Electrophysiologic responses are used to estimate hearing thresholds and fit hearing aids in young infants, but these estimates are not exact. An objective test of speech encoding could be used to validate infant fittings by showing that speech has been registered in the central auditory system. Such a test could also show the effects of auditory processing problems on the neural representation of speech. This thesis describes techniques for recording electrophysiologic responses to natural speech stimuli from the brainstem and auditory cortex. The first technique uses a Fourier analyzer to measure steady-state brainstem responses to periodicities and envelope changes in vowels, and the second uses a windowed cross-correlation procedure to measure cortical responses to the envelopes of sentences. Two studies were conducted with the Fourier analyzer. The first measured responses to natural vowels with steady and changing fundamentals, and changing formants. Significant responses to the fundamental were detected for all of the vowels, in all of the subjects, in 19 – 73 s (on average). The second study recorded responses to a vowel fundamental and harmonics. Vowels were presented in opposite polarities to distinguish envelope responses from responses to the spectrum. Significant envelope responses were detected in all subjects at the fundamental. Significant spectral responses were detected in most subjects at harmonics near formant peaks. The third study used cross-correlation to measure cortical responses to sentences. Significant envelope responses were detected to all sentences, at delays of roughly 180 ms. Responses were localized to the posterior auditory cortices. A model based on a series of overlapping transient responses to envelope changes could also account for the results, suggesting that the cortex either directly follows the speech envelope or consistently reacts to changes in this envelope. The strengths and weaknesses of both techniques are discussed in relation to their potential clinical applications.

Electrophysiologic responses are used to estimate hearing thresholds and fit hearing aids in young infants, but these estimates are not exact. An objective test of speech encoding could be used to validate infant fittings by showing that speech has been registered in the central auditory system. Such a test could also show the effects of auditory processing problems on the neural representation of speech. This thesis describes techniques for recording electrophysiologic responses to natural speech stimuli from the brainstem and auditory cortex. The first technique uses a Fourier analyzer to measure steady-state brainstem responses to periodicities and envelope changes in vowels, and the second uses a windowed cross-correlation procedure to measure cortical responses to the envelopes of sentences. Two studies were conducted with the Fourier analyzer. The first measured responses to natural vowels with steady and changing fundamentals, and changing formants. Significant responses to the fundamental were detected for all of the vowels, in all of the subjects, in 19 – 73 s (on average). The second study recorded responses to a vowel fundamental and harmonics. Vowels were presented in opposite polarities to distinguish envelope responses from responses to the spectrum. Significant envelope responses were detected in all subjects at the fundamental. Significant spectral responses were detected in most subjects at harmonics near formant peaks. The third study used cross-correlation to measure cortical responses to sentences. Significant envelope responses were detected to all sentences, at delays of roughly 180 ms. Responses were localized to the posterior auditory cortices. A model based on a series of overlapping transient responses to envelope changes could also account for the results, suggesting that the cortex either directly follows the speech envelope or consistently reacts to changes in this envelope. The strengths and weaknesses of both techniques are discussed in relation to their potential clinical applications.

Individuals with high working memory capacity (WMC) appear to be particularly good at focusing their attention (McCabe, Roediger, McDaniel, Balota, & Hambrick, 2010). Therefore, we studied the correlation between WMC and the ability to suppress neurological activity from a task-irrelevant stimulus. The research question tests the foundations of Lavie’s perceptual load theory; that early selection occurs, by testing if higher WMC enhances people’s ability to inhibit processing of task-irrelevant stimuli from low versus high load (i.e. the difference from low to high load should be smaller for high WMC than for low WMC). This was operationalised by measuring the correlation of WMC and auditory processing under low versus high visual load. Auditory processing was measured with auditory steady state responses (ASSR), and WMC was measured with an operation-letter span task. The results showed no significant correlation between WMC and ability to suppress task-irrelevant stimuli. Based on the data, it is not possible to conclude with certainty that effects of load on auditory processing are unaffected by WMC, because confidence intervals were large.

