Made available in DSpace on 2017-06-01T18:08:52Z (GMT). No. of bitstreams: 1 gabriela_nunes_catarino.pdf: 507365 bytes, checksum: 4fc758346d9198724d8fa4fbf606c4d3 (MD5) Previous issue date: 2014-03-25 / This dissertation aimed, in general, analyze the action of the clinical psychologist in the preparation and psychological care of people undergoing bariatric surgery process. Specifically seeks to identify the elements that can interfere positively and / or negatively, in relation therapist - patient, analyze the resonances that therapeutic monitoring exercises on patients undergoing bariatric surgery. Sought to both the theoretical contributions about the body in Merleau Ponty and psychoanalysis Winnicott. Mainly addressed the relationship therapist - patient by Winnicott's approach and within the context of psychologists working with the theme of obesity. This is a qualitative study, whose participants seven clinical psychologists who develop activities in the field of bariatric surgery, both in the private and public sectors and two included patients aged 33 to 56 years, who underwent surgery and continue in psychological counseling. Semistructured interview used to psychologists and for both patients through a different starter question. The analysis of the narrative was taken from the thematic analysis, which identified themes related to the issue of professional practice and theoretical concepts used by psychologists, especially axes as the nature of the bond established relationship therapist and patient, the importance of family participation in the process and especially body image experienced by the patient before, during and after surgery. O care that the psychologist should have to take into account in its therapeutic relationship , the promotion of self-knowledge and understanding about a body experienced by the patient and therefore a body guy, not objectified ; constituted themselves as elements of fundamental importance , reminding us that policies accompanying attitudes are necessary but not sufficient for successful treatment. For these reasons, we point out that intrapsychic issues and the internal resources of the patient are sufficiently worked out, thus avoiding that the same replace the symptom of obesity by another symptom of compulsion. / Esta dissertação objetivou, de forma geral, analisar a ação do psicólogo clínico no processo de preparação e acompanhamento psicológico das pessoas que se submetem à cirurgia bariátrica. De forma específica pretendeu-se identificar os elementos que podem interferir positivamente e/ou negativamente, na relação terapeuta - paciente; analisar as ressonâncias que o acompanhamento terapêutico exerce sobre os pacientes que se submetem à cirurgia bariátrica. Para tanto buscou as contribuições teóricas a respeito do corpo na filosofia de Merleau Ponty e na psicanálise de Winnicott. Sobretudo, abordou o relacionamento terapeuta paciente pela abordagem winnicottiana e dentro do contexto dos psicólogos que trabalham com o tema da obesidade. Trata-se de uma pesquisa qualitativa, que tem como participantes sete psicólogas clínicas que desenvolvem atividades na área de cirurgia bariátrica, tanto no setor privado como público e duas pacientes compreendidas na faixa etária de 33 e 56 anos, que se submeteram à cirurgia e continuam em acompanhamento psicológico. Utilizamos a entrevista semidirigida tanto para as psicólogas como para as pacientes, através de uma questão disparadora diferenciada. A análise das narrativas foi feita a partir da análise temática, que permitiu identificar eixos temáticos ligados à questão da prática profissional e às concepções teóricas utilizadas pelas psicólogas, destacando-se eixos como a natureza do vinculo estabelecido na relação terapeuta e paciente, a importância da família na participação do processo e, sobretudo, a imagem corporal vivida pelo paciente antes, durante e depois do procedimento cirúrgico. O cuidado que o psicólogo deve ter para levar em consideração no seu relacionamento terapêutico, a promoção do autoconhecimento e a compreensão a respeito de um corpo vivido pelo paciente e, portanto, um corpo sujeito, não coisificado; constituíram-se como elementos de fundamental importância, lembrando-nos que, atitudes explicativas diretivas são necessárias, mas não suficientes para o sucesso do tratamento. Por essas razões, apontamos que questões intrapsíquicas e os recursos internos do paciente sejam suficientemente trabalhados, evitando, assim, que o mesmo substitua o sintoma da obesidade por outro sintoma de compulsão.

No description available.

Le récepteur mélanocortine de type 4 (MC4R) est un récepteur couplé aux protéines G impliqué dans la régulation de la prise alimentaire et de l’homéostasie énergétique. Quatre-vingt pour cent des mutants du MC4R reliés à l’obésité morbide précoce (OMP) sont retenus à l’intérieur de la cellule. Le système de contrôle de qualité (SCQ) est probablement responsable de cette rétention, par la reconnaissance d’une conformation inadéquate des mutants. Le rétablissement de l’expression à la surface cellulaire et de la fonctionnalité de ces mutants est donc d’intérêt thérapeutique. Dans cette optique, des composés lipophiles spécifiques pour le MC4R ont été sélectionnés sur la base de leur sélectivité. Nous avons démontré qu’ils agissent à titre de chaperone pharmacologique (CP) en rétablissant l’expression à la surface cellulaire et la fonctionnalité des récepteurs mutants S58C et R165W, et qu’ils favorisent leur N-glycosylation complexe (maturation). Le suivi par BRET du site d’action des CP du MC4R suggère une action en aval de l’interaction calnexine-MC4R. De manière générale, une CP peut avoir un effet différent selon le mutant traité en induisant des conformations distinctes du récepteur plus ou moins aptes à se dissocier du SCQ et à activer la voie de signalisation, et un mutant peut répondre différemment selon la CP utilisée par des différences d’affinité pour le ligand, la CP et les effecteurs. Une meilleure compréhension du mode d’action des CP pourrait aider au développement de nouvelles approches thérapeutiques non seulement pour l’OMP, mais aussi pour d’autres maladies conformationnelles causées par le mauvais repliement de protéines. / The MC4R is a G-protein coupled receptor involved in the central regulation of food intake and energy homeostasis. Eighty percent of childhood obesity-related MC4R mutants are retained intracellularly, probably via the quality control system acting on misfolded receptors. Thus, rescuing cell surface targeting and functionality of these mutant receptors could be of therapeutic value. Cell permeable MC4R selective ligands have been tested and were able to restore cell surface expression and signalling activity of S58C and R165W MC4R mutants. Those compounds, according to their mode of action, are described as pharmacological chaperones (PC). The MC4R-PCs also helps to rescue the glycosylation pattern (maturation) of the MC4R mutants. The site of action of MC4R-PCs of the MC4R mutants monitored by BRET suggests an action downstream of the calnexin-MC4R interaction, most likely at the level of the Golgi apparatus. Generally, a CP can have different effects according to the mutant by stabilizing distinct conformations of the receptor that are more or less able to exit the quality control system and to activate the signaling pathway, and a mutant can respond differently according to the CP used by its distinct affinity to the ligand, the CP itself and the effectors. A better understanding of PCs’ mode of action could help in the design of novel therapeutic approaches not only for early-onset morbid obesity (EOMO) but also for other conformational diseases resulting from protein misfolding.

No description available.