Global ETD Search

31	Central attention and visual-spatial attention : Electrophysiological investigations of early psychological refractory period multitasking interference Brisson, Benoit January 2008 (has links) Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal. Neuroscience cognitive Cognitive neuroscience Interférence en double-tâche Dual-task interference Période réfractaire psychologique Psychological refractory period Attention centrale Central attention Attention visuospatiale Visual-spatial attention Électrophysiologie humaine Human electrophysiology Potentiels évoqués Event-related potentials P1 visuelle Visual P1 N1 occipitale Occipital N1 N2pc N2pc SPCN SPCN
32	Central attention and visual-spatial attention : Electrophysiological investigations of early psychological refractory period multitasking interference Brisson, Benoit January 2008 (has links) Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal Neuroscience cognitive Cognitive neuroscience Interférence en double-tâche Dual-task interference Période réfractaire psychologique Psychological refractory period Attention centrale Central attention Attention visuospatiale Visual-spatial attention Électrophysiologie humaine Human electrophysiology Potentiels évoqués Event-related potentials P1 visuelle Visual P1 N1 occipitale Occipital N1 N2pc N2pc SPCN SPCN
33	Metagenomic and Metabolomic Approaches to Determine Contributors to Residual Cardiovascular Disease Risk Ferrell, Marc 26 May 2023 (has links) No description available. Analytical Chemistry Animals Bioinformatics Biochemistry Biology Biostatistics Food Science Genetics Health Medicine Microbiology Molecular Biology Nutrition Organic Chemistry Public Policy Molecular Chemistry Molecules
34	Auditory and visual event-related potential alterations in fragile X syndrome Knoth, Inga Sophia 08 1900 (has links) Le syndrome du X fragile (SXF) est la première cause héréditaire de déficience intellectuelle et également la première cause monogénique d’autisme. Le SXF est causé par l'expansion de la répétition du nucléotide CGG sur le gène FMR1, ce qui empêche l’expression de la protéine FMRP. L’absence du FMRP mène à une altération du développement structurel et fonctionnel de la synapse, ce qui empêche la maturation des synapses induite par l’activité et l’élagage synaptique, qui sont essentiels pour le développement cérébral et cognitif. Nous avons investigué les potentiels reliés aux événements (PRE) évoqués par des stimulations fondamentales auditives et visuelles dans douze adolescents et jeunes adultes (10-22) atteints du SXF, ainsi que des participants contrôles appariés en âge chronologique et développemental. Les résultats indiquent un profil des PRE altéré, notamment l’augmentation de l’amplitude de N1 auditive, par rapport aux deux groupes contrôle, ainsi que l’augmentation des amplitudes de P2 et N2 auditifs et de la latence de N2 auditif. Chez les patients SXF, le traitement sensoriel semble être davantage perturbé qu’immature. En outre, la modalité auditive semble être plus perturbée que la modalité visuelle. En combinaison avec des résultats anatomique du cerveau, des mécanismes biochimiques et du comportement, nos résultats suggèrent une hyperexcitabilité du système nerveux dans le SXF. / We investigated early auditory and visual information processing in Fragile X Syndrome (FXS), the most common form of X-linked Intellectual Disability (ID) and the only known monogenetic cause of autism. FXS is caused by a trinucleotide repeat expansion in the FMR1 (‘Fragile X mental retardation 1’) gene, which prevents expression of the ‘fragile X mental retardation protein’ (FMRP). FMRP absence leads to altered structural and functional development of the synapse, while also preventing activity-based synapse maturation and synaptic pruning, which are essential for cerebral and cognitive development. We review the contribution of electrophysiological signal studies for the understanding of information processing in FXS and compare event-related potential (ERP) findings to those concerning other clinical populations that share symptoms with FXS. In our research project, we investigated ERPs evoked by basic auditory and visual stimulation in twelve adolescents and young adults (10-22) with FXS, as well as healthy chronological- and developmental- age matched controls. We found an altered ERP profile in FXS, including increased auditory N1 amplitude, relative to both control groups, as well as increased auditory P2 and N2 amplitudes and increased auditory N2 latencies. Rather than being immature, sensory processing appears to be specifically disrupted in FXS. Furthermore, the auditory modality seems to be more affected than the visual modality. In combination with brain anatomical, biochemical and behavioural findings, our results suggest a hyperexcitable nervous system in FXS. Syndrome du X fragile Déficience intellectuelle Traitement des informations sensorielles Potentiels reliée aux évènements N1 Fragile X syndrome Intellectual disability Sensory information processing Event-related potentials
