Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

The major functions of glutathione S-transferase (Glutathione S-transferase; GST) include the maintenance of intracellular redox state of substances, and detoxification of cells of endogenous and exogenous toxic substances, and therefore GST plays an important physiological role. The main purpose of this study is to find the effects of SjGST and morin on human breast cancer cell on growth and migration , and the possible mechanisms. Therefore we first carried out cell proliferation assays in vitro . Results showed that at low concentrations of SjGST could enhance the proliferation of breast cancer cell line MDA-MB435s better then high concentrations.And the cell migration assays results showen, when 36 and 48 hours that the low concentration SjGST can enhance the breast cancer cell line MDA-MB435s migration. Morin have antioxidant,anti-free radicals, and inhibitor of cancer cells growth. Therefore, we aimed at revealing the effect of more, GST and the mixture of both on growth and detoxination of MDA-MB435s. However, the results of detoxification assays shown,even add SjGST first or last or both mixed ,the concentration 5¡B10¡B50¡B100¡B200¡B500nM of SjGST still not protect the breast cancer cells (MDA-MB-435s cells line) to break away from morin .

Thesis (Ph. D.)--Columbia University, 1941. / Vita. Published also without thesis note. Bibliography: p. 418-480.

Esta pesquisa caracteriza-se pelo estudo dos principais designers de moda pertencentes à frente japonesa e belga na década de 1980, tais como: Rei Kawakubo, Yohji Yamamoto, Issey Miyake e Martin Margiela a partir da Teoria da Complexidade, do pensador francês Edgar Morin. Tem como objetivo investigar a hipótese de que o trabalho de tais designers se estabeleceu de maneira complexa como uma força de ruptura ao questionar e subverter a moda então vigente e, sobretudo, influenciar os rumos da moda contemporânea. Para tanto, a pesquisa fundamenta-se na Teoria da Complexidade enquanto base teórica e metodológica para certificar a complexidade do trabalho destes designers, bem como a complexidade da própria moda. Parte-se da premissa de que a moda é uma ciência sistêmica, e como tal, deve ser abordada por uma visão plurilateral mediante ao agrupamento e correlação de diversas áreas e, respaldada pelo caráter de não especialização proposto pela Teoria da Complexidade, esta pesquisa perpassa por diferentes campos do conhecimento como a filosofia, sociologia, história, arte e design. Isto posto, propõe-se um estudo bibliográfico e a análise iconográfica dos designers mencionados, ainda de maneira interdisciplinar, em três vertentes distintas e complementares: ideias, tecnologia e forma; e o estudo de sua respectiva influência sobre a moda contemporânea / This research is characterized by the study of the main fashion designers from the Japanese and Belgian movements in the 1980s, including Rei Kawakubo, Yohji Yamamoto, Issey Miyake and Martin Margiela, analyzed through the perspective of the Complexity Theory created by the French philosopher Edgar Morin. The objective of this study is to investigate the hypothesis that the work of these designers was based in a complex way as a force of rupture, questioning, subversion and influence to the contemporary fashion. For this, the research is based on the Complexity Theory with theoretical and methodological bases to certify the complexity in the career of these designers and also the complexity of fashion itself. It is based on the premise that fashion is a systemic science and should be approached by a plurilateral view through the grouping and correlation of several segments and, supported by the non-specialization profile proposed by Theory of Complexity, this research studies different areas of knowledge, including philosophy, sociology, history and design. The main proposal of this research is to trace a biographical study and an iconographic analysis of the designers in an interdisciplinary way with three distinct and complementary aspects: ideas, technology and form, and also study their respective influence on contemporary fashion.

