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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
141

Molekulargenetische Untersuchungen zur Heterogenität der Osteogenesis imperfecta

Trummer, Tatjana. January 2001 (has links)
Ulm, Univ., Diss., 2001.
142

Einfluss von Mutationen auf die NS2/3-Prozessierung und die Zytopathogenität von Pestiviren

Bernhard, Roger. January 2005 (has links)
Tübingen, Univ., Diss., 2005.
143

Mitochondrial alterations in solid carcinomas relationship between tumorgenesis of human kidney carcinomas and mitochondrial DNA (mtDNA) alterations

Meierhofer, David January 2005 (has links)
Zugl.: Salzburg, Univ., Diss., 2005 / Hergestellt on demand
144

Mutabiliteit en Variabiliteit

Schouten, Albert Reinard. January 1908 (has links)
Thesis--Universiteit van Amsterdam.
145

Molekular- und tumorbiologische Untersuchungen zum Beitrag von E-Cadherin-Mutationen zur Apoptose beim diffusen Magenkarzinom

Wallner, Elena. Unknown Date (has links)
Techn. Universiẗat, Diss., 2005--München.
146

The effect of C-terminal alterations of the P2Y₂ receptor on calcium signaling and desensitization /

Schiller, Amy., January 1900 (has links)
Thesis (M.S.)--Missouri State University, 2009. / "May 2009." Includes bibliographical references (leaves 42-44). Also available online.
147

L'hyperglycérolémie familiale au Saguenay-Lac-Saint-Jean : étude démogénétique et origine de la mutation N288D du gène de la glycérol kinase /

Saint-Gelais, Éric. January 2004 (has links)
Thèse (M.Sc.)--Université Laval et Université du Québec à Chicoutimi, 2004. / Bibliogr.: f. 130-136. Webographie: f. 137. Publié aussi en version électronique.
148

On the origin of spontaneous mutations in mice : evidence from mice deficient in polymerase 3'-5' exonuclease proofreading activity /

Chen, Yang. January 2004 (has links)
Thesis (M.Sc.)--York University, 2004. Graduate Programme in Biology. / Typescript. Includes bibliographical references (leaves 53-63). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11766
149

The functional effect of disease causing mutations on thin filament regulatory proteins tropomyosin, troponin T troponin I and troponin C

Robinson, Paul John Robert January 2007 (has links)
No description available.
150

Estudo das alterações genéticas da Interleucina 28B em Astrocitomas / Study of genetic changes of Interleukin 28B in Astrocytomas

Vescovo, Aline Aparecida Del [UNESP] 22 February 2016 (has links)
Submitted by ALINE APARECIDA DEL'VESCOVO null (alinedelvescovo@yahoo.com.br) on 2016-03-11T17:46:30Z No. of bitstreams: 1 Defesa Oficial Aline Ap. Del Vescovo.pdf: 1253963 bytes, checksum: c4bb222d0eaddb9111ac9d6ffcf287e1 (MD5) / Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2016-03-14T18:20:06Z (GMT) No. of bitstreams: 1 vescovo_aa_me_bot.pdf: 1253963 bytes, checksum: c4bb222d0eaddb9111ac9d6ffcf287e1 (MD5) / Made available in DSpace on 2016-03-14T18:20:06Z (GMT). No. of bitstreams: 1 vescovo_aa_me_bot.pdf: 1253963 bytes, checksum: c4bb222d0eaddb9111ac9d6ffcf287e1 (MD5) Previous issue date: 2016-02-22 / Os Astrocitomas são tumores de Sistema Nervoso Central (SNC) caracterizado, quanto à sua nomenclatura e grau de malignidade, conforme seu tipo histológico e seu potencial proliferativo, presença de necrose e invasão cortical. Os interferons (IFNs) foram inicialmente associados à resposta antiviral, contudo, estudos posteriores evidenciaram o envolvimento dessas citocinas na regulação do crescimento celular e no efeito imunomodulatório. A Interleucina 28B (IL28B), membro da família dos IFNs do tipo III, parece estar envolvida na resposta imune antiviral e antitumoral. Sendo assim, o objetivo do presente estudo foi avaliar a frequência de variações genéticas em IL28B em pacientes acometidos por Astrocitomas. Cinquenta e sete pacientes tratados pelo serviço de Neurocirurgia da UNESP de Botucatu/SP foram incluídos neste estudo. A análise do polimorfismo rs12979860 C/T não teve significância estatística quando comparou-se a frequência genotípica da população brasileira em relação a presente casuística. Foi descrito a detecção de novas variações genéticas (missense e silent) no gene IL28B ao comparar com a sequência referência disponível em banco de dados (NCBI). Estes dados sugerem uma importante relação destas variações genéticas em relação a estrutura e função das proteínas envolvidas, entretanto um estudo mais aprofundado das consequências dessas alterações na gênese e/ou progressão dos astrocitomas devem ser considerado. / The astrocytomas are tumors of the central nervous system (CNS) characterized as to its nomenclature and degree of malignancy, according to their histological type and their proliferative potential, presence of necrosis and cortical invasion. Interferons (IFNs) were originally associated with the antiviral response, however, subsequent studies revealed the involvement of these cytokines in the regulation of cell growth and immunomodulatory effect. Interleukin 28B (IL28B), member of the family of IFNs type III appears to be involved in the antiviral and anti-tumor immune response. Thus, the aim of this study was to evaluate the frequency of genetic variation in IL28B in patients suffering from astrocytomas. Fifty-seven patients treated by our service at UNESP in Botucatu / SP were included in this study. Rs12979860 C / T polymorphism analysis was not statistically significant when compared to genotypic frequency of the population in relation to this study. It described the detection of new genetic variants (missense and silent) in IL28B gene to compare with the reference sequence available in the database (NCBI). These data suggest an important relationship between these genetic variations regarding the structure and function of the proteins involved, however further study of the consequences of these changes in the genesis and / or progression of astrocytomas should be considered.

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