MOB (Mps One Binder) is a conserved gene family found in all major kingdoms. The MOB genes are essential components acting in mitotic exit and cytokinesis in both budding and fission yeasts. They are further identified as tumor suppressors in Drosophila (D.) melanogaster. Recently, they are found to be involved in the emerging Drosophila Hippo-LATS tumor suppressor pathway. Seven human homologs of yeast MOB (hMOB1A, 1B, 2A, 2B, 3, 4, 5) have been discovered. The hMOB1B is the gene that has been extensively studied and is reported to be required for the activation of LATS (Large Tumor Suppressor)/NDR (Nuclear Dbf2-related) protein kinase family, however, the functional significance of the gene remains unknown. This study is the first to elucidate the biological and biochemical functions of all seven human MOBs. By examining hMOB mRNA expression in various human tissues, we found that the hMOBs have exhibited different expression patterns. We also investigated the subcellular localization of hMOBs during interphase through immunofluorescent analysis. While hMOB2A is localized in the cytoplasm, hMOB4 is exclusively found in the nucleus. All of the other hMOBs are localized in both cytoplasm and nucleus. Furthermore, we identified hMOB1A and hMOB1B as the main binding partners of LATS and NDR in vitro. Additionally, we successfully identified a region on hMOB1B for the interaction with LATS or NDR and determined the crucial residue that is responsible for the binding of LATS2 with hMOB1B. Most significantly, we found that over-expression of hMOB1B in human cancer cells inhibits cell proliferation and induces cell death. Moreover, hMOB1B when targeted to the plasma membrane dramatically enhances the phenotype. Conversely, small interfering (si) RNA-mediated suppression of either endogenous hMOB1A or hMOB1B causes increased cell proliferation, whereas suppression of both hMOB1A and hMOB1B demonstrates a more significant enhancement in tumor cell growth. Moreover, co-expression of both LATS and hMOB1B targeted to the plasma membrane completely abolishes cell proliferation. Our findings provide convincing evidence that hMOB1A and hMOB1B function as negative regulators of cell proliferation and as pro-apoptotic proteins. Understanding hMOBs functions in the cell and their possible role in tumorigenesis can provide important information for the diagnosis and treatment of human cancers. / Thesis (Master, Pathology & Molecular Medicine) -- Queen's University, 2008-09-23 14:18:43.896

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Medicine (MMed), Johannesburg, 2018 / Mob justice fatalities are a gross violation of human rights in that they represent extra-legal punishment. There is a paucity of research relating to the demographics of at-risk groups, nature of injuries and the impact to the Forensic Pathology Service (FPS). This was a retrospective study over 10 years at Germiston Forensic Pathology medico-legal service. The objectives were to describe the demographics of the deceased, identify the profile of at-risk groups, describe the trends of the number of fatalities and causes of death over time, assess hospitalisation frequency, describe the nature and location of injuries sustained, and to report on ancillary investigations performed. Data was collected from the South African Police Service (SAPS) 180 scene investigation record form, hospital notes, final post mortem report, Notification of death (BI1663) form and additional statements. 354 cases were analysed. There was no clear trend in the number of mob justice fatalities. Six areas were highlighted to have a higher incidence of mob justice fatalities. The at-risk population was young to middleaged black South African males. The majority of deaths were due to blunt force head injury, and were so severe that most deaths occurred within 24 hours of injury. A standardised operating procedure should be developed for uniformity in managing mob justice cases. Adequate resources should be distributed to appropriate departments to enable a reasonable turnaround time of ancillary investigations and high incidence areas should receive sufficient and appropriately skilled resources to engage with and monitor the respective communities to curb these killings. / XL2019

