Thesis (Ph.D) -- Virginia Commonwealth University, 2005. / Title from title-page of electronic thesis. Prepared for: Dept. of Physiology. Bibliography: p. 160-169.

Thesis (M. Phil.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.

Thesis (Ph.D.)--University of Florida, 2004. / Typescript. Title from title page of source document. Document formatted into pages; contains 133 pages. Includes Vita. Includes bibliographical references.

Thesis (Ph.D.)--Kent State University, 2006. / Title from PDF t.p. (viewed Sept. 20, 2006). Advisor: Gary Meszaros. Keywords: cardiac fibroblasts; myofibroblasts; extracellular matrix; collagen VI; post-myocardial infarction remodeling. Includes bibliographical references (p. 135-152).

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 143-159).

Thesis (M.A.)--Northern Kentucky University, 2006. / Made available through ProQuest. Publication number: AAT 1434141. ProQuest document ID: 1130610501. Includes bibliographical references (p. 42)

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 55-63).

Η πρόσφατη άποψη, ότι η ποιότητα της HDL αποτελεί μια σημαντική παράμετρο στην αθηροπροστασία, κερδίζει όλο και περισσότερο έδαφος με ελάχιστα όμως δεδομένα να την υποστηρίζουν. Στην προσπάθεια μας να προσδιορίσουμε τις ποιοτικές παραμέτρους της HDL που σχετίζονται με αυξημένο κίνδυνο πρώιμης εμφάνισης εμφράγματος του μυοκαρδίου (ΜΙ), μελετήσαμε τα δομικά χαρακτηριστικά της HDL νεαρών ασθενών (≤35 ετών) με οξύ έμφραγμα του μυοκαρδίου. Μελετήσαμε 20 ΜΙ ασθενείς και 20 υγιείς εθελοντές ως ομάδα αναφοράς. Η HDL των ασθενών παρουσίαζε μειωμένα επίπεδα απολιποπρωτεΐνης Α-Ι(apoA-I), απολιποπρωτεΐνης Μ, και παραοξονάσης 1 και σημαντικά αθξημένα επίπεδα της απολιποπρωτεΐνης C-III(apo-CIII)(όλα p<0.005). Συγκεκριμένα ο HDL apoA-I/apoC-III λόγος ήταν 0.24±0.01 στους ασθενείς έναντι 4.88±0.90 της ομάδας αναφοράς (p<0.001). Οι δομικές αυτές αλλαγές σχετίζοντια με αυξημένη οξειδωτική ισχύ της HDL των νεαρών εμφραγματιών, συγκριτικά με την ομάδα αναφοράς (2.5 φορές, p=0.026). Η ηλεκτρονική μικροσκοπία δεν έδειξε σημαντική διαφορά στην μέση διάμετρο της HDL μεταξύ των δύο ομάδων, ωστόσο παρατηρήθηκε σημαντική διαφορά στην κατανομή των HDL διαμέτρων, υποδηλώνοντας την παρουσία διαφορετικών HDL υποπληθυσμών μεταξύ ΜΙ και της ομάδας αναφοράς. Η υπόθεση μας αυτή επιβεβαιώθηκε μετά από ανάλυση της HDL με μη αποδιατακτική δισδιάστατη ηλεκτροφόρηση, καθώς οι ΜΙ ασθενείς εμφάνιζαν μειωμένα επίπεδα pre-β1α, pre-pre-β1b και α2, και αυξημένα επίπεδα α1, α3, και pre-α4 HDL. Μείωση στον λόγο apoA-I/apoC-III HDL, έδειξε αλλαγές στην κατανομή των HDL υποπληθυσμών και αύξηση στην οξειδωτική ισχύ της HDL, παράγοντες που σχετίζονται με την ανάπτυξη εμφράγματος του μυοκαρδίου στους νεαρούς εμφραγματίες. Η πιθανότητα οι αλλαγές αυτές να δρουν ως βιοδείκτες για την πρώιμη πρόγνωση της νόσου, πρέπει να διερευνηθεί περεταίρω. / Recently, the concept that HDL quality is an important parameter for atheroprotection is gaining ground, though little data exists so far to support it. In an attempt to identify measurable qualitative parameters of HDL associated with increased risk for premature myocardial infraction (MI), we studied the structural characteristics of HDL from patients who survived an MI at a young age (≤35 years). We studied 20 MI patients and 20 healthy control subjects. HDL of patients had reduced apolipoprotein A-I (apoA-I), apolipoprotein M, and paraoxonase 1 levels and significantly elevated Apolipoprotein C-III (apoCIII) levels (all p<0.05). Specifically, the HDL apoA-I/apoC-III ratio was 0.240.01 in patients versus 4.880.90 in controls (p<0.001). These structural alterations correlated with increased oxidation potential of HDL of the MI group compared to controls (2.5 fold, p=0.026). Electron microscopy showed no significant difference in average HDL particle diameter between the two groups though a significant difference existed in HDL diameter distribution, suggesting the presence of different HDL subpopulations in MI and control subjects. Indeed, non-denaturing two-dimensional electrophoresis revealed that MI patients had reduced pre-β1α, pre-β1b and α2, and elevated α1, α3, and pre-α4 HDL. Reduction in the HDL apoA-I/apoC-III, changes in the HDL subpopulation distribution and an increase in HDL oxidation potential correlated with the development of MI in young patients. The possibility that such changes may serve as markers for the early identification of young individuals at high risk for an acute coronary event should be further explored.

