In order to combat the potential threats of climate change, effective policy setting and implementation is crucial. A variable which has been shown to have significant explanatory power on the success of different public policy areas is social capital; a multidimensional concept encompassing social relationships and norms ability to mobilize and facilitate common goals. In the context of climate change related research, the relationship between social capital or some of its components to environmental variables typically is studied in a vacuum. This using factor analysis or SEM, at times in combination with other statistical techniques. In this study a more extensive SEM is investigated, examining the potential effect of social capital on environmental policy attitudes, with the mediating component climate change beliefs. The relationship between all three concepts were found to be significant, with the proportion of the total effect which is due to the indirect effect being 23%. This present study contributes to the literature by introducing the use of more extensive models, taking the complex relationships in the area into account to a higher degree, in order for more efficient policy making.

<p>Longitudinal twin data provide important information for exploring sources of variation in human traits. In statistical models for twin data, unobserved genetic and environmental factors influencing the trait are represented by latent variables. In this way, trait variation can be decomposed into genetic and environmental components. With repeated measurements on twins, latent variables can be used to describe individual trajectories, and the genetic and environmental variance components are assessed as functions of age. This thesis contributes to statistical methodology for analysing longitudinal twin data by (i) exploring the use of random change point models for modelling variance as a function of age, (ii) assessing how nonresponse in twin studies may affect estimates of genetic and environmental influences, and (iii) providing a method for hypothesis testing of genetic and environmental variance components. The random change point model, in contrast to linear and quadratic random effects models, is shown to be very flexible in capturing variability as a function of age. Approximate maximum likelihood inference through first-order linearization of the random change point model is contrasted with Bayesian inference based on Markov chain Monte Carlo simulation. In a set of simulations based on a twin model for informative nonresponse, it is demonstrated how the effect of nonresponse on estimates of genetic and environmental variance components depends on the underlying nonresponse mechanism. This thesis also reveals that the standard procedure for testing variance components is inadequate, since the null hypothesis places the variance components on the boundary of the parameter space. The asymptotic distribution of the likelihood ratio statistic for testing variance components in classical twin models is derived, resulting in a mixture of chi-square distributions. Statistical methodology is illustrated with applications to empirical data on cognitive function from a longitudinal twin study of aging. </p>

Longitudinal twin data provide important information for exploring sources of variation in human traits. In statistical models for twin data, unobserved genetic and environmental factors influencing the trait are represented by latent variables. In this way, trait variation can be decomposed into genetic and environmental components. With repeated measurements on twins, latent variables can be used to describe individual trajectories, and the genetic and environmental variance components are assessed as functions of age. This thesis contributes to statistical methodology for analysing longitudinal twin data by (i) exploring the use of random change point models for modelling variance as a function of age, (ii) assessing how nonresponse in twin studies may affect estimates of genetic and environmental influences, and (iii) providing a method for hypothesis testing of genetic and environmental variance components. The random change point model, in contrast to linear and quadratic random effects models, is shown to be very flexible in capturing variability as a function of age. Approximate maximum likelihood inference through first-order linearization of the random change point model is contrasted with Bayesian inference based on Markov chain Monte Carlo simulation. In a set of simulations based on a twin model for informative nonresponse, it is demonstrated how the effect of nonresponse on estimates of genetic and environmental variance components depends on the underlying nonresponse mechanism. This thesis also reveals that the standard procedure for testing variance components is inadequate, since the null hypothesis places the variance components on the boundary of the parameter space. The asymptotic distribution of the likelihood ratio statistic for testing variance components in classical twin models is derived, resulting in a mixture of chi-square distributions. Statistical methodology is illustrated with applications to empirical data on cognitive function from a longitudinal twin study of aging.

