The hydrodynamics of an agitated tank have been studied byphase-Doppler anemometry. The focus is on the impeller anddischarge region of a 45o pitched blade turbine (PBT). Thestudy includes agitation of pure water as well as of a dilutesuspension of process particles. A three-dimensionalphase-Doppler anemometer is used to measure local,instantaneous, three-dimensional velocities of the fluid and ofthe suspended particles. A shaft encoding technique is used toresolve the turbulent fluctuations from the periodic velocityfluctuation due to the impeller blades, and to provide moredetailed information about the variations relative to theimpeller blade. Velocity bias is corrected for by the total3-dimensional velocity. The mean flow field, the fluctuating velocities, and thecomplete Reynolds stress tensor, are reported for the liquidphase flow. The periodic fluctuations in the flow that aregenerated by the impeller blades are eliminated in theexamination of the turbulence. The anisotropy of the turbulenceis assessed by the invariants of the anisotropy tensor. Thetrailing vortex structure is demonstrated to be associated withhigh kinetic energy and strong anisotropy of the turbulence.The vortex is still observable 130-140 degrees behind theblade. It gradually moves down from the impeller blade but thelocation in radial direction remains essentially unchanged. Theinfluence of the periodic fluctuations is examined and it isshown that the turbulence appears more isotropic when theperiodic fluctuations are not eliminated. The solid particle concentration is low below the impellerand is high above the impeller tip. The particles diverge fromthe liquid flow mean direction, especially below the agitatorclose to the tip where the strongest turbulence is found.Periodic fluctuations in the particle concentration relate tothe variations found in the angle-resolved mean velocity andfluctuating velocity. The ratio of the maximum to the minimumconcentration is about 2.0 in the present study. The baffles influence on the conditions in the impellerregion, and this influence can be observed on the fluid meanvelocity field, the angle-resolved velocities, the kineticenergy, and on the behavior of larger process particles. In theimpeller region the highest kinetic energies are about 15%higher upstream of the baffle than at the middle plane betweenthe baffles. The highest energy level in the middle plane isactually the lowest value and is therefore not representativewhen rotation symmetry is assumed. Local energy dissipation rates have been investigated, andthe integration of the local energy dissipation rates overdifferent control volumes has been compared with macroscopicenergy balance calculations. The discrepancy is significant.Different reasons have been analyzed and recommendations forfurther investigation are given. I n the outflow region there is a significant variation alsoin the direction of the instantaneous velocity, which may leadto direction bias in the case of non-spherical measurementvolume. In order to account for this direction bias, amathematical model is developed to estimate the projected areaof the measurement volume in LDA or PDA. It is shown that theprojected area variation can lead to a significant directionbias in determination of time averaged values and localparticle concentration in a highly turbulent stirred tank flow.This bias is however negligible for an orthogonal optical setup, as is used in the present study. <b>Keywords:</b>Hydrodynamics, phase-Doppler anemometer,suspension, pitched-blade turbine, anisotropy, turbulence,Reynolds stresses, trailing vortex, kinetic energy, stirredtank

