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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.068 seconds)

Spelling suggestions: "subject:"desmethyltramadol"" "subject:"demethyltramadol""

1

Tramadol in the elderly : pharmacokinetic and pharmacodynamic modelling in healthy young and elderly subjects

Skinner-Robertson, Sybil 01 1900 (has links)
No description available.
Tramadol
O-desmethyltramadol
enantiomer
non-compartmental analysis
population pharmacokinetics
population pharmacodynamics
PK/PD
pain tolerance threshold
elderly
geriatric
pain
Énantiomère
Analyse non compartimentale
Analyse populationnel pharmacocinétique
Seuil de tolérance de douleur
Personnes âgées
Gériatrique
Douleur
2

Využití hmotnostní spektrometrie pro analýzu biologicky aktivních a klinicky významných látek. / Application of Mass Spectrometry for Analysis of Biologically Active and Clinically Significant Compounds.

Štícha, Martin January 2016 (has links)
- 8 - ABSTRACT (EN) The thesis is submitted as a commented set of reviewed publications documenting and depicting the possibilities of mass spectrometry in the field of chemical, biological and pharmaceutical research; namely for the purposes of structure elucidation of selected organometallic complexes, analyses of drugs and their metabolites, monitoring of important biological markers. In course of experimental work, the following objectives were studied and solved:  Proposal and realization of micro-scale preparation of selected rhenium complexes with aromatic ligands, utilizing tetrabutyammonium tetrachlorooxorhenate as a starting material; preparation and structure characterization of oxorhenium(V) complexes with 1,2-dihydroxybenzene, 1,2,3-trihydroxybenzene, and 2,3- dihydroxynaphtalene as ligands by means of ESI/MS, APPI/MS and LDI-MS; ESI/MS and UV/Vis study of kinetic behavior of complexes arising from the reaction of tetrabutylamonnium tetrachlooxorhenate with pyrogallol and catechol as ligands. Special aim was devoted to the study of subsequent chemical transformation of primarily formed Re(V) complexes; structure characterization of selected ferrocene complexes with copper, gold and silver by means of ESI/MS.  Proposal of methodology of structure characterization and quantification of the...

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