Cette thèse porte sur la modélisation, l'analyse et la réduction de modèles biologiques, notamment de réseaux de régulation génique chez la bactérie E. coli. Différentes approches mathématiques sont utilisées. Dans la 1ère partie de la thèse, on modélise, analyse et réduit avec des outils classiques un modèle de transcription-traduction de grande dimension de l'ARN polymérase (RNAP) chez E. coli. Dans la 2de partie, l'introduction d'une nouvelle méthode appelée Analyse de Processus Principaux (PPA) nous permet d'analyser des modèles de haute dimension, en les décomposant en processus biologiques dont l'activité est évaluée pendant l'évolution du système. L'exclusion des processus inactifs réduit la dynamique du modèle à ses principaux mécanismes. La méthode est appliquée à des modèles d'horloge circadienne, de toxicologie endocrine et de voie de signalisation ; on teste également sa robustesse aux variations des conditions initiales et des paramètres. Dans la 3ème partie, on présente un modèle ODE de la machinerie d'expression génique de cellules d'E. coli dont la croissance est contrôlée par un inducteur de la synthèse de RNAP. On décrit notre contribution au développement du modèle et analyse par PPA les mécanismes essentiels du réseau de régulation. Dans une dernière partie, on modélise spécifiquement la réponse de RNAP à l'ajout d'inducteur et estime les paramètres du modèle à partir de données de cellules individuelles. On discute l'importance de considérer la variabilité entre cellules pour modéliser ce processus : ainsi, la moyenne des calibrations sur chaque cellule apparaît mieux représenter les données moyennes observées que la calibration de la cellule moyenne. / This thesis deals with modeling, analysis and reduction of various biological models, with a focus on gene regulatory networks in the bacterium E. coli. Different mathematical approaches are used. In the first part of the thesis, we model, analyze and reduce, using classical tools, a high-dimensional transcription-translation model of RNA polymerase in E. coli. In the second part, we introduce a novel method called Principal Process Analysis (PPA) that allows the analysis of high-dimensional models, by decomposing them into biologically meaningful processes, whose activity or inactivity is evaluated during the time evolution of the system. Exclusion of processes that are always inactive, and inactive in one or several time windows, allows to reduce the complex dynamics of the model to its core mechanisms. The method is applied to models of circadian clock, endocrine toxicology and signaling pathway; its robustness with respect to variations of the initial conditions and parameter values is also tested. In the third part, we present an ODE model of the gene expression machinery of E. coli cells, whose growth is controlled by an external inducer acting on the synthesis of RNA polymerase. We describe our contribution to the design of the model and analyze with PPA the core mechanisms of the regulatory network. In the last part, we specifically model the response of RNA polymerase to the addition of external inducer and estimate model parameters from single-cell data. We discuss the importance of considering cell-to-cell variability for modeling this process: we show that the mean of single-cell fits represents the observed average data better than an average-cell fit.

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This thesis engages in process modelling and description of selected business processes which are underway in the department of Economy and Operation of the Czech TV, in Television studio in Brno. The process models are created using the CASE tool Adonis. The theoretical part is focused on clarifying important concepts, methodologies and tools in the process management. In the analytical part, the selected processes are thoroughly described and graphically illustrated. The proposal part of the thesis highlights the improvement of selected business processes and assesses their effectiveness.

A thesis deals with the assessment of the information system in an engineering company, the assessment of its efficiency and the proposal of the ICT modification to improve this system. Furthermore, the thesis deals with the proposal of the information system changes in the company and the elimination of the risks related to these changes. An analytical part also deals with the company analysis, the analysis of the company processes and the analysis of the current information system. .

The object of my master’s thesis is the analysis and design of an information system for the company SAP ČR spol. s r.o., which will facilitate the process of monitoring the development of Fiori applications. The work contains a theoretical background, as a basis for processing analyses that are focused on the user. The following is the design of the information system, which helps to improve the company's internal processes.

The diploma thesis is devoted to the process analysis of realization educational programs and their optimization. The theoretical section is focused on educational programs, educational policy EU concept, process questions and connected notions. The analytical part researches implementation processes of educational programs, international activities analysis of Faculty of business, bilateral contracts and questionnaire survey. Knowledge of the analytical part is used in the proposal part, where results of the research are evaluated and drawn up procedures to improve processes. Proposals and disposals leading to increasing student´s participation and process optimization were compiled on the basis of gained information about Faculty of business and they respect educational concept of European Union.

The aim of this diploma thesis is to create and apply a methodology to improve the manufacturing process. Processes for the passage of a contract through the company and activities of the foreman were analyzed. According to this analysis, a methodology was created for continuous improvement of the manufacturing process. This methodology was applied to the data obtained in the analysis. Based on the application of the methodology, actions have been proposed to improve the production process.

This master's thesis deals with process management, especially the general principles that lead to improvements in company processes. It's looking for methods to facilitate the identification and description processes. There are those applications that have just the identification and description of the process easier. Following is a description of the practical implementation of this application to Microsoft SharePoint.

This diploma thesis deals with business process simplification. Basic terms like business or process are defined in the theoretical part of the thesis as well as selected methods of business management such as TPS, KAIZEN, 5S, Six Sigma, etc. The principal concept for this work is described in the second chapter. It’s very important to simplify things and work, which means to identify the essential parts and eliminate the rest (waste). The practical part describes company Kuličkové šrouby Kuřim, a.s. (KSK) and the study of individual processes and impacts upon them. Further on, several process simplifications from various parts of the company are presented. Each individual case is described and analysed.

Master´s thesis is focused on problems of optimizing of industry processes. Main objective was to analyze a company and project a improvement of industry process with costs saving. In the first part are recapitulated a generic knowledge about approaches of improving of industry processes. Second part is engaged in analyze of company ORTHPOM bratři Škodové spol. s r.o.. In the fine chapter is presented concept of revisions in industry process and possibilities of other optimalizations.