Diss. (sammanfattning) Umeå : Umeå universitet, 2008. / På titelsidan felaktigt: "... amylodosis" Härtill 4 uppsatser.

Diss. (sammanfattning) Umeå : Univ., 2004. / Härtill 3 uppsatser.

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

Avui en dia, els clínics no disposen de cap marcador tumoral eficaç per a realitzar el seguiment de pacients amb càncers de cap i coll (CCC). Objectius: Analitzar les característiques operatives de la prealbúmina (PRB) com a marcador d’activitat tumoral a pacients amb CCC en comparació amb altres marcadors utilitzats habitualment a pràctica clínica. Métodes: Es va dissenyar un estudi observacional prospectiu amb pacients atesos a l’ Hospital Universitari Arnau de Vilanova de Lleida amb diagnòstic principal de CCC. Durant el temps a estudi es varen recollir les principals característiques demogràfiques, clíniques i analítiques (inclosa la PRB) dels malalts a 3 fases diferents: al diagnòstic de la malaltia, al finalitzar el tractament i 12 mesos després. Resultats: Es van realitzar 174 determinacions de 138 pacients des de l’1 de gener del 2007 fins l’1 de febrer del 2010, l’edat mitja fou de 62,48(29-89) anys i 121 (88%) eren homes. Els diagnòstics histològics foren majoritàriament carcinomes escamosos 87 (63%).La mortalitat acumulada fou de 14,5% durant el període de seguiment. La sensibilitat, especificitat, així com els valors predictius positiu i negatiu foren 63,2%, 100%, 87% y 100% respectivament per a identificar activitat tumoral. Es va obtenir un àrea sota la curva ROC per a la PRB de 0,82 (interval de confiança de 0,74 a 0,90) que va ser superior a altres variables analitzades. Conclusions: La PRB és eficaç per a identificar activitat tumoral a pacients amb CCC i podria constituir una eina útil per a el clínic al seguiment de dits pacients. / Actualmente los clínicos no disponen de un marcador tumoral eficaz para realizar el seguimento de pacientes con cáncer de cabeza y cuello (CCC). Objetivos: Analizar las características operativas de la prealbúmina(PRB) como marcador de actividad tumoral en pacientes con CCC en comparación con otros marcadores habitualmente utilizados en la práctica clínica. Métodos: Se diseñó un estudio observacional prospectivo en pacientes atendidos en el Hospital Universitario Arnau de Vilanova de Lleida con diagnóstico principal de CCC. Durante el tiempo en estudio se recogieron las principales características demográficas, clínicas y analíticas (incluida la PRB) de los enfermos en 3 fases diferentes: al diagnóstico de la enfermedad, al finalizar el tratamiento y 12 meses después. Resultados. Se realizaron 174 determinaciones en 138 pacientes con CCC desde el 1 de enero del 2007 hasta el 1 de febrero del 2010. La edad media fue de 62,4 (29-89) años y 121 (88%) eran varones. El tipo histológico más frecuente fue el carcinoma escamoso (63%). La mortalidad acumulada fue del 14,5%. La sensibilidad, especificidad así como los valores predictivos positivo y negativo de la PRB para identificar actividad tumoral fue del 63,2%, 100%, 87% y 100%, respectivamente. Se obtuvo un área bajo la curva ROC para la PRB de 0,82 (IC 95%, 0,74 - 0,90), que fue superior a otras variables analizadas. Conclusiones: PRB es eficaz para identificar actividad tumoral en pacientes con CCC y podría constituir una herramienta útil para el clínico en el seguimiento de éstos enfermos. / Nowadays clinicians don’t have a useful tumoral marker to perform the follow up of patients affected of head and neck cancers (H&NC). Objectives: To Analize the operative characteristics of prealbumin (PRB) as a tumoral activity marker in those affected of head and neck cancer compared to other tumoral markers with common use in clinical practice. Methods: It was performed an observational prospective study with patiens visited in Hospital Universitari Arnau de Vilanova de Lleida with the main diagnosis of H&NC. During study time main epidemiological, clinical and analytical (including PRB) characteristics were collected in 3 times: at diagnosis, after finishing the treatment and 12 months later. Results: 174 blood samples were obertained from 138 patients from the 1st January 2007 till the 1st February 2010. Mean age was 62,48 (29-89) years and 121 (88%) were males. Most frequent histological diagnosis was scamous carcinoma 87 cases (63%). 19 patients (14,5) died during that time. Sensitivity, Specificity, positive and negative predictive values were 63,2%, 100%, 100%, 87% respectively. The area under the curve ROC was 0,82 (CI 0,74-0,90), that was better than other parameters studied. Conclussions: Prealbumin is a useful tumoral activity marker in those affected of head and neck cancer and It could be a useful tool in these patients follow up

Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 196-228).

