Made available in DSpace on 2014-12-17T15:32:17Z (GMT). No. of bitstreams: 1 ErickaJDS.pdf: 1015661 bytes, checksum: 90281c18fd958a21edee7d7e6ed2eb94 (MD5) Previous issue date: 2006-05-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Oral squamous cell carcinoma is the most common malignant neoplasm in oral cavity. Several studies have been carried out to establish biologic behaviour criteria of this neoplasm. Thus, the purpose of this experiment was to performe a clinic, morphologic and immunohistochemical analysis, by the expression of cytokeratins 7, 10, 13, 14, 16 and 19 in 30 cases of tongue squamous cell carcinoma from the files of Dr. Luiz Ant?nio Hospital (Natal-RN). It was verifeid of the immunoexpression the correlation clinic estadiament and histologic gradation system proposed by Bryne (1998), in order to investigate the use of these intermediate filaments as an indicator of tumour progression. Data was collected from the patients file and it was observed that information regarding sex, age and race was resemble to the literature. Data obtained from disease evolution, clinic estadiament, metastasis and expression of cytokeratins 7, 10, 13, 14, 16 and 19 was submited to statistical analysis (Test K2), which showed that only the histologic gradation didn t demonstrated significant correlation to the clinic variables. The expression the cytokeratins presented variation in the analysed tumours. CK 10 expression showed significant correlation to metastasis, and the presence of CK 16 was related to disease evolution (obit/remission) and also with the T3 and T4 of TNM. These results evidenced that metastasis and TNM showed a good efficacy as a prognostic indicator. The histologic gradation proposed by Bryne (1998) didn t reflect the biologic behaviour of the studied tongue squamous cell carcinoma, and the analysis of some intermediate filaments of cytokeratins seems to reflect the biologic behaviour and agressivity of some oral squamous cell carcinoma / O carcinoma epiderm?ide oral ? a neoplasia maligna mais freq?ente na cavidade oral. Muitas pesquisas desenvolvidas visam estabelecer crit?rios que determinem o comportamento biol?gico dessa neoplasia, assim, objetivou-se com esse trabalho realizar uma an?lise cl?nica, morfol?gica e imuno-histoqu?mica atrav?s da express?o das citoqueratinas 7, 10, 13, 14, 16 e 19 em 30 casos de carcinoma epiderm?ide de l?ngua retirados dos arquivos do Hospital Dr. Luiz Ant?nio (Natal-RN), correlacionando essa express?o ao estadiamento cl?nico e grada??o histol?gica de malignidade proposto por Bryne (1998), com o intuito de verificar a utiliza??o destes filamentos intermedi?rios como indicadores de progress?o tumoral. Ap?s a an?lise cl?nica das informa??es contidas nos prontu?rios desses pacientes verificamos que os dados referentes a sexo, idade e ra?a se assemelham aos da literatura pertinente. Os dados obtidos em rela??o ao desfecho da doen?a, estadiamento cl?nico, presen?a de met?stase, grada??o histol?gica de malignidade, e express?o das citoqueratinas 7, 10, 13, 14, 16 e 19 foram submetidos a an?lise estat?stica (teste Qui2), observando-se que somente a grada??o histol?gica de malignidade n?o apresentou correla??o significativa com as vari?veis cl?nicas estudadas. A express?o dessas citoqueratinas foi variada nos tumores analisados. A express?o da CK 10 mostrou correla??o estatisticamente significativa com a presen?a de met?stase, a presen?a da CK 16 correlacionou-se ao desfecho da doen?a (?bito/remiss?o) e ainda aos est?gios III e IV do TNM. Esses resultados evidenciaram que a met?stase e o estadiamento cl?nico (TNM) mostraram boa efetividade como indicadores de progn?stico. O sistema de grada??o histol?gica de malignidade proposto por Bryne (1998) n?o refletiu o comportamento biol?gico dos carcinomas epiderm?ides de l?ngua estudados, e a an?lise de alguns filamentos intermedi?rios de citoqueratinas parece refletir o comportamento biol?gico e agressividade dos carcinomas epiderm?ides orais