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1	A new approach to identification and quantification by infrared spectrometry. January 1996 (has links) by Bai Tao. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 1-21). / PART I : A new approach to identification by infrared spectrometry / Chapter Chapter 1: --- Introduction --- p.1 / Chapter Chapter 2 : --- Coding system of IR spectra --- p.13 / Chapter Chapter 3 : --- Library search system of IR spectra --- p.46 / Chapter Chapter 4 : --- Identification of pharmaceuticals by the IR database of pharmaceuticals --- p.64 / Chapter Chapter 5 : --- Identification of Chinese mineral drugs by the IR database of Chinese mineral drugs --- p.85 / Chapter Chapter 6 : --- Identification of Chinese herbal drugs by the IR database of Chinese herbal drugs --- p.114 / Chapter Chapter 7 : --- Coding and library search system for IR spectra of some Chinese mineral drugs with no apparent absorption peaks --- p.133 / Chapter Chapter 8: --- Conclusion to Part I --- p.150 / PART II : A new approach to quantification of solid samples by infrared spectrometry / Chapter Chapter 1: --- Introduction --- p.152 / Chapter Chapter 2: --- Derivative method for the IR spectrometric determination of solid samples using polyethylene film as internal standard(DISPE method) --- p.163 / Chapter Chapter 3: --- The IRQA software for quantitative analysis using IR spectrometry --- p.178 / Chapter Chapter 4: --- IR for the quantitative analysis of some Chinese mineral drugs based on the proposed DISPE method --- p.190 / Chapter Chapter 5: --- Determination of iron-containing species in inorganic mixtures using the proposed DISPE method --- p.204 / Chapter Chapter 6: --- Conclusion to Part II --- p.217 / References for Part I / References for Part II / Appendix I for Part I / Appendix II for Part II Chemistry, Pharmaceutical--Methods Spectrophotometry, Infrared Spectrum analysis--Methods
2	Chondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics Umerska, A., Paluch, Krzysztof J., Santos-Martinez, M.J., Medina, C., Corrigan, O.I., Tajber, L. 20 April 2015 (has links) Yes / A new type of self-assembled polyelectrolyte complex nanocarrier composed of chondroitin (CHON) and protamine (PROT) was designed and the ability of the carriers to bind salmon calcitonin (sCT) was examined. The response of sCT-loaded CHON/PROT NPs to a change in the properties of the liquid medium, e.g. its pH, composition or ionic strength was studied and in vitro peptide release was assessed. The biocompatibility of the NPs was evaluated in Caco-2 cells. CHON/PROT NPs were successfully obtained with properties that were dependent on the concentration of the polyelectrolytes and their mixing ratio. X-ray diffraction determined the amorphous nature of the negatively charged NPs, while those with the positive surface potential were semi-crystalline. sCT was efficiently associated with the nanocarriers (98-100%) and a notably high drug loading (13-38%) was achieved. The particles had negative zeta potential values and were homogenously dispersed with sizes between 60 and 250 nm. CHON/PROT NPs released less than 10% of the total loaded peptide in the first hour of the in vitro release studies. The enthalpy of the decomposition exotherm correlated with the amount of sCT remaining in NPs after the release experiments. The composition of medium and its ionic strength was found to have a considerable influence on the release of sCT from CHON/PROT NPs. Complexation to CHON markedly reduced the toxic effects exerted by PROT and the NPs were compatible and well tolerated by Caco-2 cells. Caco-2 cells: Calcitonin Administration & dosage Metabolism: Cell Survival Pharmaceutical Chondroitin Toxicity: Crystallography X-Ray Delayed-action preparations Drug carriers Humans Hydrogen-ion concentration Kinetics Nanomedicine Nanoparticles Osmolar concentration: Protamines chemistry & metabolism Protein binding Solubility Surface properties Technology Pharmaceutical methods Biocompatibility Peptide delivery Polyelectrolyte complex Protamine toxicity

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A new approach to identification and quantification by infrared spectrometry.

Chondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics