Thesis (Ph. D.)--Michigan State University. Dept. of Physics and Astronomy, 2006. / Title from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references (p. 124-130). Also issued in print.

Dissertation (Ph.D.)--Worcester Polytechnic Institute. / Keywords: nuclear physics, particle physics, phyiscs, resonance, nuyclear fragmentation, nucleon-nucleon interactions, radiation shileding, heavy-ion physics, space radiation. Includes bibliographical references (leaves 163-141).

Thesis (Ph.D.)--University of California, Berkeley, 1961. / "UC-34 Physics" -t.p. "TID-4500 (16th Ed.)" -t.p. Includes bibliographical references (p. 55-61).

One of the most interesting features of fragmentation models is a possibility to breach / Thesis (Ph.D.)-University of KwaZulu-Natal, Westville, 2008.

Thesis (M.S. in Physics)--United States Naval Postgraduate School, 1959. / "Physics and Mathematics" -t.p. Includes bibliographical references (p. 33).

Thesis (Ph.D.)--University of California, Berkeley, 1963. / "UC-4 Chemistry" -t.p. "TID-4500 (19th Ed.)" -t.p. Includes bibliographical references (p. 125-127).

Yiu Yun Yip. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 86-87). / Yiu Yun Yip. / Contents --- p.i / List of Figures --- p.iii / List of Tables --- p.vi / Abstract --- p.vii / Acknowledgements --- p.viii / Chapter Chapter 1. --- Introduction --- p.1 / Chapter Chapter 2. --- The Fragmentation Model --- p.4 / Chapter 2.1 --- Interaction Potential --- p.5 / Chapter 2.2 --- Initial Configuration --- p.6 / Chapter 2.2.1 --- Enforcement of momentum conservation at time zero --- p.8 / Chapter 2.3 --- Time Evolution --- p.9 / Chapter 2.4 --- Summary --- p.10 / Chapter Chapter 3. --- Results for object with an initial circular shape --- p.11 / Chapter 3.1 --- Measurement of F(m) --- p.11 / Chapter 3.2 --- Results and Analysis --- p.14 / Chapter 3.3 --- Discussion --- p.24 / Chapter Chapter 4. --- Results for object with an initial square shape --- p.35 / Chapter 4.1 --- Results and Analysis --- p.35 / Chapter 4.2 --- Discussion --- p.43 / Chapter Chapter 5. --- Comparsion with experimental observations --- p.49 / Chapter 5.1 --- The Experiment --- p.49 / Chapter 5.2 --- Comparison --- p.50 / Chapter 5.2.1 --- Relation between the power-law exponent and the falling height --- p.50 / Chapter 5.2.2 --- Relation between the falling height and the total number of fragments --- p.50 / Chapter 5.2.3 --- Relation between the power-law exponent and the total num- ber of fragments --- p.53 / Chapter 5.3 --- Summary --- p.53 / Chapter Chapter 6. --- Maximum entropy formalism for fragment distributions --- p.55 / Chapter 6.1 --- The formalism --- p.55 / Chapter 6.2 --- Average potential and kinetic energies for fragments with mass m --- p.57 / Chapter 6.3 --- Comparison with simulation results --- p.67 / Chapter 6.3.1 --- Analysis for small R --- p.67 / Chapter 6.3.2 --- Analysis for large R --- p.69 / Chapter 6.4 --- Conclusion --- p.69 / Chapter Chapter 7. --- Conclusion --- p.75 / Appendix A. Main program --- p.76 / Appendix B. Derivation of P*(nm，m) and n*(m) --- p.84 / Bibliography --- p.86

Thesis (Master's)--University of California, Berkeley, 1959. / Includes bibliographical references (p. 32-34).

Space radiation and its effects on human life and sensitive equipment are of concern to a safe exploration of space. Radiation fields are modified in quality and quantity by intervening shielding materials. The modification of space radiation by shielding materials is modeled by deterministic transport codes using the Boltzmann transport equation. Databases of cross sections for particle production are needed as input for transport codes. A simple model of nucleon-nucleon interactions is developed and used to derive differential and total cross sections. The validity of the model is verified for proton-proton elastic scattering and applied to delta-resonance production. Additionally, a comprehensive validation program of the nucleus-nucleus fragmentation cross section models NUCFRG2 and QMSFRG is performed. A database of over 300 experiments was assembled and used to compare to model fragmentation cross sections.

