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This paper investigates the prolongevitist debate; that is, the debate surrounding whether to extend human lifespans through medical technology (prolongevitism) or not (apologism). Apologists such as Daniel Callahan emphasize an approach to this debate which focuses on social self-criticism and ideology. I investigate the way the ideology of medicine Callahan describes enables modern medicine to dominate the body and discover that this ideology relies on a dualist conceptual structure. I describe the way in which mind/body dualism functions as an important component of this ideology of domination. By identifying this dualist structure as an essential component of the ideology of medicine, I make it possible to critique and find alternatives to potential solutions to this ideology of medicine. Through this strategy, I criticize standard apologist responses to the prolongevitist debate. While I share the apologist concern regarding the ideology of medicine, I believe their response to the problem of ideology is inadequate. I find alternative answers to the question of how to overcome the ideology of the body through theories of discourse and phenomenology. My new approach emphasizes cultivating a positive embodiment relationship through phenomenological practices and the criticism and creation of new discourses of the body. / Dissertation / Master of Arts (MA)

Low pressure steam turbine last stage blade behaviour was investigated and researched over duration of this PhD project period. The aim of the research was to enhance the life of last stage blades by investigation and mitigation of the accumulative damage throughout the life of the turbine blade. The research was mainly broken down in to three main themes covering erosion, High Cycle Fatigue in industrial service and High Cycle Fatigue under laboratory conditions. The three themes were then further analysed during the research analysis for correlation and the extent of accumulative damage contribution during each stage. An accumulative damage model was constructed together with mathematical expressions for each stage of accumulative damage. The erosion damage model was constructed first and separately, followed by a separate damage model for crack initiation and propagation. After this a combined damage model was constructed to represent accumulative damage throughout the turbine blade lifecycle. After the damage mechanisms were researched and understood, a damage mitigation model was constructed consisting of primary damage mechanisms and secondary damage mechanisms. The primary damage mechanisms were then investigated further and a life extension technique developed to increase turbine blade life by reducing damage rates per turbine start, giving more starts life capability to the last stage blades. The secondary mitigation mechanisms was not covered in this project and regarded as future work under the low pressure turbine life extension possibilities. The research work also gave a spin off which allowed the author to conduct and finish a separate piece of work of designing the problem out through redesigning the turbine blade and condenser space in conjunction with leading experts from the industry.

The following report presents the preliminary design and prototype development phase of a technology insertion program implemented by this author to extend the service life and to improve the performance of the United States Navy's Bathythermograph Data Recorder System onboard Submarines (AN/BQH-7) and Surface Ships (AN/BQH-7A). The performance upgrade will increase the Fleet User's ability to measure sonar performance and will provide more accurate salinity measurements used for submarine ballasting and control. This project is unique not necessarily because Commercial-off-the-Shelf (COTS) and Non-Developmental Item (NDI) componentry is being used but because the focus is on developing a systems engineering process model for (1) the implementation of COTS and NDI technologies in an open systems architecture environment, (2) a maintenance, sparing, and life cycle support model for COTS and NDI programs, and (3) a periodic technology insertion plan for keeping pace with COTS and NDI technology advances and configuration changes. It is intended that this report be used in the future as a good example of the successful implementation of Acquisition Reform and DoD 5000.2B initiatives. / Master of Science

Members of People Unlimited Inc, maintain that they are proof that physical immortality is possible, despite the death of their founder. In this dissertation, I address the paradox of immortalist lifeworlds: how can members of People Unlimited maintain that they are immortal, yet also claim that members are still susceptible to death? This dissertation is about how imagined futures make up the present for radical life extension (RLE) activists, who form part of an emergent immortalist biosocial landscape where anticipation acts as a way of recognizing the future as a model for the present. Understanding how immortalists can claim to be physically immortal in the present, yet always working toward immortality, requires consideration of the cultures and communities within the broader RLE movement, human relationships to finitude, relationships between science and religion, and biomedical imaginaries. Since little ethnographic data exists on these communities, the goal of my research is to provide a general overview of the contemporary social phenomena of immortality, with an ethnographic focus on People Unlimited and Alcor Life Extension, both in Scottsdale, Arizona, and the broader RLE community that attends the yearly Revolution Against Aging and Death Festival (RAADfest) in Las Vegas, Nevada. The dissertation argues that RLE is an emergent form of biosocial citizenship among healthy individuals, whose present biological limitations are overcome by an orientation towards the future. / Dissertation / Doctor of Philosophy (PhD) / Members of People Unlimited Inc, maintain that they are proof that physical immortality is possible, despite the death of their founder. In this dissertation, I address the paradox of immortalist lifeworlds: how can members of People Unlimited maintain that they are immortal, yet also claim that members are still susceptible to death? I argue that for many immortalists, anticipation acts as a way of recognizing the future as a model for the present. I explore how radical life extension activists, including immortalists, transhumanist, cryonicists, and others, create immortal futures through self-care regimens in the present. I connect their future and present by examining the promissory and hopeful discourses of modern bioeconomies, and the forms of affect used in the creation of immortal biosocial worlds.

