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Complex Negotiations at the Kitchen Table: A Qualitative Analysis of Pediatric Home ModificationsGlencross, Tanya 31 December 2010 (has links)
Occupational therapists assess and make recommendations for modifying home environments to facilitate caregiving of children in their homes. Children who are profoundly and permanently physically disabled remain dependent for their care throughout their lifespan. As they mature, the physical demands on family members to provide care become more challenging requiring major modifications to ease caregiving. Qualitative interview data of ten educationally influential occupational therapists (EIOTs) were collected to examine what information the EIOTs collect and how they prioritize and organize these data to make modification recommendations. The data were analyzed using grounded theory methodology. The findings detail myriad information required by the EIOT to make recommendations for modifications. Findings suggest a future oriented and highly contextualized information gathering process. The themes were integrated into a process model that suggests how therapists may be developing recommendations. The findings highlight important implications for research, education, clinical practice and service delivery policy.
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Sorption studies of the surface modified activated carbon with beta-cyclodextrinKwon, Jae Hyuck 12 September 2007
Activated Carbon (AC) is an amorphous carbon-based material characterized with a large surface area (~ 1,000 m2/g) and consists primarily of graphitic (sp2 hybrid) layers. Its amphoteric chemical property results because of the chemical treatment of the surface of AC with oxidizing agents, reducing agents, and grafting agents. β-cyclodextrin (β-CD) is a very interesting carbohydrate oligomer that provides very strong binding ability for small organic guest molecules in its inner cavity (6.0 ~ 6.5 Å) by van der Waals interactions and hydrogen bond formation between the guest molecules and the host. <p>Surface modification of AC with β-CD was synthesized by chemical methods: oxidation with HNO3, reduction with LiAlH4, and grafting β-CD onto the surface of AC via organic linkers such as glutaraldehyde and 1,4-phenylene diisocyanate. This surface grafted AC with β-CD, then, was evaluated for its surface area and sorption performance by using a solution dye sorption method using dye adsorbates. <p>Surface functional groups produced from oxidation (carboxylic acid, lactone, quinine, phenol, and nitro groups), reduction (alcohol and amine groups), and grafting (imine, hemiacetal, and urethane bonds) methods including microscopy of untreated, surface modified, and grafted ACs were characterized by various surface characterization methods: Diffuse Reflectance Infra-red Fourier Transform Spectroscopy (DRIFTS), Scanning Electron Microscopy (SEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Thermogravimetric analysis (TGA), Differential thermogravimetry (DTG), Matrix Assisted Laser Desorption Ionization Time of Flight mass spectrometry (MALDI TOF MS), and Electron spin resonance (ESR) spectroscopy. A chemical method, the Boehm method, was used for identifying surface bound acidic and basic functional groups. Nitrogen porosimetry was used to analyze the surface area and pore structure characteristics of AC, surface modified ACs, and grafted ACs. <p>p-nitrophenol (PNP) and methylene blue (MB) were used as adsorbates for the dye sorption method. PNP and MB were used to measure the sorption performance of grafted ACs at equilibrium using UV-vis spectrophotometry in aqueous solution. Sorption capacity (Qe), surface area (m2/g), and binding affinity characteristics [KF (L/g), KL (g/mol), and KBET (L/g)] were determined at equilibrium conditions using fundamental sorption models such as Langmuir, Freundlich, and BET isotherms. The sorption performance of grafted ACs and granular AC were different according to the difference in surface area and pore structure characteristics of each material.