<p>The hydrodynamics of an agitated tank have been studied byphase-Doppler anemometry. The focus is on the impeller anddischarge region of a 45o pitched blade turbine (PBT). Thestudy includes agitation of pure water as well as of a dilutesuspension of process particles. A three-dimensionalphase-Doppler anemometer is used to measure local,instantaneous, three-dimensional velocities of the fluid and ofthe suspended particles. A shaft encoding technique is used toresolve the turbulent fluctuations from the periodic velocityfluctuation due to the impeller blades, and to provide moredetailed information about the variations relative to theimpeller blade. Velocity bias is corrected for by the total3-dimensional velocity.</p><p>The mean flow field, the fluctuating velocities, and thecomplete Reynolds stress tensor, are reported for the liquidphase flow. The periodic fluctuations in the flow that aregenerated by the impeller blades are eliminated in theexamination of the turbulence. The anisotropy of the turbulenceis assessed by the invariants of the anisotropy tensor. Thetrailing vortex structure is demonstrated to be associated withhigh kinetic energy and strong anisotropy of the turbulence.The vortex is still observable 130-140 degrees behind theblade. It gradually moves down from the impeller blade but thelocation in radial direction remains essentially unchanged. Theinfluence of the periodic fluctuations is examined and it isshown that the turbulence appears more isotropic when theperiodic fluctuations are not eliminated.</p><p>The solid particle concentration is low below the impellerand is high above the impeller tip. The particles diverge fromthe liquid flow mean direction, especially below the agitatorclose to the tip where the strongest turbulence is found.Periodic fluctuations in the particle concentration relate tothe variations found in the angle-resolved mean velocity andfluctuating velocity. The ratio of the maximum to the minimumconcentration is about 2.0 in the present study.</p><p>The baffles influence on the conditions in the impellerregion, and this influence can be observed on the fluid meanvelocity field, the angle-resolved velocities, the kineticenergy, and on the behavior of larger process particles. In theimpeller region the highest kinetic energies are about 15%higher upstream of the baffle than at the middle plane betweenthe baffles. The highest energy level in the middle plane isactually the lowest value and is therefore not representativewhen rotation symmetry is assumed.</p><p>Local energy dissipation rates have been investigated, andthe integration of the local energy dissipation rates overdifferent control volumes has been compared with macroscopicenergy balance calculations. The discrepancy is significant.Different reasons have been analyzed and recommendations forfurther investigation are given. I</p><p>n the outflow region there is a significant variation alsoin the direction of the instantaneous velocity, which may leadto direction bias in the case of non-spherical measurementvolume. In order to account for this direction bias, amathematical model is developed to estimate the projected areaof the measurement volume in LDA or PDA. It is shown that theprojected area variation can lead to a significant directionbias in determination of time averaged values and localparticle concentration in a highly turbulent stirred tank flow.This bias is however negligible for an orthogonal optical setup, as is used in the present study.</p><p><b>Keywords:</b>Hydrodynamics, phase-Doppler anemometer,suspension, pitched-blade turbine, anisotropy, turbulence,Reynolds stresses, trailing vortex, kinetic energy, stirredtank</p>

<p>Air, nitrogen, argon and carbon dioxide were used as the atomizing gas in an 'air-assist' spray nozzle to determine the effect of these gases on mean droplet size, number density, velocity and their distributions in kerosene fuel spays and spray flames using a two dimensional phase Doppler interferometer. Data have been obtained with these atomizing gases using a base, air assisted case as a reference, since this is the most commonly used atomizing fluid in almost all applications. Comparisons were made between the gases on a mass and momentum flux basis. Both burning and nonburning sprays were investigated. The results show significant differences in atomization characteristics from the atomizer with different gases and under conditions of constant mass and momentum flux of the gas. The results also show that the presence of oxygen in the air atomized sprays assists in the combustion process, since it produces smaller and faster moving droplets, especially at locations near to the nozzle exit. In nonburning sprays, droplets had similar size and velocity. Lighter gases such as nitrogen more effectively atomized the fuel in comparison to the denser gases. Argon and carbon dioxide produced larger, slower moving droplets than air and nitrogen assisted cases in both the burning and nonburning sprays. Flame photographs revealed the argon and carbon dioxide atomized flames to have greater luminosity than air or nitrogen atomized flames.</p> / Master of Science

No description available.

