Hepatitis C virus (HCV) infection is a chronic blood-borne disease that affects > 4,000,000 individuals in the United States. The majority of individuals with HVC infection acquire a chronic hepatitis that predisposes them to the complications of cirrhosis and hepatoma. Chronic HCV infection is, however, associated with multiple extrahepatic manifestations as well, including recently recognized effects on the lung. These include primary effects on lung function, as well as secondary effects in the settings of progressive liver disease and drug treatment for HCV. In this article, we discuss the emerging clinical data that support a role for HCV infection in lung disease, describe the multiple pulmonary manifestations of this viral infection, and outline the therapies available for specific pulmonary complications of chronic HCV infection.

Gu Jia-Shi. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 117-148). / Abstracts in English and Chinese. / Title --- p.i / Abstract (English) --- p.iii / Abstract (Chinese) --- p.iv / Acknowledgments --- p.v / Statement of Originality --- p.vi / List of Abbreviations --- p.viii / List of Figures --- p.xi / List of Tables --- p.xiii / Table of Contents --- p.xiv / Chapter Section One : --- Introduction & Literature Review / Introduction & Objective --- p.2 / Introduction / Objective of the present study / Chapter Chapter. 1 --- A Review of Chronic lung disease (CLD) --- p.6 / Chapter 1. --- BPD 226}0ؤ an example of CLD / Chapter 2. --- Pathological change & Clinical presentation / Chapter 3. --- Clinical sequel of CLD infants / Chapter 3.1 --- O2 consumption of CLD infants / Chapter 3.1-1 --- Oxygen consumption / Chapter 3.1-2 --- Oxygen transportation / Chapter 3.1-2a --- Dissolved O2 / Chapter 3.1-2b --- Haemoglobin / Chapter 3.2 --- Energy expenditure of CLD infants / Chapter 3.3 --- Growth rate of CLD infants / Chapter 4. --- Treatment & Management of CLD infants / Chapter 4.1 --- Diuretics / Chapter 4.2 --- Bronchodilators / Chapter 4.3 --- Corticosteroids / Chapter 5. --- "Interpretations of the observed phenomena, why does CLD impair growth?" / Chapter 5.1 --- The traditional view / Chapter 5.2 --- Disagreement with the traditional view / Chapter Chapter 2 --- Measurement of oxygen consumption --- p.20 / Chapter 1. --- Invasive measurement of VO2 / Chapter 1.1 --- Cardiac output / Chapter 1.2 --- Fick method / Chapter 1.3 --- Advantages and Disadvantages of Fick method in estimating VO2 / Chapter 1.4 --- Measurement of cardiac output by thermodilution / Chapter 1.4-1 --- Advantages and Disadvantages of Thermodilution Method / Chapter 2. --- Non-invasive measurement of VO2 / Chapter 2.1 --- Metabolic analyzer---DeltatraćёØII / Chapter 2.2 --- Paramagnetic sensor / Chapter 3. --- Measured and calculated oxygen consumption / Chapter 3.1 --- Difference between mVO2 and cVO2 / Chapter 4. --- Summary / Chapter Chapter 3 --- Hypothesis --- p.34 / Chapter 1. --- Possible explanations for the difference between mV02 & cV02 / Chapter 1.1 --- Measurement variability and Mathematical error / Chapter 1.2 --- Oxygen consumption of the lung / Chapter 1.3 --- VO2pul with lung damage / Chapter 1.4 --- "Neutrophils, Macrophages and oxygen consumption" / Chapter 2. --- Hypothesis / Chapter Section Two : --- Methods & Materials / Chapter Chapter 1 --- Animal Model --- p.41 / Chapter Chapter 2. --- Materials --- p.43 / Chapter 1. --- Animals / Chapter 2. --- Chemicals used for inducing lung damage / Chapter 2.1 --- Acute damage group / Chapter 2.1-1 --- N-nitroso-N-methylurethane (NNNMU) / Chapter 2.1-2 --- Administrations to rabbits / Chapter 2.2 --- Chronic damage group / Chapter 2.2-1 --- Bleomycin (BLM) / Chapter 2.2-2 --- Pulmonary toxicity of Bleomycin / Chapter 2.2-3 --- Administration to animals / Chapter Chapter 3 --- Instruments --- p.50 / Chapter 1. --- Measurement of VO2 and VCO2 226}0ؤDeltatracIÍёØ Metabolic analzyer / Measurement of cardiac outpu´tؤCardiomax II model85 / Chapter Chapter 4 --- Methods --- p.58 / Chapter 1. --- N-nitroso-N-methylurethane (NNNMU) Preparation / Chapter 2. --- Bleomycin Preparation / Chapter 3. --- 2.5% pentobarbitone Preparation / Chapter 4. --- Animal Preparation / Chapter 4.1 --- Control (Normal) group / Chapter 4.2 --- A cute lung damage group / Chapter 4.3 --- Chronic lung damage group / Chapter 5. --- Preparation of the animals for VO2 measurement / Chapter 6. --- Measurement of oxygen consumption / Chapter 6.1 --- VO2wb measurement / Chapter 6.2 --- VO2b measurement / Chapter 7. --- Histopathology / Chapter 8. --- Statistics / Chapter Section Three : --- Results --- p.69 / Chapter 1. --- Healthy (Control) group / Chapter 1.1 --- Pulmonary histology / Chapter 2. --- Acute lung damage group / Chapter 2.1 --- Pulmonary histology / Chapter 3. --- Chronic lung damage group / Chapter 3.1 --- Pulmonary histology / Chapter 4. --- Comparison of the pulmonary oxygen consumption among the three groups / Chapter Section Four : --- Discussion --- p.97 / Chapter Section Five : --- Conclusion --- p.111 / Chapter Section Six : --- Future Studies --- p.114 / Chapter Section Seven : --- Bibliography --- p.118

Xu Feng. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (p. 205-233). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Thesis (M.S.)--University of Michigan, 1975.

Thesis (M.S.)--University of Michigan, 1975.

Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains xvii, 295 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 262-276).

Thesis (M.S.)--University of Wisconsin-Madison, 1993. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 49-54).

Thesis (doctoral)--Katholieke Universiteit te Nijmegen.

Chung Mei-lan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (leaves 118-124). / Abstracts in English and Chinese. / Abstract --- p.i / Declaration --- p.v / Acknowledgment --- p.vi / Abbreviations --- p.viii / List of Figures --- p.x / List of Tables & Graphs --- p.xi / Chapter 1. --- Background --- p.1 / Chapter Chapter 1: --- Age-Associated Changes in Nutritional Status in the Elderly --- p.1 / Chapter 1.1. --- Body Composition --- p.1 / Chapter 1.2. --- Nutritional Requirements --- p.2 / Chapter 1.2.1. --- Energy requirement in the elderly --- p.3 / Chapter 1.2.2. --- Protein requirement in the elderly --- p.3 / Chapter 1.2.3. --- Vitamin and minerals requirement in the elderly --- p.4 / Chapter 1.3. --- Food Intake --- p.4 / Chapter 1.3.1. --- Biobehavioral factors --- p.5 / Chapter 1.3.2. --- Social factors --- p.9 / Chapter 1.3.3. --- Psychological factors --- p.9 / Chapter 1.3.4. --- Physical factors --- p.10 / Chapter 