This dissertation research consists of two topics, population stochastics approximation Monte Carlo (Pop-SAMC) for Baysian model selection problems and ChIP-chip data analysis. The following two paragraphs give a brief introduction to each of the two topics, respectively. Although the reversible jump MCMC (RJMCMC) has the ability to traverse the space of possible models in Bayesian model selection problems, it is prone to becoming trapped into local mode, when the model space is complex. SAMC, proposed by Liang, Liu and Carroll, essentially overcomes the difficulty in dimension-jumping moves, by introducing a self-adjusting mechanism. However, this learning mechanism has not yet reached its maximum efficiency. In this dissertation, we propose a Pop-SAMC algorithm; it works on population chains of SAMC, which can provide a more efficient self-adjusting mechanism and make use of crossover operator from genetic algorithms to further increase its efficiency. Under mild conditions, the convergence of this algorithm is proved. The effectiveness of Pop-SAMC in Bayesian model selection problems is examined through a change-point identification example and a large-p linear regression variable selection example. The numerical results indicate that Pop- SAMC outperforms both the single chain SAMC and RJMCMC significantly. In the ChIP-chip data analysis study, we developed two methodologies to identify the transcription factor binding sites: Bayesian latent model and population-based test. The former models the neighboring dependence of probes by introducing a latent indicator vector; The later provides a nonparametric method for evaluation of test scores in a multiple hypothesis test by making use of population information of samples. Both methods are applied to real and simulated datasets. The numerical results indicate the Bayesian latent model can outperform the existing methods, especially when the data contain outliers, and the use of population information can significantly improve the power of multiple hypothesis tests.

Although anxiety disorders and conduct problems often co-occur in children and adolescents, literature describing the effects of such co-occurrence is mixed. There is evidence that symptoms of anxiety disorders may mitigate symptoms of conduct problems (buffering hypothesis) or may exacerbate symptoms of conduct problems (multiple problem hypothesis). A dual-pathway model has been proposed that suggests several possible etiological or risk processes that may differentiate these pathways (i.e., the buffering hypothesis or the multiple problem hypothesis) (Drabick, Ollendick, & Bubier, 2010). Executive functioning is one factor that has been identified that may differentially confer risk to the proposed pathways; however, little research has been done investigating its role. The purpose of the present study was to evaluate the dual-pathway model by determining whether executive functioning abilities contribute to differentiating those youth for whom anxiety exacerbates conduct problems from those for whom anxiety mitigates conduct problems. Specifically, the study sought to examine if executive functioning moderated the effect of anxiety symptom severity on conduct problems. Latent variable structural equation modeling (SEM) was used to analyze the data of 221 youth aged 9 to 16 in a residential treatment center who completed a full neuropsychological evaluation. Results of the study failed to support the hypothesis that executive functioning moderates the effect of anxiety on conduct problems. Furthermore, a structural equation model without an interaction between executive functioning and anxiety was found to fit the data better than a model with an interaction between those variables. Overall, the study found that executive functioning abilities could not distinguish youth for whom anxiety exacerbates conduct problems from youth for whom anxiety mitigates conduct problems. Recommendations for future research in light of the limitations of the current study, as well as remaining gaps in the literature, are discussed. / text

Learning and memory impairments are among the most common and enduring cognitive consequences of traumatic brain injury (TBI). Researchers have yet to reach a consensus with regard to the basic cognitive mechanism underlying new learning and memory disturbances after TBI. The purpose of the present study was to investigate the current views regarding the cognitive processes thought to explain impairments in verbal learning and memory subsequent to brain injury. Specifically, this study sought to examine the roles of the central executive component of working memory and processing speed in verbal learning ability following TBI. Latent variable structural equation modeling (SEM) was used to analyze the data of 70 post-acute care TBI patients between the ages of 16 and 65, who completed a full neuropsychological evaluation. Results indicated that verbal learning and memory difficulties following TBI were explained primarily in terms of the central executive aspects of working memory, after accounting for the relative contributions of processing speed in the model. The direct effect of processing speed on verbal learning and memory was not significant when working memory was taken into account in the model. Rather, the effects of processing speed on verbal learning ability were largely indirect through the central executive component of working memory. Results highlight the importance of both working memory and processing speed in supporting verbal learning and memory processes after TBI. Practical implications for targeting remediation efforts and directing approaches to memory rehabilitation are discussed in light of the study’s findings. / text

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Pathway is a set of genes which are predefined and serve a particular celluar or physiological function. Ranking pathways relevant to a particular phenotype can help researchers focus on a few sets of genes in pathways. In this thesis, a Bayesian hierarchical latent model was proposed using generalized linear random effects model. The advantage of the approach was that it can easily incorporate prior knowledges when the sample size was small and the number of genes was large. For the covariance matrix of a set of random variables, two Gaussian random processes were considered to construct the dependencies among genes in a pathway. One was based on the polynomial kernel and the other was based on the Gaussian kernel. Then these two kernels were compared with constant covariance matrix of the random effect by using the ratio, which was based on the joint posterior distribution with respect to each model. For mixture models, log-likelihood values were computed at different values of the mixture proportion, compared among mixtures of selected kernels and point-mass density (or constant covariance matrix). The approach was applied to a data set (Mootha et al., 2003) containing the expression profiles of type II diabetes where the motivation was to identify pathways that can discriminate between normal patients and patients with type II diabetes. / Master of Science

