<p>This thesis is concerned with a new generation of churches in Canada trying to respond to the significant changes being felt in communities across the country as a result of the federal government policies over the last 30 years dealing with immigration, refugees and multiculturalism.</p> <p>There is a growing awareness that churches will need to become more intentionally multicultural to accommodate the emerging generation. Many pastors are not equipped to minister cross-culturally and churches are often unwillingly to change to adjust to the changing communities in which they are located.</p> <p>A number of sociological and theological influences will be reviewed to determine their impact on Canadian churches. There will be a response to the issues raised by those who advocate an emerging postmodern worldview in search of genuine community. Theological observations on the possibilities of the diversity of a heterogeneous multicultural church model being a valid response to the pluralism of contemporary Canadian life will be developed.</p> <p>The research presented will be dealing with three emerging multicultural Canadian churches. These three churches are located in either Vancouver or Toronto and are representative of many other churches in Canada today. There will be a discussion on the current ministries and plans of these three churches and some common characteristics identified. An integration of the models presented, and the research observations will lead to a proposal for moving towards becoming a more intentional healthy multicultural church to meet the needs of the next generation.</p> / Doctor of Ministry (DMin)

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No description available.

Le p300/CBP acétyltransférase est un co-activateur transcriptionnel très important qui est impliqué dans la régulation d'un grand nombre de processus biologiques, comme la transcription d'ADN, le développement et l'immunité innée. Jusqu'à présent, le rôle de p300/CBP dans la régulation de l'expression des gènes a été largement étudiée, mais les mécanismes qui régulent son activité enzymatique sont encore peu connus. Des études ont montré que le dysfonctionnement de p300/CBP est associé à plusieurs formes de cancer et de maladies neurodégénératives. Dés lors, chaque progrès concernant les mécanismes de régulation de p300/CBP est devenu primordial pour le développement de nouvelles thérapies. Le 'noyau' de p300/CBP contient deux domaines pour la reconnaissance des modifications post-traductionnelles (MPTs), un bromodomaine et un PHD finger (le module BP), adjacent à un domaine HAT (ou domaine histone acétyltransférase). Plusieurs enzymes, modifiant la chromatine, contiennent des domaines de reconnaissance des MPTs. Fréquemment des groupements particuliers de ces domaines sont très conservés et liés, au sein de la même protéine ou du même complexe protéique, suggérant qu'ils réalisent des fonctions coordonnées. Ces domaines adjacents peuvent agir en concertation dans la reconnaissance simultanée de différents MPTs ou peuvent exercer des fonctions différentes de celles qui sont effectuées par ces deux domaines particuliers, tels que les fonctions de régulation enzymatique. Plusieurs études suggèrent que les cycles acétylation/désacétylation dans la boucle d'auto-inhibition, à l'intérieur du domaine HAT, jouent un rôle important dans la régulation de l'activité enzymatique de p300/CBP. La proximité du module BP et du domaine HAT suggère que la spécificité de liaison, appartenant au module BP, peut être intrinsèquement liée à la régulation de l'activité du domaine HAT. L'objectif de ma thèse est de déterminer le rôle du module BP dans la régulation de l'activité du domaine HAT. Je propose que le module BP soit impliqué dans la régulation de p300/CBP de deux façons. La première consiste à établir un lien avec le domaine HAT qui stabilise la conformation auto-inhibée de l'enzyme. La deuxième exige que le module BP joue un rôle dans le choix des substrats de p300/CBP. J'ai été en mesure de montrer que BP peut se lier au domaine HAT et à la chromatine modifiée et qu'il peut reconnaître les modifications effectuées par p300/CBP lui-même. Les données obtenues indiquent que le module BP peut être impliqué dans la régulation de l'activité de p300/CBP et dans son ciblage à la chromatine. / The p300/CBP acetyltransferase is an important transcriptional co-activator which is involved in regulating a wide range of biological processes, such as DNA transcription, development and innate immunity. To date, the role of p300/CBP in gene regulation has been extensively described but little is known about the mechanisms which regulate its activity. Since misregulation of p300/CBP has been associated to the development of several forms of cancers and neurodegenerative diseases, studies directed to decipher the mechanisms of regulation of p300/CBP are of great importance for the development of new therapies. The p300/CBP 'core' contains two post-translational modifications (PTMs) recognition motifs, a bromodomain and a PHD domain (the bromo-PHD module, BP), in close proximity to a histone acetyltransferase domain (HAT). Many chromatin modifying enzymes contain recognition modules for PTMs. Frequently particular groupings of such modules are conserved and linked within the same protein or the same multisubunit complex, suggesting that they perform concerted functions. These linked modules may act combinatorially to allow recognition of multiple PTMs or display new functions that are not possessed by the single modules, such as regulatory properties. Accumulating evidence suggests that acetylation/deacetylation in a conserved autoinhibitory loop of the p300/CBP HAT domain plays an important role in regulation of HAT activity. The close apposition of the BP module and the HAT domain suggests that BP substrate recognition is intrinsically linked to regulation of HAT activity. During my thesis work, I have investigated the role of BP in HAT regulation. I propose that the BP module is involved in p300/CBP regulation by binding to the HAT domain and stabilizing the autoinhibited conformation of the enzyme. I have also investigated substrate specificity of the BP module towards modified chromatin. I could show that the BP module binds histone modifications including those that are p300/CBP dependent. Altogether, the data suggests that the BP module is involved in regulating p300/CBP HAT activity and in targeting of chromatin.

