The Kiruna mining district, located in the northern Norrbotten ore province, Sweden, is a geologically and economically important area, being the type-locality for Kiruna iron oxide-apatite (IOA) deposits and also host to a variety of other deposits including syngenetic stratiform exhalative Cu-(Fe-Zn) (Viscaria, Eastern Pahtohavare), epigenetic stratabound Cu ± Au (Pahtohavare), and iron oxide-copper-gold (IOCG, Rakkurijärvi) deposits. However, the timing of IOA versus IOCG within the tectonic evolution is in question based on structural investigations showing Cu- and Fe-sulfides occur in late-orogenic structures. Here we use an established tectonic framework to constrain mineral systems (tectonic/thermal drives, metal and ligand sources, fluid pathways, traps, remobilization mechanisms) related to the early and late phases of the Svecokarelian orogeny in the Kiruna mining district. U-Pb zircon geochronology of intrusions in the district indicates a thermal drive was present during the early phase of the Svecokarelian orogeny from ca. 1920-1865 Ma, however remains enigmatic for the late Svecokarelian orogeny. Zircon grains from a magnetite-ilmenite gabbro yielded an age of 1881 ± 8 Ma, coeval with the Kiirunavaara IOA deposit and suggested to represent an important generation of mafic magmatism related to the ore. Lithogeochemistry of early bimodal Svecokarelian intrusions in the district indicates a within-plate to active continental margin environment with a volcanic arc affinity, pointing to a back arc environment. Epsilon Ndi and 87Sr/86Sri values calculated from the U-Pb ages for the igneous intrusions were compared to samples of ore-related alteration from epigenetic Pahtohavare and Rakkurijärvi deposits, district greenstone, and Archean samples. Results show that each deposit sourced Sr and Nd from a variety of rocks suggesting broad fluid transport. Each deposit has a distinct Sr mixing trend suggesting they formed from different ore-forming fluids and pathways. This is supported by new structural data that constrain the folding event and the ore-related quartz-carbonate-sulfide veins in the Pahtohavare area to a late orogenic timing, compared to the early orogenic timing of Rakkurijärvi. Sulfide trace element and sulfur isotope data from structurally constrained ores within the tectonic framework also record distinct characteristics between early and late deposits. However, remobilization of early Pahtohavare sulfides associated to an increase in Co content and heavier sulfur isotope compositions is recorded. The results of this study illustrate that using a structural framework approach to constrain the ingredients of mineral systems is a powerful strategy for interpreting ore deposit processes in tectonically complex terrains where both IOA and IOCG deposits occur.