L'agrégation des canaux sodium (Nav) aux nœuds de Ranvier est une étape importante pour la propagation électrique saltatoire rapide le long des axones myélinisés. L'assemblage des nœuds dépend d'interactions neurones-cellules gliales myélinisantes, les oligodendrocytes dans le système nerveux central (SNC) et les cellules de Schwann dans le système nerveux périphérique (SNP). Bien décrits dans le SNP, les mécanismes cellulaires et moléculaires restent à caractériser dans le SNC. Lors de ma thèse, je me suis focalisé sur les étapes précoces d'assemblage des nœuds dans le SNC. Ce travail montre que des agrégats de protéines nodales (ou pré-nœuds) sont formés le long des axones de neurones GABAergiques avant la myélinisation dans des cultures neurones-glies d'hippocampe et également au cours du développement chez les rongeurs. La formation de pré-nœuds dépend de protéines sécrétées par les oligodendrocytes et de la protéine axonale d'échafaudage, ankyrineG. En outre, la transition des isoformes de Nav le long des axones est régulée par la présence des cellules gliales. Enfin, les pré-nœuds permettent d'accélérer la vitesse de conduction de l'influx nerveux par un facteur 1,5, indépendamment de la myélinisation et du calibre axonal. Globalement, ces résultats renforcent notre connaissance des mécanismes d'assemblage des nœuds de Ranvier dans le SNC et suggèrent une fonction développementale de l'agrégation nodale avant le début de la myélinisation. Si la vitesse de conduction a été décrite comme liée aux propriétés isolantes de la gaine de myéline, les résultats de cette thèse apportent un concept novateur de régulation de la conduction axonale en l'absence de myéline. / The clustering of sodium channels (Nav) at the nodes of Ranvier is an important step in permitting rapid saltatory conduction along myelinated axons. Nodal assembly is neuron-glia dependent, mediated by myelinating oligodendrocytes of the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS). While the mechanisms of nodal assembly are currently best characterized in the PNS, cellular and molecular mechanisms underlying their assembly in the CNS are only partially understood. In the core of my PhD dissertation, I focused on the early developmental steps of nodal protein clustering in the CNS and show that clusters of nodal proteins, called prenodes, are detected before myelination along GABAergic axons in hippocampal neuron-glia cultures and also in the developing rodent hippocampus. Prenodal clustering requires extrinsic oligodendroglial secreted proteinaceous factors, and also the intrinsic axonal cytoskeletal scaffolding protein ankyrinG. Furthermore, the transition of sodium channels isoforms is tightly regulated along GABAergic axons during development, but this transition is lost in the absence of the physical presence of glial cells. Lastly, prenodes increase axonal conduction by a factor of 1.5x, independently of myelination and axonal caliber. Taken together, these results further our understanding of CNS nodes of Ranvier assembly mechanisms and the developmental function of nodal clustering prior to myelin ensheathment. While conduction velocity along axons has long been thought to mostly rely on the insulating properties of myelin, these results may shed light on a new concept of axonal conduction in the absence of myelination.

The diploma thesis describes localization of communications nodes in the Wireless Sensor Networks. This thesis contains basic algorithms for localization sensor's nodes as are Map-Growing and ABC (Assumption Based Coordinates). Then is chosen acceptable algorithm for simulation on random sensor networks. For research these problems is used software MATLAB. For a given the university's environment are researched appropriate algorithms with possible optimalization algorithms. The result of diploma thesis is a localization algorithm with initial multilateration system and this system is located in the center sensor's network. As algorithm IMap4-Growing (Improved Map4-Growing) with optimization, which uses optimization distance between sensors and radio range. In the diploma thesis is simulated optimalization algorithm Mass-Spring.

Master’s thesis in the first part focuses on the effectiveness of communication in the selection of reference nodes during the anchor-free localization in WSN. In this part two anchor-free localization algorithms AFL and CRP are explored. Knowledge learned on the selection of reference nodes and communication complexities of these algorithms are used in the second part. The second part is aimed at eliminating weaknesses in communication and subsequently proposed a new algorithm for selection of references. The principle of the newly proposed algorithm CASRU (Centralized Algorithm for Selection of Reference Nodes) is based on the principle of CRP. CASRU algorithm builds logical tree structure and then filters the communication through it. New algorithm achieves much greater success in the selection in randomly distributed networks while reducing the amount of communication load.

