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Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2008. / Includes bibliographical references (leaves 368-377). Also available in electronic version.

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008. / Includes bibliographical references (p. 81-84). Also available in electronic version.

Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [126]-138).

No / In the present study we evaluated the role of 5-HT1A receptors in mediating the inhibitory action of 8-OH-DPAT, a 5-HT1A receptor agonist, in motion sickness in Suncus murinus. 8-OH-DPAT (0.1 mg/kg, i. p) attenuated motion-induced emesis which was associated with an increase in the latency of the onset to the first emetic episode. Pre-treatment with methysergide (a 5-HT1/2/7 receptor antagonist, 1.0 mg/kg, i. p.), WAY-100635 (a 5-HT1A receptor antagonist, 1.0 mg/kg, i. p.), SB269970A (a 5-HT7 receptor antagonist, 1.0 and 5.0 mg/kg, i. p.), ondansetron (a 5-HT3 receptor antagonist, 1.0 mg/kg, i. p) or GR13808 (a 5-HT4 receptor antagonist, 0.5 mg/kg, i. p) failed to modify the inhibitory action of 8-OH-DPAT on motion sickness. Furthermore, the application of either methysergide, WAY-100635, SB269970A, ondansetron or GR13808 alone had no effect on motion sickness in its own right. These data indicate that neither 5-HT1A nor any 5-HT2 receptor subtypes, 5-HT3, 5-HT4 and 5-HT7 receptors are likely to be involved in the inhibition of motion-induced emesis mediated by 8-OH-DPAT.

The use of incremental and repeated exposures regimens have been put forth as effective means to mitigate visually induced motion sickness based on the Dual Process Theory (DPT) (Groves & Thompson, 1970) of neural plasticity. In essence, DPT suggests that by incrementing stimulus intensity the depression opponent process should be allowed to exert greater control over the net outcome than the sensitization opponent process, thereby minimizing side-effects. This conceptual model was tested by empirically validating the effectiveness of adaptation, incremental adaptation, habituation, and incremental habituation regimens to mitigate side-effects arising from exposure to an optokinetic drum. Forty college students from the University of Central Florida participated in the experimentation and were randomly assigned to a regimen. Efforts were taken to balance distribution of participants in the treatments for gender and motion sickness susceptibility. Results indicated that overall, the application of an incremental regimen is effective in reducing side-effects (e.g. malaise, dropout rates, postural instabilities, etc.) when compared to a non-incremented regimen, whether it be a one-time or repeated exposure. Furthermore, the application of the Motion History Questionnaire (MHQ) (Graybiel & Kennedy, 1965) for identifying high and low motion sickness susceptible individuals proved effective. Finally, gender differences in motion sickness were not found in this experiment as a result of balancing susceptibility with the gender subject variable. Findings from this study can be used to aid effective design of virtual environment (VE) usage regimens in an effort to manage cybersickness. Through pre-exposure identification of susceptible individuals via the MHQ, exposure protocols can be devised that may extend limits on exposure durations, mitigate side-effects, reduce dropout rates, and possibly increase training effectiveness. This document contains a fledgling set of guidelines form VE usage that append those under development by Stanney, Kennedy, & Kingdon (In press) and other previously established guidelines form simulator use (Kennedy et al., 1987). It is believed that through proper allocation of effective VE usage regimens cybersickness can be managed, if susceptible individuals are identified prior to exposure.

