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Ligonių, sergančių lėtiniu hepatitu c, ligos raiškos ypatumai, gydymo interferonu a–2b ir ribavirinu efekto įvertinimas ir požymių, lemiančių gydymo rezultatus, nustatymas / Peculiarities of patients with chronic hepatitis c, evaluation of the efficacy of interferon a-2b and ribavirin combination therapy and determination of the predicting factors of the treatment outcomesPetrenkienė, Vitalija 06 June 2005 (has links)
Abbreviations
ALT – alanine aminotransferase
AST – aspartate aminotransferase
BMI – body mass index
CHC – chronic hepatitis C
EBR – early biochemical response
EHR – early histological response
EIA – enzyme immunoassay
EVR – early virological response
HAI – hepatitis activity index
HCV – hepatitis C virus
HCV RNA - hepatitis C virus ribonucleic acid
Helicobacter spp. – Helicobacter species
H. pylory – Helicobacter pylori
IFN – interferon α-2b
PCR – polymerase chain reaction
PEG IFN – peginterferon
RBV – ribavirin
SVR – sustained virological response
SBR – Sustained biochemical response
INTRODUCTION
Chronic hepatitis due to hepatitis C virus (HCV) infection is a worldwide disease representing a serious public health problem. Chronic hepatitis C (CHC) infection affects nearly 170-200 million people worldwide. The prevalence of anti-HCV at this time in the general adult population of Lithuania is nearly 50 thousand (0.9%).
Without effective treatment strategies, hepatitis C - related morbidity and mortality is expected to increase nearly 3-fold by the year 2015. Current hepatitis C therapies are aimed at achieving eradication of HCV infection as a means of delaying progression to end-stage liver disease and preventing the development of hepatocellular carcinoma. The treatment options include interferon (IFN), ribavirin (RBV) and peg interferon’s a-2a and a-2b (PEG IFN). IFN-based regiments for the treatment of CHC have become increasingly effective and are to eradicate virus... [to full text]
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