1.3.5. --- Medical factors --- p.10 / Chapter 1.4. --- Age-Related Changes in Gastrointestinal Tract --- p.10 / Chapter Chapter 2: --- Energy Expenditure in the Elderly --- p.12 / Chapter 2.1. --- Total Daily Energy Expenditure (TEE) --- p.13 / Chapter 2.2. --- Basal Metabolic Rate (BMR) --- p.14 / Chapter 2.2.1. --- Mechanisms Leading to a Decrease in FFM Adjusted BMR --- p.15 / Chapter (i) --- Sex --- p.15 / Chapter (ii) --- Sympathetic Nervous System (SNS) Activity --- p.16 / Chapter (iii) --- Physical Activity --- p.17 / Chapter (iv) --- Body Weight --- p.17 / Chapter (v) --- Hormones --- p.18 / Chapter 2.3. --- Diet-Induced Thermogenesis (DIT) --- p.18 / Chapter 2.4. --- Energy Costs of Physical Activity --- p.20 / Chapter Chapter 3: --- Methods for the Measurements of Energy Expenditure --- p.22 / Chapter 3.1. --- Direct Calorimetry --- p.22 / Chapter 3.1.1. --- Principle of Direct Calorimetry --- p.22 / Chapter 3.1.2. --- Isothermal calorimetry --- p.23 / Chapter 3.1.3. --- Gradient-layer direct calorimetry --- p.23 / Chapter 3.1.4. --- Advantages and Disadvantages of Direct Calorimetry --- p.24 / Chapter 3.2. --- Indirect Calorimetry --- p.25 / Chapter 3.2.1. --- Principle of Indirect Calorimetry --- p.25 / Chapter 3.2.2. --- Whole body indirect calorimetry --- p.25 / Chapter 3.2.3. --- "Indirect calorimetry: ventilated hood system, a face mask, or mouthpiece" --- p.26 / Chapter 3.2.4. --- Advantages and Disadvantages of Indirect Calorimetry --- p.27 / Chapter 3.3. --- The Doubly-Labeled Water Method --- p.27 / Chapter 3.3.1. --- Principle --- p.27 / Chapter 3.3.2. --- Advantages and Disadvantages --- p.28 / Chapter 3.4. --- The Labeled Bicarbonate Method --- p.29 / Chapter 3.4.1. --- Principle of Isotope Dilution Method --- p.29 / Chapter 3.4.2. --- Principle of Traditional Labeled HC03 Method --- p.32 / Chapter 3.4.3. --- Labeled Bicarbonate-Urea Method --- p.34 / Chapter I. --- Calculations --- p.35 / Chapter A. --- Determination of energy equivalent of CO2 --- p.35 / Chapter B. --- Relationship between specific activity of urea and specific activity of CO2 --- p.35 / Chapter C. --- Fixation of infused label in the body --- p.36 / Chapter D. --- Calculation of CO2 production from the specific 3 activity of urinary urea --- p.6 / Chapter E. --- Two assumptions in labeled bicarbonate-urea method --- p.36 / Chapter 3.4.4. --- Advantages and Disadvantages of Labeled Bicarbonate-Urea Method --- p.37 / Chapter 3.5. --- Heart Rate Monitoring --- p.37 / Chapter 3.5.1. --- Principle --- p.37 / Chapter 3.5.2. --- Advantages and Disadvantages --- p.38 / Chapter 3.6. --- Activity Monitoring --- p.39 / Chapter 3.6.1. --- Principle --- p.39 / Chapter 3.6.2. --- Advantages and Disadvantages --- p.39 / Chapter 3.7. --- Activity Diaries --- p.40 / Chapter 3.7.1. --- Retrospective activity questionnaires --- p.40 / Chapter I. --- Principle --- p.40 / Chapter II. --- Advantages and Disadvantages --- p.40 / Chapter 3.7.2. --- Current diary method --- p.41 / Chapter I. --- Principle --- p.41 / Chapter II. --- Advantages and Disadvantages --- p.42 / Chapter 3.7.3. --- Time-and-motion study --- p.42 / Chapter I. --- Principle --- p.42 / Chapter II. --- Advantages and Disadvantages --- p.43 / Chapter Chapter 4: --- Nutritional Status and Energy Expenditure in Chronic Obstructive