For well over 200 years, scientists and doctors have been poking and prodding brains in every which way in an effort to understand how they work. The earliest pokes were quite crude, often involving permanent forms of brain damage. Though neural injury continues to be an active area of research within neuroscience, technology has given neuroscientists a number of tools for stimulating and observing the brain in very subtle ways. Nonetheless, the basic experimental paradigm remains the same; poke the brain and see what happens. For example, neuroscientists studying the visual or auditory system can easily generate any image or sound they can imagine to see how an organism or neuron will respond. Since neuroscientists can now easily design more pokes then they could every deliver, a fundamental question is ``What pokes should they actually use?' The complexity of the brain means that only a small number of the pokes scientists can deliver will produce any information about the brain. One of the fundamental challenges of experimental neuroscience is finding the right stimulus parameters to produce an informative response in the system being studied. This thesis addresses this problem by developing algorithms to sequentially optimize neurophysiology experiments. Every experiment we conduct contains information about how the brain works. Before conducting the next experiment we should use what we have already learned to decide which experiment we should perform next. In particular, we should design an experiment which will reveal the most information about the brain. At a high level, neuroscientists already perform this type of sequential, optimal experimental design; for example crude experiments which knockout entire regions of the brain have given rise to modern experimental techniques which probe the responses of individual neurons using finely tuned stimuli. The goal of this thesis is to develop automated and rigorous methods for optimizing neurophysiology experiments efficiently and at a much finer time scale. In particular, we present methods for near instantaneous optimization of the stimulus being used to drive a neuron.

In traffic safety analysis, a large number of distributions have been proposed to analyze motor vehicle crashes. Among those distributions, the traditional Poisson and Negative Binomial (NB) distributions have been the most commonly used. Although the Poisson and NB models possess desirable statistical properties, their application on modeling motor vehicle crashes are associated with limitations. In practice, traffic crash data are often over-dispersed. On rare occasions, they have shown to be under-dispersed. The over-dispersed and under-dispersed data can lead to the inconsistent standard errors of parameter estimates using the traditional Poisson distribution. Although the NB has been found to be able to model over-dispersed data, it cannot handle under-dispersed data. Among those distributions proposed to handle over-dispersed and under-dispersed datasets, the Conway-Maxwell-Poisson (COM-Poisson) and double Poisson (DP) distributions are particularly noteworthy. The DP distribution and its generalized linear model (GLM) framework has seldom been investigated and applied since its first introduction 25 years ago. The objectives of this study are to: 1) examine the applicability of the DP distribution and its regression model for analyzing crash data characterized by over- and under-dispersion, and 2) compare the performances of the DP distribution and DP GLM with those of the COM-Poisson distribution and COM-Poisson GLM in terms of goodness-of-fit (GOF) and theoretical soundness. All the DP GLMs in this study were developed based on the approximate probability mass function (PMF) of the DP distribution. Based on the simulated data, it was found that the COM-Poisson distribution performed better than the DP distribution for all nine mean-dispersion scenarios and that the DP distribution worked better for high mean scenarios independent of the type of dispersion. Using two over-dispersed empirical datasets, the results demonstrated that the DP GLM fitted the over-dispersed data almost the same as the NB model and COM-Poisson GLM. With the use of the under-dispersed empirical crash data, it was found that the overall performance of the DP GLM was much better than that of the COM-Poisson GLM in handling the under-dispersed crash data. Furthermore, it was found that the mathematics to manipulate the DP GLM was much easier than for the COM-Poisson GLM and that the DP GLM always gave smaller standard errors for the estimated coefficients.

The advantage of the geometric approach to linear model and its applications is known to many authors. In spite of that, it still remains to be rather unpopular in teaching statistics around the world and is almost missing in the Czech Republic. In this work, we use geometry of multidimensional vector spaces to derive some well-known properties of the linear model and to explain some of the most familiar statistical methods to show usefulness of this approach, also known as "free-coordinate". Besides, historical background including selected results of R. A. Fisher is briefly discussed; it follows that the geometry approach to linear model is justifiable from the historical point of view, too. Powered by TCPDF (www.tcpdf.org)

abstract: This study concerns optimal designs for experiments where responses consist of both binary and continuous variables. Many experiments in engineering, medical studies, and other fields have such mixed responses. Although in recent decades several statistical methods have been developed for jointly modeling both types of response variables, an effective way to design such experiments remains unclear. To address this void, some useful results are developed to guide the selection of optimal experimental designs in such studies. The results are mainly built upon a powerful tool called the complete class approach and a nonlinear optimization algorithm. The complete class approach was originally developed for a univariate response, but it is extended to the case of bivariate responses of mixed variable types. Consequently, the number of candidate designs are significantly reduced. An optimization algorithm is then applied to efficiently search the small class of candidate designs for the D- and A-optimal designs. Furthermore, the optimality of the obtained designs is verified by the general equivalence theorem. In the first part of the study, the focus is on a simple, first-order model. The study is expanded to a model with a quadratic polynomial predictor. The obtained designs can help to render a precise statistical inference in practice or serve as a benchmark for evaluating the quality of other designs. / Dissertation/Thesis / Doctoral Dissertation Statistics 2017

