Global ETD Search

41	The cooperation of the tumor suppressor gene Dlc1 and the oncogene Kras in tumorigenesis Buse, Cordula 25 October 2012 (has links) This thesis investigated the cooperation of the Kras2 oncogene with the tumor suppressor gene Dlc1 in lung tumor development. Dlc1 is a negative regulator of RhoGTPase proteins, which are mainly involved in the regulation of the actin cytoskeleton and cell migration. We hypothesized that loss of Dlc1 expression leads to more aggressive tumors, which should also result in increased incidence of metastasis. All experiments were performed in mice containing a heterozygous oncogenic Kras allele and a heterozygous gene trapped Dlc1 allele (KD) and in mice only carrying the oncogenic Kras allele (K+). Throughout all experiments we have consistently found no significant differences between the two groups in terms of tumor burden (tumor numbers, sizes and areas), metastases or methylation patterns. These results suggest that heterozygous downregulation of Dlc1 is not enough to increase tumor formation and metastasis development in the Kras lung tumors. lung cancer mouse model Kras Dlc1 oncogene tumor suppressor
42	The cooperation of the tumor suppressor gene Dlc1 and the oncogene Kras in tumorigenesis Buse, Cordula 25 October 2012 (has links) This thesis investigated the cooperation of the Kras2 oncogene with the tumor suppressor gene Dlc1 in lung tumor development. Dlc1 is a negative regulator of RhoGTPase proteins, which are mainly involved in the regulation of the actin cytoskeleton and cell migration. We hypothesized that loss of Dlc1 expression leads to more aggressive tumors, which should also result in increased incidence of metastasis. All experiments were performed in mice containing a heterozygous oncogenic Kras allele and a heterozygous gene trapped Dlc1 allele (KD) and in mice only carrying the oncogenic Kras allele (K+). Throughout all experiments we have consistently found no significant differences between the two groups in terms of tumor burden (tumor numbers, sizes and areas), metastases or methylation patterns. These results suggest that heterozygous downregulation of Dlc1 is not enough to increase tumor formation and metastasis development in the Kras lung tumors. lung cancer mouse model Kras Dlc1 oncogene tumor suppressor
43	Regulation of the human heme oxygenase-1 gene Hock, Thomas D. January 2007 (has links) (PDF) Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb. 7, 2008). Includes bibliographical references (p. 50-57).
44	Human papillomavirus tropism : determinants of viral tissue specificity / Mistry, Nitesh, January 2007 (has links) Diss. (sammanfattning) Umeå : Univ., 2007. / Härtill 4 uppsatser.
45	Functional proteomic study of Akt reveals novel substrates in translation / Yan, Weisi. January 2008 (has links) Thesis (Ph. D.)--Cornell University, August, 2008. / Vita. Includes bibliographical references (leaves 150-182).
46	Extra-telomeric function of telomerase and it's [sic] regulation by the AKT pathway in prostate cancer a dissertation / Ruparel, Shivani Bharat. January 2008 (has links) Dissertation (Ph.D.).--University of Texas Graduate School of Biomedical Sciences at San Antonio, 2008. / Vita. Includes bibliographical references.
47	Rapid induction of B-cell lymphomas : Insertional activation of thec-myb proto-oncogene / Kanter, Madge Ruth. January 1989 (has links) Thesis (Ph. D.)--Cornell University, 1989. / Vita. Includes bibliographical references.
48	Regulation of protein synthesis and induction of oncogenesis by a cellular protein kinase inhibitor / Tang, Norina Mei Ngon. January 1998 (has links) Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [135]-147).
49	Regulation of LASU1-mediated Mcl-1 degradation and its roles in apoptosis Warr, Matthew R., January 1900 (has links) Thesis (Ph.D.). / Written for the Dept. of Biochemistry. Title from title page of PDF (viewed 2009/06/11). Includes bibliographical references.
50	Investigation of the mechanism by which the human papillomavirus type-16 E6 oncoprotein induces telomerase in epithelial cells / Gewin, Lindy Carol, January 2004 (has links) Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 77-92).

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