The development of autonomous vehicles is progressing rapidly through extensive efforts by the automotive industry and researchers. One of the key factors for the adoption of autonomous driving technology is motion comfort and the ability to engage in non-driving tasks such as reading, socialising, and relaxing without experiencing motion sickness while travelling. Therefore, for the full success of autonomous vehicles, it is necessary to learn how to design and control the vehicles to mitigate motion sickness for the passengers.  This thesis aims to investigate methods for prediction of motion sickness in autonomous vehicles and how to mitigate it using vehicle dynamics based solutions, with an emphasis on trajectory planning. As a first step, a review and evaluation of existing motion sickness prediction methods were performed. The review highlighted the importance of accurate motion sickness assessment in the early phases of autonomous vehicle design. Two chosen methods (ISO 2631-based and sensory conflict theory-based) were evaluated to estimate individual motion sickness feelings using measured data and subjective assessment ratings from field tests. It can be concluded that the methods can be adjusted to predict individual motion sickness feelings, as shown by the comparison with the experimental data. To continue the work, a review of vehicle dynamics based motion sickness mitigation methods for autonomous vehicles was performed. Several chassis control strategies in literature like active suspension, rear-wheel steering and torque distribution have demonstrated the potential help to reduce motion sickness. Another effective approach to mitigate motion sickness in autonomous vehicles is to regulate vehicle speed and path using trajectory planning which was chosen to be further investigated. The trajectory planning was constructed as an optimisation problem where there is a trade-off between motion sickness and manoeuvre time. The impact of the trajectory planning algorithm to reduce motion sickness was analysed by simulating two different vehicle models in specific test manoeuvres. The results indicate that driving style has a significant influence on motion sickness and trajectory planning algorithms should be carefully designed to find a good balance between journey time and motion sickness. The research presented in this thesis contributes to the development of methodologies for predicting and mitigating motion sickness in autonomous vehicles, helping to achieve the goal of ensuring their overall success. / Utvecklingen av autonoma fordon går snabbt framåt tack vare omfattande insatser från fordonsindustrin och forskare. En av de viktigaste faktorerna för införandet av teknik för autonom körning är åkkomfort och möjligheten att ägna sig åt andra saker än körning, som att läsa, umgås och koppla av, utan att drabbas av åksjuka under resan. För att autonoma fordon ska lyckas fullt ut är det därför nödvändigt att förstå hur man utformar och styr fordonen för att minska risken för att passagerarna drabbas av åksjuka.  Denna licentiatuppsats syftar till att undersöka hur åksjuka kan förutsägas i vägfordon och hur den kan reduceras med hjälp av fordonsdynamikbaserade lösningar, med tonvikt på trajektorieplanering. Som ett första steg genomfördes en granskning och utvärdering av befintliga metoder för åksjukeprediktion. Granskningen belyste vikten av en korrekt bedömning av åksjuka i de tidiga faserna av autonom fordonsdesign. Två valda metoder (ISO 2631-baserad och sensorisk konfliktbaserad) utvärderades för att uppskatta individuell åksjuka med hjälp av uppmätta data och subjektiva bedömningar från fälttester. Slutsatsen är att metoderna kan justeras för att förutsäga individuell åksjuka, vilket framgår av jämförelsen med experimentella data. För att fortsätta arbetet gjordes en genomgång av fordonsdynamikbaserade metoder för att minska åksjuka i autonoma fordon. Flera chassireglerstrategier i litteraturen, såsom aktiv fjädring, bakhjulsstyrning och drivmomentfördelning, har visat sig kunna bidra till att minska åksjuka. En annan effektiv metod för att minska åksjuka i autonoma fordon är att reglera fordonets hastighet och bana med hjälp av trajektorieplanering, vilket valdes att undersökas ytterligare. Trajektorieplaneringen konstruerades som ett optimeringsproblem där det finns en avvägning mellan åksjuka och manövertid. Effekten av trajektorieplaneringsalgoritmen för att minska åksjuka analyserades genom att simulera två olika fordonsmodeller i specifika testmanövrar. Resultaten indikerar att körstil har en betydande inverkan på åksjuka och att algoritmer för trajektorieplanering bör utformas noggrant för att hitta en bra balans mellan restid och åksjuka. Forskningen som presenteras i denna uppsats bidrar till utvecklingen av metoder för att förutsäga och mildra åksjuka i autonoma fordon, vilket hjälper till att uppnå målet att säkerställa deras framgång.

