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The relation between lexico-semantic groups and modes of action (on the material of phrasal verbs with the postverb up) / Leksinių semantinių grupių ir veiksmo būdų ryšys (frazinių veiksmažodžių su postverbu up pagrindu)Žukaitė, Kristina 02 August 2011 (has links)
The subject matter of phrasal verbs is a complex linguistic phenomenon. It raises a great number of theoretical issues. These include linguistic status, derivational aspect, lexical meaning, aspectuality etc of phrasal verbs. The English postverb UP has been chosen for our research with the aim to investigate the relation between the formation of lexico-semantic groups and modes of action. We assume that our research and the data collected for it might be used in the course of lexicology, word formation and semantics of the English language. / Frazinių veiksmažodžių tyrimo objektas – sudėtingas kalbinis reiškinys, keliantis daug teorinių klausimų (kalbinę padėtį, žodžių vedybos aspektą, leksinę reikšmę, aspektualumą ir kt.). Anglų kalbos postverbas UP yra pasirinktas mokslo tiriamajame darbe siekiant ištirti ryšį tarp leksinių-semantinių grupių ir veiksmo būdų. Manome, kad mūsų mokslo tiriamasis darbas bei surinkti duomenys gali būti naudojami anglų kalbos leksikologijoje, žodžių daryboje bei semantikoje.
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Elucidating drug modes of action through transcription factor binding profiling / 転写因子結合プロファイリングによる薬剤作用機序の解析Zou, Zhaonan 23 March 2023 (has links)
付記する学位プログラム名: 京都大学卓越大学院プログラム「メディカルイノベーション大学院プログラム」 / 京都大学 / 新制・課程博士 / 博士(医科学) / 甲第24534号 / 医科博第148号 / 新制||医科||10(附属図書館) / 京都大学大学院医学研究科医科学専攻 / (主査)教授 寺田 智祐, 教授 川上 浩司, 教授 YOUSSEFIAN Shohab / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Effets d’une exposition alimentaire chronique à un mélange environnemental de PCB et PBDE sur les traits d’histoire de vie, la bioénergétique et la dynamique des populations de poissons / Effects of chronic dietary exposure to an environmental mixture of PCBs and PBDEs on life history traits, bioenergetics and fish population dynamicsHorri, Khaled 12 April 2018 (has links)
Les polychlorobiphényles (PCB) et les polybromodiphényléthers (PBDE) sont deux familles de composés hydrophobes partageant certaines propriétés physico-chimiques. Des travaux antérieurs ont montré que ces composés pouvaient affecter les traits d’histoire de vie des poissons. Il s’avère cependant que les études approchant des situations environnementales sont rares. Cette thèse se divise en trois parties. La première partie s’est attachée à évaluer les effets d’une exposition à un mélange réaliste de PCB et de PBDE sur les traits d’histoire de vie du poisson-zèbre. Les résultats ont montré une taille asymptotique plus élevée, une probabilité de ponte retardée chez les individus exposés et une faible survie des larves F1 en situation de jeûne issues des pontes précoces des individus exposés. La seconde partie a cherché à identifier, sur la base d’un modèle bioénergétique (DEB), les modes d’action physiologique (PMoA) de PCB et PBDE. Deux PMoAs probables ont été révélés: le premier est lié à l’augmentation de la fraction d’énergie allouée à la maintenance et la croissance somatique et le deuxième est lié à l’augmentation des coûts de production d’un œuf. La troisième partie de la thèse s’est intéressée à évaluer les conséquences de la contamination sur la dynamique de population de poissons. Les résultats ont montré une réduction de l’abondance numérique, une augmentation de la biomasse et un grand risque de surexploitation chez la population exposée, Les résultats de cette thèse pourraient constituer un outil d’aide à une gestion durable des stocks halieutiques qui prennent en compte les effets de multiples contaminations qui se surajoutent à la pression de pêche. / Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are two families of hydrophobic compounds sharing some similar environmental properties. Previous studies have demonstrated that these compounds could affect fish life-history traits. However, few studies have focused on environmental situations. This thesis is divided into three parts. The first part aimed to evaluate the effects of a realistic mixture of PCBs and PBDEs on the life-history traits of zebrafish. The results showed a slower growth, but to a larger asymptotic length, and delayed spawning probability in exposed fish. In addition, offspring issued from early spawning events of exposed fish exhibited a lower larval survival under starvation condition. The second part aimed to identify, on the basis of a bioenergetic model (DEB), the physiological modes of action (PMoA) of PCBs and PBDEs. Two potential PMoAs have been revealed: the first one was through an increase of the fraction of energy allocated to somatic maintenance and growth and the second one was through an increase of the cost of production of an egg. The third part focused on the population dynamical consequences of the individual life-history effects of PCBs and PBDEs. The results showed a lower abundance, a higher biomass and a higher risk of overexploitation in exposed population compared to control population. The results of this thesis could be a helpful tool for sustainable management of fish stocks that take into account the effects of multiple contaminations that are added to the fishing pressure.