Vigilantism is a reality that is going to persist into the future for as long as crime exists. The Diepsloot community is not unique to other parts of the country like Khayelitsha, New Brighton, Gugulethu and others in resorting to mob justice. The satisfaction sourced from eliminating a criminal (s) seems to fuel the resolve around this method of justice. The scourge of crime is pretexted as the main reason behind the mob attacks which the community qualifies by the claim that the police are incapable to police crime. The Diepsloot community knows the moral and legal restrictions around crime of this magnitude but their knowledge of police incapacity allows them to justify this horrendous act. Mob justice incidents may not be occurring daily but their spread across the calendar is an uncomfortable reality everyone should be concerned of. The community, especially the victims, suffer permanent scars of fear and the burden on victim families is enormous. Victim families tend to grapple with permanent problem of dependants that have been incapacitated by the mob attacks. By far, victim families believe that perpetrators continue with impunity and the law-enforcement has revised intervention strategies. Multitask teams (like churches, youth, men’s forum and sport) have been formed to reach out to the community but somehow no objective needs-analysis have been conducted thus the products are right but have no consumers. The role played by the police in community projects is acknowledged but the coordination structure is too centralised to purport local ownership. The concepts of moral regeneration and social cohesion have to find practical studies in the community of Diepsloot so as to comprehend the interest of the residents and be impactful to do paradigm shift.

This dissertation examines the role of the mob in Early American literature, and how the mob continues to be an essential part of American society. Chapter one uses Linebaugh's and Rediker's The Many-Headed Hydra to argue that early American authors acted as demagogues attempting to control the mob. These earliest American writers aligned with Federalist-leaning politicians and convey a conservative message to the reading public. For these American authors it was essential to keep the Revolutionary spirit alive, and to point the overeager mob in the direction of worthwhile causes. Just who is deciding whether a cause is a "moral" one or not is the subject of chapter two. Charles Brockden Brown's Wieland and "Trials of Arden," and Stephen Burroughs' Memoir reveal attempts by these authors to manipulate and force the reader to wrestle with "reasonable doubt." These authors frame the reader as the mob, and attempt to push the reader to think without "hasty judgment." Building on these ideas, the discussion moves to the "neutral ground" in The Spy, "My Kinsman, Major Molineux," "Rip Van Winkle," and "The Legend of Sleepy Hollow." The neutral ground, a liminal space, is the truest test of Democracy, as it is an area without formal laws and regulations. Mob rule dominates this region, and, though dangerous, it allows for the greatest freedom in the new nation. Chapter four argues that the hope of the "neutral ground" on the frontier is a myth. The sea-novels of Herman Melville, Richard Penn Smith's Col. Crockett, and political cartoons of the 1830s, reveal that corrupt captains are formed wherever Americans look for freedom, whether that be at sea or on the western frontier. The concluding chapter focuses on the current usage of "mob" in American culture--looking at the Tea Party and Occupy movements of the last decade--and asserts that mobs are currently alive and well in American literature and culture.

No / This paper seeks to demonstrate how capability approach can be used as a framework for an active rule of law and good governance to reduce or eliminate mob justice practices to create a peaceful society for sustainable development in Africa. Thus, by adopting the capability approach, and the use of the rule of law and good governance to create peace for achieving sustainable development goals (SDG 16). This will also help provide access to justice including to the poor and most vulnerable. The chapter focuses on Africa, by using Ghana as a case study.

Mob stocking is a variation of rotational stocking known for restricting a large number of animals to a small area before being moved to new grass after a few hours. This method allows a long (90-day) recovery period but was hypothesized to diminish the nutritional value of herbage relative to continuous and rotational stocking with lesser stocking density at similar stocking rates. This thesis summarizes two studies conducted in Blacksburg and Raphine, and in Steeles Tavern, VA, respectively, at a single beef cattle stocking rate of 12 animal unit months per hectare live body weight. The objectives were to: (1) compare the yield and nutritional value of herbage in pastures managed with three stocking methods, termed mob, rotational, and continuous stocking; (2) compare the abundance of seeded clover species among the stocking methods; and (3) estimate the nutritional value of herbage that is consumed by beef cattle during mob stocking using extrusa sampled from esophageally-cannulated animals. Analysis of standing herbage during two years produced several important findings. Although standing herbage mass was significantly greater in mob stocked pastures at Blacksburg and Raphine, aboveground net primary productivity in 2014 did not differ significantly among mob, rotational, and continuous stocking at any of the project locations. Herbage nutritive value did not differ significantly among stocking methods over two years at Blacksburg and Raphine; however, herbage from mob stocked pastures at Steeles Tavern contained significantly greater concentrations of crude protein in September and October relative to herbage from continuous- and rotationally-stocked pastures at those times. Differences in herbage mass likely contributed to significant differences in establishment of seeded clovers: red clover [Trifolium pratense L. Cinnamon Plus] establishment was similar among stocking methods but white clover [Trifolium repens L. Will] establishment was greater in continuously stocked pastures than mob and rotationally stocked pastures. Hand-clipped samples collected at Blacksburg in September 2014 significantly underestimated the crude protein content of the herbage selected by the steers, although the concentrations of fiber constituents in herbage did not differ significantly between clipped samples and esophageal samples. Although the nutritive value of the herbage on offer did not generally differ among stocking methods at this stocking rate, diet selected was at times less nutritious during mob stocking than continuous and rotational stocking methods. At this stocking rate, stocking method had less influence on pastures than seasonal variation in weather and plant maturity. / Master of Science

