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THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLESDuis, Christine Ann 11 October 2001 (has links)
No description available.
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Passing or Failing of Symptom Validity Tests in Academic Accessibility Populations: Neuropsychological Assessment of “Near-Pass” PatientsFarrer, Thomas Jeffrey 01 June 2015 (has links)
There is overwhelming evidence that the presence of secondary gain is an independent predictor of both performance validity and neuropsychological test outcomes. In addition, studies have demonstrated that genuine cognitive and/or psychological conditions can influence performance validity testing, both in the presence and absence of secondary gain. However, few studies have examined these factors in a large sample of academic accommodation seeking college students. The current study examined base rates of symptom validity test failure, the possibility of a “Near-Pass” intermediate group on symptom validity tests, the influence of diagnoses on performance indicators, and whether performance validity differed for “Near-Pass” patients relative to those who pass and those who fail performance validity indicators.
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Medical and Neuropsychological Predictors of Adaptive Functioning in Children with Epilepsy.Papazoglou, Aimilia 14 August 2009 (has links)
Epilepsy is one of the most common neurological disorders in children, with both seizures and their medical treatment associated with increased risk of neuropsychological impairments. Adaptive functioning in children with epilepsy is poorly understood. This study sought to identify the neuropsychological and medical predictors of optimal adaptive functioning in pediatric epilepsy. Forty-six children with epilepsy and 16 typically developing children and their parents participated in this study at two time points. Overall, adaptive functioning was found to be in the average to low average range in children with epilepsy. A composite measure assessing cumulative seizure history was able to significantly predict Adaptive Behavior Assessment System-II (ABAS-II) scores. Whether a child had experienced one or more seizures in the last year was the only individual seizure and treatment variable able to significantly predict adaptive functioning as measured by the ABAS-II. Verbal learning, executive functioning, and internalizing and externalizing behavior problems assessed at Time 1 predicted performance on the ABAS-II at Time 2. Verbal memory and attention, however, were not significant predictors of adaptive functioning. Consistent with what was hypothesized, executive functioning was found to mediate the relationship between seizure history and adaptive functioning when controlling for behavior problems at both Times 1 and 2. When behavior problems were the mediator and executive functioning was controlled for, mediation was not found. Executive functioning also mediated the relationship between group membership (monotherapy, polytherapy, and typically developing) and ABAS-II scores at Time 1, but not at Time 2 when a post-surgical group also was represented. Secondary analyses showed that the relationship between executive and adaptive functioning at Time 2 was moderated by whether or not a child had ever experienced seizures, such that children diagnosed with epilepsy evidenced greater correlations between these constructs than typically developing children. The results of this study suggest that a subset of children with epilepsy, those with active seizures and/or executive dysfunction, are at increased risk of adaptive deficits. These findings highlight the risk factors for suboptimal adaptive functioning in this population, and also suggest potential avenues for remediation.
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Serum neuron-specific enolase and neuropsychological functioning after closed head injuryHarrington, Patrick John 13 February 2015 (has links)
Not available / text
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Neuropsychological Functioning of Blind Subjects with Learning Disabilities Compared to Those with Blindness AloneRabeck, Deborah D. (Deborah Denise) 12 1900 (has links)
It has been hypothesized that a disproportionate percentage of the blind population are learning disabled. In the past, norms and technology were not available to assess in a cost effective manner the blind client's neuropsychological functioning. Norms for the Wide Range Achievement Test - Revised (WRAT-R2) are now available for a blind population without any neuropsychological dysfunctioning. This study utilized the adapted WRAT-R2 and the Comprehensive Vocational Evaluation System (CVES), a neuropsychological test battery adapted for the blind, to investigate the possibility that learning disabilities are present in the adult blind population. Suspected learning disabled, blind subjects were compared with normal blind subjects. There were significant neuropsychological differences between the two groups.
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The Effect of Temperament and Neuropsychological Functioning on Behavior Problems in Children with New-Onset SeizuresBaum, Katherine T. 21 July 2009 (has links)
No description available.
