Made available in DSpace on 2014-06-12T17:35:15Z (GMT). No. of bitstreams: 2 arquivo2204_1.pdf: 2245942 bytes, checksum: df0b37ff2780747f33cf10015d9e5bc6 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O objeto de estudo dessa dissertação são os processos de licenciamento de Pólos Geradores de Viagens PGVs.. São enfocados os aspectos legais e técnicos que os analistas dispõem atualmente para emitir os pareceres técnicos na aprovação e licenciamento de empreendimentos considerados de impacto principalmente a análise visando a atração e geração de viagens. Considerado um processo administrativo, os licenciamentos de PGVs devem obedecer os princípios fundamentais da legalidade, da impessoalidade, da moralidade da publicidade e da eficiência (Brasil, 1988). Este trabalho se propõe a contribuir com o processo administrativo municipal de licenciamento de PGVs diante da diversidade de empreendimentos que podem ser classificados como PGVs, da crescente demanda de processos de licenciamento nas instâncias municipais competentes e na observação direta de atividades que se instalam sem que aparentemente essas medidas mínimas sejam cumpridas.A pesquisa empírica foi baseada no estudo de caso de licenciamento de PGVs em Recife-PE. Para coleta de dados foram utilizados os instrumentos de entrevistas e questionários bem como colhidas informações em documentos oficiais, legislação aplicada e em registros de tramitação de processos de empreendimentos de impacto.Os resultados apontam que apesar da legislação ser criteriosa e detalhada a mesma não encontra respaldo técnico e organizacional por parte do órgão gestor para sua aplicação. Não há instrução de procedimentos administrativos nem rotinas pré-estabelecidas para análise do processo, sendo os mesmos adotados pelos técnicos, por experiência própria Não foi verificado ainda o estabelecimento de prazo para tramitação de processos de análise especial de PGV. Não existe instrumento de acompanhamento após a implantação do empreendimento

Gear drives are widely applied in mechanical transmission systems and very accurate transmission systems are needed. In the robot industry, the planetary gear train (PGT) is commonly used to promote the torque transmission. One of the advantages of an ideal PGT is that the incoming torque is divided equally among the planet gear wheels. However, different manufacturing and assembling deviations may cause uneven load distributions. This is a serious problem that affects the load capacity and the stability of the torque transmission.SwePart has designed and patented a planetary gear blazing for very high-accuracy robots and zero gaps in the gear maintained during its operating time [25]. The purpose of this project is to determine how deviations such as pitch deviation and stiffness affect the magnitude of the contact forces acting on gear teeth from the ideal geometry.In order to model the ideal geometry, an inspection of the SwePart’s gears was needed. By using SOLIDWORKS, the common normal line which is perpendicular to the teeth profiles can be defined. This means that the base circle which is tangential to that common normal line can also be found.The gear profiles of the PGTs in this study were created using the software MATLAB based on the parametric equation of involute of the base circle. The data generated by MATLAB were then used to create 3D models of the PGTs in SOLIDWORKS. The gears were split into 2N+1 parts if the number of teeth is N, since different magnitude of the pitch deviations needs to be studied. It is more informative to compare the magnitude of contact forces acting on each half tooth.When the gears which are similar to the SwePart’s gears were finished, the x_t document was exported from SOLIDWORKS and imported into MSC_ADAMS to make the simulations. After that the materials were defined in the model and contact forces were added between teeth of the planetary gear and the ring gear. The magnitude of the contact forces acting on the rigid and flexible gear teeth were then compared. So, MSC_ADAMS needs to be used to mesh the rigid bodies to the flexible ones automatically by calling MSC_Nastran.MATLAB was used to compare the results and graphs from different ADAMS models.

In ruminants, prostaglandin F2 alpha (PGF2α) is released from the endometrium in a pulsatile pattern at the time of luteolysis. The luteolytic PGF2α pulses are transported from the uterus to the corpus luteum (CL) through the utero-ovarian plexus (UOP) to cause luteolysis. At the time of establishment of pregnancy, interferon tau (IFNT) secreted by the conceptus suppresses the pulsatile release of PGF2α and thereby rescues the CL and maintains its secretion of progesterone. However, basal concentrations of PGF2α are higher in pregnant ewes than in cyclic ewes. The pulsatile release of PGF2α likely requires selective carrier-mediated transport and cannot be supported by a simple diffusion mechanism. The molecular and functional aspects of carrier mediated transport of PGF2α from the uterus to the ovary through the utero- ovarian plexus (UOP) at the time of luteolysis and recognition/establishment of pregnancy are largely unknown ruminants. Results indicate that intrauterine inhibition of (PGT) prevents the pulsatile release of PGF2α independently of spatial expressions of estrogen receptor (ESR-1) and oxytocin receptor (OXTR) proteins by the endometrium at the time of luteolysis in sheep. PGT protein is expressed in the UOP during the estrous cycle and pharmacological inhibition of PGT prevents transport of luteolytic PGF2α pulse through the UOP in sheep. IFNT activates novel JAK-SRC-EGFR-RAS-RAF-ERK1/2-EGR-1 signaling modules in endometrial luminal epithelial (LE) cells and regulates PGT- mediated release of PGF2α through these novel cell-signaling pathways. IFNT stimulates ERK1/2 pathways in endometrial LE cells and inhibition of ERK1/2 inhibits IFNT action and restores spatial expression of OXTR and ESR-1 proteins in endometrial LE cells and restores endometrial luteolytic pulses of PGF2α in sheep. Collectively, the results of the present study provide the first evidence to indicate that transport of endometrial luteolytic PGF2α pulses from the uterus to the ovary through the UOP is controlled by a PGT-mediated mechanism in sheep, new mechanistic insight into molecular mechanisms regulating cellular and compartmental transport of PGF2α at the time of luteolysis, and new mechanistic understanding of IFNT action and release of PGF2α from the endometrial LE cells and thus opens a new arena of research in IFNT signaling and PGT function.

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Plant secondary products such as flavonoids have a variety of roles in plants including UV protection, antifeedant activity, pollinator attraction, stress response, flavor, and many more. These compounds also have effects on human physiology. Glucosylation is an important modification of many flavonoids and other plant secondary products. In grapefruit, glucosylation is important in the synthesis of the bitter compound naringin and several flavonoid glucosyltransferase (GT) enzymes have been characterized from young grapefruit leaf tissue. To study structure and function of flavonoid GTs, it is necessary to isolate cDNA’s that can be cloned and manipulated. In prior work, the plant secondary product glucosyltransferase (PSPG) box was used to identify putative GT clones. We report on results from experiments to test the hypothesis that PGT clones 4 and 11 are plant secondary product GTs, specifically flavonoid GTs. Previously, PGT 4 was cloned into a bacterial expression system, however all protein was localized into inclusion bodies and GT activity could not be tested. For this work, recombinant PGT 4 and PGT 11 were transformed into yeast and the proteins expressed and screened for glucosyltransferase activity with a variety of flavonoid substrates including flavanones, flavones, and flavonols.