Made available in DSpace on 2016-07-27T13:45:11Z (GMT). No. of bitstreams: 1 MARLUCE ZACARIOTTI.pdf: 2083024 bytes, checksum: 56ab12a3c01ab835ddfb8f860d180688 (MD5) Previous issue date: 2015-08-28 / This text addresses the (in) visibility of youths (tribes) in postmodernity, with the assumption that in the virtual spaces of confluence between technology and art they can gain visibility. The approach is anchored in theory, especially in the French thinker Michel Maffesoli, whose method the comprehensive sociology. The theoretical framework articulated the maffesoliano thought to youths as a category or metaphor way of being youthful and technological implications in the process of interaction, mediation and empowerment of youth aesthetic expressions. We use Maffesoli notions as categories to understand the new forms of tribes sociality through their various art forms in cyberspace. Flash Mobs descriptions and analyzes demonstrations posted on YouTube videos and groups that maintain website - Facebook pages for dissemination of artistic and cultural meetings mediated by cyberspace allowed realize that not all tribes operate through the same dynamic, which it led us to develop the idea of intensity of youth practices both in terms of the forms of ownership, such as how to relate to what was appropriate. The aestheticemotional bias leads to identify the mode of being youthful with a Dionysian spirit. As Aphrodite s metaphor (sensuality referred not only to sexuality, but freedom is sought in living without rules, a return to nature) that, for us, also round the being-together of the tribes. Therefore we find in the artistic frames a visibility of youths plenty the dialogue on physical and virtual interface and occupy public spaces in the city. / Este trabalho aborda a (in) visibilidade das juventudes (tribos) na pós-modernidade, tendo como pressuposto que nos espaços virtuais de confluência entre a tecnologia e a arte elas podem ganhar visibilidade. A abordagem ancora-se teoricamente, principalmente, no pensador francês Michel Maffesoli, tendo como método a sociologia compreensiva. A sustentação teórica articulou o pensamento maffesoliano às juventudes como categoria ou metáfora de um modo de ser juvenil e às implicações tecnológicas no processo de interação, mediação e potencialização das expressões estéticas juvenis. Utilizamos as noções de Maffesoli como categorias para compreender as novas formas de socialidade das tribos por meio de suas diversas manifestações artísticas na cibercultura. As descrições e análises das manifestações de Flash Mobs postadas em vídeos do Youtube e grupos que mantêm Site-páginas de Facebook destinados à divulgação de encontros artísticoculturais mediados pelo ciberespaço permitiram perceber que nem todas as tribos funcionam por meio da mesma dinâmica, o que nos levou a elaborar a ideia de intensidade das práticas juvenis tanto em termos das formas de apropriar-se, como do modo de relacionar-se com o que foi apropriado. O viés estético-emocional conduz a identificação do modo de ser juvenil com um espírito dionisíaco. Assim como a metáfora de Afrodite (sensualidade que se refere não apenas à sexualidade, mas à liberdade que se busca na vivência sem regras, a um retorno à natureza) que, para nós, também ronda o estar-junto das tribos. Deparamos, portanto, com muitas possibilidades de visibilidade das juventudes nas tramas artísticas que dialogam na interface físico-virtual e ocupam os espaços públicos da cidade.

