In den vergangenen Jahren ist die Untersuchung des Risikomanagements vom Baselkomitee angeregt, um die Kredit- und Bankwesen regelmäßig zu aufsichten. Für viele multivariate Risikomanagementmethoden gibt es jedoch Beschränkungen von: 1) verlässt sich die Kovarianzschätzung auf eine zeitunabhängige Form, 2) die Modelle beruhen auf eine unrealistischen Verteilungsannahme und 3) numerische Problem, die bei hochdimensionalen Daten auftreten. Es ist das primäre Ziel dieser Doktorarbeit, präzise und schnelle Methoden vorzuschlagen, die diesen Beschränkungen überwinden. Die Grundidee besteht darin, zuerst aus einer hochdimensionalen Zeitreihe die stochastisch unabhängigen Komponenten (IC) zu extrahieren und dann die Verteilungsparameter der resultierenden IC beruhend auf eindimensionale Heavy-Tailed Verteilungsannahme zu identifizieren. Genauer gesagt werden zwei lokale parametrische Methoden verwendet, um den Varianzprozess jeder IC zu schätzen, das lokale Moving Window Average (MVA) Methode und das lokale Exponential Smoothing (ES) Methode. Diese Schätzungen beruhen auf der realistischen Annahme, dass die IC Generalized Hyperbolic (GH) verteilt sind. Die Berechnung ist schneller und erreicht eine höhere Genauigkeit als viele bekannte Risikomanagementmethoden. / Over recent years, study on risk management has been prompted by the Basel committee for the requirement of regular banking supervisory. There are however limitations of many risk management methods: 1) covariance estimation relies on a time-invariant form, 2) models are based on unrealistic distributional assumption and 3) numerical problems appear when applied to high-dimensional portfolios. The primary aim of this dissertation is to propose adaptive methods that overcome these limitations and can accurately and fast measure risk exposures of multivariate portfolios. The basic idea is to first retrieve out of high-dimensional time series stochastically independent components (ICs) and then identify the distributional behavior of every resulting IC in univariate space. To be more specific, two local parametric approaches, local moving window average (MWA) method and local exponential smoothing (ES) method, are used to estimate the volatility process of every IC under the heavy-tailed distributional assumption, namely ICs are generalized hyperbolic (GH) distributed. By doing so, it speeds up the computation of risk measures and achieves much better accuracy than many popular risk management methods.

Modern medical practice and science involve complex phenotypic definitions. Understanding patterns of association across this range of phenotypes requires co-analysis of high-dimensional association studies in order to characterise shared and distinct elements. In this thesis I address several problems in this area, with a general linking aim of making more efficient use of available data. The main application of these methods is in the analysis of genome-wide association studies (GWAS) and similar studies. Firstly, I developed methodology for a Bayesian conditional false discovery rate (cFDR) for levering GWAS results using summary statistics from a related disease. I extended an existing method to enable a shared control design, increasing power and applicability, and developed an approximate bound on false-discovery rate (FDR) for the procedure. Using the new method I identified several new variant-disease associations. I then developed a second application of shared control design in the context of study replication, enabling improvement in power at the cost of changing the spectrum of sensitivity to systematic errors in study cohorts. This has application in studies on rare diseases or in between-case analyses. I then developed a method for partially characterising heterogeneity within a disease by modelling the bivariate distribution of case-control and within-case effect sizes. Using an adaptation of a likelihood-ratio test, this allows an assessment to be made of whether disease heterogeneity corresponds to differences in disease pathology. I applied this method to a range of simulated and real datasets, enabling insight into the cause of heterogeneity in autoantibody positivity in type 1 diabetes (T1D). Finally, I investigated the relation of subtypes of juvenile idiopathic arthritis (JIA) to adult diseases, using modified genetic risk scores and linear discriminants in a penalised regression framework. The contribution of this thesis is in a range of methodological developments in the analysis of high-dimensional association study comparison. Methods such as these will have wide application in the analysis of GWAS and similar areas, particularly in the development of stratified medicine.

This thesis deals with oportunity of ROC curve usage in the description of methods that work with sound signals. Specifically, it focuses on ways of detecting of stress in speech signals. The detection itselfs is done in a range of frequencies of the sound signal. There is also a classifier designed using ROC curves that decides whether the input signal is stressed or not. The output of this thesis are findings gathered from analyses and also some recommendation based on those analyses.