Drawing Sound in Time reflects on how I have attempted, in the music written over the period of my doctoral studies (2004-2010) to use time as a basis for the mapping of sonic activity and how this aesthetical concern has helped me develop a teleological approach to form and structure. The shaping of time in my work often has its origins in the visual, either from my own drawings or from other visual stimuli. As well as considering the visual appearance of my music, I will draw on the correlation of music and art by abstract painters (most notably Paul Klee) alongside composers Iannis Xenakis and John Cage whose philosophy represent for me a way forward, not only aesthetically but also on a technical level. Additionally, the discussion will refer to astronomy as certain aspects of the subject relate to the development of techniques in my compositional language, and furthermore will often draw on the titles of the pieces (stars and constellations) as a basis for generating materials. I will address in particular the use of coding in my music that is an integral part of the way I work. My commentary will examine the main aspects of my musical language using examples from selected works in the accompanying portfolio.

Orientador: Hermogenes de Freitas Leitão Filho / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-07-18T11:53:42Z (GMT). No. of bitstreams: 1 Monteiro_JoseRobertoBorges_M.pdf: 3187606 bytes, checksum: 10e33cb30f66825f5563e8904951f245 (MD5) Previous issue date: 1993 / Resumo: O estudo foi desenvolvido em uma floresta mesófila semidecídua, na Fazenda 20 de dezembro em Chapada dos Guimarães, Mato Grosso ('15 GRAUS¿ 17' de latitude e ¿55 GRAUS¿ 48' de longitude). O solo é do tipo Latossolo Vermelho-Amarelo, argiloso a argilo-arenoso coberto por fina camada de cascalho de sesquióxido de ferro. Foram amostrados todos os indivíduos lenhosos (exceto lianas) com 15 ou mais cm de circunferência à altura do peito (C.A.P.), em duas áreas de 5.000 m2 subdividida em unidades amostrais de 100 m2 (10 X 10 m) num total de 10.000 m2 (lha). Amostrou-se 1429 indivíduos, dos quais 69 mortos, distribuídos por 43 famílias, 81 gêneros e 98 espécies (sendo 03 desconhecidas a nível genérico e 05 a nível específico). O índice de diversidade de SHANNON-WEAVER para espécies foi 3,61 para a área 1 e 3,79 para a área 2, valor semelhante ao encontrado em florestas mesófilas semidecíduas do Estado de São Paulo ... Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital / Abstract: The research was developed in one mesotropic semidecious forest, on the Farm 20 de dezembro in Chapada dos Guimarães, Mato Grosso State (15 DEGREES 17¿ lat. and ¿55 DEGREES 48¿ log.) The soil type is Latossolo-red-yellow, clay-sandness covered for thin layer of rubble from sesquioxide of iron. We sampled all of the wood individuals (except lianas) with 15 em or more of breast high eireunferenee (B.H.C.) in two areas of 5.000 m2 subdivided on sample units of 100 m2 (10 X 10m) in a total of 10.000 m2. It was sampled 1.429 individuals, from wieh 69 died, shared for 43 families, 81 genera and 98 speeie (being 3 unknown for generie level and 5 for speeifie level). The diversity index of SHANNON-WEAVER for speeie was 3,61 for the area 1 and 3,79 for the area 2, the same value was founded in forests from São Paulo State ... Note: The complete abstract is available with the full electronic digital thesis or dissertations / Mestrado / Biologia Vegetal / Mestre em Ciências Biológicas

