<p>The Swedish government has decided that waste containing more than 0.1% mercury is to</p><p>be placed in a permanent repository in the bedrock1,10. To minimize the risk of spreading</p><p>mercury, elemental mercury must first be converted into a practically insoluble</p><p>compound. In a PhD investigation of stabilization attempts at SAKAB AB in Kumla</p><p>favorable conditions for conversion of mercury to cinnabar (the sparingly soluble sulphide</p><p>form of mercury and the naturally occurring mineral) was found. In a long-term study of</p><p>diffusion of mercury it was found that water solubility of mercury varied much, from 0.05</p><p>to 5 μmolL-1.</p><p>To be able to study the water solubility of mercury as detailed as possible a speciation</p><p>method was developed and verified. This investigation includes how different parameters,</p><p>like matrix properties and Hg0/solution ratios effects the solubility of mercury and how the</p><p>different species are distributed in the water phase. The total solubility of mercury is very</p><p>dependent of both the matrix properties and the Hg0/solution ratio.</p><p>Aqueous elemental mercury (Hg0</p><p>aq) is not as matrix dependent as the oxidized species.</p><p>However, trends show that a higher Hg0/solution ratio contributes to a higher solubility of</p><p>Hg0</p><p>aq. Factors like time, pH, ionic strength and degree of stirring, greatly effects the total</p><p>solubility of mercury. The concentration of the oxidized mercury species generated from</p><p>elemental mercury increases over time and is very dependent on the properties of the</p><p>matrix. After 18 hours the solubility of Hg0</p><p>aq ranges from 0.2 to 0.7 μmolL-1, depending</p><p>on Hg0/solution ratio. The solubility for the oxidized species has a much larger variation,</p><p>ranging from 0.1 to 28.6 μmolL-1. Among other things, because the composition and</p><p>redox potential of the matrix plays an important role in what mercuric complexes can be</p><p>expected to form, and contribute to the solubility.</p> / <p>Det har beslutats av regeringen att senast år 2010 skall kvicksilverhaltigt avfall med en</p><p>kvicksilverhalt på mer än 0.1% slutförvaras i en stabiliserad from djupt ner i berggrunden.</p><p>I en doktorsavhandling som genomförts på SAKAB AB i Kumla har det konstaterats att</p><p>det är möjligt att överföra elementärt kvicksilver till cinnober, den stabila sulfidformen av</p><p>kvicksilver som för övrigt är ett naturligt förekommande mineral. Experiment som pågått</p><p>under lång tid för att studera det elementära kvicksilvrets diffusion under olika</p><p>omständigheter har också utförts. De uppmätta halterna i vattenfasen har varierat mycket,</p><p>från 0.05 till 5 μmolL-1. Det är vad som ligger till grund för det här arbetet.</p><p>För att kvicksilvers löslighet skall kunna studeras fullt ut har en specierings metod</p><p>vidareutvecklats och verifierats att den fungerar. Studien innefattar hur lösligheten av</p><p>kvicksilver påverkas av olika parametrar, som till exempel; matriser med olika egenskaper</p><p>och olika kvicksilver/vatten kvoter, samt hur fördelningen mellan oxiderade species och</p><p>det elementära kvicksilvret är i vattenfasen (Hg0</p><p>aq). Den totala lösligheten av kvicksilver</p><p>beror dels av matrisens egenskaper och mängden kvicksilver i förhållande till mängden</p><p>vätska. Lösligheten av Hg0</p><p>aq är inte lika beroende av matrisen som de oxiderade species.</p><p>Däremot finns trender som visar att högre Hg0/lösning kvot bidrar till en aningen högre</p><p>löslighet av Hg0</p><p>aq. Tid, konduktivitet, pH och omrörning spelar stor roll för vilken</p><p>totalhalt och hur stor andel oxiderade species man får i vattenfasen. Lösligheten av Hg0</p><p>aq,</p><p>efter 18 timmar, varierar mellan 0.2 till 0.7 μmolL-1, beroende på Hg0/lösning kvoten.</p><p>Efter 18 timmar är lösligheten för de oxiderade species mycket mer varierande, från 0.1</p><p>till 28.6 μmolL-1. Detta beror bland annat på att matrisens sammansättning och redoxpotential</p><p>spelar en viktig roll för vilka komplex som kan bildas med kvicksilverjonerna</p><p>och på så sätt bidra till en ökad löslighet.</p>