Modeling and discovering knowledge from multi-relational and multivariate discrete data is a crucial task that arises in many research and application domains, e.g. text mining, intelligence analysis, epidemiology, social science, etc. In this dissertation, we study and address three problems involving the modeling of multi-relational discrete data and multivariate multi-response count data, viz. (1) discovering surprising patterns from multi-relational data, (2) constructing a generative model for multivariate categorical data, and (3) simultaneously modeling multivariate multi-response count data and estimating covariance structures between multiple responses. To discover surprising multi-relational patterns, we first study the ``where do I start?'' problem originating from intelligence analysis. By studying nine methods with origins in association analysis, graph metrics, and probabilistic modeling, we identify several classes of algorithmic strategies that can supply starting points to analysts, and thus help to discover interesting multi-relational patterns from datasets. To actually mine for interesting multi-relational patterns, we represent the multi-relational patterns as dense and well-connected chains of biclusters over multiple relations, and model the discrete data by the maximum entropy principle, such that in a statistically well-founded way we can gauge the surprisingness of a discovered bicluster chain with respect to what we already know. We design an algorithm for approximating the most informative multi-relational patterns, and provide strategies to incrementally organize discovered patterns into the background model. We illustrate how our method is adept at discovering the hidden plot in multiple synthetic and real-world intelligence analysis datasets. Our approach naturally generalizes traditional attribute-based maximum entropy models for single relations, and further supports iterative, human-in-the-loop, knowledge discovery. To build a generative model for multivariate categorical data, we apply the maximum entropy principle to propose a categorical maximum entropy model such that in a statistically well-founded way we can optimally use given prior information about the data, and are unbiased otherwise. Generally, inferring the maximum entropy model could be infeasible in practice. Here, we leverage the structure of the categorical data space to design an efficient model inference algorithm to estimate the categorical maximum entropy model, and we demonstrate how the proposed model is adept at estimating underlying data distributions. We evaluate this approach against both simulated data and US census datasets, and demonstrate its feasibility using an epidemic simulation application. Modeling data with multivariate count responses is a challenging problem due to the discrete nature of the responses. Existing methods for univariate count responses cannot be easily extended to the multivariate case since the dependency among multiple responses needs to be properly accounted for. To model multivariate data with multiple count responses, we propose a novel multivariate Poisson log-normal model (MVPLN). By simultaneously estimating the regression coefficients and inverse covariance matrix over the latent variables with an efficient Monte Carlo EM algorithm, the proposed model takes advantages of association among multiple count responses to improve the model prediction accuracy. Simulation studies and applications to real world data are conducted to systematically evaluate the performance of the proposed method in comparison with conventional methods. / Ph. D. / In this decade of big data, massive data of various types are generated every day from different research areas and industry sectors. Among all these types of data, text data, i.e. text documents, are important to many research and real world applications. One challenge faced when analyzing massive text data is which documents we should investigate first to initialize the analysis and how to identify stories and plots, if any, that hide inside the massive text documents. For example, in intelligence analysis, when analyzing intelligence documents, some common questions that analysts ask are ‘How is a suspect connected to the passenger manifest on this flight?’ and ‘How do distributed terrorist cells interface with each other?’. This is a crucial task so called storytelling. In the first half of this dissertation, we will study this problem and design mathematical models and computer algorithms to automatically identify useful information from text data to help analysts to discover hidden stories and plots from massive text documents. We also incorporate visual analytics techniques and design a visualization system to support human-in-the-loop exploratory data analysis so that analysts could interact with the algorithms and models iteratively to investigate given datasets. In the second half of this dissertation, we study two problems that arise from the domain of public health. When epidemic of certain disease happens, e.g. flu seasons, public health officials need to make certain policies in advance to prevent or alleviate the epidemic. A data-driven approach would be to make such public health policies using simulation results and predictions based on historical data. One problem usually faced in epidemic simulation is that researchers would like to run simulations with real-world data so that the simulation results can be close to real-world scenarios but at the same time protect the private information of individuals. To solve this problem, we design and implement a mathematical model that could generate realistic sythetic population using U.S. Census Survey to help conduct the epidemic simulation. Using flus as an example, we also propose a mathematical model to study associations between different types of flus with the information collected from social media, like Twitter. We believe that identifying such associations between different types of flus will help officials to make appropriate public health policies.