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Effectiveness of selected components in behavioral weight-loss interventions : a meta-analysisWood, Nadine M. Schneider 08 May 1992 (has links)
Graduation date: 1992
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Sorption studies of the surface modified activated carbon with beta-cyclodextrinKwon, Jae Hyuck 12 September 2007 (has links)
Activated Carbon (AC) is an amorphous carbon-based material characterized with a large surface area (~ 1,000 m2/g) and consists primarily of graphitic (sp2 hybrid) layers. Its amphoteric chemical property results because of the chemical treatment of the surface of AC with oxidizing agents, reducing agents, and grafting agents. β-cyclodextrin (β-CD) is a very interesting carbohydrate oligomer that provides very strong binding ability for small organic guest molecules in its inner cavity (6.0 ~ 6.5 Å) by van der Waals interactions and hydrogen bond formation between the guest molecules and the host. <p>Surface modification of AC with β-CD was synthesized by chemical methods: oxidation with HNO3, reduction with LiAlH4, and grafting β-CD onto the surface of AC via organic linkers such as glutaraldehyde and 1,4-phenylene diisocyanate. This surface grafted AC with β-CD, then, was evaluated for its surface area and sorption performance by using a solution dye sorption method using dye adsorbates. <p>Surface functional groups produced from oxidation (carboxylic acid, lactone, quinine, phenol, and nitro groups), reduction (alcohol and amine groups), and grafting (imine, hemiacetal, and urethane bonds) methods including microscopy of untreated, surface modified, and grafted ACs were characterized by various surface characterization methods: Diffuse Reflectance Infra-red Fourier Transform Spectroscopy (DRIFTS), Scanning Electron Microscopy (SEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Thermogravimetric analysis (TGA), Differential thermogravimetry (DTG), Matrix Assisted Laser Desorption Ionization Time of Flight mass spectrometry (MALDI TOF MS), and Electron spin resonance (ESR) spectroscopy. A chemical method, the Boehm method, was used for identifying surface bound acidic and basic functional groups. Nitrogen porosimetry was used to analyze the surface area and pore structure characteristics of AC, surface modified ACs, and grafted ACs. <p>p-nitrophenol (PNP) and methylene blue (MB) were used as adsorbates for the dye sorption method. PNP and MB were used to measure the sorption performance of grafted ACs at equilibrium using UV-vis spectrophotometry in aqueous solution. Sorption capacity (Qe), surface area (m2/g), and binding affinity characteristics [KF (L/g), KL (g/mol), and KBET (L/g)] were determined at equilibrium conditions using fundamental sorption models such as Langmuir, Freundlich, and BET isotherms. The sorption performance of grafted ACs and granular AC were different according to the difference in surface area and pore structure characteristics of each material.
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The role of histones and histone modifying enzymes in ribosomal dna silencing in saccharomyces cerevisiaeLi, Chonghua 15 May 2009 (has links)
In S. cerevisiae, the ribosomal DNA locus is silent for RNA polymerase II (Pol
II) transcription and recombination (rDNA silencing). Our goal is to understand how
histones and histone-modifying enzymes regulate the silent chromatin at the rDNA
locus.
Sir2, a NAD+-dependent histone deacetylase, is required for rDNA silencing. To
understand how Sir2 regulates rDNA silencing, we performed chromatin
immunoprecipitation to measure the association of modified histones across the rDNA
repeat in wild-type and sir2Δ cells. We found that in sir2Δ cells, histone H3 at the rDNA
became hyperacetylated and hypermethylated. High levels of K4-methylated H3
correlate with Pol II transcription. Consistent with this, we found that the nontranscribed
spacer (NTS) region was transcribed by Pol II in sir2Δ cells. To investigate if
transcription of the NTS region regulates rDNA silencing, we overexpressed this region
both in trans and in cis. Our data showed that overexpression of the NTS region in cis
caused Pol II silencing defect and hyperrecombination at the rDNA. These data suggest
that Sir2 contributes to maintain the silent chromatin at the rDNA by repressing Pol II transcription in the NTS region. We also found that the NTS transcripts could be
translated in vitro and that they copurified with polysomes, suggesting that the
transcripts may encode proteins or that the transcripts are somehow involved in the
process of translation.
Additionally, we examined the role of linker histone H1 in regulating rDNA
silencing. We found that, unlike Sir2 that represses both Pol II transcription and
recombination, histone H1 only represses recombination at the rDNA. The
hyperrecombination defect at the rDNA is more severe in sir2Δ hho1Δ double mutant
than in either single mutant, suggesting histone H1 and Sir2 act independently.
Consistently, hho1Δ cells did not accumulate extrachromosomal rDNA circles (ERCs) or
the Holliday junction intermediates, which accumulate in sir2Δ cells. These data suggest
that histone H1 and Sir2 regulate different recombination pathways.
In summary, my research has provided insight into the mechanism of how silent
chromatin at the rDNA locus is regulated, which will help us understand how
fundamental components of chromosomes affect gene expression and genome stability.
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Simulation and Economic Screening of Improved Oil Recovery Methods with Emphasis on Injection Profile Control Including Waterflooding, Polymer Flooding and a Thermally Activated Deep Diverting GelOkeke, Tobenna 2012 May 1900 (has links)
The large volume of water produced during the extraction of oil presents a significant problem due to the high cost of disposal in an environmentally friendly manner. On average, an estimated seven barrels of water is produced per barrel of oil in the US alone and the associated treatment and disposal cost is an estimated $5-10 billion. Besides making oil-water separation more complex, produced water also causes problems such as corrosion in the wellbore, decline in production rate and ultimate recovery of hydrocarbons and premature well or field abandonment.