Cette étude s'inscrit dans le cadre de la compréhension des phénomènes ayant lieu dans les chambres de combustion aéronautiques. Ces phénomènes étant multiples et complexes, des simplifications sont nécessaires. L'étude se focalise uniquement sur l'évaporation de gouttelettes bi-composant en écoulements turbulents. De nombreux modèles d'évaporation existent mais l'influence de la turbulence dans le cas d'un spray est encore mal comprise. Alors que la turbulence augmente l'évaporation d'une goutte isolée, elle peut amener à la création d'amas de gouttes qui vont au contraire ralentir l'évaporation. Cette étude a donc pour but de fournir un certain nombre de données quantitatives permettant une meilleure compréhension de ces phénomènes et une amélioration des modèles. L'approche est expérimentale. L'objectif est de quantifier, d'une part l'évaporation et la dispersion de gouttelettes, d'autre part le mélange vapeur dans un écoulement de canal dont les caractéristiques seront connues. Afin de simplifier les conditions expérimentales, la température est moins élevée que dans le cas réel et la pression est la pression atmosphérique. De plus, les gouttelettes sont bi-composant (octane/3-pentanone). Le banc utilisé est divisé en deux parties. Sa partie supérieure est composée d'un système de génération de l'écoulement turbulent et d'un injecteur de gouttelettes. Sa partie inférieure est composée d'une veine dans laquelle l'écoulement diphasique est analysé. L'écoulement porteur est étudié sans le spray par Anémométrie Laser Doppler. L'écoulement présente une forte turbulence, des profils plats de vitesses moyennes et de f uctuations de vitesses, en zone établie. Les propriétés d'isotropie et la décroissance de la turbulence sont proches de celles obtenues en turbulence de grille. La phase dispersée est suivie à chaud à l'aide de deux méthodes : par Anémométrie Phase Doppler et par Fluorescence Laser Induite. L'Anémométrie Phase Doppler permet d'avoir accès simultanément au diamètre et à la vitesse de chaque goutte passant à travers le volume de mesure. En raison de la forte polydispersion, les comportements des gouttelettes vis à vis de la turbulence sont très différents. En revanche, l'homogénéisation est rapide quelque soit la classe de taille. La présence d'amas dont la quantité diminue en aval dans la veine est mis en avant. La Fluorescence Laser Induite mesure la quantité de molécules de 3-pentanone en phase liquide. L'évolution de la concentration liquide, des flux de masse et des amas est décrite. La Fluorescence Induite par Laser permet aussi de suivre la quantité de 3-pentanone en phase vapeur. L'évolution des prof ls radiaux et axiaux de concentration moyenne et des f uctuations de concentration est présentée. L'homogénéisation du mélange est quantifiée. / This work aims to understand the phenomena that occur in a combustion chamber. Due to the complexity of the phenomena encountered, simplifications are made. This study only focuses on multicomponent droplet evaporation in turbulent flows. Many evaporation models exist, but the influence of turbulence on a spray is yet not well understood. On one hand, turbulence increases the droplet evaporation rate. On the other hand, it may generate clusters, in which saturation stops the process. This study aims to give a database that can be used to improve the physical understanding of the process and to improve model performances. This is an experimental approach. The objective is to measure evaporation and dispersion of droplets and vapour mixing in a well-known turbulent flow. In the simplified test case studied here, the temperature is lower than in a real case and the pressure is atmospheric. The droplets are bi-component(octane/3-pentanone). The experimental set-up is divided into two parts. The first part, at the top, consists in a turbulence flow generator and a droplet injection device. The second part is a channel in which the two- hase flow is analysed. The carrier flow is measured using Laser Doppler Anemometry. The main flow properties are : high turbulence levels, flat profiles for the mean velocity and velocity fluctuations. The turbulence decreases and isotropic properties are close to those of grid turbulence. The dispersed phase is measured using Phase Doppler Anemometry (PDA) and Laser Induced Fluorescence (LIF). The velocity and diameter of each droplet passing through the measurement volume is measured by the PDA technique. There is a large variety of droplet behaviours due to the large polydispersion and turbulence. Droplet clusters are measured. Their amounts decrease with the distance from the injector. The concentration of 3-pentanone can be measured with the LIF technique. The evolution of the liquid concentration, mass flux and droplet clusters is described. The mean vapour concentration and its fluctuations are measured along the axial and radial axis. The mixing of the vapour is characterised

L’aérosolthérapie a pour objectif de délivrer un médicament dans les voies respiratoires. Le nébuliseur pneumatique est un dispositif permettant de générer des gouttelettes de liquide de diamètre micrométrique. Son processus d’atomisation a cependant été peu analysé. Ainsi, les performances du nébuliseur, caractérisées par le diamètre des gouttes et la masse de médicament inhalable par le patient, et atteignent un palier. Notre travail consiste à utiliser un modèle numérique diphasique en 3D basé sur une géométrie donnée et paramétré sous ANSYS Fluent. Plusieurs méthodes sont utilisées pour caractériser expérimentalement la génération de l’aérosol : l’ombroscopie, la diffractométrie laser et l’anémométrie phase Doppler. Notre modèle est validé par rapport aux données expérimentales et peut donc être exploité pour analyser les processus de génération. L’influence de plusieurs paramètres physiques sur les caractéristiques de l’aérosol produit est étudiée. Ainsi, l’étape de génération de gouttelettes est optimisée pour le développement d’un nouveau nébuliseur. Le transport des gouttes aux poumons du patient est optimisé empiriquement. / The purpose of aerosol therapy is to deliver drugs into respiratory airways. The jet nebulizer is a device used to generate liquid droplets with a diameter lower than 5 μm. However its atomization process was not much analyzed. Nebulizer performances, which are characterized with droplet size and drug mass inhaled by the patient, are empirically optimized and have reached a plateau. Our work consists in setting a 3D diphasic numerical model on ANSYS Fluent, based on a given geometry. Several methods are used to experimentally characterize aerosol generation: shadowgraphy, laser diffractometry and phase Doppler anemometry. Our model is validated by experimental data and helps predicting generation processes. The influence of several geometric and physical parameters on the output is studied. From these data, droplet generation is optimized for the development of a new nebulizer. Droplet transport to the patient lungs is empirically optimized.

