Background: As the population grows older and hard-to-heal wounds are more likely to affect the elderly and frail, it has become a growing global problem. It involves high costs, is resource consuming and suffering for the patient due to long treatment times. About 1–2 percent of the population in well-developed countries suffer from a hard-to-heal wound at some point during their lifetime. Aim: The aim of this study was to highlight nurses' knowledge and experiences of caring for patients with hard-to-heal wounds. Method: A literature review was conducted and data was collected from twelve scientific articles with both qualitative and quantitative methods. Fribergs three-step model was used to analyze the twelve articles. Results: The result presents three main themes and seven subthemes that describes nurses' knowledge and experiences of hard-to-heal wounds. Nurses' knowledge of wound care and hard-to-heal wounds is inadequate and further education is needed. Varying emotions were felt by the nurses, such as happiness, satisfaction, frustration and disempowerment.  Conclusion: More knowledge, training and experience in wound care and hard-to-heal wounds is needed to help nurses feel more confident to provide appropriate wound care.