35	Auditory and visual event-related potential alterations in fragile X syndrome Knoth, Inga Sophia 08 1900 (has links) Le syndrome du X fragile (SXF) est la première cause héréditaire de déficience intellectuelle et également la première cause monogénique d’autisme. Le SXF est causé par l'expansion de la répétition du nucléotide CGG sur le gène FMR1, ce qui empêche l’expression de la protéine FMRP. L’absence du FMRP mène à une altération du développement structurel et fonctionnel de la synapse, ce qui empêche la maturation des synapses induite par l’activité et l’élagage synaptique, qui sont essentiels pour le développement cérébral et cognitif. Nous avons investigué les potentiels reliés aux événements (PRE) évoqués par des stimulations fondamentales auditives et visuelles dans douze adolescents et jeunes adultes (10-22) atteints du SXF, ainsi que des participants contrôles appariés en âge chronologique et développemental. Les résultats indiquent un profil des PRE altéré, notamment l’augmentation de l’amplitude de N1 auditive, par rapport aux deux groupes contrôle, ainsi que l’augmentation des amplitudes de P2 et N2 auditifs et de la latence de N2 auditif. Chez les patients SXF, le traitement sensoriel semble être davantage perturbé qu’immature. En outre, la modalité auditive semble être plus perturbée que la modalité visuelle. En combinaison avec des résultats anatomique du cerveau, des mécanismes biochimiques et du comportement, nos résultats suggèrent une hyperexcitabilité du système nerveux dans le SXF. / We investigated early auditory and visual information processing in Fragile X Syndrome (FXS), the most common form of X-linked Intellectual Disability (ID) and the only known monogenetic cause of autism. FXS is caused by a trinucleotide repeat expansion in the FMR1 (‘Fragile X mental retardation 1’) gene, which prevents expression of the ‘fragile X mental retardation protein’ (FMRP). FMRP absence leads to altered structural and functional development of the synapse, while also preventing activity-based synapse maturation and synaptic pruning, which are essential for cerebral and cognitive development. We review the contribution of electrophysiological signal studies for the understanding of information processing in FXS and compare event-related potential (ERP) findings to those concerning other clinical populations that share symptoms with FXS. In our research project, we investigated ERPs evoked by basic auditory and visual stimulation in twelve adolescents and young adults (10-22) with FXS, as well as healthy chronological- and developmental- age matched controls. We found an altered ERP profile in FXS, including increased auditory N1 amplitude, relative to both control groups, as well as increased auditory P2 and N2 amplitudes and increased auditory N2 latencies. Rather than being immature, sensory processing appears to be specifically disrupted in FXS. Furthermore, the auditory modality seems to be more affected than the visual modality. In combination with brain anatomical, biochemical and behavioural findings, our results suggest a hyperexcitable nervous system in FXS. Syndrome du X fragile Déficience intellectuelle Traitement des informations sensorielles Potentiels reliée aux évènements N1 Fragile X syndrome Intellectual disability Sensory information processing Event-related potentials
36	The implementation of the road safety strategy towards reducing accidents and road fatalities on the N1 : a case study of Limpopo Province Maluleke, Mihloti Tyron January 2022 (has links) Thesis (MPAM.) -- University of Limpopo, 2022 / This study investigated the effectiveness of the national road safety strategy towards reducing accidents and road fatalities on the N1 in the Limpopo Province. Qualitative research was conducted to determine the experiences of the traffic law enforcement officers in implementing the road safety strategy in the Limpopo Province. Primary qualitative data were collected using the semi-structured questionnaire supplemented by telephonic interviews. Two groups of participants including the traffic law enforcement officers (n=10) and managers (n=5) participated in the study. The study established the domains of effective implementation and areas of challenges with discrepancy between the expected level of strategy implementation and availability of sufficient human and fiscal resources to enhance effective strategy implementation. The factors that impeded the effective implementation of the road safety strategy towards reducing accidents and road fatalities on the N1 in the Limpopo Province included the inadequate allocation and distribution of traffic officers in areas with a high probability of accidents, delayed recruitment of sufficient traffic law enforcement officers and unavailability of required budgeted funds for procurement of state of the art physical equipment to monitor the speed and magnitude of traffic flows and real-time surveillance and capture of road safety transgressions. The findings revealed that there is a considerable need for traffic law enforcement managers to collaborate with behavioural professionals and the police to ascertain effective behavioural change mechanisms to encourage road safety compliance. However, recruitment and constant re-training of traffic law enforcement officers on best practice strategies for traffic law enforcement could be useful to ensure the effective implementation of the road safety strategy; thereby contributing towards the reduction of accidents and road fatalities on the N1 in the Limpopo Province. Road accidents Road fatalities N1 Traffic safety Road safety
