Thesis (Ph. D.)--Virginia Commonwealth University, 2010. / Prepared for: Dept. of Human Genetics. Title from title-page of electronic thesis. Bibliography: leaves 121-137.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2006. / Samuel C. Dudley, Jr., Committee Chair ; Hanjoong Jo, Committee Member ; W. Robert Taylor, Committee Member.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2010. / Härtill 4 uppsatser.

Thesis (Ph. D.)--University of North Carolina at Greensboro, 2006. / Title from PDF title page screen. Advisor: Allan H. Goldfarb; submitted to the School of Health and Human Performance. Includes bibliographical references (p. 108-128).

Thesis (M.S.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains xii, 78 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 66-71).

Thesis (Ph. D.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains vii, 112 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

Thesis (M. Sc.)--University of Canterbury, 2006. / Typescript (photocopy). Includes bibliographical references (leaves 106-121). Also available via the World Wide Web.

Thesis (M. Sc.)(Biochemistry)--University of Pretoria, 2006. / Includes bibliographical references. Available on the Internet via the World Wide Web.

Made available in DSpace on 2014-06-11T19:23:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-17Bitstream added on 2014-06-13T20:30:19Z : No. of bitstreams: 1 rosa_cm_me_botfm.pdf: 421685 bytes, checksum: 8ab7d9072fdd2da70c93b14479d83cde (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / As doenças cardiovasculares (DCV) são responsáveis por alta taxa de morbidade e mortalidade, tanto em países desenvolvidos como em desenvolvimento e, com o envelhecimento da população, a prevalência de seus fatores de risco está aumentando em ritmo alarmante. A hipertensão arterial sistêmica (HA5) e o diabetes mellitus (DM) estão entre os principais fatores de risco para o desenvolvimento das DCVe, quando associados, aumentam o risco de lesões orgânicas e morte cardiovascular. No entanto, poucos estudos têm analisado a influência do DM sobre o coração de portadores de HA5, e os resultados são controversos. Além disso, não é do nosso conhecimento estudos experimentais no modelo de DM em animais idosos. Considerando essas questões, o objetivo foi analisar a influência do DM sobre a remodelação ventricular e o estresse oxidativo em ratos senescentes espontaneamente hipertensos. Ratos espontâneamente hipertensos (5 HR), machos, com 18 meses de idade, foram divididos em dois grupos: 5HR-Controle (5HR-CTL, n=30) e 5HR-Diabético (5HR-DM, n=50). O DM foi induzido por meio de administração intraperitoneal de estreptozotocina (4-0 mg(kg). O consumo diário de ração e água e o peso corpóreo semanal foram medidos. A avaliação estrutural e funcional in vivo do coração foi realizada por meio do ecocardiograma. O estudo funcional in vitro foi realizado pela técnica do músculo papilar do ventrículo esquerdo (VE). Para análise estrutural in vitro, foram medidos os pesos do VE, ventrículo direito e átrios. Amostras dessas estruturas, do fígado e do pulmão foram utilizadas para o cálculo da razão peso úmido(peso seco desses órgãos. Amostras do VE foram obtidas para medir o diâmetro dos miócitos, a área ocupada pelo colágeno e a concentração de hidroxiprolina. O estresse oxidativo foi avaliado pela dosagem da concentração... / Cardiovascular diseases (CVD) are responsible for high morbidity and mortality rate in both developed and developing countries. with the population aging, the prevalence of CVD risk factors is increasing at alarming rate. Arterial hypertension (AH) and diabetes mellitus (DM) are major risk factors for development of CVD, and when combined increase the risk of organ damage and cardiovascular death. However, few studies have examined the inf1uence of diabetes on the heart of hypertensive patients, and the results are controversial. Moreover, to the best of our knowledge, there is no study in the animal model of DMin the elderly. Therefore, the aim of this study was to analyze the inf1uence of diabetes on ventricular remodeling and oxidative stress m senescent spontaneously hypertensive rats. Methods: Eighteen-month old male spontaneously hypertensive rats (SHR) were divided into two groups: SHR-Control (5HR-CTL, n==30) and SHR-Diabetic (SHR-DM, n==50). DM was induced by intraperitoneal administration of streptozotocin (40 mg(kg). Daily consumption of food and water and weekly body weight were measured. In vivo cardiac structural and functional parameters were measured by echocardiography. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscles. LV,right ventricle, and atria weights were measured. Samples of these structures, liver, and lung were used to calculate the wetfdry weight ratio. LV samples were obtained to measure myocyte diameters, collagen fractional area, and hydroxyproline concentration. Oxidative stress was assessed by measuring lipid hydroperoxide concentration and superoxide dismutase and glutathione peroxidase activities, in LV tissue and serum. Comparisons between groups were performed by unpaired Student's t test 01' Mann-whítney test, according to normal 01' non-normal distribution, respectively... (Complete abstract click electronic access below)