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Deviant Peers, Substance Use, and Conduct Problems across Adolescence: Moderators of Selection and Socialization ProcessesPrice, Julia January 2012 (has links)
Although the extant literature suggests that associations with deviant peers (ADP) contribute to the persistence and exacerbation of adolescent conduct problems (CP) and substance use (SU), few studies have investigated processes through which these relations develop, the stability of ADP, risk factors for ADP, or prospective relations among patterns of ADP, CP, and SU across adolescence and substance use disorder (SUD) in early adulthood. Relations among ADP with CP and ADP with SU may be due to selection processes (i.e., youth select into ADP groups) and/or socialization processes (youth are influenced by deviant peers once they enter the ADP group). In addition, selection and socialization processes may be moderated by neuropsychological and temperamental (i.e., emotionality) factors, though there is a dearth of literature examining moderators of these processes. The present study addressed these gaps in the literature by examining five research aims: (1) identify subgroups of youth who vary in type and levels of ADP and CP/SU at three different ages using latent class analysis, (2) investigate the stability of ADP and CP/SU subgroup membership using latent transition analysis, (3) examine the prospective relations among ADP and CP/SU subgroup membership, (4) investigate potential neuropsychological and emotion regulation moderators of selection and socialization processes, and (5) evaluate prospective prediction to SUD in early adulthood from patterns of ADP and CP/SU subgroup membership across adolescence. Participants were youth who participated in a large-scale research project conducted through the Center for Education and Drug Abuse Research at the University of Pittsburgh. Youth and their families completed multiple assessments, beginning when youth were 10-12 years old, followed by assessments at 12-14, 16, and 22 years old. Results indicate (a) deviant peer groups vary based on type and severity of deviant behavior; (b) deviant peer group involvement increased across adolescence and continuity of deviant peer involvement was evident; (c) youth selected peers based on similar levels of deviant behavior across ages 10 to 16 years, but were influenced by these deviant peers to engage in CP and/or SU from ages 12-14 to 16 years; (d) relations between youth deviant behaviors and later selection of deviant friends differed according to levels of youth neuropsychological functioning and temperamental emotionality; and (e) earlier involvement with deviant peers, involvement with deviant peer groups defined by severe CP and SU, and youth engagement in both CP and SU were related to the greatest risk for SUD in early adulthood. / Psychology
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Symptom Dimensions and Neurocognitive Functioning in Adult ADHDButcher, Andrew Timothy 06 September 2001 (has links)
Ongoing controversies regarding the clinical and nosological status of ADHD in adults emphasize the need for studies examining whether <i>DSM-IV</i> ADHD symptom dimensions and subtypes identified in research with children are valid for adults. Firm symptom criteria validated by data from adult samples have not been developed. Moreover, many clinic-referred adults present with attentional complaints and exhibit symptoms, neurocognitive weaknesses, and secondary problems similar to those seen in ADHD. However, data are mixed regarding the profile of neurocognitive deficits involved in adult expressions of ADHD, and it is unknown whether patterns of weakness in neurocognitive performance can be identified that reliably discriminate adults with ADHD from those with other neurobehavioral disorders (e.g., learning disabilities, LD). The purpose of this study was to further (a) evaluate the discriminant validity of <i>DSM-IV</i> ADHD in adults, (b) examine the nature and severity of neurocognitive deficits in adult ADHD, and (c) clarify the diagnostic utility of executive functioning measures among clinic-referred adults.
Overall, results supported the discriminant validity of adult ADHD, but little support emerged for the existence of separate <i>DSM-IV</i> subtypes. Importantly, symptom ratings supported the existence of two broad symptom domains consistent with those delineated in <i>DSM-IV</i>. Moreover, principal components analysis of neuropsychological data identified three dimensions of neurocognitive executive functioning (EF; verbal working memory; sustained intention; and effortful learning) in which ADHD adults (n=35) performed significantly less well than those who received an LD diagnosis (n=24) or no diagnosis (n=21). Furthermore, composite scores in these EF domains generated correct classifications that were significantly better than chance when classifying adults that (a) did and did not meet criteria for ADHD, (b) met criteria for ADHD or LD, and (c) met criteria for ADHD or no clinical diagnosis. Classification results were robust when submitted to a jackknife (leave-one-out) validation procedure. Finally, results provided general support for the developmental lag hypothesis of frontal-subcortical functioning in ADHD when considered vis-à-vis child ADHD data, but findings also supported the notion that ADHD in adults is associated with continuing dysfunction in specific neuroanatomical pathways believed to subserve executive attentional functions (e.g., dorsolateral prefrontal-subcortical; anterior cingulate-subcortical; orbitofrontal-subcortical). / Ph. D.
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The relationship between psychometrically-defined social anxiety and working memory performancePaskowski, Timothy L. 01 May 2011 (has links)
Anxiety disorders are among the most commonly diagnosed class of mental illness in the United States, and often involve abnormally high levels of stress and social fear. Despite high lifetime prevalence rates, social anxiety disorder (SAD) has remarkably low diagnosis and treatment rates. Furthermore, while individuals with other specific psychiatric disorders tend to exhibit significant neuropsychological deficits, neuropsychological functioning in individuals with SAD remains largely untested. A majority of the few existing studies concerning neuropsychological performance in SAD samples focus on specific functions, and their limited results are highly mixed. The primary objective of this investigation was to provide a more thorough, broad assessment of both auditory and visual working memory as related to psychometrically-defined social anxiety disorder. In addition, this study aimed to help clarify as to whether such deficits are related to the construct of social anxiety, or whether any potential deficits are better explained by generalized state and/or trait (in-the-moment) anxiety. The implications of a deficit in the visual and/or auditory working memory domains are multifaceted. For example, such a deficit may lead to the inability to detect visual cues in social situations. The inability to process these social cues has the potential to exacerbate some SAD- related symptoms, such as fear of humiliation and judgment. Twenty-nine college students completed both phases of this study, including an assessment of state and trait anxiety as well as social phobia and a four-part working memory battery. An analysis of the Phase II data indicates that individual scores on the four measures of both visual and auditory working memory did not relate to trait and/or state anxiety or psychometrically-defined social anxiety.; Thus, it appears that social, generalized trait, and generalized state anxiety do not relate to a neuropsychological deficit in either type of working memory in this sample population. However, we did find a statistical trend suggesting that as social anxiety increased, there was a relative decrease in visual vs. auditory working memory. This statistical trend remained after covarying for state and trait anxiety respectively. Therefore, future research in this area should examine the discrepancy in performance between the auditory and visual working memory domains as it relates to both diagnosed social phobia and psychometrically-defined social anxiety.
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Predicting Conversion from Mild Cognitive Impairment to Alzheimer’s Disease using Partially Ordered Models of Neuopsychological MeasurementsYang, Yan January 2011 (has links)
No description available.
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