Thesis (Ph. D.)--University of Virginia, 2006. / Includes bibliographical references (leaves 109-130). Also available online through Digital Dissertations.

Thesis (Ph.D.) - University of Queensland, 2005. / Includes bibliography.

Thesis (Ph.D.) - University of Queensland, 2005. / Includes bibliography.

Thesis (M.S.)--University of Delaware, 2006. / Principal faculty advisor: Carlton R. Cooper, Dept. of Biological Sciences. Includes bibliographical references.

Thesis--Ohio State University. / Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 210-222).

Orientador: Amir Ordacgi Caldeira / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Fisica Gleb Wataghin / Made available in DSpace on 2018-08-11T11:04:40Z (GMT). No. of bitstreams: 1 Coelho_JoaodeAbreuBarbosa_M.pdf: 865659 bytes, checksum: f3befbe4283d2213924fdc6a38fda3e0 (MD5) Previous issue date: 2008 / Resumo: Nesta dissertação, analisamos o efeito dos graus de liberdade internos de um objeto na dinâmica do seu centro de massa visando a determinar sua relevância para processos de descoerência em experimentos de fenda dupla. Mostramos que esses graus de liberdade se acoplam ao centro de massa na presença de um potencial que quebra a invariância translacional do sistema, e assim fazendo, funcionam como um ambiente que evolui em conjunto com o centro de massa do objeto. Utilizando uma abordagem de espalhamento, calculamos o operador densidade do sistema composto de centro de massa e coordenadas relativas na aproximação de Born para espalhamentos elásticos. Argumentamos como esse operador densidade nos da informção sobre os processos inelásticos e concluímos que, dentro da aproximação de Born, limitações geométricas impedem que os graus de liberdade internos do objeto atuem como um fator relevante para a descoerência / Abstract: In this work, we analyze the effect of an object's internal degrees of freedom on its center of mass dynamics in order to determine its relevance to decoherence processes in double slit experiments. We show that these degrees of freedom couple to the center of mass in the presence of a potential that breaks the translational invariance of the system, and in so doing, act as an environment that evolves together with the object's center of mass. Using a scattering approach, we compute the density operator of the system composed of its center of mass and relative coordinates, in the Born approximation, for elastic scattering. We argue how this density operator gives us information about inelastic processes and conclude that, within the Born approximation, geometric constraints prevent the internal degrees of freedom from acting as a relevant factor for decoherence / Mestrado / Física Clássica e Física Quântica : Mecânica e Campos / Mestre em Física

Doctor of Philosophy / Department of Chemistry / Duy H. Hua / Small molecules are of great importance in drug discovery currently. The first three chapters discussed the design, synthesis and bio-evaluation of three different classes of small molecules and exploration of their biological targets. Triacsin C analogs were designed as long chain fatty acyl-CoA synthetase (ACSL) inhibitors for attenuating ischemia and reperfusion (I/R) injury. Oxadiazole derivatives were designed as T-type calcium channel inhibitors, which have potential application in the treatment of seizure and epilepsy. Tricyclic pyrone derivatives were reported as anti-Alzheimer lead compounds in previous research done by the Hua group. TP70 and CP2 were synthesized to explore their pharmacokinetics properties. Chapter 4 described chiral-substituted poly-N-vinylpyrrolidones (CSPVP) supported Cu/Au nanoclusters mediation of cyclization reaction of 5-substituted nona-1,8-dien-5-ols. A five-member cyclized lactone possessing a stereogenic tetrasubstituted carbon center was formed in a one-step Cu/Au nanoclusters-hydrogen peroxide oxidation reaction. This developed a novel and simple method to synthesize tetrasubstituted carbon stereogenic center. Drawbacks of the method in my initial study were low reaction yield and moderate enantioselectivity. The chemical yield and enantioselectivity have been significantly improved by introducing bulkier substitution in C3 and C4 positions of CSPVP according to the updates of ongoing research.

The importance of Cytotoxic T-Cell (CTL) reponses during the course of intracellular infections has received a lot of attention during the past few decades. CTLs respond to epitopes presented by the Major Histocompatibility Complex (MHC) originating from intracellular proteins for which they have an appropriate T-Cell Receptor (TCR) for. This response is crucial for the control of pathogens such as Influenza, Hepatitis, HIV and others by destroying the cell in which the pathogen replicates. Due to the extreme polymorphism of MHC molecules, Computational Immunology techniques have been developed to detect potential MHC ligands and as a consequence, potential CTL epitopes. The polymorphism factor needs to be taken into account especially when concerning the design of vaccines with a CTL response component to maximize population coverage. Tools have been constructed that combine the predictions tools concerning major steps in this pathway, that is, proteasomal cleavage, Transporter associated with Antigen Presentation (TAP) affinity, Major Histocompatibility Complex (MHC) affinity and Immunogenicity. In this study, a novel method is developed to combine the different steps in the pathway, which includes the development of a novel TAP predictor. Furthermore, by using a BLOSUM-based score in conjunction with the epitope prediction results, a novel CTL epitopebased clustering method was developed. Two pathogens with major CTL epitope components, but vastly different mutation rates were chosen to infer whether the aforementioned methods can be used to detect potential CTL epitopes and group sequences together based on shared immunogenicity. / Dissertation (MSc)--University of Pretoria, 2011. / Bioinformatics and Computational Biology Unit / unrestricted

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