Thesis (Ph. D.)--Carleton University, 2002. / Includes bibliographical references (p. 129-138). Also available in electronic format on the Internet.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 68-76).

No description available.

It is hypothesized in this study that children reared with "concerned" mothers (N) will display significantly superior intellectual performance and less neurological impairment as compared with children reared with neglectful mothers (MN) and children diagnosed as failure to thrive (FTT, falling below the third percentile in height and weight). The FTT children will show significantly more deficits than both N and MN groups. The participants in this study were forty-five children rigidly matched on all possible variables. F-tests and Newman-Keuls' analyses reveal severe intellectual deficits in both MN and FTT groups. The FTT group displayed significantly more neurological deficits lending support for a nutritional basis of this syndrome as opposed to the traditional psychogenic explanation.

Dor em pediatria tem sido o foco de muitos estudos nas últimas décadas devido ao fato de que neonatos apresentam menor limiar a estímulos nocivos e inócuos em relação aos adultos. Desta forma, o uso de analgésicos é frequente para sedação e analgesia em UTIs pediátricas, e entre os opioides, a morfina é um dos mais utilizados. Adicionalmente, exposição a estímulos estressantes como a deprivação materna está entre os fatores ambientais relacionados a alterações no desenvolvimento neural. O estresse social ou a negligência do cuidado parental, e mais precisamente do cuidado materno em ratos, está associado a importantes alterações comportamentais na vida adulta. Entre estas alterações apresentadas ao longo da vida estão alterações na resposta ao estresse, e à alteração na sensibilidade a estímulos dolorosos, indexadas por hiperalgesia. Consquentemente, o estresse social gerado pela deprivação materna está relacionado a prejuízos cognitivos, emocionais e sociais, além de alterações neuroquímicas de longo prazo. Deste modo, é necessário atenção, prevenção e tratamento a esses eventos físicos, emocionais e comportamentais no período neonatal e durante a infância, uma vez que as bases neurobiológicas envolvidas nestes fenômenos ainda não foram completamente elucidadas. Considerando a relevância do tema, o objetivo deste estudo foi verificar os efeitos do tratamento com 5 μg de morfina, uma vez ao dia, do P8 ao P14 e a exposição a deprivação materna por 3 horas durante os primeiros 10 dias de vida em curto (P16), médio (P30) e longo prazo (P60), sobre o desenvolvimento dos reflexos neuromotores da prole por meio do Reflexo de Endireitamento, Geotaxia Negativa e Marcha; comportamento nociceptivo por meio dos testes Tail-Flick e Placa Quente, respectivamente. Um total de 58 filhotes foi utilizado. Os animais foram divididos em 5 grupos: controle total (C), que não recebeu nenhuma intervenção; salina (S), que recebeu solução salina; morfina (M), que recebeu morfina; deprivado salina (DS), que foram submetidos a deprivação maternal e receberam solução salina; e deprivado morfina (DM), que foram submetidos a deprivação maternal e receberam morfina. Em relação aos testes neuroquímicos, foram analisados níveis de BDNF, NGF, IL-1β e IL-4 em tronco e córtex cerebral que estão relacionados a fenômenos modulatórios em sistemas nervoso e imune. Os animais que receberam morfina e os deprivados maternos que receberam morfina apresentaram atraso no desenvolvimento dos reflexos iniciais. Alterações neuroquímicas também foram observadas. Os níveis de BDNF no tronco encefálico foram diminuídos em animais que receberam morfina e deprivação materna. Animais deprivados apresentaram um aumento nos níveis de NGF no tronco encefálico. Além disso, observou-se um aumento nos níveis de NGF do córtex cerebral em animais que receberam morfina, deprivados maternos e deprivados maternos que receberam morfina. Uma diminuição no limiar nociceptivo foi observada em animais que receberam morfina, deprivados maternos e os deprivados maternos que receberam morfina. Também houve interações em tronco encefálico e córtex cerebral nos níveis de BDNF, IL-1β e IL-4 entre as variáveis independentes: tratamento, deprivação e tempo, o que levou à modificação nos níveis centrais dos neuroimunomoduladores avaliados. Estes dados demonstram a importância de estudos focados nos efeitos do tratamento com morfina no período neonatal ao longo da vida, assim como na busca por alternativas terapêuticas que possam reverter possíveis alterações decorrentes da separação materna no período neonatal. / Pediatric pain has been the focus of many studies in the last decades due to the fact that neonates have a lower threshold for innocuous and noxious stimuli than for adults. Thus, the use of analgesics is frequent for sedation and analgesia in pediatric intensive care units, and among opioids, morphine is one of the most used. Additionally, exposure to stressful stimuli such as maternal deprivation is among the environmental factors related to changes in neural development. The social stress or neglect of parental care, and more precisely maternal care in rats, is associated with important behavioral changes in adult life. Among these changes presented throughout life are changes in the response to stress, and the change in sensitivity to painful stimuli, indexed by hyperalgesia. Consequently, the social stress generated by maternal deprivation is related to cognitive, emotional and social impairments, further to long-term neurochemical changes. Thus, attention, prevention and treatment are necessary to these physical, emotional and behavioral events in the neonatal period and during childhood, since the neurobiological bases involved in these phenomena have not yet been fully elucidated. Considering the relevance of the subject, the objective of this study was to verify the effects of treatment with 5 μg of morphine once a day from P8 to P14 and exposure to maternal deprivation for 3 hours during the first 10 days of short (P16), medium (P30) and long- term (P60), on the development of neuromotor reflexes of offspring through the righting Reflex, Negative Geotaxis and Gait; nociceptive behavior through the Tail-Flick and Hot Plate tests, respectively. A total of 58 puppies were utilized. The animals were divided in 5 groups: the total control group (C), which did not receive any intervention; saline group (S), which receive saline solution; morphine group (M), which receive morphine; deprived saline (DS), which were subjected to maternal deprivation and receive saline solution; and deprived morphine group (DM), which were subjected to maternal deprivation and receive morphine. In relation to the neurochemical tests, levels of BDNF, NGF, IL-1β and IL-4 were analyzed in the brainsteam and cerebral cortex and are related to modulatory phenomena of the nervous and immune systems. Animals that received morphine and deprived animais that received morphine showed a delay in the development of early reflexes. Neurochemical changes were also observed. BDNF levels in the brainstem were decreased in animals receiving morphine and maternal deprivation. Deprived animals had an increase in NGF levels in the brainstem. Besides, an increase in NGF levels of the cerebral cortex was observed in animals receiving morphine, maternal deprivation and maternal deprivation receiving morphine. A decrease in the nociceptive threshold was observed in animals receiving morphine, maternal deprivation, and maternal deprivation receiving morphine. There were also interactions in the brainstem and cerebral cortex in the levels of BDNF, IL-1β and IL-4 among the independent variables: treatment, deprivation and time, which led to the modification in the central levels of the neuroimmunomodulators evaluated. These data demonstrate the importance of studies focused on the effects of treatment with morphine in the neonatal period throughout life, as well as on the search for therapeutic alternatives that may reverse possible changes due to maternal deprivation in the neonatal period.