Submitted by JOSIANE SANTOS DE OLIVEIRA (josianeso) on 2018-04-11T11:15:15Z No. of bitstreams: 1 Camila Pinheiro Bergenthal_.pdf: 1788975 bytes, checksum: f06c447960db4bfeaa9100261dedbd60 (MD5) / Made available in DSpace on 2018-04-11T11:15:15Z (GMT). No. of bitstreams: 1 Camila Pinheiro Bergenthal_.pdf: 1788975 bytes, checksum: f06c447960db4bfeaa9100261dedbd60 (MD5) Previous issue date: 2017-12-06 / Nenhuma / A estratégia da globalização, em que pese ter contribuído para o avanço de diversos setores econômicos, acabou por exacerbar a perda de direitos, humanos e trabalhistas, agravando a exclusão social e as marcas de pobreza por todo o globo, sobretudo no segmento têxtil. Flagrantes de trabalhadores submetidos a situações análogas à escravidão, jornada exaustiva, trabalho forçado, condições degradantes, servidão por dívida, utilização de mão de obra infantil, hoje reconhecidos como práticas de escravidão moderna, são recorrentes na indústria da moda, não obstante a existência de esparsa legislação, no âmbito nacional e internacional, contrária a qualquer tipo de escravidão. Nesse sentido, a presente dissertação aborda as respostas não estatais de combate à precarização do trabalho na indústria têxtil: o papel dos direitos humanos e da autorregulação. A pesquisa justifica-se em face da ineficiência dos Estados-Nações na proteção de garantias fundamentais dos trabalhadores que atuam no segmento têxtil. Logo, é mais do que nunca atual e merece destaque diante dos reiterados casos de precarização do trabalho. Lança-se uma proposta sistemática alicerçada no método dialético. / Although the globalization strategy has contributed for the advance of several economic sectors, it has ended up contributing to the loss of human and labour rights, and to the aggravation of social exclusions and signs of poverty around the globe, specially in the textile sector. Despite the existence of broad legislation in the national and international scope, contrary to any type of slavery, flagrant of workers under situations analog to slavery, international human traffic, sexual exploitation of women and use of child labour, practices nowadays recognized as modern slavery, are recurrent in the fashion industry. In this sense, the present paper addresses non-state responses to the precariousness of work in the textile industry: the role of human rights and self-regulation. The research is justified in the face of the inefficiency of the Nation States in the protection of fundamental guarantees of the workers who work in the textile segment. Therefore, it is more than ever current and deserves attention in the face of repeated cases of precarious work. A systematic proposal based on the dialectical method is launched.

Objective: The primary purpose of this investigation was to determine the effect of multitalker babble on ASSRs in adult subjects with normal hearing (NH) and sensorineural hearing loss (HI). The secondary purpose was to investigate the relationships among ASSRs, word recognition in quiet, and word recognition in babble. Design: ASSRs were elicited by a complex mixed-modulation tonal stimulus (carrier frequencies of 500, 1500, 2500, and 4000 Hz; modulation rate of 40 or 90 Hz) presented in quiet and in babble. The level of each carrier frequency was adjusted to match the level of the multitalker babble spectrum, which was based on the long term speech spectrum average. Word recognition in noise (WIN) performance was measured and correlated to ASSR amplitude and ASSR detection rate. Study Sample: Nineteen normal-hearing adults and nineteen adults with sensorineural hearing loss were recruited. Results and Conclusions: The presence of babble significantly reduced the ASSR detection rate and ASSR amplitude for NH subjects, but had minimal effect on ASSRs for HI subjects. In addition, babble enhanced ASSR amplitude at high stimulus levels. ASSR detection rate and ASSR amplitude recorded in quiet and babble were significantly correlated with word recognition performance for NH and HI subjects. Sumario Objetivo: El objetivo fundamental de esta investigación fue determinar el efecto de balbuceo de hablantes múltiples en los ASSR de adultos jóvenes con audición normal (NH) y con pérdidas auditivas sensorineurales (HI). El objetivo secundario fue investigar las relaciones entre los ASSR, el reconocimiento de palabras en silencio y el reconocimiento de palabras con en medio de balbuceo. Diseño: Los ASSR fueron evocados por estímulo tonal de modulación mezclada compleja (frecuencias portadoras de 500, 1500, 2500 y 4000 Hz; tasa de modulación de 40 o 90 Hz) presentadas en silencio y con el balbuceo. Se ajustó el nivel de cada frecuencia portadora para emparejar el nivel del espectro del balbuceo de hablantes múltiples, el cual se basó en el promedio del espectro a largo plazo. Se midió el rendimiento para el reconocimiento de palabras en ruido (WIN) y se correlacionó con la amplitud de los ASSR y con la tasa de detección de los ASSR. Muestra Del Estudio: Se reclutaron diez y nueve adultos normoyentes y diez y nueve adultos con pérdida auditiva sensorineural. Resultados Y Conclusiones: La presencia del balbuceo reduce significativamente la tasa de detección de los ASSR y la amplitud de los ASSR en sujetos NH, pero tiene efectos mínimos en los ASSR de sujetos HI. Además, el balbuceo aumenta la amplitud de los ASSR con estímulos de niveles altos. La tasa de detección de los ASSR y la amplitud de los ASSR registrada en silencio y con balbuceo, fueron significativamente correlacionadas con el rendimiento para reconocer palabras en sujetos NH y HI.