La fluorescence induite par laser multibande est une technique non intrusive permettant d’accéder à la température de la phase liquide dans des milieux complexes. L’application de cette technique dans des liquides monophasiques où le chemin optique est variable (produit de la concentration moléculaire du traceur et de la distance dans le milieu liquide entre le volume de mesure et l’optique de détection) a été considérée. Le rapport des intensités de fluorescence collectées sur deux bandes spectrales permet de s’affranchir de la concentration en traceur fluorescent, de l’intensité laser incidente et du volume de mesure. Une troisième bande spectrale de détection permet de prendre en compte le terme de ré-absorption de la fluorescence dans le cas de chemins optiques non-négligeables et variables. Puis l’application de la technique à la mesure de la température de la phase liquide d’un spray est présentée. Un traitement spécifique du signal a été développé afin de tenir compte de la nature aléatoire du signal de fluorescence liée à la présence de gouttes dans le volume de mesure. De plus, ce traitement a été adapté afin de rendre possible le couplage des données de fluorescence avec des mesures granulométriques effectuées par la technique phase Doppler dans la perspective finale d’obtenir des températures de goutte par classe de taille. Cependant plusieurs phénomènes perturbateurs ont été mis en évidence : - une dépendance inattendue et non linéaire à la taille de goutte du rapport des intensités de fluorescence collectées sur deux bandes spectrales. - une forte diffusion de la lumière laser incidente par le nuage de gouttelettes induit une fluorescence bien au delà de la zone d’excitation laser. Cette fluorescence parasite est néanmoins détectée dans la profondeur de champ du dispositif optique et se conjugue avec l’effet non-linéaire de la taille des gouttes. Une stratégie de correction de ces différents phénomènes est proposée et une expérience de validation est réalisée sur un spray chauffé injecté dans une cellule saturée en vapeur / Multiband laser-induced fluorescence is a non-intrusive technique able to provide a measurement of the liquid phase of complex media. The application of this technique in single phase liquids, with a variable optical path (product of the fluorescent tracer molecular concentration by the distance between the probe volume and the collection optics in the liquid) was considered. The ratio of the fluorescence intensities collected on two spectral bands allows removing the influence of the fluorescence tracer concentration, incident laser intensity and probe volume. A third spectral band of detection is used to take into account the re-absorption of the fluorescence in the case of non negligible and variable optical paths. Then, the application of this technique to the measurement of the temperature of the liquid phase of a spray is presented. A specific data processing was developed in order to take into account the random presence of droplets in the probe volume. Moreover, the processing was adapted to achieve combined fluorescence and droplet size measurements using the phase Doppler technique. The overall foreseen goal is to measure temperature per droplet size class. However, several disturbing phenomena were highlighted: - an unexpected non-linear dependence on the droplet size of the ratio of the fluorescence intensities collected on two spectral bands, - a strong incident laser light scattering by the droplets cloud, which induces a fluorescence beyond the excitation zone. This fluorescence is also collected in the depth of field of the optical device and combines with the non-linear size dependence. A correction strategy of these phenomena was implemented and a validation experiment on a heated spray injected in a vapour-saturated cell was performed