37	Comparative analysis of Navy and Marine Corps planning, programming, budgeting and execution systems from a manpower perspective Barry, John C., Gillikin, Paul L. 03 1900 (has links) "S. Dooley: Tertiary Reader" / Approved for public release, distribution is unlimited / This study provides analysis, conclusions and recommendations to assist the Deputy Commandant (DC), Manpower and Reserve Affairs Department (M&RA) and DC, Programs and Resources Department (P&R) in structure and process decisions concerning Marine Corps Manpower budget execution. DC, M&RA is the owner of the Marine Human Resource Development Process (HRDP) and the Military Personnel Marine Corps (MPMC) appropriation sponsor, while the DC, P&R has budgetary (1517) authority for MPMC budget execution. In contrast, the Navy has both sponsorship and 1517 authority within one cell at N1. By comparing these two services' organizational factors and Planning, Programming, Budgeting, and Execution Systems (PPBES), relevant differences surface, conclusions are drawn, and recommendations offered for improvements. Recommendations include realignment of 1517 authority within MPMC execution, and the melding of the Programs and Budget Branch of Manpower Plans Division, M&RA with the Military Personnel Branch, Fiscal Division, P&R (RFM). This new office will be responsible for all facets of MPMC programming, budgeting, and execution. / Captain, United States Marine Corps Manpower planning United States Budget Deputy Commandant DC Marine Corps Manpower Budget Execution Military Personnel Marine Corps (MPMC) N1 1517 authority Military personnel branch Fiscal division P&R (RFM)
38	An electrophysiological examination of visuomotor activity elicited by visual object affordances Dixon, Thomas Oliver January 2016 (has links) A wide literature of predominantly behavioural experiments that use Stimulus Response Compatibility (SRC) have suggested that visual action information such as object affordance yields rapid and concurrent activation of visual and motor brain areas, but has rarely provided direct evidence for this proposition. This thesis examines some of the key claims from the affordance literature by applying electrophysiological measures to well established SRC procedures to determine the verities of the behavioural claims of rapid and automatic visuomotor activation evoked by viewing affording objects. The temporal sensitivity offered by the Lateralised Readiness Potential and by visual evoked potentials P1 and N1 made ideal candidates to assess the behavioural claims of rapid visuomotor activation by seen objects by examining the timecourse of neural activation elicited by viewing affording objects under various conditions. The experimental work in this thesis broadly confirms the claims of the behavioural literature however it also found a series of novel results that are not predicted by the behavioural literature due to limitations in reaction time measures. For example, while different classes of affordance have been shown to exert the same behavioural facilitation, electrophysiological measures reveal very different patterns of cortical activation for grip-type and lateralised affordances. These novel findings question the applicability of the label ‘visuomotor’ to grip-type affordance processing and suggest considerable revision to models of affordance. This thesis also offers a series of novel and surprising insights into the ability to dissociate afforded motor activity from behavioural output, into the relationship between affordance and early visual evoked potentials, and into affordance in the absence of the intention to act. Overall, this thesis provides detailed suggestions for considerable changes to current models of the neural activity underpinning object affordance. 616.8
39	Development and Validation of Novel Polymer-based DNA Delivery Systems for Effective and Affordable Non-viral Gene Therapies Zhang, Jun 23 May 2022 (has links) No description available. Animal Diseases Biochemistry Biology Biomedical Engineering Biomedical Research Cellular Biology Developmental Biology Engineering Environmental Health Health Health Sciences Immunology Materials Science Medicine Molecular Biology Molecules Nanoscience Nanotechnology Neurobiology Neurology Neurosciences Organic Chemistry Pharmaceuticals Pharmacy Sciences Polymer Chemistry Polymers Public Health Toxicology Therapy Virology gene therapy gene delivery DNA delivery polymer non-viral nonviral therapeutic polyethylenimine PEI in vitro in vivo C2C12 muscle muscular M17 neuro neural brain transfection cell penetrating peptide neurodegenerative Alzheimer Parkinson prion PrP N1 C1 amyloid-β Aβ Tau α-synuclein αSyn α-cleavage ADAM8 pscAAV

Search results