The Swedish government has decided that waste containing more than 0.1% mercury is to be placed in a permanent repository in the bedrock1,10. To minimize the risk of spreading mercury, elemental mercury must first be converted into a practically insoluble compound. In a PhD investigation of stabilization attempts at SAKAB AB in Kumla favorable conditions for conversion of mercury to cinnabar (the sparingly soluble sulphide form of mercury and the naturally occurring mineral) was found. In a long-term study of diffusion of mercury it was found that water solubility of mercury varied much, from 0.05 to 5 μmolL-1. To be able to study the water solubility of mercury as detailed as possible a speciation method was developed and verified. This investigation includes how different parameters, like matrix properties and Hg0/solution ratios effects the solubility of mercury and how the different species are distributed in the water phase. The total solubility of mercury is very dependent of both the matrix properties and the Hg0/solution ratio. Aqueous elemental mercury (Hg0 aq) is not as matrix dependent as the oxidized species. However, trends show that a higher Hg0/solution ratio contributes to a higher solubility of Hg0 aq. Factors like time, pH, ionic strength and degree of stirring, greatly effects the total solubility of mercury. The concentration of the oxidized mercury species generated from elemental mercury increases over time and is very dependent on the properties of the matrix. After 18 hours the solubility of Hg0 aq ranges from 0.2 to 0.7 μmolL-1, depending on Hg0/solution ratio. The solubility for the oxidized species has a much larger variation, ranging from 0.1 to 28.6 μmolL-1. Among other things, because the composition and redox potential of the matrix plays an important role in what mercuric complexes can be expected to form, and contribute to the solubility. / Det har beslutats av regeringen att senast år 2010 skall kvicksilverhaltigt avfall med en kvicksilverhalt på mer än 0.1% slutförvaras i en stabiliserad from djupt ner i berggrunden. I en doktorsavhandling som genomförts på SAKAB AB i Kumla har det konstaterats att det är möjligt att överföra elementärt kvicksilver till cinnober, den stabila sulfidformen av kvicksilver som för övrigt är ett naturligt förekommande mineral. Experiment som pågått under lång tid för att studera det elementära kvicksilvrets diffusion under olika omständigheter har också utförts. De uppmätta halterna i vattenfasen har varierat mycket, från 0.05 till 5 μmolL-1. Det är vad som ligger till grund för det här arbetet. För att kvicksilvers löslighet skall kunna studeras fullt ut har en specierings metod vidareutvecklats och verifierats att den fungerar. Studien innefattar hur lösligheten av kvicksilver påverkas av olika parametrar, som till exempel; matriser med olika egenskaper och olika kvicksilver/vatten kvoter, samt hur fördelningen mellan oxiderade species och det elementära kvicksilvret är i vattenfasen (Hg0 aq). Den totala lösligheten av kvicksilver beror dels av matrisens egenskaper och mängden kvicksilver i förhållande till mängden vätska. Lösligheten av Hg0 aq är inte lika beroende av matrisen som de oxiderade species. Däremot finns trender som visar att högre Hg0/lösning kvot bidrar till en aningen högre löslighet av Hg0 aq. Tid, konduktivitet, pH och omrörning spelar stor roll för vilken totalhalt och hur stor andel oxiderade species man får i vattenfasen. Lösligheten av Hg0 aq, efter 18 timmar, varierar mellan 0.2 till 0.7 μmolL-1, beroende på Hg0/lösning kvoten. Efter 18 timmar är lösligheten för de oxiderade species mycket mer varierande, från 0.1 till 28.6 μmolL-1. Detta beror bland annat på att matrisens sammansättning och redoxpotential spelar en viktig roll för vilka komplex som kan bildas med kvicksilverjonerna och på så sätt bidra till en ökad löslighet.

