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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Developing an in vivo reporter system for the monitoring of therapeutic effects on neuroblastoma

Tam, Pui-see, Patricia., 談沛詩. January 2009 (has links)
published_or_final_version / Surgery / Master / Master of Medical Sciences
2

Excitotoxic model of posttraumatic syringomyelia in the rat

Yang, Liqun. January 1999 (has links) (PDF)
Bibliography: leaves 112-127. Study using an animal model (Sprague-Dawley rats) to elucidate the role of EAAs and spinal subarachnoid blockade in posttraumatic syringomelia. Results support the proposal that in posttraumatic spinal cord injury, primary injury and exitotoxic cell death, occuring secondary to elevated levels of EAAs, contribute to a pathologic process leading to the formation of spinal cavities, and a subarachnoid block by arachnoiditis is one of the pathogenic factors most responsible for initiating extension of the cavity.
3

Investigation on the correlation between redox changes and oxidative stress in diabetes, and their role in transcription factors activation in vitro and in vivo

Chung, Wai Shing 01 January 2002 (has links)
No description available.
4

Investigating the potential significance of tau protein in corticosterone-induced depression and neurodegeneration : implication in Alzheimer's disease

Tsang, Wing-ting, Andrea, 曾詠婷 January 2014 (has links)
Alzheimer’s disease (AD) is a devastating neurodegenerative disease with growing prevalence in our society. Patients suffering from this debilitating disorder also develop neuropsychiatric symptoms. Depression is one of the most frequently conveyed comorbidity; moreover, depression is also a risk factor associated with AD development. There is a complex interplay between the neurobiology of depression and AD, but their concomitant disease mechanisms remain largely unknown. Retraction of axons and dendrites has been reported to be a common occurrence in both illnesses, proposing the involvement of cytoskeletal dysfunction. Tau is a microtubule-associated protein that undergoes aberrant processing to form neurofibrillary tangles in neurodegenerative diseases such as AD. However, the role of tau in depression has not been well studied. The elucidation of pathophysiological mechanisms in depression is important to provide a more holistic understanding of AD pathogenesis. This study proposes the potential participation of tau phosphorylation in the pathogenesis of depression. In addition, this study will also investigate tau modifications under concomitant models of depression and AD. Primary cultures of hippocampal neurons were exposed to independent and cotreatments of corticosterone and β-amyloid (Aβ), to induce in vitro models of depression and AD, respectively. Sprague Dawley rats were subcutaneously injected with corticosterone for 14 days to induce an in vivo model of depression. Tau phosphorylation, aggregation and interaction with microtubules were examined. Results demonstrated that in both in vitro and in vivo models of corticosterone-induce depression, tau underwent increased phosphorylation at residues S396 and S404. Phosphorylated tau showed decreased interactions with microtubules and increased vulnerability to aggregate. Furthermore, the in vivo model of depression illustrated an altered localization of tau in the CA3 region of the hippocampus. Co-treatment of corticosterone and Aβ exacerbated aberrant tau phosphorylation and aggregation. In conclusion, this study provides evidence for the role of tau in depression, suggesting the occurrence of abnormal tau phosphorylation as an early event in the pathogenesis. Additionally, the pathophysiology of depression and AD may involve similar mechanisms in tau phosphorylation and aggregation. This study provides insight into the neurobiological linkages between depression and AD, and emphasizes the importance of tau-targeted interventions in neuropsychiatric disorders. / published_or_final_version / Anatomy / Master / Master of Philosophy
5

Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter

Ramjiawan, Angela 10 September 2010 (has links)
PGC-1α regulates cardiac mitochondrial biogenesis and energy metabolic gene expression, thus transcriptional regulation of PGC-1α gene expression is of great importance in understanding metabolic gene expression in cardiac health and disease. We provide evidence that estrogen related receptor α (ERRα, which also plays a role in cardiac energy metabolism, regulates expression of the PGC-1α gene via direct interaction with the PGC-1α gene promoter. In the presence of an inverse agonist to ERRα PGC-1α gene expression was significantly decreased, while over-expression of ERRα increased PGC-1α gene expression. We have also demonstrated that expression of PGC-1α was down regulated in hypoxic cardiomyocytes due to histone deacetylation. Our data identify ERRα as a novel regulator of cardiac PGC-1α gene expression, and suggests that promoter deacetylation in hypoxia plays a role in reduced PGC-1α expression. These results reveal a new mechanism that may contribute to energetic derangement in the heart during ischemia and/or failure.
6

Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter

Ramjiawan, Angela 10 September 2010 (has links)
PGC-1α regulates cardiac mitochondrial biogenesis and energy metabolic gene expression, thus transcriptional regulation of PGC-1α gene expression is of great importance in understanding metabolic gene expression in cardiac health and disease. We provide evidence that estrogen related receptor α (ERRα, which also plays a role in cardiac energy metabolism, regulates expression of the PGC-1α gene via direct interaction with the PGC-1α gene promoter. In the presence of an inverse agonist to ERRα PGC-1α gene expression was significantly decreased, while over-expression of ERRα increased PGC-1α gene expression. We have also demonstrated that expression of PGC-1α was down regulated in hypoxic cardiomyocytes due to histone deacetylation. Our data identify ERRα as a novel regulator of cardiac PGC-1α gene expression, and suggests that promoter deacetylation in hypoxia plays a role in reduced PGC-1α expression. These results reveal a new mechanism that may contribute to energetic derangement in the heart during ischemia and/or failure.
7

Leukocyte elastase and anti-elastases in pulmonary emphysema

Walsh, Robert Leo. January 2001 (has links) (PDF)
Includes bibliographical references (leaves 218-249) The preferred theory to explain the aetiology of emphysema points to an imbalance in the protease-antiprotease systems within the lung with human leukocyte elastase and [alpha]1-protease inhibiter being the main candidates. Examines some aspects of this theory.
8

Temporomandibular joint pathological changes in the prehistoric New Zealand Maori and Moriori

Latimer, Christopher Paul, n/a January 2001 (has links)
Diseases and disorders of the temporomandibular joint are commonly encountered clinically. This has lead to most temporomandibular research focusing upon the pathologies that affect the joint and their proposed aetiologies. Little of this research has been conucted on the prehistoric Polynesians. Therefore, this study was developed in order to determine the type and pattern of any temporomandibular pathologies in the prehistoric Maori and Moriori and to investigate their possible aetiologies. For this study a sample of 89 prehistoric Maori and Moriori skulls were used. All temporomandibular pathologies were recorded by type, location, and severity. Where possible, the ecological and geographical provenance of each individual was recorded and their sex and age estimated. This enabled an analysis of whether the prevalence and severity of temporomandibular degeneration varied between provenances or sexes, and if the occurrence of temporomandibular pathology increased with age. The condition of the dentition was also recorded for each individual as the dentition has been implicated in many previous studies to be an aetiological factor in temporomandibular degeneration. The dental conditions examined include; tooth attrition, inflammation of infection of the alveolar bone, dental caries, and fern root planes. Finally, the presence of any congenital or developmental anomalies and condylar enthesophytes were recorded in order to investigate if these conditions had any relationship to the occurrence of temporomandibular degeneration. A high prevalence of temporomandibular degenerative joint disease was found in this sample. No primary relationship was seen between age, congenital or developmental anomalies, condylar enthesophytes and temporomandibular degeneration. Furthermore, despite a high proportion of these individuals having very worn teeth, with consequent infection and tooth loss, no primary relationships were found between the selected dental conditions and temporomandibular degeneration either. However, a significant association was found between the selected dental conditions and temporomandibular degeneration either. A significant association was found between the sex of the individual and temporomandibular pathology, with males being more frequently and severely affected than the females. This appeared to be due differences in dietary type between the sex of the individual and temporomandibular pathology, with males being more frequently and severely affected than the females. This appeared to be due to differences in dietary type between the sexes resulting in more severe biomechanical degeneration recorded may be caused by excessive biomechanical loading possibly resulting from the diet or as a consequence of the Polynesian morphology. Interestingly, over one third of the sample had grooving in at least one fossae. It is proposed that this grooving may have either a hereditary component, or result from a specific morphological variation that is present in the prehistoric Maori and Moriori.
9

Age-related physiological and pathological changes in the regulation of endothelium-dependent relaxations in mice and rats

Kong, Wing-cheung, Billy., 江詠璋. January 2011 (has links)
published_or_final_version / Pharmacology and Pharmacy / Doctoral / Doctor of Philosophy
10

Evaluating appropriateness for the use of 6-hydroxydopamine as an experimental model for Parkinson's disease to investigate involvement of tau protein in cognitive dysfunctions of Parkinson's disease

Leung, Yen, 梁欣 January 2015 (has links)
abstract / Anatomy / Master / Master of Philosophy

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