Laser-driven plasma accelerators can produce high-energy, high peak current ion beams by irradiating solid materials with ultra-intense laser pulses. This innovative concept attracts a lot of attention for various multidisciplinary applications as a compact and energy-efficient alternative to conventional accelerators. The maturation of plasma accelerators from complex physics experiments to turnkey particle sources for practical applications necessitates breakthroughs in the generated beam parameters, their robustness and scalability to higher repetition rates and efficiencies. This thesis investigates viable optimisation strategies for enhancing ion acceleration from thin foil targets in ultra-intense laser-plasma interactions. The influence of the detailed laser pulse parameters on plasma-based ion acceleration has been systematically investigated in a series of experiments carried out on two state-of-the-art high-power laser systems. A central aspect of this work is the establishment and integration of laser diagnostics and operational techniques to advance control of the interaction conditions for maximum acceleration performance. Meticulous efforts in continuously monitoring and enhancing the temporal intensity contrast of the laser system, enabled to optimise ion acceleration in two different regimes, each offering unique perspectives for applications. Using the widely established target-normal sheath acceleration (TNSA) scheme and adjusting the temporal shape of the laser pulse accordingly, proton energies up to 70 MeV were reliably obtained over many months of operation. Asymmetric laser pulses, deviating significantly from the standard conditions of an ideally compressed pulse, resulted in the highest particle numbers and an average energy gain ≥ 37 %. This beam quality enhancement is demonstrated across a broad range of parameters, including thickness and material of the target, laser energy and temporal intensity contrast. To overcome the energy scaling limitations of TNSA, the second part of the thesis focuses on an advanced acceleration scheme occurring in the relativistically induced transparency (RIT) regime. The combination of thin foil targets with precisely matched temporal contrast conditions of the laser enabled a transition of the initially opaque targets to transparency upon main pulse arrival. Laser-driven proton acceleration to a record energy of 150 MeV is experimentally demonstrated using only 22 J of laser energy on target. The low-divergent high-energy component of the accelerated beam is spatially and spectrally well separated from a lower energetic TNSA component. Start-to-end simulations validate these results and elucidate the role of preceding laser light in pre-expanding the target along with the detailed acceleration dynamics during the main pulse interaction. The ultrashort pulse duration of the laser facilitates a rapid succession of multiple known acceleration regimes to cascade efficiently at the onset of RIT, leading to the observed beam parameters and enabling ion acceleration to unprecedented energies. The discussed acceleration scheme was successfully replicated at two different laser facilities and for different temporal contrast levels. The results demonstrate the robustness of this scenario and that the optimum target thickness decreases with improved laser contrast due to reduced pre-expansion. Target transparency was found to identify the best-performance shots within the acquired data sets, making it a suitable feedback parameter for automated laser and target optimisation to enhance stability of plasma accelerators in the future. Overall, the obtained results and described optimisation strategies of this thesis may become the guiding step for the further development of laser-driven ion accelerators.:1 Introduction 1.1 Motivation 1.2 Thesis outline 2 Fundamentals of laser-matter interactions 2.1 Plasma 2.1.1 Plasma properties 2.1.2 Dispersion relation of a plasma 2.1.3 Laser propagation in a plasma 2.2 Laser-matter interactions 2.2.1 Ionisation processes 2.2.2 Electron dynamics in the laser field 2.2.3 Ponderomotive force 2.2.4 Plasma heating processes 2.3 Laser-driven ion acceleration mechanisms 2.3.1 Target normal sheath acceleration 2.3.2 Radiation pressure acceleration 2.3.3 Acceleration in the relativistically induced transparency regime 3 Methodology for high-power laser experiments 3.1 High-power lasers 3.1.1 High-power laser techniques 3.1.2 Temporal contrast of high-power laser systems 3.1.3 DRACO laser system 3.1.4 J-KAREN-P laser system 3.2 Experimental Area 3.2.1 Short-f chamber at HZDR 3.2.2 Short-f chamber at KPSI 3.3 Targets 3.4 Optical diagnostic 3.4.1 Transmitted and reflected laser light 3.4.2 Spectral phase measurements 3.5 Particle diagnostic 3.5.1 Thomson parabola spectrometer 3.5.2 Time of flight measurements 3.5.3 Spatial proton beam profiler 3.5.4 Radiochromic films 3.5.5 Nuclear activation measurements 4 Optimisation of sheath acceleration for high-quality proton beams 4.1 Introduction 4.2 Temporal contrast at experimental environment 4.3 Plasma mirror 4.3.1 Plasma mirror implementation at DRACO-PW 4.3.2 Plasma mirror characterisation at DRACO-PW 4.4 Temporal pulse shaping by spectral phase modification 4.4.1 Theory on temporal pulse shaping 4.4.2 Experimental realisation and results 4.5 Proton acceleration under optimised temporal contrast conditions 4.6 Experimental results 4.7 Discussion on numerical simulations 4.8 Conclusions 5 Enhanced ion acceleration in the relativistic transparency regime 5.1 Introduction 5.2 Experimental setup using the J-KAREN-P laser 5.3 Experimental results 5.4 Laser-induced breakdown and target pre-expansion 5.5 Elucidating ion acceleration in the relativistically induced transparency regime 5.5.1 Details on simulation methodology 5.5.2 Simulation results 5.6 Acceleration in the RIT regime for modified temporal contrast 5.6.1 Experimental setup using the DRACO-PW laser 5.6.2 Experimental results using the DRACO-PW laser 5.6.3 Simulation results for modified temporal contrast 5.7 Conclusions 6 Ion acceleration beyond the 100 MeV frontier from cascading acceleration schemes 6.1 Introduction 6.2 Experimental setup 6.3 Experimental results 6.3.1 Analysis of acceleration performance 6.3.2 Spatial proton beam profile 6.3.3 Nuclear activation measurement 6.3.4 Scaling of maximum proton energy 6.4 Numerical simulations 6.4.1 Simulation setup 6.4.2 Simulation results & discussion 6.5 Conclusions 7 Summary and outlook Appendix References