Despite recent research advances, there are still several common medical conditions whose underlying mechanisms are poorly understood. In conditions with few or diffuse physical findings, it can be difficult to diagnose and determine the state of the condition and its effects on working ability or performance, and the health care practitioners have to rely on the patient’s self-reports. Identification of objective measurements that are sensitive enough to aid in diagnosis or determination of the state of these conditions would thus be valuable. Psychophysiological measurements are generally non-invasive and have the potential to serve as such diagnostic or prognostic tools. In this thesis, psychophysiological reactions to different stressors were recorded in two selected medical conditions; namely motion sickness and chronic trapezius myalgia (musculoskeletal pain). These subjective conditions are unpleasant, unwanted and apparently serve no survival purpose. It is therefore important to elucidate any physical findings associated with them to, eventually, find new means to prevent the development of these conditions or to ameliorate symptoms. The overall aim of the thesis was to explore the development of psychophysiological responses to stressors in relation to performance and subjective reports in healthy individuals and in women with chronic trapezius myalgia. More in detail, the purpose was to identify psychophysiological responses that could provide information about the mechanisms behind, or serve as candidates for characterization of motion sickness and chronic trapezius myalgia, respectively. Responses to motion sickness, triggered by optokinetic stimulation, were studied in healthy individuals, whereas responses to repetitive low-force work and psychosocial stress were studied in women with chronic trapezius myalgia and in pain-free controls. In both medical conditions, the psychophysiological responses were accompanied by subjective reports. The effects of motion sickness on two different aspects of memory performance were tested during exposure to optokinetic stimulation. In the studies of chronic trapezius myalgia, psychophysiological responses were also related to health status, i.e., being a patient or a pain-free control and measurements of pain intensity, psychological symptoms, sleep-related problems and quality of life. The psychophysiological responses to optokinetic stimulation were inconclusive. Moderate levels of motion sickness did not affect memory performance, whereas decreased short term memory performance was seen in subjects reporting high levels of motion sickness. The autonomic responses and stress hormone secretion in response to low-force repetitive work and psychosocial stress in the chronic trapezius myalgia group were similar to those of the pain-free controls. However, muscle activity in the trapezius muscle was generally higher in the chronic trapezius myalgia group. There were indications of negative psychological states being related to a slower response and lower circadian variations of stress hormone secretion. With the present methods, it was possible to measure general stress responses but none of the measurements showed sufficient specificity to serve as predictors or indicators of motion sickness and chronic musculoskeletal pain, respectively. Summarizing, I cannot objectively measure how you feel; I still have to rely on your description of your condition.

This thesis presents a systematic study of human responses to different motions and strategies of car body tilt control regarding ride comfort, working/reading ability and motion sickness on high-speed tilting trains. Experiments with test subjects were performed in a tilting train on curved track as well as in a moving vehicle simulator. The study is multi-disciplinary, combining knowledge and methods from the fields of railway technology, human factors and vestibular science. The main experiment in a tilting train was performed with about 75 seated test subjects, mainly students from Linköping University, making three test runs. In total, these subjects participated in about 210 individual test rides, each with a duration of about 3 hours. Additional tests on comfort disturbances with pushbutton technique have been reported in the project. The simulator experiments used a total of about 75 subjects, making some 320 test rides each of about 30 minutes duration. Test motions consisted of combinations of horizontal (lateral) acceleration and roll acceleration, together with either roll or horizontal acceleration. Rate of change of horizontal acceleration (jerk) and roll velocity were of the same order of magnitude as in a tilting train environment, but horizontal acceleration alone was about half the magnitude. Horizontal and vertical vibrations from a tilting train were added to the test motions, and train seats and interior train noise were also introduced to create a "train feeling". Test designs and methodology have been developed during the course of the experiments. The test subjects answered questionnaires, four times per test run in the train experiment and each 5 minute in the simulator experiment. The investigated variables were: estimated average ride comfort, estimated ability to work or read, and occurrence of symptoms of motion sickness (dizziness, nausea and not feeling well). Lateral and vertical accelerations together with roll motions were monitored and recorded for later evaluation. Results from the train experiments show that the estimated average ride comfort was about 4 on a 5-degree scale, which indicates “good”. Results also show that a reduced tilt compensation of the lateral acceleration while curving together with a reduced tilt velocity of the car body reduce the provocation of motion sickness. However, a reduction in tilt compensation may produce an increased number of comfort disturbances due to lateral acceleration in the car body. Regression analysis shows that motion doses from roll acceleration may be used to predict the incidence of motion sickness. The simulator experiments show that the primary sources of provocation of nausea and motion sickness are the motion doses from roll and lateral acceleration in the horizontal plane. The study proposes a hypothesis and a model of provocation of motion sickness. It is shown that motion sickness has a time decay, or leakage. A model for this leakage is proposed. The determinative types of motion for provocation of nausea and motion sickness in tilting trains are identified and future tilting train and/or simulator experiments are proposed in order to further investigate their influence. / <p>NR 20140805</p>

<p>MobileMe is a recently developed system for monitoring and recording physiological variables. It is wireless, and can therefore be suitable for field research, for example when measuring motion sickness symptoms.</p><p>The aim of this thesis was to conclude whether the MobileMe recording system was valid for research studies. A validation study, consisting of two parts and including 10 subjects, was performed. The first part was a laboratory study, where data from MobileMe and a reference equipment were compared. A field study was also performed, onboard a combat boat, to determine the equipment’s validity in uncontrolled environments. Furthermore, the field study included an investigation of motion sickness symptoms, and provided data for evaluation of motion sickness rating scales.</p><p>Statistical results from the laboratory study, and results from evaluation of data from the field study, showed that MobileMe was valid in both controlled and uncontrolled environments.</p>