The purpose of this research was to evaluate whether serum prealbumin levels would serve as a predictor of hospital length of stay for elderly orthopedic patients who underwent hip replacement surgery. The study consisted of a set of 54 patients admitted to a hospital in Bristol, Tennessee. Patients with depleted prealbumin levels, low to low/normal prealbumin levels, or normal prealbumin levels were analyzed. Data collected from a retrospective chart review included: age, length of stay, serum glucose, sodium, potassium, hematocrit, hemoglobin, BUN, creatinine, WBC, prealbumin, and post operative diet consumption. Data were analyzed using analysis of variance for treatment effects. Because of the limited size of the data set, probabilities approaching p<0.10 were considered and levels of p<0.05 were considered significant. The research failed to show a significant relationship between prealbumin levels at admission and length of patient stay during post-operative recovery.

No description available.

Objetivos: O objetivo do presente estudo foi avaliar a dosagem da transferrina e pré-albumina séricas como marcadoras da resposta ao suporte nutricional em pacientes com câncer de esôfago. Métodos: Estudo clínico não-controlado com 45 pacientes internados com câncer de esôfago submetidos ao suporte nutricional antes de iniciar a terapia oncológica. De acordo com o estado nutricional, os pacientes receberam dieta por sonda nasoentérica, via oral ou combinada (via oral e sonda nasoentérica). O gasto energético basal foi estimado pela equação de Harris-Benedict. Pré-albumina e transferrina séricas foram dosadas antes e após o suporte nutricional. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do tempo de suporte nutricional foi de quatorze dias (±4,72). Houve aumento significativo dos níveis séricos de transferrina (p<0,001) e pré-albumina (p=0,002) após suporte nutricional. Aumento dos níveis de transferrina esteve associado com ingestão calórica (p=0,034), ao contrário dos níveis de préalbumina (p=0,864). Não houve relação estatisticamente significativa entre a ingestão de proteína com a variação dos níveis de transferrina (p=0,243) e préalbumina (p=0,913) do pré para o pós-suporte nutricional. Perda de peso na internação se correlacionou significativamente com os níveis de pré-albumina (- 0,545;p<0,001) e transferrina (r=-0,347;p=0,021). Houve associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o póssuporte nutricional (r=0,568; p<0,001). Conclusões: Houve um aumento significativo dos níveis séricos de préalbumina e transferrina após o suporte nutricional. Foi encontrada uma associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o pós-suporte nutricional. / Objectives: This study evaluated serum transferrin and prealbumin levels as markers of response to nutritional support in patients with esophageal cancer. Methods: Clinical, uncontrolled study with 45 hospitalized patients with esophageal cancer who received preoperative nutritional support. According to their nutritional status, patients received nasoenteric tube feeding, an oral diet, or a combined diet (oral and nasoenteric tube feeding. Resting energy expenditure were calculated using the Harris-Benedict equation. Serum prealbumin and transferrin levels were measured before and after nutritional support. P< 0.05 was considered statistically significant. Results: The mean nutritional support duration was 14 (±4.72) days. There was a significant increase in serum transferrin (P<0.001) and prealbumin (P=0.002) levels after nutritional support. The increase in transferrin levels (P=0.034), but not in prealbumin levels (P=0.861), was associated with calorie intake. There was no statistically significant difference between protein intake and variations in the levels of transferrin (P=0.243) and prealbumin (P=0.913) from pre- to post-nutritional support. Weight loss at admission was significantly associated with levels of prealbumin (r=- 0.545; P<0.001) and transferrin (r=-0.347; P=0.021). There was a statistically significant association between transferrin and prealbumin variations from pre- to post-nutritional support (r=0.568; P<0.001). Conclusions: There was a significant increase in serum transferrin and prealbumin levels after nutritional support. A significant association was found between serum transferrin and prealbumin variations.