Accurate single-shot visualization of laser wakefield structures can improve our fundamental understanding of plasma-based accelerators. Previously, frequency domain holography (FDH) was used to visualize weakly nonlinear sinusoidal wakes in plasmas of density n[subscript e] < 0.6 × 10¹⁹/cm³ that produced few or no relativistic electrons. Here, I address the more challenging task of visualizing highly nonlinear wakes in plasmas of density n[subscript e] ~ 1 to 3× 10¹⁹/cm³ that can produce high-quality relativistic electron beams. Nonlinear wakes were driven by 30 TW, 30 fs, 800 nm pump pulses. When bubbles formed, part of a 400 nm, co-propagating, overlapping probe pulse became trapped inside them, creating a light packet of plasma wavelength dimensions--that is, an optical "bullet"--that I reconstruct by FDH methods. As ne increased, the bullets first appeared at 0.8 × 10¹⁹/cm³, the first observation of bubble formation below the electron capture threshold. WAKE simulations confirmed bubble formation without electron capture and the trapping of optical bullets at this density. At n[subscript] >1× 10¹⁹/cm³, bullets appeared with high shot-to-shot stability together with quasi-monoenergetic relativistic electrons. I also directly observed the temporal walk-off of the optical bullet from the beam-loaded plasma bubble revealed by FDH phase shift data, providing unprecedented visualization of the electron injection and beam loading processes. There are five chapters in this thesis. Chapter 1 introduces general laser plasma- based accelerators (LPA). Chapter 2 discusses the FDH imaging technique, including the setup and reconstruction process. In 2006, Dr. N. H. Matlis used FDH to image a linear plasma wakefield. His work is also presented in Chapter 2 but with new analyses. Chapter 3, the main part of the thesis, discusses the visualization of LPAs in the bubble regime. Chapter 4 presents the concept of frequency domain tomography. Chapter 5 suggests future directions for research in FDH. / text

Ultra-high dose rate proton radiation has the potential to improve cancer treatment by reducing the normal tissue complication probability and, at the same time, reaching the tumor control probability known from conventional photon radiation therapy. Here, the ultra-high dose rate leads to normal tissue sparing via the FLASH effect. Before a clinical implementation is possible, the proton FLASH effect requires translational research via in-vivo irradiation studies with small animals. Laser plasma-based accelerators (LPAs) for protons offer unique opportunities for studying the proton FLASH effect, since the proton dose rate at LAPs is in the order of 10^9 Gy/s, which is unreached at conventional medical proton accelerators. Different to medical proton accelerators, LPAs are operated in a pulsed mode and feature a lower beam stability caused by inherent pulse-to-pulse fluctuations of the acceleration process. To ensure successful in-vivo irradiation studies, advanced beam delivery, monitoring and dosimetry concepts for an online-monitored application of the 3D dose distribution in the target volume (TV) of the in-vivo sample are needed. The detectors and dosimetric concept developed in this thesis enable the world wide frst pilot radiobiological in-vivo study with LPA protons, where mouse ear tumors are irradiated with ultra-high dose rate proton pulses. For performing the radiobiological study, the ALBUS-2S (Advanced Laser-driven Beamlines for User-specifc Studies - 2 Solenoids) beamline is used, which is installed at the compact petawatt (PW) laser system DRACO (Dresden laser acceleration source) at HZDR (Helmholtz-Zentrum Dresden-Rossendorf). In this thesis, a scintillator-based time-of-fight (ToF) beam monitoring sytem (BMS) is developed, which records single-pulse proton energy spectra in transmission at the ALBUS-2S beamline. A relative energy uncertainty of 5.5 % (1σ) is reached for the ToF BMS, allowing for a Monte Carlo simulation-based prediction of depth dose profiles at the irradiation site. The ToF BMS is used for characterization of the ALBUS-2S LPA beamline for application-oriented parameters, in order to qualify the LPA proton source for radiobiological in-vivo studies. Furthermore, a dosimetry and beam monitoring concept for in-vivo irradiations of small target volumes with LPA protons is presented in this thesis. With the overall relative dose uncertainty of 7.4 % (2σ) for the specifc mouse ear tumor irradiation scenario, the concept enables verifcation of accurate volumetric dose delivery to the mm-scale TVs. In addition, tomography-based approaches with scintillators are investigated as detectors for online 3D dose measurement at LPAs. The miniature scintillator dosimeter (miniSCIDOM) detector, which is developed in the scope of this thesis, is used for online 3D dose measurements in 1 cm^3 volumes with < 1 mm^3 resolution at the irradiation site of the ALBUS-2S beamline. For online 3D dose measurements directly behind the LPA proton source of the DRACO PW laser system, the optical cone beam tomograph for proton online dosimetry (OCTOPOD) detector is developed. The OCTOPOD detector has a sensitive volume of 5 cm-diameter and water equivalent thickness of 4.3 cm, which is sufficient to stop 70 MeV protons. It is designed to reach a spatial resolution of 1 mm^3. The detectors developed in this thesis are optimized tools for source-to-sample characterization of LPA beamlines and hence are an essential contribution for radiobiological in-vivo studies with LPA protons.