Ve všeobecnosti, poznatky o design slitin, jejich výrobě a výběru legujúcich prvků sú omezené na slitiny s jedním základním prvkem. Tento fakt ale výrazně limituje možnosti a volnost výběru prvků pro dosáhnuti speciálních vlastností a mikrostruktur. V poslední dekádě se ukázalo, že materiálová věda a inženýrství nejsou ještě zdaleka prozkoumané v důsledku objevu nové třídy materiálů nazvané vysoko entropické slitiny (HEA high entropy alloys). Jejich objev upoutal pozornost vědecké komunity. Základní koncept pro jejich design je, že namísto jednoho, nebo dvou základních prvků obsahují minimálně 5 prvků v podobných atomových koncentracích. V posledních letech se objevila skupina materiálů odvozená od HEA, nazvaná slitiny so střednou entropii (MEA medium entropy alloys). Na rozdíl od HEA ale obsahují 3, nebo 4 prvky. Táto práce je věnovaná studiu přípravy a charakterizaci HEA, MEA a jejich kompozitů s pomocí metod práškové metalurgie. V této práci byli dohromady zkoumány tři kompozice: AlCoCrFeNiTi0.5, Co1.5Ni1.5CrFeTi0.5 a CoCrNi, kompozity s kovovou matricí (MMC metal matrix composites) vyztužené částicemi B4C s CoCrNi jako matricí. Hloubková mikrostrukturní a mechanická analýza těchto materiálů byla provedena pomoví metod rastrovací a transmisní elektronové mikroskopie spojené s tahovými a ohybovými zkouškami. V průběhu celé studie se objevovaly problémy s kontaminací kyslíkem, co se projevilo vznikem značného množství oxidů v připravených materiálech. U Slitiny AlCoCrFeNiTi0.5 byla naměřena tvrdost přesahující 800 HV. Její houževnatost ale byla velice omezena. V její mikrostruktuře byly identifikovány částice in-situ TiC v důsledku přítomnosti organického, anti-aglomeračního činidla (metanolu) v mlecí misce. Tato reakce může být použita v budoucnu k přípravě MMC se záměrnou disperzí TiC. Na druhé straně, slitina CoCrNi ukázala vysoké hodnoty tažnosti (26%) a meze pevnosti přes 1000 MPa. Mikrostruktura obsahovala majoritní FCC fázi s BCC precipitáty. Tahle slitina byla z důvodu vysoké tažnosti zvolena pro přípravu kompozitu s výztuží B4C. V průběhu slinování ale došlo k reakci mezi přítomným Cr a B4C, které výsledkem byl Cr5B3 borid. Tento kompozit mel pevnost v tahu 1400 MP a extrémne jemnozrnnou strukturu. Celková tažnost ale klesla na 1.9 %. Slitina AlCoCrFeNiTi0.5, která mela strukturu složenou jen z FCC tuhého roztoku dosáhla nejlepší kombinaci mechanických vlastností s pevností přesahující 1300 MPa a dostatečnou tažností 4%. Prášková metalurgie se ukázala jako vhodná metoda pro přípravu HEA a MEA slitin a jejich kompozitů, s dobrou kombinací pevnosti a tažnosti. Tato metoda dovoluje měnit mikrostrukturní parametry připravených materiálů jednoduchou úpravou parametrů procesu.

This paper deals with the problem of abdominal aortic aneurysms (AAA), taking into account the possibility of using mechanical tests of aortic tissues for improvement of level of their constitutive models. First part of thesis deals with the introduction into the problem, description of the structure of the wall of the healthy aorta, its main components and the degenerative changes which lead to formation of AAA. This is followed by a brief excursion into constitutive modeling, which focuses closely on the description of the models used to describe the mechanical behavior of soft tissues. The theoretical part is then supplemented by a narrower selection of constitutive models used for modeling aortic wall and intraluminal thrombus, together with published results, which are reviewed and discussed at the end of this section. The main part of this thesis is devoted to tests of mechanical properties of arterial tissues. First, the methodology is presented together with the description of the customizations of the laboratory equipments together with the test rig. In addition, attention is focused on the results of mechanical tests of intraluminal thrombus, where the results of both uniaxial tensile tests and equbiaxial testing are presented. Also the influence of distance ILT from the lumen on the mechanical properties of the thrombus is examined. Another area of interest is the investigation of the effect of elastase on the chnage of mechanical properties of pig aorta. In this case, porcine aortas are experimentally tested only by biaxial testing, and the time of elastase action to alter the mechanical properties is analyzed so that the resulting tissue has a similar stress-strain response as aneurysmal tissue. Finally, the results of experimental measurements, limitations and other possible ways of research are summarized.

This thesis deals with determination of representative constitutive model for describing atherosclerotic carotid artery behavior. The first part of the thesis provides brief summary of medical knowledge needed as well as detailed describtion of current experimental methods for determination of mechanical properties of atherosclerotic arteries. The main part is focused on mechanical testing of atheroslecotic carotid arteries. The description of sample preparation, testing device and the experiment itself is involved. Statistical analysis of measured data is done, focusing on comparison of factors potentially influencing mechanical behavior. In conclusion, the FEA analysis on simplified geometry of carotid artery with atheroma is performed. Emphasis is placed on the impact of material model obtained from experiments on equivalent stress in fibrous cap.