Mob programming is a collaborative software development method that has gained increasing attention in both industry and research. While the focus of mob programming is on the benefits of teams programming together, there are also potential benefits for other aspects of the software development process. However, there is a lack of research on the use of the method outside the domain of programming. This study explores user-centred design (UCD) in mob programming through a case study of three software development teams at Sveriges Television, a Swedish public broadcasting company. Results show that the teams use the method for a variety of tasks in their daily work, calling for a rebranding of the method to mob development to encompass the broader scope. The integration of UCD is analysed through the principles of user-centred agile software development. The results indicate that a revision of these principles is needed to include the cross-functional and social factors that mob development adds to the software development process.

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Au cours de ces dernières années, les communications sans fil connaissent une croissance vertigineuse, avec le développement de standards de communication de plus en plus nombreux, qui ouvrent la voie à de multiples applications telles que : la téléphonie mobile, le biomédical, le maritime, le civil et le militaire. De nos jours, les communications sans fil se sont diversifiées et multipliées. Cela entraîne la conception d’antennes toujours plus innovantes, performantes et de taille de plus en plus réduite (miniaturisation). Le projet FLEXBEA (FLEXible BEAcon) a pour but le développement d’un nouveau concept de balises de détresse miniatures (AIS et COSPAS-SARSAT), faible coût, intégrées dans des équipements de sécurité maritime tels qu’un radeau de survie et un gilet de sauvetage. Ces équipements sont destinés aux professionnels de la mer et aux plaisanciers. L’atout majeur de ce nouveau concept est l’intégration dans des équipements de sécurité maritime d’une fonction de détresse en cas de problème majeur : homme à la mer (MOB, Man OverBoard) par exemple lors d’un naufrage. Différentes antennes ont été étudiées. Nous présentons des antennes planaires (de type dipôle ou monopôle imprimé) développées dans la bande UHF : une solution de dipôle avec brins repliés est proposée afin de réduire l'encombrement, et deux modes d'alimentation (symétrique / dissymétrique) sont comparés. Des exemples d'antenne monopôle sont ensuite présentés avec une modification de leur géométrie (structures de type Bow-tie ou méandre) pour assurer une miniaturisation optimale. Puis les antennes filaires retenues pour le projet, avec une modélisation de ces antennes par un circuit équivalent (RLC). Des formules analytiques sont proposées afin de déterminer les valeurs de composants RLC qui interviennent dans le modèle circuit. Ensuite, nous sommes passés à la conception de l’antenne de la balise. Deux antennes ont été conçues et mesurées. Un monopôle ruban avec introduction de composants localisés pour la balise AIS et COSPAS-SARSAT, et une antenne hélice fonctionnant dans la bande AIS, intégrée dans la balise "SIMY". De nombreuses réalisations et mesures ont été effectuées pour caractériser ses antennes. / Over the last few years, wireless communications have grown dramatically, with the development of more and more communication standards, which open the way to multiple applications such as: mobile telephony, biomedical, maritime, the civilian and the military. Today, wireless communications have diversified and multiplied. This leads to the design of antennas that are always more innovative, more efficient and smaller in size (miniaturization). The FLEXBEA project (FLEXible BEAcon) aims to develop a new concept of low cost miniature distress beacons (AIS and COSPAS-SARSAT) integrated into marine safety equipment such as a life raft and a lifejacket safety. This equipment is intended for professionals of the sea and boaters. The main advantage of this new concept is the integration in maritime safety equipment of a distress function in case of major problem: man overboard (MOB, Man OverBoard) for example during a shipwreck. Different antennas have been studied. We present planar antennas (dipole type or printed monopoly) developed in the UHF band: a dipole solution with folded strands is proposed to reduce the bulk, and two modes of supply (symmetrical / asymmetrical) are compared. Examples of monopole antennas are then presented with a modification of their geometry (Bow-tie or meander type structures) to ensure optimal miniaturization. Then the wired antennas selected for the project, with a modeling of these antennas by an equivalent circuit (RLC). Analytical formulas are proposed to determine the RLC component values ​​involved in the circuit model. Then we went to the design of the beacon antenna. Two antennas were designed and measured. A ribbon monopoly with introduction of localized components for the AIS and COSPAS-SARSAT beacon, and a helix antenna operating in the AIS band, integrated into the "SIMY" beacon. Many achievements and measurements have been made to characterize its antennas.