abstract: The primary purpose of this study is to examine the effect of knowledge for teaching mathematics and teaching practice on student mathematics achievement growth. Thirty two teachers and 299 fourth grade students in three elementary schools from one school district in urban area participated in the study. Most of them are Hispanic in origin and about forty percent is English Language Learners (ELLs). The two level Hierarchical Linear Model (HLM) was used to investigate repeated measures of teaching practice measured by Classroom Assessment Scoring System (CLASS) instrument. Also, linear regression and a multiple regression to examine the relationship between teacher knowledge measured by Learning for Mathematics Teaching (LMT) and Developing Mathematical Ideas (DMI) items and teaching practice were employed. In addition, a three level HLM was employed to analyze repeated measures of student mathematics achievement measured by Arizona Assessment Consortium (AzAC) instruments. Results showed that overall teaching practice did not change weekly although teachers' emotional support for their students improved by week. Furthermore, a statistically significant relationship between teacher knowledge and teaching practice was not found. In terms of student learning, ELLs have significantly lower initial status in mathematics achievement than non-ELLs, as were growth rates for these two groups. Lastly, teaching practice significantly predicted students' monthly mathematics achievement growth but teacher knowledge did not. The findings suggest that school systems and education policy makers need to provide teachers with the chance to reflect on their teaching and change it within themselves in order to better support student mathematics learning. / Dissertation/Thesis / Ph.D. Curriculum and Instruction 2012

abstract: Nowadays product reliability becomes the top concern of the manufacturers and customers always prefer the products with good performances under long period. In order to estimate the lifetime of the product, accelerated life testing (ALT) is introduced because most of the products can last years even decades. Much research has been done in the ALT area and optimal design for ALT is a major topic. This dissertation consists of three main studies. First, a methodology of finding optimal design for ALT with right censoring and interval censoring have been developed and it employs the proportional hazard (PH) model and generalized linear model (GLM) to simplify the computational process. A sensitivity study is also given to show the effects brought by parameters to the designs. Second, an extended version of I-optimal design for ALT is discussed and then a dual-objective design criterion is defined and showed with several examples. Also in order to evaluate different candidate designs, several graphical tools are developed. Finally, when there are more than one models available, different model checking designs are discussed. / Dissertation/Thesis / Ph.D. Industrial Engineering 2013

Modelling of complex corroding industrial systems is ritical to effective inspection and maintenance for ssurance of system integrity. Wall thickness and corrosion rate are modelled for multiple dependent corroding omponents, given observations of minimum wall thickness per component. At each inspection, partial observations of the system are considered. A Bayes Linear approach is adopted simplifying parameter estimation and avoiding often unrealistic distributional assumptions. Key system variances are modelled, making exchangeability assumptions to facilitate analysis for sparse inspection time-series. A utility based criterion is used to assess quality of inspection design and aid decision making. The model is applied to inspection data from pipework networks on a full-scale offshore platform.

A long record of daily data is used to study the lake levels of Lake Neusiedl, a large steppe lake at the eastern border of Austria. Daily lake level changes are modeled as functions of precipitation, temperature, and wind conditions. The occurrence and the amount of daily precipitation are modeled with logistic regressions and generalized linear models.

The problem of estimating mean and covariances of a multivariate normal distributedrandom vector has been studied in many forms. This thesis focuses on the estimatorsproposed in [15] for a banded covariance structure with m-dependence. It presents theprevious results of the estimator and rewrites the estimator when m = 1, thus makingit easier to analyze. This leads to an adjustment, and a proposition for an unbiasedestimator can be presented. A new and easier proof of consistency is then presented.This theory is later generalized into a general linear model where the correspondingtheorems and propositions are made to establish unbiasedness and consistency. In thelast chapter some simulations with the previous and new estimator verifies that thetheoretical results indeed makes an impact.

This thesis is intent on using mixtures of probability distributions in generalized linear model. The theoretical part is divided into two parts. In the first chapter a generalized linear model (GLM) is defined as an alternative to the classical linear regression model. The second chapter describes the mixture of probability distributions and estimate of their parameters. At the end of the second chapter, the previous theories are connected into the finite mixture generalized linear model. The last third part is practical and shows concrete examples of these models.