Pulmonary Disease (COPD) Patients --- p.44 / Chapter 4.1. --- Nutritional Status --- p.44 / Chapter 4.1.1. --- Body weight --- p.44 / Chapter 4.1.2. --- Fat-free mass (FFM) --- p.44 / Chapter 4.2. --- REE --- p.46 / Chapter 4.3. --- DIT --- p.47 / Chapter 4.4. --- TEE --- p.47 / Chapter 4.5. --- Nutrition Repletion by Caloric Supplement --- p.48 / Chapter 2. --- Objectives --- p.50 / Chapter 3. --- Subject and Method --- p.51 / Chapter 3.1. --- Part A: Subject and Methods I --- p.51 / Chapter 3.1.1. --- Subjects --- p.51 / Chapter 3.1.2. --- Methods --- p.51 / Chapter I. --- Anthropometric Assessment --- p.51 / Chapter II. --- Nutrient Intake --- p.52 / Chapter III. --- Clinical Assessment --- p.52 / Chapter IV. --- Energy Expenditure --- p.53 / Chapter V. --- Mini Nutritional Assessment Questionnaire --- p.53 / Chapter VI. --- Statistical Analysis --- p.54 / Chapter 3.2. --- Part B: Subject and Methods II --- p.55 / Chapter 3.2. --- Subjects --- p.55 / Chapter I. --- Patients --- p.55 / Chapter II. --- Control subjects --- p.55 / Chapter 3.2.2. --- Methods --- p.56 / Measurement of TEE by Labeled Bicarbonate-Urea Method --- p.56 / Chapter I. --- Study Protocol --- p.56 / Chapter Figure 6: --- Study protocol in Hospital --- p.57 / Chapter II. --- Clinical Protocol --- p.58 / Chapter A. --- Preparing the infusion --- p.58 / Chapter B. --- "Inserting the subcutaneous cannula, and starting the infusion" --- p.58 / Chapter C. --- Urine collection --- p.59 / Chapter D. --- Blood sample --- p.59 / Chapter III. --- Laboratory Procedures --- p.60 / Chapter A. --- Measuring the radioactivity of the infused bicarbonate solution --- p.60 / Chapter B. --- Measuring of specific activity of urea --- p.60 / Chapter (i) --- Titration of hyamine hydroxide solution --- p.60 / Chapter (ii) --- Urine radioactivity quantification --- p.61 / Chapter (1) --- Removal of dissolved CO2 from urine --- p.61 / Chapter (2) --- Determination of specific activity of C02 --- p.62 / Chapter (a) --- Principle --- p.62 / Chapter (b) --- Laboratory procedures for the determination of specific activity of urea --- p.62 / Chapter IV. --- Measurement in Hospital --- p.63 / Chapter A. --- Anthropometry --- p.63 / Chapter B. --- Indirect calorimetry --- p.63 / Chapter (i) --- Principle --- p.63 / Chapter (ii) --- Measurement of REE --- p.64 / Chapter (iii) --- Measurement of DIT --- p.65 / Chapter C. --- Food supply and dietary record during the study --- p.65 / Chapter D. --- Record of physical activity in rehabilitation program --- p.66 / Chapter E. --- Mini Nutritional Assessment Questionnaire --- p.67 / Chapter V. --- Statistical Analysis --- p.67 / Chapter 4. --- Results --- p.68 / Chapter 4.1. --- Results of Part A Study --- p.68 / Chapter 4.1.1. --- Anthropometry --- p.68 / Chapter 4.1.2. --- Nutrient Intake --- p.69 / Chapter 4.1.3. --- Caloric Balance --- p.71 / Chapter 4.1.4. --- Mini Nutritional Assessment Questionnaire --- p.72 / Chapter 4.2. --- Results of Part B Study --- p.73 / Chapter 4.2.1. --- Anthropometric Data --- p.73 / Chapter 4.2.2. --- REE --- p.74 / Chapter 4.2.3. --- DIT --- p.75 / Chapter 4.2.4. --- Nutrient Intake --- p.75 / Chapter 4.2.5. --- TEE --- p.76 / Chapter 4.2.6. --- Caloric Balance --- p.77 / Chapter 4.2.7. --- Mini Nutritional Assessment Questionnaire --- p.77 / Chapter 4.3. --- Table 1-1 --- p.78 / Chapter 4.4. --- Table 2-1 --- p.89 / Chapter 4.5. --- Graph1 --- p.100 / Chapter 5. --- Discussion --- p.103 / Chapter 5.1. --- Anthropometry in COPD patients --- p.103 / Chapter 5.2. --- Caloric and Nutrient intake in COPD patients --- p.105 / Chapter 5.3. --- Resting Energy Expenditure (REE) --- p.107 / Chapter 5.4. --- Diet-Induced Thermogenesis (DIT) --- p.108 / Chapter 5.5. --- Total Daily Energy Expenditure (TEE) --- p.108 / Chapter 5.6. --- Caloric Balance --- p.109 / Chapter 5.7. --- Limitation of this Study --- p.112 / Chapter 5.7.1. --- 24-hrs dietary recall --- p.112 / Chapter 5.7.2. --- Bicarbonate-urea method --- p.113 / Chapter 5.7.3. --- Anthropometry of community healthy elderly --- p.113 / Chapter 5.8. --- Recommendations --- p.114 / Chapter 5.8.1. --- Anthropometry monitoring in COPD patients --- p.114 / Chapter 5.8.2. --- Caloric supplements --- p.114 / Chapter 5.8.3. --- Physical activity in COPD patients --- p.115 / Chapter 6. --- Conclusions --- p.117 / Chapter 7. --- References --- p.118 / Chapter 8. --- Appendix I --- p.125 / Chapter A. --- Calculation of Total Energy Expenditure (TEE) --- p.125 / Chapter B. --- Sample of Calculation of Total Energy Expenditure (TEE) in Part B of the Study --- p.129 / Chapter 9. --- Appendix II - Equations --- p.133 / Chapter 10. --- Appendix III - Flow Calibration --- p.136

Introdução: A área do músculo peitoral (AMP) é uma avaliação facilmente derivada da tomografia computadorizada do tórax com potencial de fornecer informações relevantes sobre outros músculos esqueléticos. A Disfunção muscular respiratória e periférica é cada vez mais reconhecida em pacientes com doença pulmonar intersticial (DPI). A sua relação com a capacidade de exercício tem sido controversa. Nosso objetivo foi investigar se AMP está relacionada com a força muscular esquelética respiratória e periférica em pacientes com DPI, e se a função dos músculos esqueléticos estaria reduzida e independentemente relacionada com a capacidade de exercício e dispneia nesses pacientes. Métodos: Estudo transversal onde foi realizado teste de exercício cardiopulmonar incremental em cicloergômetro com mensuração de pressão inspiratória máxima (PImax), pressão expiratória máxima (PEmax) e contração voluntária máxima (CVM) do quadríceps, antes e após o exercício. Os testes de função pulmonar em repouso e TC de tórax foram obtidos da rotina assistencial dos pacientes. / Background: Pectoralis muscle area (PMA) is an easily derived computed tomography-based assessment that can provide insight into clinical features of other skeletal muscles. Respiratory and locomotor muscle dysfunction has been increasingly recognized in patients with interstitial lung disease (ILD). Its contribution to exercise performance has been controversial. We aimed investigate if PMA is related with respiratory and locomotor skeletal muscle strength in ILD patients, and if skeletal muscle function is compromised and independently related with exercise capacity and dyspnea in these patients. Methods: Cross-sectional study where subjects performed incremental cycling cardiopulmonary exercise testing with maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and quadriceps maximal voluntary contraction (MVC) before and after exercise.