Gintaras Žaržojus Polio laikomosios gebos vertinimai Lietuvos gruntuose SANTRAUKA Šiame darbe yra išnagrinėti tokie uždaviniai: 1. šiuolaikinių polio laikomosios gebos vertinimo metodų apžvalga; 2. Lietuvos kvartero nuogulos kaip polinių pamatų pagrindas; 3. vibromonolitinio polio ir pagrindo sąveikos I ribinėje būklėje fizinio modelio sudarymas. Pirmojo uždavinio sprendimui buvo trumpai išnagrinėta Europos šalių polio laikomosios gebos skaičiavimų metodikos, kurias butų galima suskirstyti į tris grupes:  skaičiavimas pagal polių bandymų metu gautus duomenis;  skaičiavimas pagal laboratorinių tyrimų metu gautus duomenis;  skaičiavimas naudojant įvairių in-sitų atliktų zondavimų duomenis. Antrajam uždaviniui išspręsti buvo sudarytas polio pagrindo laikomosios gebos vidurkinių verčių žemėlapis (M 1:1500 000). Šis žemėlapis yra sudarytas pagal pasirinktą polio modelį ir skaičiavimo metodiką (EN 1997-3). Trečiajam uždaviniui išspręsti buvo atlikti penki lauko bandymai ir išanalizuoti kai kurie šiuolaikiniai grunto ir polio santykio modeliai. Pagrindinės šio darbo išvados būtų šios: 1. polio laikomosios gebos skaičiavimo metodai įvairiose šalyse yra skirtingi dėl savitų geologinių sąlygų, dėl tyrėjų (inžinierių) subjektyvumo. Dėl metodų nesutapimo yra gaunami skirtingi to paties polio galutiniai skaičiavimo rezultatai; 2. didžiausią Lietuvos teritorijos dalį sudaro vidutinio stiprumo ir stiprūs gruntai kaip polių pagrindai; 3. pagal sudarytą hipotetinį... [toliau žr. visą tekstą] / Gintaras Žaržojus ESTIMATION FOR PILES BEARING CAPACITY IN LITHUANIAN SOILS SUMMARY In this work such tasks are analyzed: 1. Review of up-to-date pile bearing capacity estimation methods; 2. Lithuanian quaternary sediments as the base for pile foundation; 3. The creation of physical model of the vibromonolithic pile and foundation interaction while in the I marginal state. For the solution of the first task, the calculation methodology of the pile bearing capacity of the European countries’ was briefly analyzed, and it can be divided into three groups: » calculation according to the data received during pile testing; » calculation according to the data received during laboratory analysis; » calculation using the data of the various probing completed in-situ. For the solution of the second task, the map of the pile base bearing capacity average values was designed (M 1:1500 000). This map is designed according to the chosen pile model and calculation methodology (EN 1997-3). For the solution of the third task the five outdoor tests were performed and the some of the up-to-date soil and pile ratio models were analyzed. The main conclusions would be: 1. The pile bearing capacity calculation methods are different in various countries, because of the individual geological conditions and because of the subjectivity of the researchers (engineers). Due to the method discrepancy, final calculation results for the same pile are different; 2. The biggest part of the Lithuanian territory... [to full text]

Despite the existence of effective vaccines for both diseases, measles and poliomyelitis still cause significant worldwide morbidity and mortality. The live-attenuated measles and inactivated polio vaccines are both given using a standard needle and syringe injection. This method of delivery poses many problems for large-scale vaccination campaigns. Microneedles are micron-scale needles which have the potential to overcome many of these hurdles. In the first study, we showed that the measles vaccine could be successfully incorporated into a solid, metal microneedle system which induced potent neutralizing antibody titers after administration into cotton rats. This response was statistically identical to the same dose delivered using a subcutaneous injection. The second study focused on enhancing the stability of the measles vaccine after drying and long-term storage. Using a new assay developed from a measles virus variant engineered to encode for green fluorescent protein, it was determined that a combination of sucrose and threonine provided the highest stabilizing effect. Vaccine mixed with this solution retained more than 90% of its activity after 6 months of storage at 4°C and 25°C. The third study involved the incorporation of the measles vaccine into a dissolving microneedle patch. These patches were used to vaccinate rhesus macaques and the immune response was found to be statistically identical to the same dose delivered by syringe injection. Furthermore, after creation and storage, these patches retained 100% of their infectivity after 2 months at 4°C and 25°C. The final study attempted to create a dissolving microneedle patch containing a full dose of the inactivated polio vaccine. These patches were then used to deliver a full dose of IPV into the skin of a rhesus macaque. This delivery method produced neutralizing antibody titers to IPV type 1 and 2 that were statistically identical to the same dose delivered using a needle and syringe. Overall, these studies show that the microneedle patch was a safe, simple and effective method for measles and polio vaccination. This delivery platform has the potential to overcome many of the hurdles that currently stand in the way of measles elimination and polio eradication.

No description available.

No description available.

No description available.

Diss. Umeå : Univ., 2004.