The aim of the paper is showing, how projection methods can be used for computing contact problems in elasticity for different classes of obstacles. Starting with the projection idea for handling hanging nodes in finite element discretizations the extension of the method for handling penetrated nodes in contact problems will be described for some obstacle classes.

No description available.

Mobile wireless sensor networks are not widely implemented in the real world, even after years of research carried out in this field. One reason is the lack of understanding of the impact that mobility has on network performance. The simulation and emulation of mobile wireless sensor networks is necessary before they are deployed for the real-world applications. This thesis presents a simulation-based study of different mobility models. The total area coverage that depends on the pattern of node movements is observed through simulations. The spatial distribution of node locations is also studied. Various synthetic mobility models available are explored based on their theoretical descriptions. ‘BonnMotion' is used as the network simulator for investigating different mobility scenarios. The results obtained after simulations are imported to MATLAB and the analysis of node movements is done through various plots and inferences from the data. The comparison of mobility models is also discussed based on their spatial node distribution in the simulated scenarios.

Purpose – This study aims to look into how foreignness and outsidership affect the market entry of a SME and the individual firm's ability to access the correct network as well as look at which support structures are available for the individual firms entering into a new market. Theory/Design & Research Questions – By looking through the lens of Social Network theory, aspects of trust, legitimacy, nodes, foreignness and outsidership, this study has looked into the journey of a large hamburger chain in Sweden that has successfully entered into different markets outside of Sweden. The research questions explored were (i) how SMEs can overcometheir liabilities and leverage network connections to form strategic partnerships with other firms or organizations, and (ii) how centrality of nodes can be utilized by SMEs to gain access to valuable information and resources, and (iii) how intermediary networks can support SMEs in their efforts to enter new markets, and what policies and programs have proven effective in this regard. Methodology – The data was gathered using a non-probability sampling by conducting a semi-structured qualitative interview and was complemented with secondary sources from the company profile. Findings – Depending on the size of the firm the level of ability to access networks can differ. Smaller firms are more inclined to seek help from intermediaries compared to larger firms. Furthermore actors that are more central have been found to have a key role for firms entering foreign markets.

No description available.

International Telemetering Conference Proceedings / October 20-23, 2003 / Riviera Hotel and Convention Center, Las Vegas, Nevada / A large selection of hardware and software components are readily available for supporting Internet communication in the ground network environment. These components can be used to construct very powerful and flexible communication systems. The Operating Missions as Nodes on the Internet (OMNI) project at NASA/GSFC has been defining and demonstrating ways to use standard Internet technologies for future space communication. Theses concepts and technologies are also applicable to test range telemetry applications. This paper identifies the network equipment and protocols to support end-to-end IP communication from range sensors and spacecraft instruments to end users. After identifying the end-to-end network hardware and software components, the paper discusses which ones are currently available and lists specific examples of each. This includes examples of space missions currently using Internet technology for end-to-end communication. It also lists missing pieces and includes information on their current status. The goal of this paper is also to stimulate thought and discussion on what steps need to be taken to start filling in the remaining missing pieces for end-to-end range and space network connectivity.

International Telemetering Conference Proceedings / October 21, 2002 / Town & Country Hotel and Conference Center, San Diego, California / This paper presents work being done at NASA/GSFC by the Operating Missions as Nodes on the Internet (OMNI) project to demonstrate the application of Internet communication technologies to space communication. The goal is to provide global addressability and standard network protocols and applications for future space missions. It describes the communication architecture and operations concepts that will be deployed and tested on a Space Shuttle flight in July 2002. This is a NASA Hitchhiker mission called Communication and Navigation Demonstration On Shuttle (CANDOS). The mission will be using a small programmable transceiver mounted in the Shuttle bay that can communicate through NASA’s ground tracking stations as well as NASA’s space relay satellite system. The transceiver includes a processor running the Linux operating system and a standard synchronous serial interface that supports the High-level Data Link Control (HDLC) framing protocol. One of the main goals will be to test the operation of the Mobile IP protocol (RFC 2002) for automatic routing of data as the Shuttle passes from one contact to another. Other protocols to be utilized onboard CANDOS include secure login (SSH), UDP-based reliable file transfer (MDP), and blind commanding using UDP. The paper describes how each of these standard protocols available in the Linux operating system can be used to support communication with a space vehicle. It will discuss how each protocol is suited to support the range of special communication needs of space missions.