The thesis’ study of life expansion proposes a framework for artistic, design-based approaches concerned with prolonging human life and sustaining personal identity. To delineate the topic: life expansion means increasing the length of time a person is alive and diversifying the matter in which a person exists. For human life, the length of time is bounded by a single century and its matter is tied to biology. Life expansion is located in the domain of human enhancement, distinctly linked to technological interfaces with biology. The thesis identifies human-computer interaction and the potential of emerging and speculative technologies as seeding the promulgation of human enhancement that approach life expansion. In doing so, the thesis constructs an inquiry into historical and current attempts to append human physiology and intervene with its mortality. By encountering emerging and speculative technologies for prolonging life and sustaining personal identity as possible media for artistic, design-based approaches to human enhancement, a new axis is sought that identifies the transhuman and posthuman as conceptual paradigms for life expansion. The thesis asks: What are the required conditions that enable artistic, design-based approaches to human enhancement that explicitly pursue extending human life? This question centers on the potential of the study’s proposed enhancement technologies in their relationship to life, death, and the human condition. Notably, the thesis investigates artistic approaches, as distinct from those of the natural sciences, and the borders that need to be mediated between them. The study navigates between the domains of life extension, art and design, technology, and philosophy in forming the framework for a theory of life expansion. The critical approach seeks to uncover invisible borders between these interconnecting forces by bringing to light issues of sustaining life and personal identity, ethical concerns, including morphological freedom and extinction risk. Such issues relate to the thesis’ interest in life expansion and the use emerging and speculative technologies. 4 The study takes on a triad approach in its investigation: qualitative interviews with experts of the emerging and speculative technologies; field studies encountering research centers of such technologies; and an artistic, autopoietic process that explores the heuristics of life expansion. This investigation forms an integrative view of the human use of technology and its melioristic aim. The outcome of the research is a theoretical framework for further research in artistic approaches to life expansion.

Thesis advisor: John B. Williamson / The desire to defy the aging process and to prolong the lifespan has long captured the human imagination. Recognized as one of the most ancient known pieces of literature, the Epic of Gilgamesh documents a King’s quest to find immortality. More recent examples include the story of Ponce de Leon’s 16th century search to discover the Fountain of Youth, Sir Francis Bacon’s (1659) assertion that humans are naturally immortal “potens non mori,” and Benjamin Franklin’s desire to be preserved in a vat of madeira until science is capable of life extension. Developments in science and technology, including telomere manipulation, genetic engineering, cloning, nanotechnology, the potential to create new organs from stem cells, and the creation of therapeutic pharmaceuticals that could significantly postpone disease, have served to inspire; aging in the 21st century is no longer regarded by scientists as an inevitable process programmed by evolution (Olshansky et al. 2006). Situated within a detailed historical overview, this qualitative research project explores the experiences of individuals engaged in practices currently implicated in potentially delaying aging and even extending life. Based on information from 44 in-depth interviews, this research explores issues such as lay understandings of the biology of aging, conceptualizations of the inner body, the use of and experience with optimization technologies, and the embodied effects of participation in anti-aging and life-extension body regimens. / Thesis (PhD) — Boston College, 2008. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Sociology.

Mushrooms are one of the protein rich foods, however they have a short pro-harvest life (2 to 3 days) compared to most vegetables. The aim of this study was to evaluate whether applying an anti-browning solution using vacuum impregnation and then electron beam irradiation can be used to extend the shelf life of fresh-cut mushrooms (Agaricus bisporus). Solutions made with (a) 2% ascorbic acid + 1% calcium lactate, (b) 2% citric acid + 1% calcium lactate, (c) 1% chitosan + 1% calcium lactate, and (d) 1% calcium lactate were used to impregnate mushroom slices at different vacuum pressures, vacuum pressure times, and atmospheric restoration times. Mushrooms were also irradiated at a dose of 1 kGy using a 1.35 MeV e-beam accelerator and their quality was evaluated in terms of color, texture, and microbial growth during 15 days storage at 4 degrees C. The best vacuum impregnation treatment was the 2% ascorbic acid and 1% calcium lactate solution using a vacuum pressure of 50 mmHg for 5 minutes and an atmospheric restoration time of 5 minutes. The control (not treated) and impregnated samples lost their structure (softening) during storage. The irradiated samples lost their firmness by day 4 of storage. The addition of calcium lactate to the samples during the treatment helped to keep the product’s texture during the 15 days storage time. Color of the mushrooms changed during storage for all the control and impregnated samples and only the irradiated samples showed an acceptable color by the end of day 15. Aerobics and psychrotrophics counts were significantly reduced by irradiation; while yeast and molds population increased by day 9 and were not completely inactivated with a dose of 1 kGy. Sensory panelists preferred the treated samples over the controls. The best treatment was the combination of vacuum impregnation with irradiation according to the consumer studies.

