Background: Despite our distinct impression to the contrary, we are only conscious of a fraction of all the neural activity underlying our thoughts and behavior. Most neural processes occur non-consciously, and in parallel with our conscious experience. However, it is still unclear what the limits of non-conscious processes are in terms of higher cognitive functions. Many recent studies have shown that increasingly more advanced functions can operate non-consciously, but non-conscious information is still thought to be fleeting and undetectable within 500 milliseconds. Here we used various techniques to render information non-conscious, together with functional magnetic resonance imaging (fMRI), to investigate if non-consciously presented information can be retained for several seconds, what the neural substrates of such retention are, and if it is consistent with working memory maintenance. Results: In Study I we used an attentional blink paradigm to render stimuli (single letters) non-conscious, and a variable delay period (5 – 15 s) prior to memory test. It was found that non-conscious memory performance was above chance after all delay durations, and showed no signs of decline over time. Univariate fMRI analysis showed that the durable retention was associated with sustained BOLD signal change in the prefrontal cortex and cerebellum during the delay period. In Study II we used continuous flash suppression (CFS) to render stimuli (faces and tools) non-conscious, and a variable delay period (5 or 15 s) prior to memory test. The durable retention of up to 15 s was replicated, and it was found that stimuli identity and spatial position was retained until prospective use. In Study III we used CFS to render tools non-conscious, and a variable delay period (5 – 15 s) prior to memory test. It was found that memory performance was not better than chance. However, by using multi-voxel pattern analysis it was nonetheless possible to detect the presence vs. absence of non-conscious stimuli in the frontal cortex,and their spatial position (left vs. right) in the occipital cortex during the delay. Conclusions: Overall these findings suggest that non-consciously presented information (identity and/or position) can be retained for several seconds,and is associated with BOLD signal in frontal and posterior regions. These findings are consistent with working memory maintenance of non-consciously presented information, and thereby constrain models of working memory and theories of consciousness.

L’objectif de cette thèse était d’explorer les bases cognitives et cérébrales des processus de compréhension du langage figuré via l’utilisation d’outils de neuroimagerie (EEG et IRMf). Nous nous sommes particulièrement intéressés aux processus inférentiels sémantiques et pragmatiques. Afin de mieux les cerner, nous avons étudié la compréhension de la métaphore verbale nouvelle (« catapulter ses paroles ») et de l’ironie verbale (« Il est détesté de tous. Cet homme est très populaire. »). Ce choix repose sur l’hypothèse selon laquelle chacune de ces figures sollicite spécifiquement un type de processus inférentiel ; de nature sémantique pour la métaphore et pragmatique pour l’ironie. Conformément à cette hypothèse, nos résultats indiquent que la compréhension des métaphores verbales nouvelles se fonde sur des processus de recherche et d’intégration d’informations sémantiques, supportant l’hypothèse d’un traitement séquentiel. L’examen des bases cérébrales du traitement de ces expressions précédées d’un contexte a mis en évidence des régions cérébrales postérieures, suggérant la mise en œuvre d’un processus de manipulation conceptuelle. Concernant le traitement de l’ironie, nous avons observé un processus tardif d’intégration d’informations plus important pour les énoncés ironiques comparés aux énoncés littéraux, suggérant un traitement pragmatique plus difficile. Enfin, nous avons mis en évidence un réseau fronto-temporal bilatéral lors du traitement de l’ironie, dont une part serait sensible au contraste entre le contexte et l’énoncé et à l’humour des énoncés. Nos résultats sont confrontés aux théories psycholinguistiques et cognitives du traitement du langage figuré. / Our main aim was to assess the cognitive and neural basis of the figurative language processing using neuroimaging tools (EEG and fMRI). We were especially interested in semantic and pragmatic inferential processes. In order to better grasp these processes, we have studies the comprehension of novel verbal metaphor (“to catapult his/her words”) and verbal irony (“Everybody thinks he is foul. He is a very popular man.”). This choice was based upon the hypothesis that each of these figurative expressions specifically engages one of the two inferential processes: semantic for metaphors and pragmatic for irony. Following this hypothesis, our results point out that the comprehension of novel metaphoric expression is built on the research and the integration of a semantic congruent information, supporting a sequential processing hypothesis. The assessment of the cerebral basis of the processing of such expressions embedded in a context has revealed regions in posterior areas, suggesting a conceptual manipulation process. Concerning the irony processing, we observed a greater late integration processing for ironic sentences than literal ones, suggestion a more effortful pragmatic processing. Finally, we observed a fronto-temporal network specific to irony processing. Some part of this network could be involved in both the contrast between the utterance and the context and the humor processing of the sentences. Our results are confronted with psycholinguistic and cognitive theories about figurative language processing.