Made available in DSpace on 2014-08-13T14:50:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-11-29Bitstream added on 2014-08-13T18:01:10Z : No. of bitstreams: 1 000736321_20141129.pdf: 359412 bytes, checksum: 2b097cc17fda8e667e01f3cd49b99769 (MD5) Bitstreams deleted on 2014-12-01T14:49:47Z: 000736321_20141129.pdf,Bitstream added on 2014-12-01T14:50:25Z : No. of bitstreams: 1 000736321.pdf: 4184687 bytes, checksum: 6844804819f4dc3ee8faded627f4a83d (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Doenças cardiovasculares como infarto do miocárdio e acidente vascular encefálico ainda representam a principal causa de morte no Brasil. A aterosclerose é uma doença progressiva e silenciosa classificada como fator de risco para o desenvolvimento de doenças cardiovasculares. É caracterizada pelo aumento dos níveis de colesterol no plasma os quais são oxidados por radicais livres originando a lipoproteína de baixa densidade oxidada (LDLox). A fagocitose de LDLox por macrófagos permite a transformação destes em células espumosas, que são depositadas na camada íntima dos vasos. Após o rompimento do endotélio há o extravasamento do conteúdo da placa aterosclerótica para a circulação levando à formação de trombo. Este interrompe o fluxo sanguíneo em artérias e vasos, levando ao desenvolvimento de doenças cardiovasculares como infarto do miocárdio e acidente vascular encefálico. A terapia preventiva contra eventos aterotrombóticos é realizada com fármacos antiagregantes plaquetários. O ácido acetilsalicílico (AAS) é um dos fármacos mais utilizados na prevenção de aterotrombose, mas apresenta limitações como indução de ulcerações gástricas e bloqueio de somente uma via de agregação plaquetária. Neste sentido, e em continuidade com a linha de pesquisa visando à busca de novos fármacos antiagregantes plaquetários obtidos por estratégia de modificação molecular implantados no Laboratório de Pesquisa e Desenvolvimento de Fármacos (Lapdesf – UNESP Araraquara), realizou-se a hibridação molecular das subunidades presentes no AAS e furoxanos sendo ambas partes espaçadas pela subunidade N-acilhidrazona. O furoxano é conhecido por suas propriedades doadoras de óxido nítrico (NO) responsável pelo efeito antiagregante plaquetário. Assim, o objetivo deste trabalho é a síntese de novos compostos derivados do AAS, mais potentes e seguros para serem usados como antiagregantes plaquetários. Os ... / Cardiovascular diseases such as myocardial infarction and stroke still represents the leading cause of death in Brazil. Atherosclerosis is a silent progressive disease classified as a risk factor for developing cardiovascular diseases. It is characterized by increased levels of plasma cholesterol which are oxidized by free radicals resulting in oxidized low density lipoprotein (oxLDL). The oxLDL phagocytosis by macrophages allows for transformation into foam cells, which are deposited in the intima of vessels. After the disruption of the endothelium occurs the leak plaque’s contents into the circulation driving to thrombus formation. This blocks the blood flow in arteries and vessels, leading to the development of cardiovascular diseases such as myocardial infarction and stroke. The preventive therapy against atherothrombotic events is performed with antiplatelet drugs. Acetylsalicylic acid (ASA) is a drug commonly used to prevent atherothrombosis, but it has limitations such as induction of gastric ulcer and blocking only one route of platelet aggregation. Continuing goals finding new antiplatelet drugs obtained by molecular modification strategy implemented in the Laboratory of Drug Research and Development (Lapdesf - UNESP Araraquara), held the molecular hybridization of subunits present in AAS and furoxans being spaced by subunit N-acylhydrazone. The furoxano is known for its donor properties of nitric oxide (NO) responsible for the antiplatelet effect. The objective of this work is the synthesis of new compounds derived from AAS, most powerful and safe to use as antiplatelet agents. Compounds were synthesized using divergent route for obtaining derivatives furoxans, N-acilhidrazones spacers and the hybrid compounds. All compounds were purified and characterized by analytical methods such as, Infrared Absorption Spectroscopy, Mass Spectrometry and Nuclear Magnetic Resonance. N-acilhidrazones spacers was possible to perform the ...

Background: Myocardial infarction is one of the most common diseases that cause death in the world. The diagnosis has an immediate impact on the person's life. It's important that nurses are aware of the paramount importance of their role as caregivers and also as their role in monitoring the patient after discharge from hospital. Aim: The aim of the study was to describe patients' experiences after myocardial infarction. Method: In order to understand patients' experiences following myocardial infarction and to contribute to evidence-based nursing, present study was a literature study based on qualitative research. Analysis was conducted according to Friberg's five-step analysis method, which gave four themes and eight subthemes. Results: The result shows that patients had experience of physical and mental changes after myocardial infarction. They felt a loss of energy and strength and experienced fatigue, which limited them in everyday life. Getting support from healthcare professionals was considered important to implement the lifestyle changes that were recommended and to get a pleased recovery. Patients' relatives were also considered important during recovery as they constituted support for the patient and helped them to see a bright future. Conclusion: It´s important that nurses maintain continuous contact with patients after discharge from hospital in order to make a good support system and to encourage the patients for a healthy living.