Demonstrations that ageing and life-span can be manipulated in model animal species have increased hopes that the length of the human life-span may also be dramatically extended. The possibility of human life-span extension has provoked debate amongst bioethicists. Proponents of life-extension cite the benefits of a longer and healthier life. Opponents argue that these technologies: violate human nature; may not necessarily increase the quality of life; and, they will lead to overpopulation and social strife that outweighs any benefits to individuals. Others see problems of equity and justice in access to any potential life-extension technologies. The attitudes of members of the public have largely been neglected in ethical and policy discussions of human life-extension. In the absence of empirical evidence on public attitudes, proponents and opponents have assumed either widespread public enthusiasm for life-extension or strong opposition because of concerns about its moral acceptability or its adverse social consequences. All agree that public attitudes could be a powerful facilitator or a major obstacle to the development of life-extending technologies. The goal of this thesis is to characterise public attitudes towards life-extension and describe factors that influence these views. It examines the following questions: (1) What is the prevalence of public support for (or opposition to) life-extension research? (2) How much interest is there among the public in using a technology that could increase life-span by slowing ageing? (3) What issues are important to members of the public in forming their attitudes? (4) What ethical issues, if any, do members of the public identify? (5) Are these ethical and moral issues the same ones expressed by ethicists and social scientists? (6) How do these ethical attitudes affect their overall interest in, or support for, life-extension? (7) How are attitudes towards life-extension related to demographic characteristics such as age, gender, education, and religious beliefs? Three empirical studies were designed using a mixed methodology to answer these questions. Study 1 (focus groups) and Study 2 (individual interviews) were qualitative investigations of public attitudes towards life-extension. The results of these two studies informed the design of Study 3 - a quantitative survey of attitudes towards life-extension via telephone interviews with 605 adult members of the Australian public. Participants in Study 3 were presented with a vignette outlining the prospect of a life-extension pharmaceutical that could increase life-span to 150 years by slowing the ageing process. They were then asked to express their level of agreement with a series of statements about ethical, social and personal implications of life-extension, and their overall support and interest in using such a technology. All three studies found mixed public attitudes towards the development and use of life-extension technologies. Participants in Studies 1 and 2 were concerned about whether life-extension would be accompanied by good quality of life. Studies 1 and 2 also suggested that participants were concerned about social and ethical issues that included: the potential impact on society; whether life-extension was “natural”; and whether access to life-extension technologies would be fair and equitable. Study 3 confirmed the diversity of public views identified in the qualitative phase. While 65% supported such research, only 35% said that they would use a life-extension technology if one became available. Men were more supportive of research and more disposed to use life-extension technologies than women. 58% of participants expressed ethical or moral concerns about life-extension technologies. When asked to weigh up the potential benefits and negatives that they identified as important, almost half (48%) said that life-extension technologies would do more harm than good to society, and 40% thought that taking a life-extension pharmaceutical would do them more harm than good personally. Study 3 also showed that valid scales could be constructed to assess the strength of concerns about social and ethical issues. These scales were: personal benefits/negatives; social benefits/negatives; and natural concerns. Higher levels of support for using and developing life-extension technologies were associated with higher levels of perceived personal and societal benefits from life-extension. Participants who had more ethical concerns, and perceived more personal and social negatives were less likely to support or express an interest in using life-extension technologies. Perceptions of personal and social benefits, and having concerns about the “naturalness” of life-extension were the best predictors of support or interest in using life-extension technologies. This thesis shows that public attitudes towards life-extension are more varied than some ethicists have assumed. While there are substantial minorities who were clearly “pro” or “con”, many members of the public are concerned about ethical and social issues. It would be unwise for researchers of life-extension not to take account of public attitudes and concerns if they hope to foster public support for their work.

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