Apesar do grande volume de pesquisas e dos avanços da produção in vitro (PIV) de embriões bovinos, a eficiência da técnica ainda está distante do desejável, principalmente quando comparada a embriões produzidos in vivo. A maturação in vitro é etapa importante da PIV, visto que a qualidade dos embriões é dependente da qualidade do oócito e, assim, modificações nas condições de maturação in vitro podem trazer avanços à produção de embriões. A melatonina é um hormônio que foi detectado no fluido folicular de humanos, suínos e, mais recentemente, de bovinos. Ainda, seus receptores foram localizados em oócitos e células da granulosa. Estudos in vitro apontam efeitos benéficos de sua utilização na maturação e cultivo in vitro de oócitos e embriões, embora os resultados sejam por vezes contraditórios. O presente trabalho teve por objetivo avaliar o efeito da melatonina na maturação in vitro (MIV) de oócitos bovinos e também seu potencial como indutor de genes de enzimas antioxidantes e inibidor de fragmentação nuclear em células do cumulus. Para tanto, complexos cumulus-oócitos (CCOs), obtidos de ovários de abatedouro, foram maturados in vitro na presença de melatonina (10-9 e 10-6 M), FSH (controle positivo) ou sem hormônios (controle negativo). As taxas de maturação nuclear foram avaliadas às 6, 12, 18 e 24 horas de cultivo (Experimento 1). No Experimento 2, os mesmos grupos experimentais foram avaliados quanto à abundância relativa de transcritos de genes de enzimas antioxidantes (Cu,ZnSOD, MnSOD e GPx) em oócitos e células do cumulus (24 horas de MIV) por PCR em tempo real. No Experimento 3 foi avaliado o efeito dos tratamentos sobre a fragmentação nuclear em células do cumulus pela técnica de TUNEL e citometria de fluxo (24 horas de MIV). A taxa de maturação avaliada às 6 h de MIV foi de 100% de oócitos imaturos em vesícula germinativa (VG) (P>0,05). Às 12 horas de cultivo foi observado o efeito da melatonina similar ao FSH, variando a proporção de oócitos em metáfase I (MI) de 54,0 a 80,7 % entre os grupos (P<0,05). Após 18 h de MIV observou-se que a maioria dos oócitos já havia atingindo o estádio de metáfase II (MII) variando de 57,2 a 74,2 % (P>0,05). Após 24 h de MIV, observou-se que a maioria dos oócitos atingiu o estádio de MII (50,7 a 89,5%), sendo que a melatonina na maior concentração apresentou efeito similar ao da gonadotrofina (P<0,05). Em relação à expressão de enzimas antioxidantes em oócitos não houve efeito de nenhum tratamento (P>0,05%). Já em células do cumulus houve maior expressão do MnSOD no grupo com FSH em relação ao grupo maturado sem hormônios ou imaturo (P<0,05). A melatonina nas diferentes concentrações apresentou efeito similar ao da gonadotrofina (P>0,05). Transcritos para a enzima Cu,ZnSOD foram mais abundantes em cumulus de CCOs maturados com a maior concentração de melatonina (10-6 M) em relação ao grupo imaturo (P<0,05), não havendo variação nos demais (P>0,05). GPX4 não foi afetado pelos tratamentos (P>0,05). A quantidade de células do cumulus com fragmentação nuclear não foi afetada por nenhum tratamento (33,4 a 41,5/10.000 células; P>0,05) Com base nestes resultados conclui-se que a melatonina nas concentrações avaliadas (10-9 e 10-6 M), embora seja capaz de estimular a maturação nuclear e induzir a expressão de alguns genes antioxidantes em células do bovinas, ainda que de forma semelhante ao FSH, não provocou redução da fragmentação nuclear nestas células. / Nevertheless the great volume of research and the advances in in vitro production (IVP) of bovine embryos, the efficiency of this techinque is still beyond the desireable, specially when compared to embryos produced in vivo. in vitro maturation (IVM) is an important step in IVP, since the quality of embryos is dependent on the quality of oocytes, and, therefore, modifications to in vitro maturation conditions can bring improvements to embryo production. Melatonin is a hormone which has been detected in the folicular fluid of humans, pigs, and more recently, in bovine. Also, its receptores have been identified in oocytes and granulosa cells. Studies in vitro have shown that melatonin may have beneficial effects when used in oocyte maturation and embryo culture, although results are sometimes contradictory. The aim of the present work was to assess the effect of melatonin during IVM on nuclear maturation of bovine oocytes as well as its potential to induce expression of antioxidant enzymes and to reduce nuclear fragmentation in cumulus cells. Cumulus-oocyte comprexes (COCs), obtained from abbattoir ovaries, were matured in vitro in the presence of melatonin (10-9 e 10-6 M), FSH (positive controle) or without hormones (negative control). Maturation rates were evaluated at 6, 12, 18 and 24 h (Experiment 1). In Experiment 2, the same groups were evaluated for the relative abundance of transcripts encoding antioxidant enzymes (Cu,ZnSOD, MnSOD and GPx) in oocytes and cumulus cells (24 h IVM) by real time PCR. In Experiment 3, the effect of treatments on nuclear fragmentation in cumulus cells was determined by TUNEL and flow cytometry (24 h IVM). At 6 h IVM, all oocytes were at immature germinal vesicle (GV) stage. After 12 h of cuture the effect of melatonin was similar to that of FSH, with proportions of oocytes in metaphase I (MI) varying from 54.0 to 80.7% between groups (P>0.05). After 18 h IVM most oocytes had reached metaphase II (MII) stage (57.2 to 74.2%, P>0.05). At 24 h IVM, oocytes were also mostly in MII stage (50.7 to 89.5%), and the highest melatonin concentration was similar to the gonadotrophin (P>0.05). Regarding expression of antioxidant enzymes in oocytes there was no effect of treatments for any of the genes (P>0.05). However, in cumulus cells MnSOD expression was higher in FSH compared with the groups matured without hormones or immature cells (P<0.05). Melatonin in both concentrations were similar to FSH (P>0.05). Transcripts for Cu,ZnSOD were more abundant in cumulus from COCs matured with the highest melatonin concentration (10-6 M) in relation to immature cells (P<0.05), but was not diferent from other groups (P>0.05). GPx was not affected by treatments (P>0.05). The number of nuclear fragmentation in cumulus cells was also not affected by treatments (33.4 to 41.5/10,000 cells; P>0.05). According to these results it is concluded that melatonin is able to induce meiosis resumption in oocytes (10-9 and 10-6 M) and expression of some antioxidant genes in bovine cumulus cells, similar to the effect of FSH, but was ineffective in reducing nuclear fragmentation in these cells.