Hodgkin lymphoma with symptomatic osseous involvement can have a similar presentation to osteomyelitis. Common findings in symptoms, laboratory workup, and imaging can make it very difficult to distinguish between the two diseases. Excisional biopsy should be pursued if fine-needle biopsy is equivocal and suspicion of lymphoma is high. We report a case of a 40-year-old man who presented with a history of marine animal sting on his neck and later developed erythema in the area, chest pain, constitutional symptoms, adenopathy, and imaging classic for sternal osteomyelitis. Fortunately, initial biopsy prompted the possibility of lymphoma, and further workup was initiated, which confirmed Hodgkin lymphoma. This case is a good reminder that malignancies and infections can share many common features, and keeping a broad differential diagnosis can be lifesaving. Proper staging and risk stratification of Hodgkin lymphoma help determine the optimal treatment. (C) 2017 The Author(s) Published by S. Karger AG, Basel

Mantle cell lymphoma (MCL) is a rare lymphoproliferative disorder (LPD) that has very poor survival. Like other LPDs, the neoplastic cells of MCL have an intimate dependence upon accessory cells within haematopoietic tissues. Understanding and exploiting the tissue-relationships of the mantle cells may therefore lead to further new approaches to treatment. This study work has set out to construct an in vitro system to model relevant aspects of the tissue-dependent behaviour of the neoplastic mantle cells, seeking to establish the link between in vitro behaviour and clinical phenotype, and establishing the feasibility of this system to study the effects of different therapeutic interventions. The first experimental chapter employs relevant mouse and human stromal models to mirror the tissue environment of MCL in vivo. Testing relevant agents, the work establishes that the system can identify different behaviour between indolent and aggressive forms of MCL, and demonstrates a particular importance for CD40 ligand both in the proliferation and survival of the neoplastic mantle cells, but shows also how these effects are modulated by the soluble factors interleukin-4 (IL-4) and the toll-like receptor-9 ligand (TLR9-L). The second experimental chapter examines the adhesion molecules expressed on MCL cells. Considerable variation in the level of expression is observed between cases, but overall the cases express particularly high levels of the integrin receptors LFA-1 (detected by alpha chain CD11a) and VLA-4 (detected by alpha chain CD49d). Cases also showed a significant difference in overall adhesion and chemokine-receptor expression between cases that had either a nodal or leukaemic clinical pattern, although no single adhesion molecule was characteristic of clinical phenotype. The final experimental chapter looked at 3-D culture of MCL. Within tissues MCL grows in a 3-D rather than 2-D matrix and it is recognised that cells employ different forms of adhesion and migration within the different spatial environments. This chapter establishes the feasibility of growing cells in 3-D systems and looks at optimal conditions to preserve and examine the cellular characteristics of cells within a 3-D environment. Overall, this thesis demonstrates the feasibility and pathobiological relevance of ex vivo culture of MCL cells giving insights into the factors that drive MCL survival and proliferation and the correlation between in vitro behaviour and clinical phenotype. It is proposed that this work can be expanded to examine therapeutic interventions in the disorder.

No description available.

Background: We characterized B-cell non-Hodgkin lymphoma (NHL) cases over ten years at a tertiary children's hospital to contribute to the body of knowledge on pediatric lymphoma in developing countries with a high human immunodeficiency virus (HIV) burden. Methods: A retrospective cohort study using clinical and laboratory records of children newly diagnosed with B-cell NHL from January 2005 to December 2014. Results: Seventy-five children ≤ 15 years were included. The majority had Burkitt lymphoma (n = 61). Twenty-five percent (n = 19) were HIV positive and 16% (n = 12) had concurrent active tuberculosis. Bulky disease was present in 65.7% (n = 46) and 30.1% (n = 22) were classified as Lymphomes Malins B (LMB) risk group C. The five year survival estimates for HIV-negative and HIV-positive children were similar in our cohort: 81% vs. 79% for eventfree survival and 85% vs. 83.9% for overall survival. Of three children with Burkitt lymphoma, HIV and LMB group C, two died within one year. Conclusions: Irrespective of HIV status, the survival of children in our B-cell NHL cohort compares favorably with cure rates in developed nations, although advanced disease remains associated with a poor prognosis. Characterization of childhood NHL cases contributes to accurate risk stratification and tailored treatment.

La progression des traitements dans le lymphome amène à s’intéresser à la qualité de vie des survivants. La fatigue chronique est le problème le plus fréquemment décrit par les survivant. Dans le cadre du lymphome hodgkinien, le niveau de fatigue revêt une importance particulière par les patients ont entre 20 et 40 ans et sont confronté aux problématiques de retour à l’emploi. Dans la première partie de cette thèse, nous traiterons des causes de la fatigue et de sont évolutions pour les lymphomes hodgkinien et les lymphomes non-hodgkinien. En particulier, nous mettrons en lumière l’impacte des comorbidités sur les niveaux de fatigue ainsi que les différences d’évolution de la fatigue entre les survivants d’un lymphome hodgkinien et d’un lymphome non-hodgkinien. Dans la deuxième partie, nous traiterons de l’intégration de la fatigue dans l’évaluation des traitement dans le cadre du lymphome hodgkinien avec les problématiques de faible inclusion et de fort taux de survie. / The progression of treatment in lymphoma leads to an interest in the quality of life ofsurvivors. Chronic fatigue is the most frequently described problem among survivors. Inhodgkin lymphoma, the level of fatigue is of particular importance to patients between20 and 40 years of age and faces problems of return to employment. In the first part of thisthesis, we will deal with the causes of fatigue and are evolutionary for hodgkin lymphomaand non-hodgkin lymphoma. In particular, we will highlight the impact of comorbiditieson fatigue levels as well as differences in fatigue patterns between survivors of hodgkinlymphoma and non-hodgkinian lymphoma. In Part Two, we will deal with the integrationof fatigue into the assessment of treatment in hodgkin lymphoma with low-inclusion andhigh survival problems.

No description available.

No description available.

No description available.

No description available.

No description available.