A exposição contínua ao ruído de alta intensidade é o fator ambiental mais importante como causa de problemas auditivos em adultos. Esses tipos de perdas crônicas e irreversíveis causadas pelo ruído são chamados de Perdas Auditivas Induzidas por Ruído (PAIR). O objetivo desse estudo foi estudar a influência de fatores genéticos na susceptibilidade à PAIR. Para atingir esse objetivo comparamos uma amostra de indivíduos com PAIR e de indivíduos sem PAIR que trabalharam expostos ao ruído em relação à etnia, à história familial de perda auditiva, idade, tempo de exposição ao ruído, tabagismo e alcoolismo social. Para verificar a possível contribuição de fatores genéticos, testamos a presença de mutações conhecidas como causas freqüentes de surdez. As mutações testadas foram 35delG e 167delT no gene GJB2, as deleções Δ(GJB6-D13S1830) e Δ(GJB6-D13S1854) no gene GJB6 e A1555G (RFLP) no gene MT-RNR1. Determinamos as freqüências alélicas e genotípicas de um polimorfismo no gene GJB2 (SNP RS877098) e dos polimorfismos do tipo presença/deleção dos genes GSTM1 e GSTT1. Também verificamos a ocorrência e a freqüência de variações nas seqüências dos genes mitocondriais MT-RNR1 e MT-TS1, dois genes mitocondriais importantes como causa de surdez de herança materna. Nossa amostra constituiu-se de 107 indivíduos que apresentavam audiometrias sugestivas de PAIR (grupo PAIR), 44 indivíduos afetados por perdas de audição com curvas audiométricas que não eram sugestivas de PAIR (grupo PANO) e 104 indivíduos com audição normal (grupo NORMAL). Nossos resultados apontaram aumento significativo no número de parentes afetados por problemas de audição no grupo PAIR. O tabagismo, a idade e o tempo de exposição ao ruído também influenciaram significativamente na manifestação da PAIR. Aparentemente, não houve contribuição das mutações associadas à manifestação de surdez, 35delG e 167delT no gene GJB2, Δ(GJB6-D13S1830) e Δ(GJB6-D13S1854) no gene GJB6 e A1555G no gene MT-RNR1. Não houve diferença significativa nas freqüências dos alelos do SNP RS87098 (gene GJB2) entre os afetados e os não afetados. Observamos um aumento significativo do genótipo que corresponde a presença dos dois genes das enzimas GSTM1 e GSTT1 entre os indivíduos do grupo PAIR, sugerindo possível papel dessas enzimas relacionadas a proteção contra espécies reativas de oxigênio na etiologia da PAIR. Não observamos associação significativa entre nenhuma das 54 variantes de seqüências do DNA mitocondrial averiguadas nos genes MT-RNR1 e MT-TS1 (32 já previamente descritas e 22 detectadas nesse estudo) e a ocorrência de PAIR. Não observamos associação significativa da PAIR com o número total de variantes de seqüência do DNA mitocondrial observado em cada indivíduo. Não foi detectada associação significativa com os haplótipos constituídos por pares de variantes de seqüência do DNA mitocondrial. A comparação entre a concentração de peróxidos e de grupos sulfidril no soro de 15 indivíduos com PAIR com amostras de 15 indivíduos sem PAIR não revelou diferenças significativas. Em resumo, nosso estudo evidenciou a influência da história familial de perda auditiva na probabilidade de manifestação da PAIR e o possível papel das enzimas GSTT1 e GSTM1 na susceptibilidade a essa condição. Nossos achados reforçam a idéia de que a susceptibilidade à PAIR possa ser determinada por fatores genéticos. / Chronic exposure to loud noise is the most important environmental cause of hearing impairment among adults. Chronic and irreversible hearing loss due to exposure to noise is named Noise Induced Hearing Loss (NIHL). The aim of this study was to investigate the influence of genetic factors in the susceptibility to NIHL. We compared individuals with and without NIHL regarding ethnic origin, familial history of hearing loss, age, noise exposure time, alcohol consumption and smoking habits. In order to investigate genetic factors associated to NIHL we screened frequent deafness causative mutations. The investigated mutations were 35delG and 167delT in the GJB2 gene, Δ(GJB6- D13S1830) and Δ(GJB6- D13S1854) in the GJB6 gene and A1555G in the MT-RNR1 gene. Allelic and genotypic frequencies were determined for the SNP RS877098 in the GJB2 gene, and for the polymorphic deletions of GSTM1 and GSTT1 genes. We also investigated the frequency of variants in the mitochondrial genes MT-RNR1 and MT-TS1, which are known to harbor many hearing loss causative mutations. Our sample comprised 107 individuals with suggestive NIHL audiograms, 44 individuals with hearing impairment and non-suggestive NIHL audiograms, and 104 normal hearing individuals. A significant increase in the number of relatives affected by hearing impairment was detected in the NIHL group, when compared to the normal hearing group. Smoking habits, age and noise exposure time significantly affected the probability of NIHL. We did not detected any effect of the deafness-causing mutations 35delG and 167delT in the GJB2 gene, Δ (GJB6- D13S1830) and Δ (GJB6- D13S1854) in the GJB6 gene, and A1555G in the MT-RNR1 gene. There was no significant difference in allelic and genotypic frequencies of SNP RS87098 (gene GJB2), but the presence of the two genes encoding GSTM1 and GSTT1 enzymes was increased in the NIHL group. We did not detect any significant association of any of the 54 sequence variants in the mitochondrial genes MT-RNR1 and MT-TS1 (32 previously described and 22 novel) with the occurrence of NIHL. No significant associations were observed between NIHL and either the total number of sequence variants detected in each individual or haplotypes (combinations of two variants). The comparison of peroxides and sulfhydryl groups concentrations in serum from 15 individuals with NIHL and 15 individuals without NIHL did not show significant differences. In conclusion, our study demonstrated a significant effect of family history of hearing loss on the probability of presenting NIHL and pointed to a possible role of GSTT1 and GSTM1 enzymes on the susceptibility to this condition. These findings reinforce the idea that susceptibility to NIHL has a genetic basis.

