Evidence suggests that purple dye was produced on the islet of Mitrou, a Bronze Age and Early Iron Age site in central Greece. The goal of this study is to determine the chronological and spatial patterning of Murex shells in order to better understand the emergence of dye manufacture. The research hypothesis is that Murex dye production was related to the rise of a visible political elite and that the scale of production was large enough at Mitrou to have exceeded the needs of the household, thus providing a cash crop for this elite to obtain imports from the Eastern Mediterranean. Multi-layered statistical analyses were employed to test this two-pronged hypothesis. The first hypothesis that Murex dye production was related to the rise of the elite at Mitrou was confirmed by a series of chi-squared analyses. Based on site-wide estimates of original Murex population, the second hypothesis that dye production exceeded domestic scale cannot be rejected. Since we know the prehistoric Mycenaeans produced very ornate, multi-colored and often banded garments, it is possible that Murex dye was produced at Mitrou to color raw wool for the production of thread, which could then be embroidered on fabric or traded as such. If it was in fact colored thread that was being produced, the site-wide estimates suggest that dye production could have exceeded domestic levels at Mitrou and dyed thread could have been a lucrative trading commodity.

In Anbetracht der enormen Verbesserung der HCV-Therapie durch die Entwicklung hochwirksamer und direkt wirkender Virostatika (DAA) dient diese Studie der Analyse von HCV-Koinfektionen unter den gemeldeten HIV-Neudiagnosen in Deutschland. Zunächst wurde die Eignung zweier kommerzieller HCV Ag/Ab ELISAs, dem Murex (Abbott) und dem Monolisa (Bio-Rad), zum Nachweis von HCV in getrockneten Serumspots (DSS) verglichen. Der Murex-ELISA zeigte sich sensitiver bei Antigen-positiven Plasma-HCV-Serokonversionsproben während der Monolisa eine höhere Sensitivität bei HCV-Antikörper-positiven DSS-Eluaten. Des Weiteren wurde ein Aviditätstest zur Unterscheidung von neuen und bereits länger bestehenden Infektionen bei einem Aviditätsindex Cut-off von 40% und einem Zeitraum von 364 Tagen etabliert. Von den insgesamt 6.097 untersuchten Proben der Jahre 2015-2017 waren 396 HCV-ELISA-reaktiv (6,5%). Von diesen wurden 256 (64,6%) als aktive und 140 (35,4%) als ausgeheilte Infektionen identifiziert. Ein hoher Anteil der HCV-Koinfektionen wurde bei intra-venösen Drogenkonsumenten (77,8%, n=168/216), in der Altersgruppe der 30-39 Jährigen (9%, n=179/1.978) und bei Menschen osteuropäischer Herkunft (38,3%, n=124/324) beobachtet. Im Vergleich zum Jahr 2016 hat sich der Anteil der ausgeheilten Infektionen im Jahr 2017 bei der Gesamtzahl der Patienten (p<0,01) sowie insbesondere bei Personen ausländischer (p<0,01) und osteuropäischer (p<0,05) Herkunft erhöht. Die HCV Subtypen (St)-1a, St-3a und St-1b waren mit 33,9% (n=79/233), 33,5% (n=78/233) und 23,3% (n=52/233) vorherrschend. Der Anteil der St-1a- und St-1b-Proben, deren HCV-Sequenz gegen DAAs resistent ist, war in allen untersuchten Jahren hoch (25%-42,9%). Der beobachtete Anstieg des Anteils der ausgeheilten HCV-Koinfektionen kann auf die DAA-Therapie zurückgeführt werden. Es sind jedoch weitere Anstrengungen erforderlich, damit Gruppen mit weiterhin hoher HCV-Prävalenz von dieser Behandlung profitieren. / In light of the major shift in HCV therapy resulting from the availability of highly potent direct acting antivirals (DAA), this study performed a surveillance of HCV coinfections among reported HIV new diagnoses in Germany. First the suitability of two HCV Ag/Ab ELISAs, Murex (Abbott) and Monolisa (Bio-Rad) for dried serum spots (DSS) was compared. The Murex was more sensitive in antigen positive plasma HCV seroconversion samples while the Monolisa showed a higher sensitivity in HCV antibody positive DSS eluates. Furthermore, an avidity test was established to distinguish between new and already longer existing infections at an avidity index cut-off of 40% and a period of 364 days. Of the total of 6,097 samples examined for the years 2015-2017, 396 were HCV ELISA reactive (6.5%). Of these, 256 (64.6%) were identified as active and 140 (35.4%) as resolved infections. A high proportion of HCV coinfections were observed in intravenous drug users (77.8%, n=168/216), in the age group 30-39 years (9%, n=179/1,978) and in people of Eastern European origin (38.3%, n=124/324). Compared to 2016, the proportion of resolved infections in 2017 has increased in the total number of patients (p<0.01) and especially in people of foreign (p<0.01) and Eastern European (p<0.05) origin. HCV subtypes (St)-1a, St-3a, and St-1b were predominant with 33.9% (n=79/233), 33.5% (n=78/233) and 23.3% (n=52/233), respectively. The proportion of St-1a and St-1b samples whose HCV sequence has resistance to DAAs was high in all diagnoses years (25%-42.9%). The observed increase in the proportion of resolved HCV coinfections can be attributed to DAA therapy. However, further efforts are needed to ensure that groups with continued high HCV prevalence benefit from this treatment.

Phoenician ships in the broadest sense of the word are the focus of this dissertation and it encompasses the entire period of both Phoenician and Punic seafaring. The study is quantitative, largely historical and archaeological, with the use of secondary sources as well as iconography. The origins of the Phoenician construction technique, the mortise-and-tenon joints, are investigated as well as the various types of Phoenician ships. These are analysed under the headings Merchant ships, Warships and Utility ships. The materials mentioned in Ezekiel’s prophecy about ‘The Ship Tyre’, are analysed, whether they fit the purpose for which they are mentioned. The production process of purple cloth with the use of Murex molluscs is described in detail including an analysis of the boats used to catch the molluscs. The possibility is investigated of whether the Ashkelon Dog Burials could be related to the Phoenician trade in dogs, and whether they could have served as ship dogs. Lastly the difficulties encountered in sailing through the narrow sea straits of the Mediterranean Sea are described, which are subject to Internal waves, affecting the surface water. / Old Testament & Ancient Near Eastern Studies / M. A. (Biblical Archaeology)

Phoenician ships in the broadest sense of the word are the focus of this dissertation and it encompasses the entire period of both Phoenician and Punic seafaring. The study is quantitative, largely historical and archaeological, with the use of secondary sources as well as iconography. The origins of the Phoenician construction technique, the mortise-and-tenon joints, are investigated as well as the various types of Phoenician ships. These are analysed under the headings Merchant ships, Warships and Utility ships. The materials mentioned in Ezekiel’s prophecy about ‘The Ship Tyre’, are analysed, whether they fit the purpose for which they are mentioned. The production process of purple cloth with the use of Murex molluscs is described in detail including an analysis of the boats used to catch the molluscs. The possibility is investigated of whether the Ashkelon Dog Burials could be related to the Phoenician trade in dogs, and whether they could have served as ship dogs. Lastly the difficulties encountered in sailing through the narrow sea straits of the Mediterranean Sea are described, which are subject to Internal waves, affecting the surface water. / Biblical and Ancient Studies / M. A. (Biblical Archaeology)