The invention of the vaccine has been one of the greatest public health triumphs of the modern world. Each new vaccine has saved thousands - even millions - of lives worldwide, but this success has been fraught with controversy over the safety and even the effectiveness of vaccines. Vaccines have not always had a spotless safety record, but today’s vaccines are incredibly safe and continue to protect millions of people against diseases that have significantly declined or nearly disappeared from the developing world. It is this very success that has led many people to forget, or never discover, what those diseases are and how destructive they can be. This report tells the story of several families whose lives were deeply affected by vaccine-preventable diseases, accompanied with images that help tell their story. Following these stories is a broader discussion of the issues related to vaccines, the misunderstandings and misinformation that often circulate about them, a brief mention of their safety and efficacy, and a general discussion of many of the diseases they can prevent. / text

How it is a consequence of that title, this extended essay deals with problems of people suffering from poliomyelitis (infantile paralysis). Thanks to the systematic vaccination, this disease has not been found in the Czech Republik since the 1960s. The people who had got over paralysis after acute poliomyelitis in a successful way were feeling sureness for years. The return of the illness, respectively its late consequences after a few decades of a normal life means a change-over from the state of full or - as the case may be {--} only mildly reduced abilities to the state of lifelong invalidity for them. Handicapped people have to get over great numbers of obstructions and limits which arise partly from the existence of hte certain handicap and which are given by the handicaps {--} limits the organization of the society put in their way in the course of ist development in parts. Over recent years, the Czech Rebublik has ranged with the countries which realize a greater responsibility for the elimination of barriers keeping the handicapped citizens away from a full - value participation in the life of the society. The aim of the essay was to obtain a comprehensive view of possibilities of keeping social needs of people suffering from poliomyelitis {--} infantile paralysis and to evaluate the barriers which have to be got over by that group. It was also a very important thing to find the quality of life and satisfaction with a realization of aims of life as far as people suffering from poliomyelitis and to compare it with the quality of life as regards the current population. Three following hypotheses were set in line with this aim. Hypothesis No 1: In spite of the current legislation concerning the elimination of architectonic barriers, the handicapped people are limited in the participation in the public life. Hypothesis No 2: Considering the dependence on the other person´ s aid, the people suffering from postpoliomyelitis syndrome appreciate financial guarantees ensuing from the social service law in a high degree. Hypothesis No 3: The quality of life of people suffering from poliomyelitis is reduced, in comparison with the quality of life as far as healthy people. Hypothese 1 and 2 were confirmed by my research, hypothesis No 3 was not verified. The detailed analysis of the given hypotheses is included in the part of discussion in the extended essay. With respect to the relevance of the mentioned topic I suppose that the obtained results could be a contribution to the organizacions dealing with questions if the handicapped people . The essay can be presented at a public meeting of Assotiatin Polio various specialists and the lay public take part in.

This dissertation examines the broad social impacts of the multiple polio epidemics that occurred in Manitoba between 1928 and 1953, a period I refer to as the epidemic era. It argues that examining the six major polio epidemics as an era, and the disabilities it engendered are useful windows into twentieth-century social history, particularly in terms of the capacities and limits of the state to control and manage disease, illness, and health, and the myriad ways the family negotiated discourses about disability and the intersections of disability and gender. It also examines the changes to nurses’ labour during the epidemic era, particularly in terms of the introduction of two new technologies of care – respirators and the Kenny method – both of which led to nursing shortages in the later epidemic, exposing the lingering gendered conceptions about women and voluntary nursing. This project also considers the post-war development of rehabilitation programs, and argues that they worked to discursively transform people with an illness into people with disabilities, in need of reformation in order to become useful, contributing citizens. Finally, this dissertation examines the impact of polio-related disabilities on the lived experiences of a number of Manitobans, and argues that while polio and ideologies about disability worked to shape their lives in many ways, these were not the only forces to impact people’s lives and that people with polio-related disabilities negotiated the quotidian aspects of life much like anyone else. Polio tested, but did not break, the bonds of family. This dissertation draws on a variety of sources, including oral histories, the records of social welfare organizations, hospital records and annual reports, newspapers, and other public records. By exploring the broad social impact of polio, this dissertation adds to a number of literatures and works to bring the history of disability and people with disabilities out of the margins and into the mainstream of Canadian social history.

This dissertation examines the broad social impacts of the multiple polio epidemics that occurred in Manitoba between 1928 and 1953, a period I refer to as the epidemic era. It argues that examining the six major polio epidemics as an era, and the disabilities it engendered are useful windows into twentieth-century social history, particularly in terms of the capacities and limits of the state to control and manage disease, illness, and health, and the myriad ways the family negotiated discourses about disability and the intersections of disability and gender. It also examines the changes to nurses’ labour during the epidemic era, particularly in terms of the introduction of two new technologies of care – respirators and the Kenny method – both of which led to nursing shortages in the later epidemic, exposing the lingering gendered conceptions about women and voluntary nursing. This project also considers the post-war development of rehabilitation programs, and argues that they worked to discursively transform people with an illness into people with disabilities, in need of reformation in order to become useful, contributing citizens. Finally, this dissertation examines the impact of polio-related disabilities on the lived experiences of a number of Manitobans, and argues that while polio and ideologies about disability worked to shape their lives in many ways, these were not the only forces to impact people’s lives and that people with polio-related disabilities negotiated the quotidian aspects of life much like anyone else. Polio tested, but did not break, the bonds of family. This dissertation draws on a variety of sources, including oral histories, the records of social welfare organizations, hospital records and annual reports, newspapers, and other public records. By exploring the broad social impact of polio, this dissertation adds to a number of literatures and works to bring the history of disability and people with disabilities out of the margins and into the mainstream of Canadian social history.