<p>  </p> <p>Metastases are responsible for approximately 90% of all cancer-related deaths, with metastatic breast cancer (BC) holding a 5-year survival rate of only 27%. Recent research has highlighted a complex dynamic between cancer cells and the tumor microenvironment as essential for the formation of macrometastases. Within this field, tissue stiffening through matrix accumulation and altered matrix organization at the primary tumor site were recently linked with sustained proliferation and increased migration of tumor cells. Separately, elevated levels of the glycoprotein, fibronectin, were correlated to poor patient survival in BC and were linked to enhanced seeding of disseminated tumor cells at metastatic sites. Through my doctoral work, we have identified several mechanisms through which accumulated fibronectin impacts the metastatic potential of BC cells. First, we identified a transient increase in extracellular fibronectin in the lungs, which peaked before overt metastasis, coupled with a non-transient increase in total lung volume. To better recapitulate physiological conditions, we then developed a novel magnetically-actuated platform with the ability to apply tensile strain on cells at various amplitudes and frequencies in a high-throughput multi-well culture plate using suspended fibrillar fibronectin for 3D cell culture that is not reliant on a synthetic substrate. Using this as a biomimetic lung model, we found that cyclic mechanical force acted as a suppressor of cancer cell growth in a biomimetic lung model, implicating the accumulation and reorganization of extracellular matrix as an attempt by the cancer cells to alter the mechanical properties of the lung tissue and resist entering dormancy. However, our results showed that BC cells could not organize extracellular fibronectin independently. Instead, BC cells altered the accumulation and architecture of fibronectin by conditioning fibroblasts through soluble factors and extracellular vesicles. We observed that the fibronectin produced by conditioned fibroblasts varied as an effect of both the method of conditioning and the phenotype of the BC cell as the conditioning source. Taken together, these results have increased our knowledge of the relationship between disseminated breast cancer cells, fibroblasts, and fibronectin architecture in the early metastatic lung niche that paves the way for further investigation on targeting disseminated BC cells during early disease intervention in order to inhibit later overt metastatic outgrowth.</p>

隨著IC卡的使用，它正深深地影響著我們的未來生活方式，其應用發展趨勢也是值得我們重視的課題。本研究主要從「IC智慧卡成為主流的資訊載具」、「我國內政部、衛生署、交通部及財政部等中央各部，對IC卡之應用發展各擁管轄範圍且各自發展」、「民間業者各自引進或發行電子現金儲值卡」等三方面，說明其可能造成的結果及相關重要課題，以作為本研究之動機。 本研究從我國IC卡應用發展相關文獻中，搜集和本研究主題較相關者，提出IC卡票證整合、IC卡安全整合機制及IC卡規模經濟等值得研究課題，以作為進行IC卡應用發展趨勢研究之參考。 對於IC卡目前應用發展現況，本研究主要說明政府推動國民卡的沿革、政府推動自然人憑證的沿革、政府推動健保IC卡沿革及交通IC票卡目前應用發展，以利了解我國IC卡目前應用發展現況。 針對交通IC票卡，本研究說明北、中、南各地區電子票證IC智慧卡應用發展，包括悠遊卡、台中ｅ卡通、Taiwan Money Card等，後續說明IC票卡規格發展及交通IC票卡系統架構發展，以更深入了解交通IC票卡目前應用發展現況。 本研究針對IC卡應用發展問題，進行更深入的分析，主要論述面向，包括技術面(IC卡規格、IC卡系統架構) 、法令面(IC卡法令規定)、經營管理面(含IC卡管理組織、發行、經營模式)等方面，以發掘問題，分析問題及提出解決策略。 本研究針對所提出之解決策略，予以聚焦，以提出更關鍵的解決策略，包括：(一)技術面：1.建立IC卡共同憑證。2.建立IC卡安全認證。3.建立IC卡整合架構。(二)法律面：1.修改銀行法及交通運輸相關法規中不合IC卡現有運作之規定。2.增訂電子票證法規。(三)經營管理面：1.建立規模經濟發卡量。2.建立IC卡發卡機構經營模式。 3.建立憑證認證機構公信力。4.建立IC卡資訊交換中心。 本研究針對三個構面，提出核心解決策略為「一卡通用」及其整體解決架構及實施步驟，且對整體解決策略之構想方案，提出IC卡卡片規格整合矩陣架構圖，以找出更為適當的IC卡規格方案，該矩陣架構圖，以「共同憑證一卡整合」及「多憑證一卡整合」二構面為縱軸，及「IC卡規格中不存放各類別資料」和「IC卡規格中存放各類別資料」二構面為橫軸，提出四種IC卡片規格整合架構，並列出其優缺點，經研析後，本研究建議初期以具有共同憑證及各類別憑證但不存放各類別資料之架構，作為一卡通用整合規格初期架構，稱為「IC卡共同多憑證不存放各類別資料一卡整合」，最後本研究提出長期一卡通用願景，以「IC卡共同憑證不存放各類別資料一卡整合」為目標。 本研究之結論為：1.