The aim of this work was to analyze nuclear microsatellite markers, which were processed by methods of landscape genetics and then compared with mitochondrial sequences (mtDNA) from previous research. Microsatellite analysis was performed using 11 microsatellite sequences with a total of 188 alleles. A total of 94 individuals were analyzed, divided into 3 subpopulations. The average expected heterozygosity of 0.82 and the average observed heterozygosity of the whole population was 0.72. There is a gene flow between the subpopulations. Transport infrastructure affects the flow of genes to a small extent.

Little Ice Age (LIA) deposits are recognized on Mt. Tbielsen, southern Oregon Cascades (43° 9' N, 122° 3' W), based on particle morphology and relative position. The initial advance, Lathrop 1, created a sharp-crested moraine and a protalus rampart within 200 m of the headwall. The retreat of the glacier and recent ice movement, Lathrop 2, is recognized by the deformation of the moraine and a mantle of "protalus till" creating a polygenetic "push-deformation'' moraine. Both the moraine and the protalus rampart have sparse vegetation, no lichens, and a lightly weathered Cox/C soil. This sequence is correlative with LIA Phase 1 and Phase 2 on Mt. Jefferson, central Oregon Cascades, and is broadly correlated with LIA deposits throughout the Cascades, Sierra Nevada, and Rocky Mountains. There is no evidence for pre-LIA deposits at Mt. Thielsen. The ELA on Lathrop Glacier (2450 m) is lower than ELAs on nearby glaciers. The glacier probably exists because of its preferential topographic position and extensive debris cover; thus, if annual snowfall decreases the glacier will persist longer than a similar sized bare ice glacier. Conversely, a growing protalus rampart may indicate an increase in annual snowfall but not necessarily a decrease in annual temperatures. The lack of older Neoglacial deposits on Mt. Thielsen may be a result of insufficient snowfall to maintain or advance the Lathrop Glacier. As such, the LIA may represent a period when climatic conditions were more severe than at any other time in the Neoglacial. Boulder size, shape, and orientation proved useful for classifying geomorphic features and assessing the relative ages of slopes. However, soils are the best method for correlating deposits in the cirque with other locations. Soils beyond the moraine are developed in Mazama ash and have moderately developed Bw horizons, depth to weathering over 70 cm, and Harden's PDI for B horizons of 2.10-3.64. Soils are Typic Vitricryands.

京都大学 / 0048 / 新制・課程博士 / 博士(情報学) / 甲第20022号 / 情博第617号 / 新制||情||107(附属図書館) / 33118 / 京都大学大学院情報学研究科知能情報学専攻 / (主査)教授 黒橋 禎夫, 教授 田中 克己, 教授 河原 達也 / 学位規則第4条第1項該当 / Doctor of Informatics / Kyoto University / DFAM

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