Objetivos: O objetivo do presente estudo foi avaliar a dosagem da transferrina e pré-albumina séricas como marcadoras da resposta ao suporte nutricional em pacientes com câncer de esôfago. Métodos: Estudo clínico não-controlado com 45 pacientes internados com câncer de esôfago submetidos ao suporte nutricional antes de iniciar a terapia oncológica. De acordo com o estado nutricional, os pacientes receberam dieta por sonda nasoentérica, via oral ou combinada (via oral e sonda nasoentérica). O gasto energético basal foi estimado pela equação de Harris-Benedict. Pré-albumina e transferrina séricas foram dosadas antes e após o suporte nutricional. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do tempo de suporte nutricional foi de quatorze dias (±4,72). Houve aumento significativo dos níveis séricos de transferrina (p<0,001) e pré-albumina (p=0,002) após suporte nutricional. Aumento dos níveis de transferrina esteve associado com ingestão calórica (p=0,034), ao contrário dos níveis de préalbumina (p=0,864). Não houve relação estatisticamente significativa entre a ingestão de proteína com a variação dos níveis de transferrina (p=0,243) e préalbumina (p=0,913) do pré para o pós-suporte nutricional. Perda de peso na internação se correlacionou significativamente com os níveis de pré-albumina (- 0,545;p<0,001) e transferrina (r=-0,347;p=0,021). Houve associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o póssuporte nutricional (r=0,568; p<0,001). Conclusões: Houve um aumento significativo dos níveis séricos de préalbumina e transferrina após o suporte nutricional. Foi encontrada uma associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o pós-suporte nutricional. / Objectives: This study evaluated serum transferrin and prealbumin levels as markers of response to nutritional support in patients with esophageal cancer. Methods: Clinical, uncontrolled study with 45 hospitalized patients with esophageal cancer who received preoperative nutritional support. According to their nutritional status, patients received nasoenteric tube feeding, an oral diet, or a combined diet (oral and nasoenteric tube feeding. Resting energy expenditure were calculated using the Harris-Benedict equation. Serum prealbumin and transferrin levels were measured before and after nutritional support. P< 0.05 was considered statistically significant. Results: The mean nutritional support duration was 14 (±4.72) days. There was a significant increase in serum transferrin (P<0.001) and prealbumin (P=0.002) levels after nutritional support. The increase in transferrin levels (P=0.034), but not in prealbumin levels (P=0.861), was associated with calorie intake. There was no statistically significant difference between protein intake and variations in the levels of transferrin (P=0.243) and prealbumin (P=0.913) from pre- to post-nutritional support. Weight loss at admission was significantly associated with levels of prealbumin (r=- 0.545; P<0.001) and transferrin (r=-0.347; P=0.021). There was a statistically significant association between transferrin and prealbumin variations from pre- to post-nutritional support (r=0.568; P<0.001). Conclusions: There was a significant increase in serum transferrin and prealbumin levels after nutritional support. A significant association was found between serum transferrin and prealbumin variations.

Objetivos: O objetivo do presente estudo foi avaliar a dosagem da transferrina e pré-albumina séricas como marcadoras da resposta ao suporte nutricional em pacientes com câncer de esôfago. Métodos: Estudo clínico não-controlado com 45 pacientes internados com câncer de esôfago submetidos ao suporte nutricional antes de iniciar a terapia oncológica. De acordo com o estado nutricional, os pacientes receberam dieta por sonda nasoentérica, via oral ou combinada (via oral e sonda nasoentérica). O gasto energético basal foi estimado pela equação de Harris-Benedict. Pré-albumina e transferrina séricas foram dosadas antes e após o suporte nutricional. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do tempo de suporte nutricional foi de quatorze dias (±4,72). Houve aumento significativo dos níveis séricos de transferrina (p<0,001) e pré-albumina (p=0,002) após suporte nutricional. Aumento dos níveis de transferrina esteve associado com ingestão calórica (p=0,034), ao contrário dos níveis de préalbumina (p=0,864). Não houve relação estatisticamente significativa entre a ingestão de proteína com a variação dos níveis de transferrina (p=0,243) e préalbumina (p=0,913) do pré para o pós-suporte nutricional. Perda de peso na internação se correlacionou significativamente com os níveis de pré-albumina (- 0,545;p<0,001) e transferrina (r=-0,347;p=0,021). Houve associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o póssuporte nutricional (r=0,568; p<0,001). Conclusões: Houve um aumento significativo dos níveis séricos de préalbumina e transferrina após o suporte nutricional. Foi encontrada uma associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o pós-suporte nutricional. / Objectives: This study evaluated serum transferrin and prealbumin levels as markers of response to nutritional support in patients with esophageal cancer. Methods: Clinical, uncontrolled study with 45 hospitalized patients with esophageal cancer who received preoperative nutritional support. According to their nutritional status, patients received nasoenteric tube feeding, an oral diet, or a combined diet (oral and nasoenteric tube feeding. Resting energy expenditure were calculated using the Harris-Benedict equation. Serum prealbumin and transferrin levels were measured before and after nutritional support. P< 0.05 was considered statistically significant. Results: The mean nutritional support duration was 14 (±4.72) days. There was a significant increase in serum transferrin (P<0.001) and prealbumin (P=0.002) levels after nutritional support. The increase in transferrin levels (P=0.034), but not in prealbumin levels (P=0.861), was associated with calorie intake. There was no statistically significant difference between protein intake and variations in the levels of transferrin (P=0.243) and prealbumin (P=0.913) from pre- to post-nutritional support. Weight loss at admission was significantly associated with levels of prealbumin (r=- 0.545; P<0.001) and transferrin (r=-0.347; P=0.021). There was a statistically significant association between transferrin and prealbumin variations from pre- to post-nutritional support (r=0.568; P<0.001). Conclusions: There was a significant increase in serum transferrin and prealbumin levels after nutritional support. A significant association was found between serum transferrin and prealbumin variations.