在行列設計(row-column design)的架構下，當行總和與列總和皆為總試驗處理數的倍數時，我們考慮行效果與列效果的相互比較之最適性。延續Shah和Sinha(1993)的結果，在給定行總和及列總和的情況下，我們導出達成齊一最適設計(uniformly optimal design)的充分條件。此外，當總實驗單位固定時，達成全域最適設計(universally optimal design)的充分條件亦被求出。我們同時列舉許多相關的設計排列法。 / We consider the problem of comparing row effects and column effects in the row-column design setup when the row sizes and column sizes are all multiples of the number of treatments. Following the work of Shah and Sinha (1993), we derive a sufficient condition for uniformly optimal designs for given values of the row sizes and column sizes. We also derive a sufficient condition for universally optimal designs when the total number of experimental units is fixed. Several examples of designs with high efficiencies are provided.

Cheng and Wu (2001) introduced a method for response surface exploration using only one design by using a 3-level design to first screen a large number of factors and then project onto the significant factors to perform response surface exploration. Previous work generally involved selecting designs based on projection properties first and aliasing structure second. However, having good projection properties is of little concern if the correct factors cannot be identified. We apply Jones and Nachtsheim’s (2009) method for finding optimal designs with minimal aliasing to find 18, 27, and 30-run designs to use for single-step screening and optimization. Our designs have better factor screening capabilities than the designs of Cheng and Wu (2001) and Xu et al. (2004), while maintaining similar D-efficiencies and allowing all projections to fit a full second order model.

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 98-101).

abstract: Generalized Linear Models (GLMs) are widely used for modeling responses with non-normal error distributions. When the values of the covariates in such models are controllable, finding an optimal (or at least efficient) design could greatly facilitate the work of collecting and analyzing data. In fact, many theoretical results are obtained on a case-by-case basis, while in other situations, researchers also rely heavily on computational tools for design selection. Three topics are investigated in this dissertation with each one focusing on one type of GLMs. Topic I considers GLMs with factorial effects and one continuous covariate. Factors can have interactions among each other and there is no restriction on the possible values of the continuous covariate. The locally D-optimal design structures for such models are identified and results for obtaining smaller optimal designs using orthogonal arrays (OAs) are presented. Topic II considers GLMs with multiple covariates under the assumptions that all but one covariate are bounded within specified intervals and interaction effects among those bounded covariates may also exist. An explicit formula for D-optimal designs is derived and OA-based smaller D-optimal designs for models with one or two two-factor interactions are also constructed. Topic III considers multiple-covariate logistic models. All covariates are nonnegative and there is no interaction among them. Two types of D-optimal design structures are identified and their global D-optimality is proved using the celebrated equivalence theorem. / Dissertation/Thesis / Doctoral Dissertation Statistics 2018

In this work, we introduce the Sensitivity Equation Method (SEM) as a method for approximately solving infinite dimensional optimal design problems. The SEM couples a trust-region/quasi-Newton optimization algorithm with gradient information provided by apprOXimately solving the sensitivity equation for (design) sensitivities. The sensitivity equation is (in the problems considered here) a partial differential equation (POE) which describes the influence of a design parameter on the state of the system. It is shown that obtaining design sensitivities from the sensitivity equation has advantages over finite difference and semi-analytical methods in that there is no need to remesh or compute mesh sensitivities (even if the domain is parameter dependent), the sensitivity equation is a linear POE for the sensitivities and can be approximated in an efficient manner using the same approximation scheme used to approximate the states. The applicability of the SEM to shape optimization problems, where the state is described by the Euler equations, is studied in detail. In particular, we prove convergence of the method for a one dimensional test problem. These results are used to speculate on the applicability of the method for more complex problems. Finally. we solve a two dimensional forebody simulator design problem (for use in wind tunnel experiments) using the SEM, which is shown to be a very efficient method for this problem. / Ph. D.

This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. In order to obtain precise parameter estimates it is important to choose efficient estimation approaches and to use optimal designs to control the level of the doses administered to the patients in the study. We provide some optimal designs that are efficient for estimating the parameters, a subset of the parameters, and a function of the parameters in multi-response Emax models. The function of interest is an estimate of the best dose to administer to a group of patients. More specifically the dose that maximizes the Clinical Utility Index (CUI) which assesses the net benefit of a drug taking both effects and side-effects into account. The designs derived in this thesis are locally optimal, that is they depend upon the true parameter values. An important part of this thesis is to study how sensitive the optimal designs are to misspecification of prior parameter values. For multi-response Emax models it is possible to derive maximum likelihood (ML) estimates separately for the parameters in each dose response relation. However, ML estimation can also be carried out simultaneously for all response profiles by making use of dependencies between the profiles (system estimation). In this thesis we compare the performance of these two approaches by using a simulation study where a bivariate Emax model is fitted and by fitting a four dimensional Emax model to real dose response data. The results are that system estimation can substantially increase the precision of parameter estimates, especially when the correlation between response profiles is strong or when the study has not been designed in an efficient way. / <p>At the time of the doctoral defence the following papers were unpublished and had a status as follows: Paper 1: Manuscript; Paper 2: Manuscript; Paper 3: Manuscript; Paper 4: Manuscript.</p>

Two-level factorial experiments are widely used in experimental design because they are simple to construct and interpret while also being efficient. However, full factorial designs for many factors can quickly become inefficient, time consuming, or expensive and therefore fractional factorial designs are sometimes preferable since they provide information on effects of interest and can be performed in fewer experimental runs. The disadvantage of using these designs is that when using fewer experimental runs, information about effects of interest is sometimes lost. Although there are methods for selecting fractional designs so that the number of runs is minimized while the amount of information provided is maximized, sometimes the design must be augmented with a follow-up experiment to resolve ambiguities. Using a fractional factorial design augmented with an optimal follow-up design allows for many factors to be studied using only a small number of additional experimental runs, compared to the full factorial design, without a loss in the amount of information that can be gained about the effects of interest. This thesis looks at discovering regularities in the number of follow-up runs that are needed to estimate all aliased effects in the model of interest for 4-, 5-, 6-, and 7-factor resolution III and IV fractional factorial experiments. From this research it was determined that for all of the resolution IV designs, four or fewer (typically three) augmented runs would estimate all of the aliased effects in the model of interest. In comparison, all of the resolution III designs required seven or eight follow-up runs to estimate all of the aliased effects of interest. It was determined that D-optimal follow-up experiments were significantly better with respect to run size economy versus fold-over and semi-foldover designs for (i) resolution IV designs and (ii) designs with larger run sizes.

Zhang Chongqi. / "November 2001." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (p. 127-141). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Thesis (Ph. D.)--University of Sydney, 2009. / Title from title screen (viewed May 1, 2009) Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy Economics to the Faculty of Economics and Business, University of Sydney. Degree awarded 2009; thesis submitted 2008. Bibliography: leaves 93-97. Also available in print form.

Thesis advisor: Dale Zimmerman. Includes bibliographic references (p. 81-82).