Global ETD Search

371	Pharmacokinetic disposition of norapomorphine derivatives and its influence on the elicitation of stereotypical gnawing / Van Tyle, William Kent January 1972 (has links) No description available. Health Sciences Apomorphine Mice
372	Mice reared with rats : changes in inter- and intraspecific social behavior / Booth, Cathryn Louise January 1974 (has links) No description available. Psychology Mice Rats
373	The influence of the otoliths on semicircular canal induced nystagmus / Coccia, Maria Regina January 1975 (has links) No description available. Biology Otoliths Nystagmus Mice
374	The effect of acute and chronic amphetamine administration on seizure susceptibility and brain catecholamines in mice / Riffee, William H. January 1975 (has links) No description available. Health Sciences Amphetamine Mice
375	Population Ecology of the Beach Mouse, Peromyscus Polionotus Niveiventris Extine, Douglas Dale 01 April 1980 (has links) (PDF) No description available. Peromyscus polionotus Mice Biology
376	Myosin expression and podocyte function in kidney structure and function, in heterozygous MHY9 knockout mice Belghasem, Mostafa E. January 2011 (has links) Thesis (M.A.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / The gene Myh9 encodes non-muscle myosin heavy chain I lA, an essential podocyte cytoskeleton structural protein. Abnormalities in the MYH9 gene are associated with chronic kidney disease (common in people of African ancestry) and rare hereditary autosomal dominant syndromes. In the current study, preexisting heterozygous Myh9 knockout mice aged 9 and 17 months were investigated to assess the biological role of the gene Myh9 product, non-muscle myosin IIA, in kidney structure and function. The objective was to determine the effects of potentially decreased expression of Myh9 genetic alteration and the role of Myh9 in the pathogenesis of chronic kidney disease (especially focal segmental glomerulosclerosis), and to develop a model to further study Myh9- related kidney disorders. Our results demonstrated that deletion of one allele of Myh9 in 129/Sv mice had no effect on the kidney structure compared with wildtype mice despite a significant decrease in expression of Myh9 in the heterozygous mice. / 2031-01-01 MYH9 gene Kidneys Mice
377	The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice Swaminathan, Karthic, Campbell, A., Papalazarou, V., Jaber-Hijazi, F., Nixon, C., McGhee, E., Strathdee, D., Sansom, O.J., Machesky, L.M. 08 September 2020 (has links) Yes / BRAF V600E is the most common driver mutation in human cutaneous melanoma and is frequently accompanied by loss of the tumor suppressing phosphatase PTEN. Recent evidence suggests a co-operative role for RAC1 activity in BRAF V600E -driven melanoma progression and drug resistance. However, the underlying molecular mechanisms and the role of RAC1 downstream targets are not well explored. Here, we examine the role of the NCKAP1 subunit of the pentameric cytoskeletal SCAR/WAVE complex, a major downstream target of RAC1, in a mouse model of melanoma driven by BRAF V600E; PTEN loss. The SCAR/WAVE complex is the major driver of lamellipodia formation and cell migration downstream of RAC1 and depends on NCKAP1 for its integrity. Targeted deletion of Nckap1 in the melanocyte lineage delayed tumor onset and progression of a mutant Braf ; Pten loss driven melanoma mouse model. Nckap1 depleted tumors displayed fibrotic stroma with increased collagen deposition concomitant with enhanced immune infiltration. Nckap1 loss slowed proliferation and tumor growth, highlighting a role in cell cycle progression. Altogether, we propose that NCKAP1-orchestrated actin polymerization is essential for tumor progression and maintenance of tumor tissue integrity in a mutant Braf ; Pten loss driven mouse model for melanoma. Melanoma Mice RAC1
378	Effect of Heat Exposure On Allogeneic Cytotoxic T Lymphocyte Responses in Mice Sukumaran, M K January 1996 (has links) (PDF) No description available. Mice - Lymphocytes Mice - Heat Exposure Mice - Immunobilization Stress Mice - Cold Stress Mice - Heat Stress Allogenic Cytoxic T Lymphocyte (CTL) Immunology
379	Study on the function and regulation of stanniocalcin in mouse neuroblastoma cells 楊可儀, Yeung, Ho-yee. January 2003 (has links) published_or_final_version / Zoology / Doctoral / Doctor of Philosophy Peptide hormones. Neuroblastoma. Mice - Cytology - Research. Mice as laboratory animals.
380	Regulation of the mouse hoxb-3 gene in the neural expression domains during embryogenesis 邱大安, Yau, Tai-on. January 2001 (has links) published_or_final_version / Biochemistry / Doctoral / Doctor of Philosophy Genetic regulation. Gene expression. Mice - Nervous system. Mice - Genetics.

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