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Caractérisation, criblage et mise en oeuvre de souches bactériennes issues du vignoble bordelais pour la lutte biologique contre les champignons impliqués dans la Pourriture grise et l'Esca de la vigne / Characterization, screening and implementation of bacterial strains from Bordeaux vineyards for biological control of fungal pathogens involved in Gray mold and Esca of grapevineHaidar, Rana 11 October 2016 (has links)
Contre la pourriture grise et les maladies du bois (MdBs), qui sont des maladies cryptogamiques majeures de la vigne, la lutte biologique a un potentiel de développement considérable dans le contexte actuel de réduction des intrants chimiques en viticulture.L’objectif de cette thèse est de sélectionner et d'étudier des souches bactériennes antagonistes de Botrytis cinerea (Pourriture grise) et de deux champignons pathogènes clefs liés aux MdBs: Phaeomoniella chlamydospora et Neofusicoccum parvum. Les expériences de screening principales sont réalisées in vivo et in planta sur 46 souches bactériennes isolées dans le vignoble bordelais. Le niveau de protection par les souches antagonistes dépend significativement de la souche bactérienne, de l’espèce de champignon pathogène ciblée, du tissu ou organe végétal hôte, mais aussi pour N. parvum, du mode d’application de la souche bactérienne et, pour B. cinerea, du génotype lié aux transposons : transposa ou vacuma.Une réduction significative de 40 à 64% de la taille des nécroses dues à P. chlamydospora et/ou N. parvum est induite par trois souches bactériennes Pantoea agglomerans (S1), Paenibacillus sp. (S19) et Bacillus pumilus (S32) sur des boutures de vigne non greffées. Ces souches ont fait l'objet d'investigations approfondies pour déterminer leurs principaux modes d’action : Antibiose, production de composés volatils qui ont été identifiés et/ou induction de différents gènes de défense de la vigne.Concernant B. cinerea, les souches Enterobacter cowanii (S22), Enterobacter sp. (S23), Bacillus ginsengihumi (S38) et Bacillus sp. (S43, S46) présentent un pouvoir antagoniste important par production de composés volatils et diffusibles anti-Botrytis, ainsi que par compétition pour les nutriments par E. cowanii (S22). / Biological control of gray mold and grapevine trunk diseases (GTDs), which are major fungal diseases of grapevine, has a considerable potential development in the current context of reduction of chemical input in viticulture.The aim of this study was to select and study bacterial strains for antagonism against Botrytis cinerea, the causal agent of gray mold, and two key pathogens involved in GTDs: Phaeomoniella chlamydospora and Neofusicoccum parvum. The main screening experiments for antagonistic activity of 46 bacterial strains, isolated from Bordeaux vineyards, have been carried out under different in vivo and in planta conditions. The efficacy of protection by the antagonistic strains significantly depended on the bacterial strain, the targeted pathogen species, the host plant tissue or organ and, for N. parvum, also on the application mode of the bacterial strain and, for B. cinerea, on the transposon genotype: transposa or vacuma.A significant reduction in length of necrosis due to P. chlamydospora and/or N. parvum, ranging between 40 and 64% in non-grafted vine cuttings, resulted from three bacterial strains: Pantoea agglomerans (S1), Paenibacillus sp. (S19) and Bacillus pumilus (S32). These strains were thoroughly further investigated to determine their major modes of action by i) Antibiosis ii) production of antifungal volatile organic compounds, which have been identified, and/or iii) induction of different grapevine defense genes. Concerning B. cinerea, Enterobacter cowanii (S22), Enterobacter sp. (S23) Bacillus ginsengihumi (S38), Bacillus sp. (S43, S46) were of prime importance in the biocontrol by producing anti-Botrytis volatile and diffusible compounds or by competing for nutrients (case of E. cowanii S22).
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Use and Abuse of Southwestern Rivers: The Pueblo DwellerDiPeso, Charles C. 23 April 1971 (has links)
From the Proceedings of the 1971 Meetings of the Arizona Section - American Water Resources Assn. and the Hydrology Section - Arizona Academy of Science - April 22-23, 1971, Tempe, Arizona / In response to the 20th century crisis of environmental destruction by unrestricted technological exploitation, some archaeologists are studying alternative modes of resource development as practiced by earlier men. The pueblo Indians of the arid southwestern deserts were basically upland corn farmers, who, after A.D. 1000, found it necessary to exploit their environment because of varying combinations of climatic change and increased population pressures. In the northeastern part of the state of Chihuahua, urban engineers, ca 1050, harnessed the entire Casas Grandes dendritic pattern by installing a set of linked hydraulic appointments which included various upslope protective devices such as linear border, check dams and riverside and hillside terraces. Not only were they able to visualize an entire dendritic pattern as the target area, but also they were able to conceive of rainfall and topsoil as a single factor in their control designs. Although large amounts of human labor were needed to construct and maintain these systems, few raw materials were needed. When the mountain-born waters reached the lower valleys, they were clear and sluggish, did not flood the bottomlands, and because of the reduced speed, could easily be diverted into canals and reservoirs, supplying the cities with domestic water and the farmers with irrigation water. Many further studies are needed of these pre-Columbian systems.
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Management of Artificial Recharge Wells for Groundwater Quality ControlWilson, L. G. 23 April 1971 (has links)
From the Proceedings of the 1971 Meetings of the Arizona Section - American Water Resources Assn. and the Hydrology Section - Arizona Academy of Science - April 22-23, 1971, Tempe, Arizona / Recharge wells may be used in various problems relating to chemical water quality because of the phenomenon of in-aquifer mixing. This paper reviews specific recharge well-mixing techniques of possible utility in underground mixing operations for nitrate control. Illustrative data from field studies at a recharge site near Tucson, Arizona are presented. Both single- and 2-well types of mixing were investigated. In single-well operations, effluent recharge and pumping of the subsequent mixture occur at the same well. Differences in chlorine ion levels were used to distinguish between recharge effluent and native groundwater. Undiluted effluent was discharged in single-well operations until a pumped volume ratio of about 0.4 was attained. Dilution increased steadily with increased pumping and the relative concentration versus pumped volume curve was s-shaped. Seven-day pauses after effluent recharge resulted in immediate pumping of almost completely diluted water, probably because groundwater movement swept the effluent beyond the pumping unit during the pause. With 2-well pumping, the chlorine breakthrough curve reached a constant level at about 13 days and was close to that of the pause-type, single-well regime.
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