Le filtrage multiobjet est une technique de résolution du problème de détection et/ou suivi dans un contexte multicible. Cette thèse s'intéresse au filtre PHD (Probability Hypothesis Density), une célèbre approximation du filtre RFS (Random Finite Set) adaptée au cas où les observations sont le fruit d'un seul capteur. La première partie propose une construction rigoureuse du filtre PHD multicapteur exact et son expression simplifiée, sans approximation, grâce à un partitionnement joint de l'espace d'état des cibles et des capteurs. Avec cette nouvelle méthode, la solution exacte du filtre PHD multicapteur peut être propagée dans des scénarios de surveillance simples. La deuxième partie aborde le problème de gestion des capteurs dans le cadre du PHD. A chaque itération, le BET (Balanced Explorer and Tracker) construit une prédiction du PHD multicapteur a posteriori grâce au PIMS (Predicted Ideal Measurement Set) et définit un contrôle multicapteur en respectant quelques critères opérationnels simples adaptés aux missions de surveillance / The aim of multi-object filtering is to address the multiple target detection and/or tracking problem. This thesis focuses on the Probability Hypothesis Density (PHD) filter, a well-known tractable approximation of the Random Finite Set (RFS) filter when the observation process is realized by a single sensor. The first part proposes the rigorous construction of the exact multi-sensor PHD filter and its simplified expression, without approximation, through a joint partitioning of the target state space and the sensors. With this new method, the exact multi-sensor PHD can be propagated in simple surveillance scenarii. The second part deals with the sensor management problem in the PHD framework. At each iteration, the Balanced Explorer and Tracker (BET) builds a prediction of the posterior multi-sensor PHD thanks to the Predicted Ideal Measurement Set (PIMS) and produces a multi-sensor control according to a few simple operational principles adapted to surveillance activities

This thesis provides an analysis of supervisory interactions between PhD supervisors and their students within social science disciplines, using the Competing Values Framework (CVF). Traditionally, such work has been conducted using a supervisor-centred perspective, and this thesis adds to the literature by adopting a student-centred view to look at supervisor's behaviours during the interaction, from a role performance perspective in light of the CVF. Drawing primarily on semi-structured interpersonal process recall interview data, the thesis considers a number of interlinking analytical themes. These can be divided into three broad groups. The first focuses on investigating the CVF roles that are adopted by the supervisor during the interaction and recognized by the students as important component parts of the most helpful supervisory moments. In line with the previous literature, I note that the most effective supervisory behaviours reflect the performance of all the eight CVF roles with the producer and the director occupying the dominant position. The second group is closely linked with the first and investigates CVF managerial roles represented by the least helpful supervision moments selected by the student. I note how PhD supervisors inadequate use, including both overuse and underuse of the CVF roles are related to the least effective supervisory moments. The director and the producer are again the most represented ones which are reported as being mostly underused. The third group analyses students advice on further improvements . In conclusion, I relate my analysis to existing literature and examined the contributions of the thesis to three main areas of research. This research finds that instances of positive and negative supervisee feedback reflect an increased influence of marketorientation and manageralism on research students and correspondingly inadequate use of managerial roles by supervisors.

Because of the highly complex expectations of new nursing graduates "nursing education needs teachers with a deep nursing knowledge who also know how to teach and conduct research...in order to address the specific educational demands of teaching the complex practice of nursing" (Benner, Sutphen, Leonard, & Day, 2010, p. 6). Currently, the educational requirement for a nurse educator in a university setting is a doctoral degree, preferably a PhD. However, Cronon(2006) emphasized that "many PhD recipients are ill prepared to function effectively in the settings in which they work...particularly those related to teaching" (p. 5). The purpose of this study was to document the perceptions of experienced nurse educators both prepared, and currently preparing at the doctoral (PhD) level, to understand to what extent PhD work prepared them for their role in the delivery of nursing education. A case study approach was selected, using a constructivist paradigm. Data were collected from ten participants at three sites of a university school of nursing using three semi-structured interviews. Primary data were supplemented by institutional foundation documents and a field journal. Four themes emerged from the data as follows: the ambiguities associated with the interpretation of the term nurse educator influenced how a nurse educator described their role; doctoral (PhD) education enhanced approaches to thinking in relation to increased breadth and depth of knowledge base, in addition to research capabilities; the PhD credential was found to be indicative of research credibility both within and across the disciplines and enhanced the potential for funding opportunities; and doctoral (PhD) education did not support the pedagogical aspects, specifically formal teaching preparation, of the nurse educator's role. While this study provided insight in understanding how doctoral (PhD) education supported experienced nurse educators in their roles, it identified issues that impacted on how these nurse educators enacted their roles. These issues included both a disconnection and a perceived inequality between research and teaching, in addition to a marked variation in the interpretation of the scholarship of teaching. Among the implications of this study on theory are its contributions to understanding the experiences of nurse educators in relation to their doctoral (PhD) education as supporting their roles in the delivery of nursing education. Among the implications of this study for research is the need to investigate how doctoral (PhD) education could better support the pedagogical aspect of nurse educators' roles, or whether other doctoral (EdD) education might be more effective in providing this pedagogical foundational knowledge. Additional implications of this study for research are to identify ways in which thinking, research, and practice could function collectively, rather than as separate entities. Among the implications for practice are a greater understanding of the teacher-scholar model in relation to the components of discovery, integration, application, and teaching (Boyer, 1990), and how learning organizations and communities of knowledge could facilitate this deeper understanding.

My novel, Away, is mainly the story of a woman travelling alone, leaving all friends and relatives behind. She seeks out remote, beautiful and difficult places where, firstly, she has travelled to before and, then, different locations that she hasn’t known in the past. We discover that, through trauma, she has lost her sense of identity – she is in the midst of a psychological crisis that becomes clear only after the journey has been underway for some time, when circumstances force her to accept help from others. With the protagonist my aim was to portray a permanent and continuous possibility of ending, stretching endlessly. This idea is irretrievable from the notion of space, as conceived here. In Part I, I explore how not only this main character, but also, Fred embody space. Here, I examine the conception of space, taking in various perspectives raging from philosophy, geography, culture and literature studies, where we find an interdisciplinary approach to space. My contention, drawing on mainly Lefebvre’s and Massey’s investigations, is that space is produced and is simultaneously a product embodied by the characters. In addition, I analyse how a particular territory – the desert – enacts the nature of space, as defined before, in selected works by T. E. Lawrence, Wilfred Thesiger and Paul Bowles. Also, I argue that this conception of space is explored in some narratives of Paul Auster - CG, MC and CLT - in part II. Further, I examine other features of space. I contend that Auster’s writing explores space as a realm upon which Auster’s characters engage in a process of construction and disintegration both of space and their identity. Therefore, here, space is considered as a sphere constituted by a process of an ever-opened, changing and ongoing interrelation with the characters and the text. Finally, although space is presented in this essay as the major tool for investigation through composition and critical analysis, other tools, intrinsically, and I argue inseparable in fact, I proceed to an investigation, in part III, of notions of time, identity, writing and narrator in my creative work. Beside these, I investigate particularly the relationships between characters. The thesis concludes by demonstrating that writing as space evolves in more subtle, more transient and labyrinthian ways through the reference to other writers whose writing has significantly influenced my creative work.