Electrostatic properties of formulation component materials and blends play an important role in dry powder inhalation (DPI) products, and that valid measurement of charge distribution will lead to more precise control of powder behavior in DPI manufacturing processes. Ultra-fine powders are known to be bipolarly charged, have non-spherical shapes and tend to be highly cohesive. Real time, non-invasive techniques need to be developed to obtain a precise and accurate time-history characteristic of electrically charged powders as they aerosolize from a DPI product, and how this measure relates to materials behavior throughout the various steps of a manufacturing process i.e. from drug micronisation, blending with lactose, through to filling dose units. A novel non-invasive technique for simultaneous measurement of size and charge of pharmaceutical powders is considered which employs the Phase Doppler Anemometry (PDA) system. Previous research demonstrated the advantages of this technique in measuring the bipolar charge distribution on a population of particles. These findings led to significant improvements in understanding performance of dry powder formulations, manufacturing processes and development of new platforms for inhaled drug delivery. The main aim of this research is to perform an investigation of electrostatic propertiesof pharmaceutical dry aerosols using the PDA system. The PDA technique was used to track the motion of charged particles in the presence of an electric field. The magnitude as well as the polarity of the particle charge can be obtained by solving the equation of particle motion in DC and AC fields combined with the simultaneous measurement of its size and velocity. The results show the capability of the technique to allow real-time size and charge distribution in the control of dry powder attributes that are critical to fully understanding manufacturing design space. The data obtained from initial investigations of electrical properties of pharmaceutical powders and bipolar charge measurements was used to perform an in-depth study of electrostatic properties of pharmaceutical aerosols dispensed by dry powder inhaler (DPI) devices. The delivery of a drug to the lungs can only be achieved by a combination of inhaler device and drug formulation which is capable of producing an aerosol of an aerodynamic diameter smaller than 5 μm and of appropriate charge. The aerosols generated by these devices are often bipolarly charged and can influence specific site deposition in human lung. By controlling the electrostatic charge generated by tribielectrification, it may be possible to achieve the desired drug deposition in the airways. Bipolary charged dispensed ultrafine particles are inhaled through the extrathoracic and tracheobronchial airways down into the alveolar region. Anatomically realistic respiratory airways and computation fluid dynamics (CFD) models have been created to study airflow structures and predict aerosol deposition within the human respiratory system using visible human data sets, human casts and morphometric data. Many theoretical studies of charged aerosol deposition in human respiratory systems have been developed, however getting real time, non-intrusive data of bipolar charge levels on aerosols dispensed from DPI’s within the human respiratory system represents a challenging issue. This research project presents a simplified human upper airway model which combined with the modified Phase Doppler Anemometry (PDA) system is able to provide real time bipolar charge distributions of aerosols delivered from several commercially available DPI devices. A three dimensional (3D) reconstruction of the upper respiratory system was performed from two dimensional (2D) images obtained from computerized tomography (CT), magnetic resonance imaging (MRI) and cryosectioned images available from Visible Human Server data set (Ecole Polytechnique Fédérale de Lausanne). The resulting dimensions of the model were consistent with morphometric data from the literature from which the simplified upper airway model consisting of two connected segments, i.e., the oral airways from the mouth to trachea (Generation G0), was created. The findings of this study provided a better understanding of the interaction between specific active ingredients and DPI devices. These results may be used in designing future generation DPI devices and a better understanding of aerosol transport and deposition efficiency within the human airways.

No description available.

The objective of this thesis was to develop a novel understanding of the mechanics of two phase gas-liquid flows and sprays injected through industrial effervescent nozzles. This was done using detailed experimental investigations and scaling for two-phase flows and sprays. This study helps to quantify near-field liquid and gas phase statistics that are challenging and impossible to measure in the reactors due to inaccessibility restrictions. The development of nozzles is generally performed on air-water systems. My plan was to begin with the study of small-scale sprays (air and water) to compare to full scale industrial conditions at pilot operation (air-water) or at commercial operation (steam-bitumen), to determine size scaling relationships. The relationship between the lab scale air-water experiments and real industrial scale steam-bitumen has never been fully examined. Knowledge from this thesis will make the development of future nozzles with much less dependent on trial and error. This thesis was an attempt to establish fundamental scaling relationships for the prediction of two-phase spray behavior that can be applied directly to full scale industrial size nozzles that would be of very significant value to industries and to the scientific community in general. Understanding the performance of two phase nozzles through established scaling laws will aid in optimizing the two phase nozzle flow conditions and will serve as a major tool in nozzle design and development for future generation nozzles for many industrial applications.