Spelling suggestions: "subject:"nucleocytoplasmic abtransport"" "subject:"nucleocytoplasmic ortransport""
1 |
RNA-protein interactions of the adenovirus proteins E1B 55K and E4 Orf6Horridge, Jackie J. January 1998 (has links)
No description available.
|
2 |
Characterization of inactive and stress-induced active forms of the transcription factor HSF1 : an analysis at the cellular levelVujanac, Milos January 2000 (has links)
No description available.
|
3 |
Nucleocytoplasmic transport ofmRNA in Saccharomyces cerevisiaeKadowaki, Tatsuhiko January 1994 (has links)
No description available.
|
4 |
The role of Ran-binding protein 3 during influenza A virus replication2014 April 1900 (has links)
Influenza A virus (family Orthomyxoviridae) is one of the most important human pathogens, causing annual epidemics with significant worldwide mortality, and sporadic but potentially devastating pandemics. The influenza A viral genome encodes 14 proteins and consists of 8 segments of negative-stranded RNA. During infection, the virus exploits the host cell signaling machinery to ensure efficient replication. The PI3K/Akt and Ras/ERK are two of the signaling cascades that are induced for virus survival.
Influenza A virus replicates in the nucleus, hence the newly synthesized RNPs must be exported from the nucleus and exported to the cell membrane. Although the detailed mechanism of vRNP nuclear export is not yet fully elucidated, several studies on this process have begun to emerge. Influenza A virus nucleoprotein nuclear export is CRM1-dependent. Ran-binding protein 3 (RanBP3) is a Ran-interacting protein that is best known for its role as a cofactor of CRM1-mediated cargo nuclear export. In this study, we investigated the role of RanBP3 during the influenza A virus life cycle. We found that RanBP3 was phosphorylated at Ser58 in early and late phases of infection. Knockdown of RanBP3 expression led to a vRNP nuclear retention, suggesting that RanBP3 is involved in vRNP nuclear export. Moreover, we demonstrated that RanBP3’s function during vRNP nuclear export is regulated by phosphorylation at Ser58, and the RanBP3 phosphorylation is modulated by both PI3K/Akt and Ras/ERK/RSK pathways in the late phase of viral infection. In conclusion, this study has shown that RanBP3 is a host factor that has a vital role during the late stage of influenza A virus replication, specifically as a co-factor in CRM1-mediated nuclear export. Identifying this host factor will contribute to the understanding of the mechanism of vRNP transport.
|
5 |
Mechanisms of Nuclear Export in Cancer and Resistance to ChemotherapyEl-Tanani, Mohamed, Dakir, El-Habib, Raynor, Bethany, Morgan, Richard 08 March 2016 (has links)
Yes / Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins need a nuclear export signal (NES) to bind to nuclear exportin proteins, including CRM1 (Chromosomal Region Maintenance protein 1), and the energy for this process is provided by the RanGTP/RanGDP gradient. Due to the loss of DNA repair and cell cycle checkpoints, drug resistance is a major problem in cancer treatment, and often an initially successful treatment will fail due to the development of resistance. An important mechanism underlying resistance is nuclear export, and a number of strategies that can prevent nuclear export may reverse resistance. Examples include inhibitors of CRM1, antibodies to the nuclear export signal, and alteration of nuclear pore structure. Each of these are considered in this review.
|
6 |
Sumoylation of Nuclear Transport Receptors and the small GTPase RanSakin, Volkan 22 October 2012 (has links)
No description available.
|
7 |
Identification and Characterization of Importin 13 SubstratesBaade, Imke 07 September 2017 (has links)
No description available.
|
8 |
MS-based quantitative analysis of the CRM1 export pathway and spatial proteomics of the Xenopus laevis oocyteKaraca, Samir 27 October 2014 (has links)
No description available.
|
9 |
Nuclear transport of the androgen receptor /Shank, Leonard Carl. January 2007 (has links)
Thesis (Ph. D.)--University of Virginia, 2007. / Includes bibliographical references. Also available online through Digital Dissertations.
|
10 |
Structural and functional investigation of cargo recognition by exportinsAksu, Metin 17 November 2015 (has links)
No description available.
|
Page generated in 0.0774 seconds