This document describes an experimental investigation into dense collections of hard spherical particles just large enough to be studied using a light microscope. These particles display colloidal properties, but also some similarities with granular materials. We improve the quantitative analysis of confocal micrographs of dense colloidal systems, which allows us to show that methods from simulations of granular materials are useful (but not sufficient) in analysing colloidal systems, in particular colloidal glasses and sediments. Collections of spheres are fascinating in their own right, but also make convincing models for real systems. Colloidal systems undergo an entropy-driven fluid-solid transition for hard spheres and a liquid-gas transition for suitable inter-particle attraction. Furthermore, experimental colloidal systems display a so far not well-understood glass transition at high densities, so that the equilibrium state is not achieved. This may be due to limited experimental timescales, but experiments under reduced gravity (both using the Space Shuttle and densitymatching solvents) suggest that it is not. Most colloidal studies have used scattering (i.e. non-microscopical) techniques, which provide no local information. Microscopy (particularly confocal) allows individual particles and their motion to be followed. However, quantitative microscopy of densely-packed, solidlyfluorescent particles, such as colloidal glasses, is challenging. We report, to our knowledge for the first time, a quantitative measure of confidence in individual particle locations and use this measure in an iterative best-fit procedure. This method was crucial for the investigation of the colloidal samples reported in this thesis. One of the disadvantages of microscopy is that it requires particles too large to be truly colloidal; gravity is no longer negligible. The particles used here rapidly sediment to form solid ”plugs”, which are supposedly ”random close packed” (RCP). At least in some cases, this is not the case, since some particles remain free to move. This observation, as well as some literature results, suggest that gravity has some influence on the structure of the sediment. In this document we consider some ideas from literature not normally considered in colloidal studies. Firstly, we discuss the RCP state, and the preferred Maximally Random Jammed state. Secondly, we borrow a technique designed to identify structures known as bridges in simulations of granular materials. Finding bridges, i.e. structures stable against gravity, in colloidal samples is the primary aim of this thesis. Gravity is important in colloidal sphere packings both in sediments and in glasses; its effect is not known but the best available candidate is bridging. The basic results of this analysis, the bridge size distributions, are close to those for granular systems, but differ little for samples of different volume fractions. We identify important stages of the analysis which require more investigation. Whilst questioning the usefulness of the bridge properties, we identify some related packing properties which show interesting trends. No theoretical predictions exist for these quantities. We investigated initially a non-density-matched system, but compare our results with a nearly density-matched system. The results from both systems are similar, despite the particles apparently acquiring a charge in the latter case. This thesis shows that reliable confocal microscopy of very dense systems of solidly-fluorescent particles is possible, and provides a range of unreported properties of dense sedimenting and sedimented nearly-Brownian sphere packings. It provides several suggestions for further analysis of these experimental systems, as well as some to be performed by those who simulate granular matter.

This thesis uses insights from a modern theory of communication, Relevance Theory, to examine the function of certain particles - in particular the conjunction hina - in Koine Greek. This particle has been regarded from the time of Classical Greek as an introducer of purpose clauses and so has been thought to have the lexical meaning of ‘in order that.’ More recently, however, scholars have recognised that in the New Testament at least, no more than 60% of the uses of hina merit such a translation, with a considerable number of independent clauses being introduced by this particle also. Apart from the New Testament it is the case that pagan writers of Koine used this particle to introduce a wider range of clauses than merely those with a telic relationship to the main clause of the sentence. This is particularly noticeable in the Discourses of Epictetus, a philosopher who taught in the latter half of the first century of the Christian era. In addition, Dionysius of Halicarnassus, a notable critic of literary style and the historian Polybius, both writing within the Koine period used hina to introduce indirect commands and noun clauses as well as purpose clauses. The frequency of such uses (approximately 10% of all the instances of this particle) in their writings is considerably less than that of Epictetus, but those uses are nevertheless present in their works. Since iota-nu-alpha was used for this wider range of clauses by pagan, non-Jewish authors, some of whom spoke Greek as their first language, it seems extremely implausible to attribute such use to the incompetence of the implied authors of the New Testament, or ‘Semitic interference’. Since the many instances of non-telic hina in the New Testament are identified with reference to the context in which they occur, the telic instances should also be deduced from such context. I claim that the function of this particle is not to introduce a purpose clause nor does it have a fixed lexical meaning of ‘in order that’, but rather that it alerts the reader to expect an interpretation of the thought of the speaker or implied author. Of course in many instances a clause introduced by hina will be a purpose clause, but this is inferred from context rather than solely from the presence of this particle. This thesis proposes a unified account of the function of hina which fits the developing pattern of the language and relates it to the particle 'hina', and provides a theoretical basis for its use as an indicator of speaker or subject’s thought, thus enabling a reader to re-examine biblical texts whose interpretation has been problematic to date.