我國各類別IC卡規格各行其道，未有整合前瞻性。2.各產業IC卡系統運作架構未整合，導致我們卡滿為患。3.IC卡應用發展於法律面應積極訂定「交通運輸業電子票證法」。4.「非銀行不得發行現金儲值卡」已超越母法規定應修法。5.IC票卡發行機構透過銀行發卡可享有發卡權利金等商機。6.建立IC票卡資訊中心作為全台IC票卡整合運作中心。7.IC票卡業者透過整合可增加發卡量，共創雙贏。8.IC卡於技術面應發展整合技術，以達成一卡通用目標。9.IC卡一卡通用宜建立IC卡資訊交換中心及憑證整合認證中心。10.IC卡一卡通用宜建立整體解決架構之實施步驟。11.IC卡一卡通用卡片規格整合可建立矩陣架構圖，以利分析。12.IC卡一卡通用共同憑證之運作於技術上為可行方案。 最後建議未來可持續探討之課題：1.IC卡一卡通用宜建立認證API(Application Programming Interface)程式介面及標準作業程序。2.IC卡一卡通用宜建立憑證整合認證中心及資訊中心之經營模式。3.IC卡一卡通用宜評估對IC卡產業及憑證認證產業之衝擊。 / A study of trends in the applications and developments of IC cards The IC card is being used widely and it will deeply affect our future living mode. Therefore, trends in its applications and developments have become important subjects of study. This research explores the possible outcome and related important subjects for the utilization of IC card, based on the following three propositions. 1. The IC card is one of the modern world’s primary information media. 2. Government units such as the Ministry of the Interior, the Ministry of Transportation and Communications, the Ministry of Finance ROC, the Department of Health and the Executive Yuan ROC all have jurisdiction over the development and control of development and potential applications of the IC card. 3. Private enterprises have introduced or developed electronic cash-stored cards. The information related to the research subject was collected from the relevant literatures in regard to the applications and developments of IC card in Taiwan, presenting the current safety and integration mechanism of IC ticket cards and the economical magnitude of IC card use, which are both topics that should be taken into consideration in the study of the applications and developments of IC cards. Based on the current situation of the applications and developments for IC cards, the main purpose of this research is to show the evolution of IC cards promoted by the our government, including National Card, Citizen Digital Certificate IC Card, National Health Insurance IC Card, as well as current applications and developments of the Transportation IC Card, in order to help understand the current situation for the applications and developments for existing IC cards in Taiwan. In the Transportation sector, this research shows the applications and developments of various IC smart cards in north, central and south Taiwan, i.e. Easy Card, Taichung e-Cartoon Ticket Card and Taiwan Money Card. It also shows the development of the specification for IC Ticket Cards as well as the development of Transportation IC Cards’ systematic infrastructure, in order to help understand the present situation for the applications and developments of a Transportation IC Card. This research is an analysis of IC card’s applications and developments, covering technical issues (specification and systematic framework of IC card), legislation issues (laws and regulations for IC Card), management issues (operation and administration, release and business model for IC cards), so as to discover and analyze the possible problems as well as propose solutions. Focusing on strategies for finding solutions, presenting more critical strategies for IC Cards, consisting of: 1. Technical: (1) To establish a common certificate (2) To establish safety authentication (3) To establish integration infrastructure 2. Legislation: (1) To revise the Banking Law as well as the laws and regulations relating to public transportation, which are not suitable for the existing operations (2) To revise and augment the laws and regulations for electronic tickets 3. Management: (1) To establish an economic circulation of scale (2) To establish the