Global ETD Search

1	Biochemical studies on muscarinic cholinergic receptors Carson, Susan January 1982 (has links) A novel solubilising agent (0.l% sodium cholate-lM NaCl) has been developed which will solubilise 10-30% of muscarinic cholinergic receptors from bovine caudate nucleus. Using the muscarinic antagonist quinuclidinyl benzilate (QNB), a single saturable binding component was found with an equilibrium constant of ZOOpM, approximately 10-fold higher than the membrane receptor and 4-fold higher than the ratio k<sub>-l</sub>/k<sub>l</sub> determined kinetically in the soluble material. This latter difference may indicate that the binding of QNB to the solubilised receptor is not a simple second-order process. Inhibition constants for a variety of muscarinic agonists and antagonists were 10 to 20-fold higher than in the membrane state and non-muscarinic ligands were without effect. The decrease in affinity was shown to be due to the presence of high salt. Evidence was presented that the apparent increase in Hill coefficient for muscarinic agonist binding to soluble material was not due to a differential solubilisation of muscarinic receptors or to a conformational change of high to low affinity agonist sites during the solubilisation. Instead the Hill coefficient of the soluble material decreased as the percentage of total binding sites solubilised increased. The stability of receptor binding at different temperatures was shown to be dependent on the protein: cholate (w/w) ratio. Results from gel filtration, affinity chromotography and immunization studies are also reported. The results of this thesis are discussed in the light of the possible importance of phospholipids for receptor activity. 572
2	The role of acetylcholine and galanin in synaptic plasticity in the perirhinal cortex Massey, Peter Vernon January 2002 (has links) No description available. 573 Muscarinic receptors
3	CHOLINERGIC REGULATION OF STIMULATION-SECRETION COUPLING IN THE EXOCRINE PANCREAS AND MODELS OF PANCREATIC DISEASE Ackerman, Martha Susan, 1961- January 1986 (has links) No description available. Muscarinic receptors. Acetylcholine -- Receptors.
4	Muscarinic receptor-effector coupling in Chinese hamster ovary cells Bulseco, Dylan A. 11 July 1996 (has links) Graduation date: 1997 Hamsters Muscarinic receptors Mutagenesis
5	Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor Vogel, Walter Kevin 21 August 1997 (has links) Graduation date: 1998 Muscarinic receptors Site-specific mutagenesis
6	Ligand binding to the muscarinic receptor : equilibrium and kinetic studies Hirschberg, Birgit T. 11 November 1993 (has links) Graduation date: 1994 Muscarinic receptors Ligand binding (Biochemistry)
7	Molecular characterization and expression of Gq/11 protein in fishes Radhakrishnan, Varsha, January 2007 (has links) Thesis (M.S.)--Texas State University-San Marcos, 2007. / Vita. Includes bibliographical references (leaves 68-75).
8	Molecular characterization and expression of Gq/11 protein in fishes / Radhakrishnan, Varsha, January 2007 (has links) Thesis (M.S.)--Texas State University-San Marcos, 2007. / Vita. Includes bibliographical references (leaves 68-75).
9	Ontogeny of muscarinic acetylcholine receptor expression in the eyes of zebrafish Nuckels, Richard J. January 2006 (has links) Thesis (M.S.)--Texas State University-San Marcos, 2006. / Vita. Appendix: leaves 31-35. Includes bibliographical references (leaves 36-39).
10	Ontogeny of muscarinic acetylcholine receptor expression in the eyes of zebrafish / Nuckels, Richard J. January 2006 (has links) Thesis (M.S.)--Texas State University-San Marcos, 2006. / Vita. Appendix: leaves 31-35. Includes bibliographical references (leaves 36-39).

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