Esta pesquisa caracteriza-se pelo estudo dos principais designers de moda pertencentes à frente japonesa e belga na década de 1980, tais como: Rei Kawakubo, Yohji Yamamoto, Issey Miyake e Martin Margiela a partir da Teoria da Complexidade, do pensador francês Edgar Morin. Tem como objetivo investigar a hipótese de que o trabalho de tais designers se estabeleceu de maneira complexa como uma força de ruptura ao questionar e subverter a moda então vigente e, sobretudo, influenciar os rumos da moda contemporânea. Para tanto, a pesquisa fundamenta-se na Teoria da Complexidade enquanto base teórica e metodológica para certificar a complexidade do trabalho destes designers, bem como a complexidade da própria moda. Parte-se da premissa de que a moda é uma ciência sistêmica, e como tal, deve ser abordada por uma visão plurilateral mediante ao agrupamento e correlação de diversas áreas e, respaldada pelo caráter de não especialização proposto pela Teoria da Complexidade, esta pesquisa perpassa por diferentes campos do conhecimento como a filosofia, sociologia, história, arte e design. Isto posto, propõe-se um estudo bibliográfico e a análise iconográfica dos designers mencionados, ainda de maneira interdisciplinar, em três vertentes distintas e complementares: ideias, tecnologia e forma; e o estudo de sua respectiva influência sobre a moda contemporânea / This research is characterized by the study of the main fashion designers from the Japanese and Belgian movements in the 1980s, including Rei Kawakubo, Yohji Yamamoto, Issey Miyake and Martin Margiela, analyzed through the perspective of the Complexity Theory created by the French philosopher Edgar Morin. The objective of this study is to investigate the hypothesis that the work of these designers was based in a complex way as a force of rupture, questioning, subversion and influence to the contemporary fashion. For this, the research is based on the Complexity Theory with theoretical and methodological bases to certify the complexity in the career of these designers and also the complexity of fashion itself. It is based on the premise that fashion is a systemic science and should be approached by a plurilateral view through the grouping and correlation of several segments and, supported by the non-specialization profile proposed by Theory of Complexity, this research studies different areas of knowledge, including philosophy, sociology, history and design. The main proposal of this research is to trace a biographical study and an iconographic analysis of the designers in an interdisciplinary way with three distinct and complementary aspects: ideas, technology and form, and also study their respective influence on contemporary fashion.

This study is about Michel Morin's opera omnia, a contemporary Quebec essayist and philosopher. The first part analyzes Morin's work with a sustained attention given to the question of the essay as a specific literary and philosophical genre (with references to Vigneault, Lukacs, Adorno, Barthes). Morin's work is for us the occasion to develop a reflection on the relationship between literature and philosophy (with references to Nietzsche, Kierkegaard, Bergson, Heidegger). Finally, going forward, we elaborate the concept of philosophy as Ideational Novel to read Morin's work, a concept that describes Morin's intellectual adventure and involvement in the reflexive text. The second part proposes a more detailed analysis of Michel Morin's reflexive adventure through four distinct moments. All Morin's essays will be studied. Issues and beacons-ideas will be analyzed without ever losing sight of the genuine style of his writing.

The poetical works of Paul Morin are not very well known, and are rarely ever read today. And yet, he was the successor of Emile Nelligan and Albert Lozeau. Paul Morin is one of the first French Canadians to publish his works in France and it was said of his collection of poems Le Paon d'email that it was the spark that ignited the famous "Querelle des regionalistes et des exotiques" in French Canada. Unfortunately, the negative reactions of some of his first critics, were to determine for a long time those of future generations. / This thesis focuses on the critical reception of Paul Morin's first two published books: Le Paon d'email (1911) and Poemes de cendre et d'or (1922), and attempts as well to retrace their critical fortunes up until the beginning of the sixties.

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No description available.

La presente investigación está orientada a reflexionar sobre el problema de la complejidad a partir de la tesis del pensamiento complejo del filósofo Edgar Morín, puesto en contradicción con la filosofía de Aristóteles. Con respecto a nuestros estudios, vemos que Morin comienza con una perspectiva antropológica y biológica que le permite analizar la constitución del hombre desde el principio o la noción de complejidad; busca comprender la complejidad en la vida humana aplicando lo complejo como método, origen y destino. No se trata de un nuevo relativismo, sino de una nueva forma de entender la relación entre los opuestos. Es necesario reflexionar sobre el pensamiento complejo como un método, entendido como pensamiento de él, de carácter original y peculiar.