Water production can be more problematic during waterflooding in a highly heterogeneous reservoir with vertical communication between layers leading to unevenness in the flood front, cross-flow between high and low permeability layers and early water breakthrough from high permeability layers. Some of the different technologies that can be used to counteract this involve reducing the mobility of water or using a permeability block in the higher permeability, swept zones.
This research was initiated to evaluate the potential effectiveness of the latter method, known as deep diverting gels (DDG) to plug thief zones deep within the reservoir and far from the injection well. To evaluate the performance of DDG, its injection was modeled, sensitivities run for a range of reservoir characteristics and conditions and an economic analysis was also performed. The performance of the DDG was then compared to other recovery methods, specifically waterflooding and polymer flooding from a technical and economic perspective.
A literature review was performed on the background of injection profile control methods, their respective designs and technical capabilities. For the methods selected, Schlumberger's Eclipse software was used to simulate their behavior in a reservoir using realistic and simplified assumptions of reservoir characteristics and fluid properties. The simulation results obtained were then used to carry out economic analyses upon which conclusions and recommendations are based. These results show that the factor with the largest impact on the economic success of this method versus a polymer flood was the amount of incremental oil produced. By comparing net present values of the different methods, it was found that the polymer flood was the most successful with the highest NPV for each configuration followed by DDG.
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CARDIOPROTECTIVE MECHANISMS OF LIFESTYLE MODIFICATIONS AND PHARMACOTHERAPIES ON CARDIAC REMODELING AND DYSFUNCTION IN HYPERTENSIVE HEART DISEASE: AN OVERVIEWHattori, Takuya, Nagata, Kohzo 08 1900 (has links)
No description available.
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Characterization of the nuclease of Vibrio vulnificusWu, Hui-Chi 22 June 2001 (has links)
The periplasmic nuclease of Vibrio vulnificus, Vvn, has been purified to homogeneity by a one step purification procedure using chromatography on a SP Sepharose column. The purified enzyme showed different mobilities on reducing and non-reducing SDS-PAGE, suggesting that disulfide bonds are involved in the maintenance of a stable tertiary conformation of the protein. Vvn randomly cleaved single and double stranded DNA and RNA, and possessed endonucleolytic activity. The enzyme exhibited an optimal activity between pH 8.0 and pH 10.0, and the optimal temperatures for the DNase and RNase activity were 40 oC ¡V 60 oC and 40 oC ¡V 50 oC, respectively. The enzymatic activity was inhibited by EDTA and EGTA, indicating that Vvn was a metalloenzyme. The DNase and RNase activity of Vvn had different requirements for divalent cations. Chemical modification studies on Vvn revealed the involvement of lysine, arginine, tryptophan and carboxylate residues in the catalytic activity of the enzyme. The extents of inactivation of the DNase and RNase activity of Vvn by modification of the carboxylate group with EDC were different. Substrate DNA and RNA protected the DNase and RNase activity of Vvn from inactivation by PLP, PGO, NBS and EDC which modified lysine, arginine, tryptophan and the carboxylate group. Mg2+ could not protect the DNase and RNase activity of Vvn against the inactivation by PLP and PGO. Whereas Mg2+ protection was observed in NBS- and EDC-mediated inactivation of the DNase but not the RNase activity of Vvn . From these results, it is postulate that there may be two distinct but overlapping active sites, for the DNase and RNase activity, respectively.
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Immediate and subsequent effects of fixed-time delivery of therapist attention on problem behavior maintained by attentionWalker, Stephen Frank. Smith, Richard G., January 2009 (has links)
Thesis (M.S.)--University of North Texas, Aug., 2009. / Title from title page display. Includes bibliographical references.
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An interpretation of operant learning in terms of substitution processes /Delgado, Diana M. January 2008 (has links)
Thesis (Ph. D.)--University of Nevada, Reno, 2008. / "December 2008." Includes bibliographical references (leaves 124-135). Library also has microfilm. Ann Arbor, Mich. : ProQuest Information and Learning Company, [2009]. 1 microfilm reel ; 35 mm. Online version available on the World Wide Web.
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