management pattern for card-issuing organization (3) To establish public credibility for a certificate authentication organization (4) To establish information interchange center To consolidate the above-mentioned three areas, this research proposes a core strategic solution – the concept of “one card for common use (All-in-One Card)” along with integrated solution scheme and operation steps. In addition, for an overall solution strategic plan, in this research it also presents a matrix composition for the integration of specifications to discover a more applicable specification scheme for the IC card. The matrix composition is proposed in four types of framework of specification integration with a file of advantages/disadvantages, based on the concept of X, Y coordinate system – X axis being “One Card integrated with Common Certificate” and “One Card integrated with Multi-Certificates”, Y axis being “No data deposited in the IC card specification” and “All sorts of data deposited in the IC the card specification”. Through detailed research and analysis, it is suggested that at the primary stage, to create the “One card for common use” with an integration of “Common Certificate and Multi-Certificates but no data depositing in the IC card specification”, which is called “One card with common and multi-certificates but no any data deposited in the specification.” The long-term goal will be to achieve “One card with common certificate only and no data deposited in the card specification” for long-term use. Conclusions: 1. In this country, various IC cards have their own specifications and there is still no prospect for integration. 2. The IC card system being used by different industries is still not being integrated, so the market is full of different IC cards. 3. The enactment of the “law on electronic tickets” should be pursued more vigorously for the IC card applications and developments. 4. The stipulation of “A non-bank may not issue a stored value card” might have overtaken the stipulation of “Banking Act”. It should be amended. 5. So long as the IC Ticket Card agency issues IC cards through a bank, the agency will possess the business opportunity of charging the bank a card-issuing fee. 6. To establish an IC Ticket Card information center to integrate the operation of the many IC ticket cards using in Taiwan area. 7. It will be a win-win situation, if IC ticket card operations can be integrated, and this will increase card-issuing quantity as well. 8. On the technical front, integration technology for IC cards should be developed in order to achieve the goal of an “All-in-One Card”. 9. An “IC Card Information Interchange Center” and an “Authentication Center of Certificate Integration” for the “All-in-One Card” should be established. 10. A standardized operational procedure should be established for an overall solution to the “All-in-One IC Card”. 11. The integration of the specifications of the “All-in-One IC Card” can be done through a matrix composition to assist analysis. 12. Technically, an “All-in-One IC Card” with “Common Certificate” is a feasible plan. In the end, this research also offers suggestion on valuable topics that can be the subject of continued discussion in the future: 1. “All-in-One IC Cards” should have an authentication with API (Application Programming Interface) program as well as a standard operational procedure. 2. A business model for “IC Card Information Center” and “Authentication Center of Certificate Integration” should be established. 3. An evaluation of the impact on the IC card industry and the certificate authentication industry should be made.