No description available.

Many women in prison are likely to have children, but for various reasons may not be playing the role of primary caregiver prior to incarceration, and may be unable to fulfill this role when released. This research was designed to investigate the interpersonal difficulties that may contribute to the parenting problems of this unique population. Female offenders have an increased likelihood of personality pathology and history of abuse, creating a set of circumstances that affect these women's ability to have satisfactory relationships. This may be manifested in an orientation towards relationships that could be classified as an insecure attachment style, although it is not the relationship per se that is classified as an insecure attachment style; rather, the insecure attachment style (or pattern) refers to the individual's view of themselves and others, and their attachment style may then influence their responses to others in intimate relationships (e.g., their warmth, caregiving, jealousy, ability to trust, etc). The female offender population provides a distinctive opportunity for investigating the relationships between attachment styles and incarcerated women's personality pathology, experiences with their primary caregivers, as well as their own experiences as mothers. The attachment styles of one hundred eleven incarcerated female inmates were assessed using the Relationship Questionnaire (RQ; Bartholomew & Horowitz, 1991) and the Experience in Close Relationships Inventory (ECRI; Brennan, Clark, & Shaver, 1998), and a sub-sample of these women were interviewed using the Peer Attachment Interview (Bartholomew & Horowitz, 1991). Offenders were also assessed for quality of relationships with parents using the Egna Minnen Betraffande Uppfostran (EMBU; Perris, Jacobsson, Lindstrom, von Knorring, & Perris, 1980), as well as with children using the Parental Stress Scale (PSS; Berry & Jones, 1995) and a Parental Bonding Interview (created specifically for this research to gather information about parent-child relationships, the level of caregiving provided to the child, and the mother's subjective account of her parenting experiences). The SCID-Il Clinical Interview (First, Gibbon, Spitzer, Williams, & Benjamin, 1997) was used to assess for personality disorder characteristics, which have been found in previous research to be prevalent in female offender populations. It was found that three-quarters of the women in the sample had given birth to children, however, 88.4% were no longer playing the role of primary caregiver upon incarceration. Nearly 61% of respondents claimed that social services had taken at least one child away, and 38.2% claimed that they had voluntarily given their children away. Reasons for no longer having custody varied, but the majority of women (70%) reported that drug and alcohol abuse was a major factor. Further, it was found that women in the sample were characterized by insecure attachment styles. Characteristics of personality disorders were present in over 73% of the sample. Results showed a high rate of abuse in childhood by primary caregivers, high levels of parental rejection, and low levels of parental warmth. In addition, participants reported unstable relationships with the fathers of their children. Further, the presence of an insecure attachment style was related to higher mean number of personality disorder characteristics, higher reported means of maternal and paternal rejection, and higher reported means of emotional and physical abuse by fathers. Impression management was found to be an issue with the respect to the majority of the measured utilized in the research. The goal of this research was to attain a greater understanding of the interpersonal difficulties of the female offender population, and how family, romantic, and peer relationships are related to parenting difficulties for these women. These issues, as well as limitations surrounding the use of current attachment measures, are discussed herein.

The two-hit hypothesis of schizophrenia proposes that the development of the illness involves an early neurodevelopmental stress component which increases vulnerability to later stressful life events, in combination leading to overt disease. This thesis describes a two-hit animal model, comprising of an early first hit in the form of 24 hours maternal deprivation on postnatal day 9, and a late second hit simulated by 2 weeks of corticosterone administration from 8 to 10 weeks of age in rats. The project included behavioural studies on prepulse inhibition (PPI) regulation, locomotor activity, and learning and memory, and neurochemical and molecular studies on dopaminergic parameters, brain-derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression. / In the two-hit animals, there was little effect on baseline PPI or locomotor activity. However, the effect of acute treatment with the dopaminergic stimulants, apomorphine, amphetamine and quinpirole, was markedly diminished. There were differential effects of either maternal deprivation or corticosterone administration on the action of these drugs. However, there was no change in any of the groups in the effect of the serotonin-1A receptor agonist, 8-OH-DPAT, on PPI, or the effect of amphetamine and phencyclidine on locomotor activity. (For complete abstract open document)

Thesis (M.A.)--Lancaster Bible College, 2005. / Abstract. Includes bibliographical references (leaves 65-68).

Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 6 uppsatser.