronic access below)

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Made available in DSpace on 2014-10-09T12:25:57Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:06:45Z (GMT). No. of bitstreams: 1 10921.pdf: 2839004 bytes, checksum: c375129d3c2c573c9d513c0bb7daa333 (MD5) / Dissertacao (Mestrado) / IEA/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

Made available in DSpace on 2014-10-09T12:25:57Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:06:45Z (GMT). No. of bitstreams: 1 10921.pdf: 2839004 bytes, checksum: c375129d3c2c573c9d513c0bb7daa333 (MD5) / Dissertacao (Mestrado) / IEA/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

A soluble form of cytochrome b_5, with a 413/280 nm ratio of nearly unity, has been isolated and purified from porcine kidney using fractional precipitation, ion exchange resins, and gel filtration procedures. The cytochrome b_5 shows heat stability up to 50° and is stable in the pH range 6.0 to 8.5. The oxidized protein exhibits an absorption maximum at 413 nm, while the reduced form shows three peaks: 423, 526, 556 nm. Molecular weight determinations have given variable results, suggesting the possibility of a polymer composed of four and eight units of a 13,500 molecular weight protomer. This study has used no lipases, proteases, or detergents in the solubilization of the cytochrome, and the possibility exists that the cytochrome found represents newly formed cytochrome b_5 which is as yet unattached to the microsomes, and which reflects the form found in intact cells.

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