Ces travaux de recherche portent sur l’étude de l’injection du cuivre. Dans une optique d’amélioration des propriétés du cuivre injecté sous pression, deux grands thèmes de réflexion ont été abordés. La première voie de réflexion porte sur l’influence des paramètres de fusion et d’éléments d’alliages ajoutés en faible quantité sur les caractéristiques des démonstrateurs technologiques produits. La seconde partie discute de l’influence du procédé de fonderie en lui-même, notamment au travers de l’étude de deux paramètres : l’influence du régime d’écoulement du métal en fusion dans l’empreinte, et l’influence de l’emprisonnement de l’air sur les propriétés des pièces injectées. / This research focuses on the study of high pressure die casting (HPDC) of copper. In order to improve the properties of die-cast copper, two main issues were investigated. In the first part, attention is paid to the influence of melting parameters and of addition of alloying elements in small amounts on the characteristics of the specimen produced. The second part discusses the influence of the foundry process itself on properties of die cast part, in particular by studying two parameters : the metal flow type during cavity filling, and the air entrapment.

<p>The extracellular matrix (ECM) plays a significant role in defining the mechanical properties of biological tissues. The proteins, proteoglycans, and glycosaminoglycans that constitute the ECM are arranged into highly organized structures (<i>e.g.</i> fibrils and networks). Cellular behavior is affected by the stiffness of the microenvironment and influenced by the composition and organization of the ECM. Mechanosensing of ECM stiffness by cells occurs at the fibrillar (mesoscale) level between the single molecule (microscale) and the bulk tissue (macroscale) levels. However, the mechanical behavior of ECM proteins at the mesoscale are not well defined. Thus, better understanding of the ECM building blocks responsible for functional tissue assembly is critical in order to recapitulate <i>in vivo</i> conditions. There is a need for the mechanical characterization of the ECM networks formed by proteins synthesized <i>in vivo</i> while in their native configuration. </p> <p>To address this gap, my goals highlighted in this dissertation were to develop appropriate experimental and computational methodologies and investigate the 3D organization and mechanical behavior of ECM networks <i>in situ</i>. The ECM of developing mouse tissues was used as a model system, taking advantage of the low-density networks present at this stage. First, we established a novel decellularization technique that enhanced the visualization of ECM networks in soft embryonic tissues. Based on this technique, we then quantified tissue-dependent strain of immunostained ECM networks <i>in situ</i>. Next, we developed mesoscale and macroscale testing systems to evaluate ECM networks under tension. Our systems were used to investigate tendon mechanics as a function of development, calculating tangent moduli from stress - strain plots. Similarly, we characterized ECM network deformation while uniaxially loading embryonic tissues, since this testing modality is ideal for fibril and network mechanics. Taken together, this information can facilitate the fabrication of physiologically relevant scaffolds for regenerative medicine by establishing mechanical guidelines for microenvironments facilitate functional tissue assembly.</p>

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Ceramics are very important materials with many unique properties used in numerous industrial applications. Ceramics could be very hard and very strong in comparison to metals; however, they are very brittle, thus they are prone to instantaneous and catastrophic failure. Therefore, their reliability is compromised and it is very important to have advanced techniques that allow evaluating their mechanical behavior in many unusual stress states. One of such testing methods is biaxial strength method, that allows to measure properties not only unidirectional, but also in a biaxial way. The research work for this thesis will be built on design and development of ring-on-ring test jigs that will measure a biaxial strength of thin ceramic disks.

<p> Laser powder bed fusion (LPBF) is a rapidly emerging manufacturing technology capable of producing complex part geometries through the repeated, precise laser melting of metallic powder layers. At present, the process is primarily employed in high-value-added applications which exist in the aerospace, biomedical, and dental industries. As industrial implementation of LPBF has matured, research has focused on established materials for which there are already large bodies of literature and regulatory approval, such as Inconel 718, Inconel 625, Ti-6Al-4V, and 316 stainless steel. However, the rapid solidification process inherent to LPBF leads to vastly different microstructures with improved strength compared to these traditional materials in cast or wrought forms. In general, the high solidification velocity and thermal gradients result in cellular and dendritic solidification structures with finer grain and precipitate sizes than conventionally processed alloys. These microstructure changes warrant the exploration of new alloy systems and reevaluation of historically cast compositions with optimized microstructures, especially considering the tunability of a digitally controlled fabrication process. This work examines laser powder bed fusion of Mar-M 509, a carbide-strengthened cobalt alloy that is typically investment cast directly into complex-shaped components such as nozzle guide vanes (NGVs). NGVs are stationary components in gas turbine engines for propulsion and energy production which require strength under moderate mechanical loading at high temperatures. Investment cast microstructures have porosity defects in slower-cooled regions due to lack of liquid feed to interdendritic regions. As-printed, the cellular and dendritic Mar-M 509 LPBF microstructures lead to the formation of continuous, fiber-like, eutectic carbide structures in the intercellular and interdendritic regions, which limit macroscopic ductility. Thermo-Calc is used for calculation of phase diagrams (CALPHAD) to estimate the equilibrium transformation temperatures of MC, M23C6, and M7C3-type carbides, which informs design of isothermal heat treatments to engineer microstructures with enhanced ductility over the as-printed or cast versions of Mar-M 509 while maintaining tensile strength. Scanning and transmission electron microscopy reveals the composition and distribution of carbide phases as a function of heat treatment temperature. Lastly, heat treatment recommendations for nozzle guide vanes are made.  </p>