Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T11:57:11Z No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:22:44Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:22:41Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:23:34Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Made available in DSpace on 2014-12-18T12:23:37Z (GMT). No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) Previous issue date: 2014 / O efeito do consumo cr?nico do cigarro no perfil inflamat?rio, estresse oxidativo e desempenho f?sico t?m sido investigado em fumantes assintom?ticos, contudo, estes estudos na sua maioria ainda s?o poucos e divergentes. Sendo assim, o objetivo deste estudo foi avaliar o efeito cr?nico do tabagismo no perfil inflamat?rio, estresse oxidativo, fun??o muscular esquel?tica perif?rica e aptid?o cardiorrespirat?ria de homens adultos assintom?ticos. Os sujeitos do estudo foram divididos igualmente entre o grupo fumante (GF, n= 20) e grupo controle (GC, n= 20), composto por sujeitos n?o fumantes. A fun??o pulmonar de todos participantes foi avaliada pela espirometria. O perfil inflamat?rio foi avaliado pela mensura??o das concentra??es plasm?ticas das citocinas IL-6, TNF-?, IL-10 e pelos receptores sol?veis de TNF-? (sTNFR1 e sTNFR2). O estresse oxidativo foi avaliado pela mensura??o das concentra??es plasm?ticas das subst?ncias reativas ao ?cido tiobarbit?rico (TBARS), da atividade das enzimas antioxidantes super?xido dismutase (SOD) e catalase de eritr?citos e pela capacidade antioxidante total do plasma. A fun??o muscular esquel?tica perif?rica foi avaliada por meio das medidas de pico de torque dos m?sculos extensores e flexores de joelho e da resist?ncia e fadiga muscular dos m?sculos extensores de joelho; e a aptid?o cardiorrespirat?ria foi avaliada atrav?s da mensura??o do consumo pico de oxig?nio (VO2pico), frequ?ncia card?aca m?xima (FCmax) e dist?ncia caminhada em um teste m?ximo de caminhada/corrida. Sujeitos do GF apresentaram aumentos significativos das concentra??es plasm?ticas de TBARS e do receptor sol?vel sTNFR1 e diminui??es significativas da atividade da enzima catalase em lisado eritrocit?rio, comparados ao GC. Al?m disso, sujeitos do GF exibiram menor resist?ncia muscular dos m?sculos extensores de joelho como determinado pelas medidas de trabalho, com inalterado ?ndice de fadiga dos m?sculos extensores de joelho e pico de torque dos m?sculos extensores e flexores de joelho. A aptid?o cardiorrespirat?ria foi similar entre os sujeitos do GF e do GC. Este estudo demonstrou que homens fumantes cr?nicos e assintom?ticos exibiram altera??es no perfil inflamat?rio, no estresse oxidativo e na fun??o muscular esquel?tica perif?rica, quando comparados a n?o fumantes. / The effect of chronic cigarette smoking on inflammatory profile, oxidative stress and physical performance has been investigated in asymptomatic smokers, however, these studies are few and divergent. Thus, the aim of this study was to evaluate the chronic effect of smoking on inflammatory profile, oxidative stress, peripheral skeletal muscle function and cardiorespiratory fitness in asymptomatic adult men. The subjects of the study were divided equally between the smoking group (SG, n = 20) and control group (CG, n = 20) composed of non-smoking subjects. The lung function of all participants was assessed by spirometry. The inflammatory response was assessed by measurement of plasma concentrations of IL- 6, TNF- ?, IL -10 and soluble receptors for TNF-? (sTNFR1 and sTNFR2). Oxidative stress was evaluated by measuring plasma concentrations of thiobarbituric acid reactive substances (TBARS), the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase in erythrocytes and the total antioxidant capacity of plasma. The peripheral skeletal muscle function was assessed by measuring the peak torque of the extensor and flexor muscles of the knee; and resistance and muscle fatigue of the knee extensor muscles; and cardiorespiratory fitness was assessed by measurement of peak uptake oxygen (VO2peak), maximum heart rate (HRmax) and distance walked on a maximum test of the walk/run. SG subjects showed significant increases in plasma concentrations of TBARS and soluble receptors sTNFR1 and significant decreases in erythrocyte catalase enzyme activity, compared to the CG. In addition, SG subjects exhibited less muscle strength of knee extensors muscles as determined by measures of work and unchanged fatigue index of the knee extensors muscles and peak torque of knee extensors and flexors muscles. Cardiorespiratory fitness was similar between subjects SG and CG. This study demonstrated that male chronic smokers, healthy adult, exhibited changes in the inflammatory response, oxidative stress and peripheral skeletal muscle function, when compared to non-smokers. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2014.