In individuals claiming compensation for occupational noise induced hearing loss, a population with a high incidence of nonorganic hearing loss, a reliable and valid behavioural pure tone (PT) threshold is not always achievable. Recent studies have compared the accuracy of behavioural PT threshold estimation using the slow cortical auditory evoked potentials (SCAEP) and auditory steady-state responses (ASSR) but there is no consensus regarding recommended technique. A review of the literature indicated that no comparison has been completed on the use of SCAEP and a single frequency ASSR technique. A research project was therefore initiated with the aim of comparing the clinical effectiveness (accuracy) and clinical efficiency (time required) of SCAEP and ASSR for behavioural PT threshold estimation in adults exposed to occupational noise. Adult participants were divided into a group with normal hearing (behavioural PT thresholds < 20 dBHL; n = 15) and a group of participants with hearing loss (n = 16 adults), the latter of which were recruited from individuals referred for audiometric screening, as part of hearing conservation programs, and who were, therefore, exposed to occupational noise. The GSI Audera electrophysiological system was used for both SCAEP and ASSR threshold measurement at 0.5, 1, 2 and 4 kHz. Use was made of tone burst stimuli for the SCAEP (rise and fall of 10 ms with 80 ms plateau), while amplitude and frequency modulated (AM/FM) stimuli was used during ASSR testing. The system’s 40 Hz protocol was chosen for use during ASSR recording while participants slept because this led to lparticipants. ASSR thresholds could not be measured in two of the three sleeping participants in the preliminary study using an 80 Hz modulation rate due to excessive noise. The mean SCAEP difference scores (SCAEP threshold minus behavioural PT threshold) for both participant groups were -0.2+10.2, 2.8+10.1,5.8+9.7, 0.5+10.4 at 0.5, 1, 2, and 4 kHz respectively, while ASSR difference scores were 25.3+12.8, 21.7+11.3,32.3+12.2, 27.1+13.8. The SCAEP correlations with behavioural PT thresholds across frequencies (r = 0.85) were also stronger than ASSR correlations (r = 0.75). Therefore, with regard to proximity of auditory evoked potentials (AEP) to behavioural PT thresholds and consistency of this relationship, the SCAEP, rather than ASSR, is the AEP of choice. However, the SCAEP took on average 10.1 minutes longer to complete than the ASSR. Clinical effectiveness was given comparably more weight than the clinical efficiency of the AEP technique to estimate behavioural PT thresholds due to the impact on overcompensation for occupational noise induced hearing loss. As such, the study acknowledged the SCAEP as the AEP of choice for the purpose of behavioural PT thresholds in adults exposed to occupational noise. It is important to note that the conclusion reached in the current study arose from the comparison of the SCAEP with a specific ASSR technique. Accuracy of ASSR estimation of behavioural PT thresholds is strongly influenced by stimulus and recording parameters of the system used, and by the participant variables. Copyright / Dissertation (MCommunication Pathology)--University of Pretoria, 2010. / Speech-Language Pathology and Audiology / Unrestricted