Survival models are used in analysing time-to-event data. This type of data is very common in medical research. The Cox proportional hazard model is commonly used in analysing time-to-event data. However, this model is based on the proportional hazard (PH) assumption. Violation of this assumption often leads to biased results and inferences. Once non-proportionality is established, there is a need to consider time-varying effects of the covariates. Several models have been developed that relax the proportionality assumption making it possible to analyse data with time-varying effects of both baseline and time-updated covariates. I present various approaches for handling time-varying covariates and time-varying effects in time-to-event models. They include the extended Cox model which handles exogenous time-dependent covariates using the counting process formulation introduced by cite{andersen1982cox}. Andersen and Gill accounts for time varying covariates by each individual having multiple observations with the total-at-risk follow up for each individual being further divided into smaller time intervals. The joint models for the longitudinal and time-to-event processes and its extensions (parametrization and multivariate joint models) were used as it handles endogenous time-varying covariates appropriately. Another is the Aalen model, an additive model which accounts for time-varying effects. However, there are situations where all the covariates of interest do not have time-varying effects. Hence, the semi-parametric additive model can be used. In conclusion, comparisons are made on the results of all the fitted models and it shows that choice of a particular model to fit is influenced by the aim and objectives of fitting the model. In 2002, an AntiRetroviral Treatment (ART) service was established in the Cape Town township of Gugulethu, South Africa. These models will be applied to an HIV/AIDS observational dataset obtained from all patients who initiated ART within the programme between September 2002 and June 2007.

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Aktuelle Affektforschung betont die Bedeutung mikrolängsschnittlicher Daten für das Verstehen täglichen affektiven Funktionierens, da sie es erlauben affektive Dynamiken und potentiell zugrunde liegende Prozesse zu beschreiben. Dynamische Längsschnittmodelle werden entsprechend attraktiver. In dieser Dissertation komme ich Forderungen nach einer Integration kontextueller Informationen in die Untersuchung täglichen affektiven Funktionierens nach. Speziell modifiziere ich populäre dynamische Modelle so, dass sie kontextuelle Variationen einbeziehen. In einem ersten Beitrag werden Personen als in Kontexte eingebettet begriffen. Der vorgeschlagene Ansatz der festen moderierten Zeitreihenanalyse berücksichtigt systemische Reaktionen auf kontextuelle Veränderungen, indem Veränderungen in allen Parametern eines dynamischen Zeitreihenmodells auf kontextuelle Veränderungen bedingt schätzt werden. Kontextuelle Veränderungen werden als bekannt und assoziierte Parameterveränderungen als deterministisch behandelt. Folglich sind Modellspezifikation und -schätzung erleichtert und in kleineren Stichproben praktikabel. Es sind allerdings Informationen über den Einfluss kontextueller Faktoren erforderlich. Anwendbar auf einzelne Personen erlaubt der Ansatz die uneingeschränkte Exploration interindividueller Unterschiede in kontextualisierten affektiven Dynamiken. In einem zweiten Beitrag werden Personen als mit Kontexten interagierend begriffen. Ich implementiere eine Prozessperspektive auf kontextuelle Schwankungen, die die Dynamiken täglicher Ereignisse über autoregressive Modelle mit Poisson Messfehler abbildet. Die Kombination von Poisson und Gaußscher autoregressiver Modellierung erlaubt eine Formalisierung des dynamischen Zusammenspiels kontextueller und affektiver Prozesse. Die Modelle sind hierarchisch aufgesetzt und erfassen so interindividuelle Unterschiede in intraindividuellen Dynamiken. Die Schätzung erfolgt über simulationsbasierte Verfahren der Bayesschen Statistik. / Recent affect research stresses the importance of micro-longitudinal data for understanding daily affective functioning, as they allow describing affective dynamics and potentially underlying processes. Accordingly, dynamic longitudinal models get increasingly promoted. In this dissertation, I address calls for an integration of contextual information into the study of daily affective functioning. Specifically, I modify popular dynamic models so that they incorporate contextual changes. In a first contribution, individuals are characterized as embedded in contexts. The proposed approach of fixed moderated time series analysis accounts for systemic reactions to contextual changes by estimating change in all parameters of a dynamic time series model conditional on contextual changes. It thus treats contextual changes as known and related parameter changes as deterministic. Consequently, model specification and estimation are facilitated and feasible in smaller samples, but information on which and how contextual factors matter is required. Applicable to single individuals, the approach permits an unconstrained exploration of inter-individual differences in contextualized affective dynamics. In a second contribution, individuals are characterized as interacting reciprocally with contexts. Implementing a process perspective on contextual changes, I model the dynamics of daily events using autoregressive models with Poisson measurement error. Combining Poisson and Gaussian autoregressive models can formalize the dynamic interplay between contextual and affective processes. It thereby distinguishes not only unique from joint dynamics, but also affective reactivity from situation selection, evocation, or anticipation. The models are set up as hierarchical to capture inter-individual differences in intra-individual dynamics. Estimation is carried out via simulation-based techniques in the Bayesian framework.